Paolo Pinton Lab__Signal Transduction
Home – Lab members – Research – Lab facilities – Publications – Selected Publications — Lab funds – Map – Contacts & Information
- Pinton P, Rimessi A, Marchi S, Orsini F, Migliaccio E, Giorgio M, Contursi C, Minucci S, Mantovani F, Wieckowski MR, Del Sal G, Pelicci PG, Rizzuto R (2007) Protein Kinase C ß and Prolyl isomerase 1 regulate mitochondrial effects of the lifespan determinant p66Shc. Science 315: 659-63
- Romagnoli A, Aguiari P, De Stefani D, Leo S, Marchi S, Rimessi A, Zecchini E, Pinton P, Rizzuto R (2007) The ER/mitochondria Ca2+ crosstalk. Novartis Found Symp 287: 122-31
- Marchi S, Rimessi A, Giorgi C, Baldini C, Ferroni L, Rizzuto R, Pinton P (2008) Akt kinase reducing Endoplasmic Reticulum Ca2+ release protects cells from Ca2+-dependent apoptotic stimuli. Biochem Biophys Res Commun 375:501-5
- Rizzuto R, Marchi S, Bonora M, Aguiari P, Bononi A, De Stefani D, Giorgi C, Leo S, Rimessi A, Siviero R, Zecchini E, Pinton P (2009) Ca(2+) transfer from the ER to mitochondria: when, how and why. Biochim Biophys Acta 1787:1342-51
- Rimessi A, Marchi S, Fotino C, Romagnoli A, Huebner K, Croce CM, Pinton P, Rizzuto R (2009) Intramitochondrial calcium regulation by the FHIT gene product sensitizes to apoptosis. Proc Natl Acad Sci USA 106:12753-8
- Giorgi C, Agnoletto C, Baldini C, Bononi A, Bonora M, Marchi S, Missiroli S, Patergnani S, Poletti F, Rimessi A, Zavan B, Pinton P (2010) Redox control of Protein Kinase C: cell and disease specific significances. Antioxid Redox Signal 13(7):1051-85
- Goitre L, Balzac F, Degani S, Degan P, Marchi S, Pinton P, Retta SF (2010) KRIT1 Regulates the Homeostasis of Intracellular Reactive Oxygen Species. PLoS One 5(7):e11786
- Bononi A, Agnoletto C, De Marchi E, Marchi S, Patergnani S, Bonora M, Giorgi C, Missiroli S, Poletti F, Rimessi A, Pinton P (2011) Protein kinases and phosphatases in the control of cell fate. Enzyme Res 2011:329098
- Patergnani S, Suski JM, Agnoletto C, Bononi A, Bonora M, De Marchi E, Giorgi C, Marchi S, Missiroli S, Poletti F, Rimessi A, Duszynski J, Wieckowski MR, Pinton P (2011) Calcium signaling around Mitochondria Associated Membranes (MAMs). Cell Commun Signal 9(1):19
- Marchi S, Giorgi C, Suski J, Agnoletto C, Bononi A, Bonora M, De Marchi E, Missiroli S, Patergnani S, Poletti F, Rimessi A, Duszynski J, Wieckowski MR, Pinton P (2012) Mitochondria-ROS crosstalk in the control of cell death and aging. J Signal Transduct 2012:329635
- Giorgi C, Agnoletto C, Bononi A, Bonora M, De Marchi E, Marchi S, Missiroli S, Patergnani S, Poletti F, Rimessi A, Suski JM, Wieckowski MR, Pinton P (2012) Mitochondrial calcium homeostasis as potential target for mitochondrial medicine. Mitochondrion 12:77-85
- Bononi A, Missiroli S, Poletti F, Suski JM, Agnoletto C, Bonora M, De Marchi E, Giorgi C, Marchi S, Patergnani S, Rimessi A, Wieckowski MR, Pinton P (2012) Mitochondria-associated membranes (MAMs) as hotspot Ca2+ signalling units. Adv Exp Med Biol 740:411-38
- Marchi S, Marinello M, Bononi A, Bonora M, Giorgi C, Rimessi A, Pinton P (2012) Selective modulation of subtype III IP3R by Akt regulates ER Ca2+ release and apoptosis. Cell Death Dis 3:e304
- Bonora M, Patergnani S, Rimessi A, De Marchi E, Suski JM, Bononi A, Giorgi C, Marchi S, Missiroli S, Poletti F, Wieckowski MR, Pinton P (2012) ATP synthesis and storage. Purinergic Signalling 8:343–357
- Giorgi C, Baldassari F, Bononi A, Bonora M, De Marchi E, Marchi S, Missiroli S, Patergnani S, Rimessi A, Suski JM, Wieckowski MR, Pinton P (2012) Mitochondrial Ca2+ and apoptosis. Cell Calcium 52:36-43
- Marchi S, Lupini L, Patergnani S, Rimessi A, Missiroli S, Bonora M, Bononi A, Corrà F, Giorgi C, De Marchi E, Poletti F, Gafà R, Lanza G, Negrini M, Rizzuto R, Pinton P (2013) Downregulation of the mitochondrial calcium uniporter by cancer-related miR-25. Current Biology 23:58-63
- Bonora M, Bononi A, De Marchi E, Giorgi C, Lebiedzinska M, Marchi S, Patergnani S, Rimessi A, Suski JM, Wojtala A, Wieckowski MR, Kroemer G, Galluzzi L, Pinton P (2013) Role of the c subunit of the FO ATP synthase in mitochondrial permeability transition. Cell Cycle 12(4):674-683
- Marchi S, Pinton P (2013) Mitochondrial Calcium Uniporter, MiRNA and Cancer: Live and Let Die. Commun Integr Biol 6(3):e23818
- Bonora M, Giorgi C, Bononi A, Marchi S, Patergnani S, Rimessi A, Rizzuto R, Pinton P (2013) Subcellular calcium measurements in mammalian cells using jellyfish photoprotein aequorin-based probes. Nat Protoc 8(11):2105-18
- Patergnani S, Marchi S, Rimessi A, Bonora M, Giorgi C, Mehta KD, Pinton P (2013) PRKCB/protein kinase C β and the mitochondrial axis as key regulators of autophagy. Autophagy 9(9):1367-85
- Bononi A, Bonora M, Marchi S, Missiroli S, Poletti F, Giorgi C, Pandolfi PP, Pinton P (2013) Identification of PTEN at the ER and MAMs and its regulation of Ca2+ signaling and apoptosis in a protein phosphatase-dependent manner. Cell Death Diff 20:1631-43
- Rimessi A, Bonora M , Marchi S , Patergnani S, Marobbio CMT , Lasorsa FM, Pinton P (2013) Perturbed mitochondrial Ca2+ signals as causes or consequences of mitophagy induction. Autophagy 9(11):1677-86
- Marchi S, Patergnani S, Pinton P (2014) The endoplasmic reticulum-mitochondria connection: One touch, multiple functions. Biochim Biophys Acta (Bioenergetics) 1837:461-469
- Marchi S, Pinton P (2014) The mitochondrial calcium uniporter complex: molecular components, structure and physiopathological implications. J Physiol 592(Pt 5):829-39
- Rimessi A, Marchi S, Patergnani S, Pinton P (2014) H-Ras-driven tumoral maintenance is sustained through caveolin-1-dependent alterations in calcium signaling. Oncogene 33:2329-40
- Bonora M, De Marchi E, Patergnani S, Suski JM, Celsi F, Bononi A, Giorgi C, Marchi S, Rimessi A, Duszyński J, Pozzan T, Wieckowski MR, Pinton P (2014) Tumor necrosis factor-α impairs oligodendroglial differentiation through a mitochondria-dependent process. Cell Death Differ 21:1198–1208
- Marchi S, Pinton P (2014) Molecular characterization of the dominant negative role of cancer-associated PTEN mutants: sometimes null is better. Front Oncol 4(276):1-2
- Marchi S, Pinton P (2014) The RED light is on! New tools for monitoring Ca2+ dynamics in the endoplasmic reticulum and mitochondria. Biochem J 464:e5-e6
- Marchi S, Giorgi C, Oparka M, Duszynski J, Wieckowski MR, Pinton P (2014) Oncogenic and oncosuppressive signal transduction at mitochondria-associated endoplasmic reticulum membranes (MAM). Molecular & Cellular Oncology 1(2):e956469
- Rimessi A, Bezzerri V, Patergnani S, Marchi S, Cabrini G, Pinton P (2015) Mitochondrial Ca 2+-dependent NLRP3 activation exacerbates the Pseudomonas aeruginosa-driven inflammatory response in cystic fibrosis. Nat Commun 6:6201
- Patergnani S, Missiroli S, Marchi S, Giorgi C (2015) Mitochondria-Associated Endoplasmic Reticulum Membranes Microenvironment: Targeting Autophagic and Apoptotic Pathways in Cancer Therapy. Front Oncol 5:173
- Marchi S, Corricelli M, Trapani E, Bravi L , Pittaro A, Delle Monache S, Ferroni L, Patergnani S, Missiroli S, Goitre L, Trabalzini L, Rimessi A, Giorgi C, Zavan B, Cassoni P, Dejana E , Retta SF, Pinton P (2015) Defective autophagy is a key feature of cerebral cavernous malformations. EMBO Mol Med 7(11):1403-17
- Morciano G, Giorgi C, Balestra D, Marchi S, Perrone D, Pinotti M, Pinton P (2016) Mcl-1 involvement in mitochondrial dynamics is associated with apoptotic cell death. Mol Biol Cell 27(1):20-34
- Marchi S, Retta SF, Pinton P (2016) Cellular processes underlying cerebral cavernous malformations: Autophagy as another point of view. Autophagy 12(2):424-425
- Marchi S, Trapani E, Corricelli M, Goitre L, Pinton P, Retta SF (2016) Beyond Multiple Mechanisms and Unique Drugs: Defective Autophagy as Pivotal Player in Cerebral Cavernous Malformation Pathogenesis and Implications for Targeted Therapies. Rare Dis 4(1):e1142640
- Marchi S, Pinton P (2016) Alterations in calcium homeostasis in cancer cells. Curr Opin Pharmacol 29:1-6
- Patergnani S , Fossati V , Bonora M, Giorgi C, Marchi S, Missiroli S, Rusielewicz T, Wieckowski MR, Pinton P (2017) Mitochondria in multiple sclerosis: molecular mechanisms of pathogenesis. Int Rev Cell Mol Biol 328:49-103
- Sbano L, Bonora M , Marchi S , Baldassari F , Medina DL, Ballabio A , Giorgi C, Pinton P (2017) TFEB-mediated increase in peripheral lysosomes regulates store-operated calcium entry. Sci Rep 7:40797
- Marchi S, Bonora M, Patergnani S, Giorgi C, Pinton P (2017) Methods to Assess Mitochondrial Morphology in Mammalian Cells Mounting Autophagic or Mitophagic Responses. Methods Enzymol 588:171-186
- Morciano G, Sarti A, Marchi S, Missiroli S, Falzoni S, Raffaghello L, Pistoia V, Giorgi C, Di Virgilio F, Pinton P (2017) Using luciferase probes to measure ATP in living cells and animals. Nat Protoc 12(8):1542-62
- Marchi S, Bittremieux M, Missiroli S, Morganti C, Patergnani S, Sbano L, Rimessi A, Kerkhofs M, Parys JB, Bultynck G, Giorgi C, Pinton P (2017) Endoplasmic Reticulum-Mitochondria Communication Through Ca2+ Signaling: The Importance of Mitochondria-Associated Membranes (MAMs). Adv Exp Med Biol 997:49-67
- Kerkhofs M, Giorgi C, Marchi S, Seitaj B, Parys JB, Pinton P, Bultynck G, Bittremieux M (2017) Alterations in Ca2+ Signalling via ER-Mitochondria Contact Site Remodelling in Cancer. Adv Exp Med Biol 997:225-254
- Patergnani S , Castellazzi M , Bonora M , Marchi S , Casetta I, Pugliatti M , Giorgi C , Granieri E, Pinton P (2018) Autophagy and mitophagy elements are increased in body fluids of Multiple Sclerosis-affected individuals. J Neurol Neurosurg Psychiatry 89(4):439-441
- Marchi S, Patergnani S, Missiroli S, Morciano G, Rimessi A, Wieckowski MR, Giorgi C, Pinton P (2018) Mitochondrial and Endoplasmic Reticulum Calcium Homeostasis and Cell Death. Cell Calcium 69:62-72
- Tozzi A, Tantucci M, Marchi S, Mazzocchetti P, Morari M, Pinton P, Mancini A, Calabresi P (2018) Dopamine D2 receptor-mediated neuroprotection in a G2019S Lrrk2 genetic model of Parkinson’s disease. Cell Death Dis 9:204
- Giorgi C*, Marchi S*, Simoes ICM*, Ren Z*, Morciano G*, Perrone M, Patalas-Krawczyk P, Borchard S, Jędrak P, Pierzynowska K, Szymański J, Wang DQ, Portincasa P, Węgrzyn G, Zischka H, Dobrzyn P, Bonora M, Duszynski J, Rimessi A, Karkucinska-Wieckowska A, Dobrzyn A, Szabadkai G, Zavand B, Oliveira PJ, Sardao VA, Pinton P, Wieckowski MR (2018) Mitochondria and reactive oxygen species in aging and age related diseases. Int Rev Cell Mol Biol 340:209-344 *equally contributed
- Morciano G, Marchi S, Morganti C, Sbano L, Bittremieux M, Kerkhofs M, Corricelli M, Danese A, Karkucinska-Wieckowska A, Wieckowski MR, Bultynck G, Giorgi C, Pinton P (2018) Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific Settings. Neoplasia 20(5):510-523
- Pignani S, Todaro A, Ferrarese M, Marchi S, Lombardi S, Balestra D, Pinton P, Bernardi F, Pinotti M, Branchini A (2018)
The chaperone-like sodium phenylbutyrate improves factor IX intracellular trafficking and activity impaired by the frequent p.R294Q mutation. J Thromb Haemost 16:1-9 - Giorgi C*, Marchi S*, Pinton P (2018) The machineries, regulation and cellular functions of mitochondrial calcium. Nat Rev Mol Cell Biol 19(11):713-730 *equally contributed
- Valladares D, Utreras-Mendoza Y, Campos C, Morales C, Diaz-Vegas A, Contreras-Ferrat A, Westermeier F, Jaimovich E, Marchi S, Pinton P, Lavandero S (2018) IP3 receptor blockade restores autophagy and mitochondrial function in skeletal muscle fibers of dystrophic mice. Biochim Biophys Acta (Molecular Basis of Disease) 1864:3685-95
- D’Eletto M, Rossin F, Occhigrossi L, Farrace MG, Faccenda D, Desai R, Marchi S, Refolo G, Falasca L, Antonioli M, Ciccosanti F, Fimia GM, Pinton P, Campanella M, Piacentini M (2018) Transglutaminase Type 2 Regulates ER-Mitochondria Contact Sites by Interacting with GRP75. Cell Rep 25:3573-81
- Marchi S, Corricelli M, Branchini A, Vitto VAM, Missiroli S, Morciano G, Perrone M, Ferrarese M, Giorgi C, Pinotti M, Galluzzi L, Kroemer G, Pinton P (2019) Akt-mediated phosphorylation of MICU1 regulates mitochondrial Ca2+ levels and tumor growth. EMBO J 38(2):e99435
- Marchi S, Vitto VAM, Patergnani S, Pinton P (2019) High mitochondrial Ca2+ content increases cancer cell proliferation upon inhibition of mitochondrial permeability transition pore (mPTP). Cell Cycle 18(8):914-916
- Marchi S, Vitto VAM, Danese A, Wieckowski MR, Giorgi C, Pinton P (2019) Mitochondrial calcium uniporter complex modulation in cancerogenesis. Cell Cycle 18(10):1068-1083
- Vieceli Dalla Sega F, Mastrocola R, Aquila G, Fortini F, Fornelli C, Zotta A, Cento AS, Perrelli A, Boda E, Pannuti A, Marchi S, Pinton P, Ferrari R, Rizzo P, Retta SF (2019) KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction. Int J Mol Sci 20(19) pii: E4930
- Lombardi S, Ferrarese M, Marchi S, Pinton P, Pinotti M, Bernardi F, Branchini A (2020) Translational readthrough of GLA nonsense mutations suggests dominant-negative effects exerted by the interaction of wild-type and missense variants. RNA Biol 17(2):254-263
- Rimessi A, Pedriali G, Vezzani B, Tarocco A, Marchi S, Wieckowski MR, Giorgi C, Pinton P (2020) Interorganellar calcium signaling in the regulation of cell metabolism: A cancer perspective. Semin Cell Dev Biol 98:167-180
- Morciano G, Patergnani S, Bonora M, Pedriali G, Tarocco A, Bouhamida E, Marchi S, Ancora G, Anania G, Wieckowski MR, Giorgi C, Pinton P (2020) Mitophagy in cardiovascular diseases. J Clin Med 9:892
- Morganti C, Bonora M, Marchi S, Ferroni L, Gardin C, Wieckowski MR, Giorgi C, Pinton P, Zavan B (2020) Citrate mediates crosstalk between mitochondria and the nucleus to promote human mesenchymal stem cell in vitro osteogenesis. Cells 9:1034
- Marchi S, Retta SF, Pinton P (2020) Detection of p62/SQSTM1 Aggregates in Cellular Models of CCM Disease by Immunofluorescence. Methods Mol Biol 2152:417-426
- Marchi S, Giorgi C, Galluzzi L, Pinton P (2020) Ca2+ Fluxes and Cancer. Mol Cell 78:1055-1069
- Danese A, Marchi S, Vitto VAM, Modesti L, Leo S, Wieckowski MR, Giorgi C, Pinton P (2020) Cancer-related increases and decreases in calcium signaling at the Endoplasmic Reticulum-mitochondria interface (MAMs). Rev Physiol Biochem Pharmacol doi: 10.1007/112_2020_43
-
Crivellari I, Pecorelli A, Cordone V, Marchi S, Pinton P, Hayek J, Cervellati C, Valacchi G (2021) Impaired mitochondrial quality control in Rett Syndrome. Arch Biochem Biophys 700:108790
-
Marchi S, Zanella M, Pinton P, Crafa S, Boniolo G (2021) MitopatHs: a new logically-framed tool for visualizing multiple mitochondrial pathways. iScience 24:102324
-
Patergnani S, Bonora M, Ingusci S, Previati M, Marchi S, Zucchini S, Perrone M, Wieckowski MR, Castellazzi M, Pugliatti M, Giorgi C, Simonato M, Pinton P (2021) Antipsychotic drugs counteract autophagy and mitophagy in multiple sclerosis. Proc Natl Acad Sci U S A 118(24):e2020078118
-
Patergnani S, Bonora M, Bouhamida E, Danese A, Marchi S, Morciano G, Previati M, Pedriali G, Rimessi A, Anania G, Giorgi C, Pinton P (2021) Methods to Monitor Mitophagy and Mitochondrial Quality: Implications in Cancer, Neurodegeneration, and Cardiovascular Diseases. Methods Mol Biol 2310:113-159
-
Patergnani S, Marchi S, Delprat B, Wieckowski MR (2021) Editorial: Organelles Relationships and Interactions: A Cancer Perspective. Front Cell Dev Biol 9:678307
- Fiorito V, Allocco AL, Petrillo S, Gazzano E, Torretta S, Marchi S, Destefanis F, Pacelli C, Audrito V, Provero P, Medico E, Chiabrando D, Porporato PE, Cancelliere C, Bardelli A, Trusolino L, Capitanio N, Deaglio S, Altruda F, Pinton P, Cardaci S, Riganti C, Tolosano E (2021) The heme synthesis-export system regulates the tricarboxylic acid cycle flux and oxidative phosphorylation. Cell Rep 35(11):109252
- Marchi S, Morroni G, Pinton P and Galluzzi L (2021) Control of host mitochondria by bacterial pathogens. Trends Microbiol. S0966-842X(21)00237-7 Download
- Marchi S, Pinton P (2022) Mitochondria in the line of fire. Cell Death Differ 10.1038/s41418-022-01034-8
- Danese A*, Patergnani S*, Maresca A, Peron C, Raimondi A, Caporali L, Marchi S, La Morgia C, Del Dotto V, Zanna C, Iannielli A, Segnali A, Di Meo I, Cavaliere A, Lebiedzinska-Arciszewska M, Wieckowski MR, Martinuzzi A, Moraes-Filho MN, Salomao SR, Berezovsky A, Belfort Jr R, Buser C, Ross-Cisneros FN , Sadun AA, Tacchetti C, Broccoli V, Giorgi C, Tiranti V, Carelli V and Pinton P (2022) Pathological mitophagy disrupts mitochondrial homeostasis in Leber's hereditary optic neuropathy. Cell Rep 40(3):111124