Paolo Pinton Lab__Signal Transduction

 

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  1. Giorgi C, Agnoletto C, Baldini C, Bononi A, Bonora M, Marchi S, Missiroli S, Patergnani S, Poletti F, Rimessi A, Zavan B, Pinton P (2010) Redox control of Protein Kinase C: cell and disease
 specific significances. Antioxid Redox Signal 13(7):1051-85
  2. Bononi A, Agnoletto C, De Marchi E, Marchi S, Patergnani S, Bonora M, Giorgi C, Missiroli S, Poletti F, Rimessi A, Pinton P (2011) Protein kinases and phosphatases in the control of cell fate. Enzyme Res 2011:329098
  3. Patergnani S, Suski JM, Agnoletto C, Bononi A, Bonora M, De Marchi E, Giorgi C, Marchi S, Missiroli S, Poletti F, Rimessi A, Duszynski J, Wieckowski MR, Pinton P (2011) Calcium signaling around Mitochondria Associated Membranes (MAMs). Cell Commun Signal 9(1):19
  4. Marchi S, Giorgi C, Suski J, Agnoletto C, Bononi A, Bonora M, De Marchi E, Missiroli S, Patergnani S, Poletti F, Rimessi A, Duszynski J, Wieckowski MR, Pinton P (2012) Mitochondria-ROS crosstalk in the control of cell death and aging. J Signal Transduct 2012:329635
  5. Giorgi C, Agnoletto C, Bononi A, Bonora M, De Marchi E, Marchi S, Missiroli S, Patergnani S, Poletti F, Rimessi A, Suski JM, Wieckowski MR, Pinton P (2012) Mitochondrial calcium homeostasis as potential target for mitochondrial medicine. Mitochondrion 12:77-85
  6. Bononi A, Missiroli S, Poletti F, Suski JM, Agnoletto C, Bonora M, De Marchi E, Giorgi C, Marchi S, Patergnani S, Rimessi A, Wieckowski MR, Pinton P (2012) Mitochondria-associated membranes (MAMs) as hotspot Ca2+ signalling units. Adv Exp Med Biol 740:411-38
  7. Bonora M, Patergnani S, Rimessi A, De Marchi E, Suski JM, Bononi A, Giorgi C, Marchi S, Missiroli S, Poletti F, Wieckowski MR, Pinton P (2012) ATP synthesis and storage. Purinergic Signalling 8:343–357
  8. Giorgi C, Baldassari F, Bononi A, Bonora M, De Marchi E, Marchi S, Missiroli S, Patergnani S, Rimessi A, Suski JM, Wieckowski MR, Pinton P (2012) Mitochondrial Ca2+ and apoptosis. Cell Calcium 52:36-43
  9. Marchi S, Lupini L, Patergnani S, Rimessi A, Missiroli S, Bonora M, Bononi A, Corrà F, Giorgi C, De Marchi E, Poletti F, Gafà R, Lanza G, Negrini M, Rizzuto R, Pinton P (2013) Downregulation of the mitochondrial calcium uniporter by cancer-related miR-25. Current Biology 23:58-63
  10. Bononi A, Bonora M, Marchi S, Missiroli S, Poletti F, Giorgi C, Pandolfi PP, Pinton P (2013) Identification of PTEN at the ER and MAMs and its regulation of Ca2+ signaling and apoptosis in a protein phosphatase-dependent manner. Cell Death Diff 20:1631-43
  11. Gibellini L, Pinti M, Boraldi F, Giorgio V, Bernardi P, Bartolomeo R, Nasi M, De Biasi S, Missiroli S, Tesei A, Pinton P, Quaglino D, Cossarizza A (2014) Silencing of mitochondrial Lon protease deeply impairs mitochondrial proteome and function in colon cancer cells. FASEB J 0892-6638/14/0028-0001:1-14
  12. Giorgi C, Bonora M, Sorrentino G, Missiroli S, Poletti F, Suski JM, Ramirez FG, Rizzuto R, Di Virgilio F, Zito E, Pandolfi PP, Wieckowski MR, Mammano F, Del Sal G, Pinton P (2015) p53 at the endoplasmic reticulum regulates apoptosis in a Ca 2+ -dependent manner. Proc Natl Acad Sci USA 112(6):1779-84
  13. Giorgi C, Bonora M, Missiroli S, Poletti F, Ramirez FG, Morciano G, Morganti C, Pandolfi PP, Mammano F, Pinton P (2015) Intravital imaging reveals p53-dependent cancer cell death induced by phototherapy via calcium signaling. Oncotarget 6(3):1435-45
  14. Giorgi C, Missiroli S, Patergnani S, Duszyński J, Wieckowski MR, Pinton P (2015) Mitochondria-associated Membranes (MAMs): Composition, Molecular Mechanisms and Physiopathological Implications. Antioxid Redox Signal 22(12):995-1019
  15. Patergnani S, Giorgi C, Maniero S, Missiroli S, Maniscalco P, Bononi I, Martini F, Cavallesco G, Tognon M, Pinton P (2015) The endoplasmic reticulum mitochondrial calcium cross talk is downregulated in malignant pleural mesothelioma cells and plays a critical role in apoptosis inhibition. Oncotarget 6(27):23427-49
  16. Patergnani S, Missiroli S, Marchi S, Giorgi C (2015) Mitochondria-Associated Endoplasmic Reticulum Membranes Microenvironment: Targeting Autophagic and Apoptotic Pathways in Cancer Therapy. Front Oncol 5:173
  17. Marchi S, Corricelli M, Trapani E, Bravi L , Pittaro A, Delle Monache S, Ferroni L, Patergnani S, Missiroli S, Goitre L, Trabalzini L, Rimessi A, Giorgi C, Zavan B, Cassoni P, Dejana E , Retta SF, Pinton P (2015) Defective autophagy is a key feature of cerebral cavernous malformations. EMBO Mol Med 7(11):1403-17
  18. Missiroli S, Morganti C, Giorgi C, Pinton P (2016) Methods to Study PTEN in Mitochondria and Endoplasmic Reticulum. Methods in Molecular Biology 1388:187-212
  19. Giorgi C, Bonora M, Missiroli S, Morganti C, Morciano G, Wieckowski MR, Pinton P (2016) Alterations in mitochondrial and endoplasmic reticulum signaling by p53 mutants. Front Oncol 6:42
  20. Missiroli S, Bonora M, Patergnani S, Poletti F, Perrone M, Gafà R, Magri E, Raimondi A, Lanza G, Tacchetti C, Kroemer G, Pandolfi PP, Pinton P, Giorgi C (2016) PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development. Cell Rep 16(9):2415-27
  21. Patergnani S , Fossati V , Bonora M, Giorgi C, Marchi S , Missiroli S, Rusielewicz T, Wieckowski MR, Pinton P (2017) Mitochondria in multiple sclerosis: molecular mechanisms of pathogenesis. Int Rev Cell Mol Biol 328:49-103
  22. Missiroli S, Danese A, Iannitti T, Patergnani S, Perrone M, Previati M, Giorgi C, Pinton P (2017) Endoplasmic reticulum-mitochondria Ca2+ crosstalk in the control of the tumor cell fate. Biochim Biophys Acta (Molecular Cell Research) 1864:858-864
  23. Morciano G, Sarti A, Marchi S, Missiroli S, Falzoni S, Raffaghello L, Pistoia V, Giorgi C, Di Virgilio F, Pinton P (2017) Using luciferase probes to measure ATP in living cells and animals. Nat Protoc 12(8):1542-62
  24. Marchi S, Bittremieux M, Missiroli S, Morganti C, Patergnani S, Sbano L, Rimessi A, Kerkhofs M, Parys JB, Bultynck G, Giorgi C, Pinton P (2017) Endoplasmic Reticulum-Mitochondria Communication Through Ca2+ Signaling: The Importance of Mitochondria-Associated Membranes (MAMs). Adv Exp Med Biol 997:49-67
  25. Kuchay S, Giorgi C, Simoneschi D, Pagan J, Missiroli S, Saraf A, Florens L, Washburn MP, Collazo-Lorduy A, Castillo-Martin M, Cordon-Cardo C, Sebti SM, Pinton P, Pagano M (2017) PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth. Nature 546:554-558
  26. Missiroli S, Bonora M, Patergnani S, Giorgi C (2017) Novel function of the tumor suppressor PML at ER-mitochondria sites in the control of autophagy. Oncotarget 8(47):81723-81724
  27. Marchi S, Patergnani S, Missiroli S, Morciano G, Rimessi A, Wieckowski MR, Giorgi C, Pinton P (2018) Mitochondrial and Endoplasmic Reticulum Calcium Homeostasis and Cell Death. Cell Calcium 69:62-72
  28. Missiroli S, Patergnani S, Caroccia N, Pedriali G, Perrone M, Previati M, Wieckowski MR, Giorgi C (2018) Mitochondria-associated membranes (MAMs) and inflammation. Cell Death Dis 9(3):329
  29. Giorgi C, Danese A, Missiroli S, Patergnani S, Pinton P (2018) Calcium dynamics as a machine for decoding signals. Trends Cell Biol 28(4):258-273
  30. Morciano G, Preti D, Pedriali G, Aquila G, Missiroli S, Fantinati A, Caroccia N, Pacifico S, Bonora M, Talarico A, Morganti C, Rizzo P, Ferrari R, Wieckowski MR, Campo G, Giorgi C, Trapella C, Pinton P (2018) Discovery of novel 1,3,8-triazaspiro[4.5]decane derivatives that target the c subunit of F1/FO-adenosine triphosphate (ATP) synthase for the treatment of reperfusion damage in myocardial infarction. J Med Chem 61:7131-43
  31. Previati M, Missiroli S, Perrone M, Caroccia N, Paliotto F, Milani D, Giorgi C (2018) Functions and dys-functions of promyelocytic leukemia protein PML. Rendiconti Lincei 29(2):411-420
  32. Morganti C, Missiroli S, Lebiedzinska-Arciszewska M, Ferroni L, Morganti L, Perrone M, Ramaccini D, Occhionorelli S, Zavan B, Wieckowski MR, Giorgi C (2019) Regulation of PKCβ levels and autophagy by PML is essential for high-glucose-dependent mesenchymal stem cell adipogenesis. Int J Obes 43(5):963-973
  33. Pozzer D, Varone E, Chernorudskiy A, Schiarea S, Missiroli S, Giorgi C, Pinton P, Canato M, Germinario E, Nogara L, Blaauw B, Zito E (2019) A maladaptive ER stress response triggers dysfunction in highly active muscles of mice with SELENON loss. Redox Biology 20:354-366
  34. Marchi S, Corricelli M, Branchini A, Vitto VAM, Missiroli S, Morciano G, Perrone M, Ferrarese M, Giorgi C, Pinotti M, Galluzzi L, Kroemer G, Pinton P (2019) Akt-mediated phosphorylation of MICU1 regulates mitochondrial Ca2+ levels and tumor growth. EMBO J 38(2):e99435
  35. Perrone M, Caroccia N, Genovese I, Missiroli S, Modesti L, Pedriali G, Vezzani B, Vitto VAM, Antenori M, Lebiedzinska-Arciszewska M, Wieckowski MR, Giorgi C, Pinton P (2020) The role of mitochondria-associated membranes in cellular homeostasis and diseases. Int Rev Cell Mol Biol 350:119-196
  36. Missiroli S, Perrone M, Genovese I, Pinton P, Giorgi C (2020) Cancer metabolism and mitochondria: finding novel mechanisms to fight tumours. EBioMedicine 59:102943
  37. Fiorica F, Colella M, Taibi R, Bonetti A, Giuliani J, Perrone M, Missiroli S, Giorgi C (2020) Glioblastoma: Prognostic Factors and Predictive Response to Radio- And Chemotherapy. Curr Med Chem 27(17):2814-2825
  38. Missiroli S, Genovese I, Perrone M, Vezzani B, Vitto VAM, Giorgi C (2020) The Role of Mitochondria in Inflammation: From Cancer to Neurodegenerative Disorders. J Clin Med 9(3):740
  39. Filipe A, Chernorudskiy A, Arbogast S, Varone E, Villar-Quiles RN, Pozzer D, Moulin M, Fumagalli S, Cabet E, Dudhal S, De Simoni MG, Denis R, Vadrot N, Dill C, Giovarelli M, Szweda L, De Palma C, Pinton P, Giorgi C, Viscomi C, Clementi E, Missiroli S, Boncompagni S, Zito E, Ferreiro A (2021) Defective endoplasmic reticulum-mitochondria contacts and bioenergetics in SEPN1-related myopathy. Cell Death & Differentiation 28(1):123-138
  40. Sarti AC, Vultaggio-Poma V, Falzoni S, Missiroli S, Giuliani AL, Boldrini P, Bonora M, Faita F, Di Lascio N, Kusmic C, Solini A, Novello S, Morari M, Rossato M, Wieckowski MR, Giorgi C, Pinton P, Di Virgilio F (2021) Mitochondrial P2X7 Receptor Localization Modulates Energy Metabolism Enhancing Physical Performance. Function 2(2):zqab005
  41. Bonora M, Missiroli S, Perrone M, Fiorica F, Pinton P, Giorgi C (2021) Mitochondrial Control of Genomic Instability in Cancer. Cancers (Basel) 13(8):1914
  42. Missiroli S, Perrone M, Boncompagni C, Borghi C, Campagnaro A, Marchetti F, Anania G, Greco P, Fiorica F, Pinton P, Giorgi C (2021) Targeting the NLRP3 Inflammasome as a New Therapeutic Option for Overcoming Cancer. Cancers (Basel) 13(10):2297
  43. Fiorica F, Tebano U, Gabbani M, Perrone M, Missiroli S, Berretta M, Giuliani J, Bonetti A, Remo A, Pigozzi E, Tontini A, Napoli G, Luca N, Grigolato D, Pinton P, Giorgi C (2021) Beyond Abscopal Effect: A Meta-Analysis of Immune Checkpoint Inhibitors and Radiotherapy in Advanced Non-Small Cell Lung Cancer. Cancers (Basel) 13(10):2352
  44. Morciano G, Vezzani B, Missiroli S, Boncompagni C, Pinton P, Giorgi C (2021) An Updated Understanding of the Role of YAP in Driving Oncogenic Responses. Cancers 13:3100
  45. Silvagni E, Missiroli S, Perrone M, Patergnani S, Boncompagni C, Bortoluzzi A, Govoni M, Giorgi C, Alivernini S, Pinton P, Scirè CA (2021) From Bed to Bench and Back: TNF-α, IL-23/IL-17A, and JAK-Dependent Inflammation in the Pathogenesis of Psoriatic Synovitis. Front Pharmacol 12:672515
  46. Patergnani S, Missiroli S, Morciano G, Perrone M, Mantovani CM, Anania G, Fiorica F, Pinton P and Giorgi C (2021) Understanding the Role of Autophagy in Cancer Formation and Progression Is a Real Opportunity to Treat and Cure Human Cancers. Cancers 13(22), 5622
  47. Missiroli S, Giorgi  C, Pinton P. (2022) The LRRC8C-STING-p53 axis in T cells: A Ca 2+ affair. Cell Calcium 2022 May 13;105:102596
  48. De Ventura T, Perrone M, Missiroli S, Pinton P, Marchetti P, Strazzabosco G, Turrin G, Illuminati D, Cristofori V, Fantinati A, Fabbri M, Giorgi C, Trapella C, Zanirato V (2022) Synthesis and NLRP3-Inflammasome Inhibitory Activity of the Naturally Occurring Velutone F and of Its Non-Natural Regioisomeric Chalconoids. Int J Mol Sci
  49. Perrone M, Raimondi E, Costa M, Rasetto G, Rizzati R, Lanza G, Gafà R, Cavallesco G, Tamburini N, Maniscalco P, Mantovani MC, Tebano U, Coeli M, Missiroli S, Tilli M, Pinton P, Giorgi C, Fiorica F. Inflammatory Microenvironment in Early Non-Small Cell Lung Cancer: Exploring the Predictive Value of Radiomics. Cancers (Basel). 2022 Jul 8;14(14):3335
  50. Gabbani M, Giorgi C, Napoli G, Tebano U, Perrone MS, Missiroli S, Berretta M, Mandarà M, Zaninelli M, Luca N, Grigolato D, Muraro M, Rinaldi G, Pinton P, Fiorica F. Outcomes of Locally Advanced Rectal Cancer Patients Treated with Total Neoadjuvant Treatment: A Meta-Anaysis of Randomized Controlled Trials. Clin Colorectal Cancer. 2022 Sep 17:S1533-0028(22)00103-7
  51. Missiroli S, Perrone M, Gafà R, Nicoli F, Bonora M, Morciano G, Boncompagni C, Marchi S, Lebiedzinska-Arciszewska M, Vezzani B, Lanza G, Kricek F, Borghi A, Fiorica F, Ito K, Wieckowski MR, Di Virgilio F, Abelli L, Pinton P, Giorgi C. PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment. Cell Death Differ. 2022 Nov 30:1–13. doi: 10.1038/s41418-022-01095-9.
  52. Albanese V, Missiroli S, Perrone M, Fabbri M, Boncompagni C, Pacifico S, De Ventura T, Ciancetta A, Dondio G, Kricek F, Pinton P, Guerrini R, Preti D, Giorgi C. Novel Aryl Sulfonamide Derivatives as NLRP3 Inflammasome Inhibitors for the Potential Treatment of Cancer. J Med Chem. 2023 Mar 27.
  53. Silvagni E, Missiroli S, Patergnani S, Boncompagni C, D'Ugo C, Garaffoni C, Ciliento MS, Lanza G, Bonora M, Gafà R, Perrone M, Bortoluzzi A, Giorgi C, Govoni M, Scirè CA, Pinton P. Tofacitinib restores psoriatic arthritis fibroblast-like synoviocytes function via autophagy and mitochondrial quality control modulation. J Autoimmun. 2024 Feb;143:103159.
  54. Licini C, Morroni G, Lucarini G, Vitto VAM, Orlando F, Missiroli S, D'Achille G, Perrone M, Spadoni T, Graciotti L, Bigossi G, Provinciali M, Offidani A, Mattioli-Belmonte M, Cirioni O, Pinton P, Simonetti O, Marchi S. ER-mitochondria association negatively affects wound healing by regulating NLRP3 activation. Cell Death Dis. 2024 Jun 11;15(6):407.
  55. Raby A, Missiroli S, Sanatine P, Langui D, Pansiot J, Beaude N, Vezzana L, Saleh R, Marinello M, Laforge M, Pinton P, Buj-Bello A, Burgo A. Spastin regulates ER-mitochondrial contact sites and mitochondrial homeostasis. iScience. 2024 Aug 6;27(9):110683.
  56. Palumbo L, Carinci M, Guarino A, Asth L, Zucchini S, Missiroli S, Rimessi A, Pinton P, Giorgi C. The NLRP3 Inflammasome in Neurodegenerative Disorders: Insights from Epileptic Models. Biomedicines. 2023 Oct 18;11(10):2825.