Paolo Pinton Lab__Signal Transduction

 

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  1. Missiroli S, Bonora M, Patergnani S, Poletti F, Perrone M, Gafà R, Magri E, Raimondi A, Lanza G, Tacchetti C, Kroemer G, Pandolfi PP, Pinton P, Giorgi C (2016) PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development. Cell Rep 16(9):2415-27
  2. Missiroli S, Danese A, Iannitti T, Patergnani S, Perrone M, Previati M, Giorgi C, Pinton P (2017) Endoplasmic reticulum-mitochondria Ca2+ crosstalk in the control of the tumor cell fate. Biochim Biophys Acta (Molecular Cell Research) 1864:858-864
  3. Szymanski J, Janikiewicz J, Michalska B, Patalas-Krawczyk P, Perrone M, Ziółkowski W, Duszynski J, Pinton P, Dobrzyn A, Wieckowski MR (2017) Interaction of mitochondria with the endoplasmic reticulum and plasma membrane in calcium homeostasis, lipid trafficking and mitochondrial structure. Int J Mol Sci 18:1576
  4. Missiroli S, Patergnani S, Caroccia N, Pedriali G, Perrone M, Previati M, Wieckowski MR, Giorgi C (2018) Mitochondria-associated membranes (MAMs) and inflammation. Cell Death Dis 9(3):329
  5. Giorgi C, Marchi S, Simoes ICM, Ren Z, Morciano G, Perrone M, Patalas-Krawczyk P, Borchard S, Jędrak P, Pierzynowska K, Szymański J, Wang DQ, Portincasa P, Węgrzyn G, Zischka H, Dobrzyn P, Bonora M, Duszynski J, Rimessi A, Karkucinska-Wieckowska A, Dobrzyn A, Szabadkai G, Zavand B, Oliveira PJ, Sardao VA, Pinton P, Wieckowski MR (2018) Mitochondria and reactive oxygen species in aging and age related diseases. Int Rev Cell Mol Biol 340:209-344
  6. Previati M, Missiroli S, Perrone M, Caroccia N, Paliotto F, Milani D, Giorgi C (2018) Functions and dys-functions of promyelocytic leukemia protein PML. Rendiconti Lincei 29(2):411-420
  7. Marchi S, Corricelli M, Branchini A, Vitto VAM, Missiroli S, Morciano G, Perrone M, Ferrarese M, Giorgi C, Pinotti M, Galluzzi L, Kroemer G, Pinton P (2019) Akt-mediated phosphorylation of MICU1 regulates mitochondrial Ca2+ levels and tumor growth. EMBO J 38(2):e99435
  8. Morganti C, Missiroli S, Lebiedzinska-Arciszewska M, Ferroni L, Morganti L, Perrone M, Ramaccini D, Occhionorelli S, Zavan B, Wieckowski MR, Giorgi C (2019) Regulation of PKCβ levels and autophagy by PML is essential for high-glucose-dependent mesenchymal stem cell adipogenesis. Int J Obes 43(5):963-973
  9. Perrone M, Caroccia N, Genovese I, Missiroli S, Modesti L, Pedriali G, Vezzani B, Vitto VAM, Antenori M, Lebiedzinska-Arciszewska M, Wieckowski MR, Giorgi C, Pinton P (2020) The role of mitochondria-associated membranes in cellular homeostasis and diseases. Int Rev Cell Mol Biol 350:119-196
  10. Missiroli S*, Perrone M*, Genovese I, Pinton P, Giorgi C (2020) Cancer metabolism and mitochondria: finding novel mechanisms to fight tumours. EBioMedicine 59:102943 *equally contributed
  11. Fiorica F, Colella M, Taibi R, Bonetti A, Giuliani J, Perrone M, Missiroli S, Giorgi C (2020) Glioblastoma: Prognostic Factors and Predictive Response to Radio- And Chemotherapy. Curr Med Chem 27(17):2814-2825
  12. Missiroli S, Genovese I, Perrone M, Vezzani B, Vitto VAM, Giorgi C (2020) The Role of Mitochondria in Inflammation: From Cancer to Neurodegenerative Disorders. J Clin Med 9(3):740
  13. Bonora M, Missiroli S, Perrone M, Fiorica F, Pinton P, Giorgi C (2021) Mitochondrial Control of Genomic Instability in Cancer. Cancers (Basel) 13(8):1914
  14. Missiroli S, Perrone M, Boncompagni C, Borghi C, Campagnaro A, Marchetti F, Anania G, Greco P, Fiorica F, Pinton P, Giorgi C (2021) Targeting the NLRP3 Inflammasome as a New Therapeutic Option for Overcoming Cancer. Cancers (Basel) 13(10):2297
  15. Fiorica F, Tebano U, Gabbani M, Perrone M, Missiroli S, Berretta M, Giuliani J, Bonetti A, Remo A, Pigozzi E, Tontini A, Napoli G, Luca N, Grigolato D, Pinton P, Giorgi C (2021) Beyond Abscopal Effect: A Meta-Analysis of Immune Checkpoint Inhibitors and Radiotherapy in Advanced Non-Small Cell Lung Cancer. Cancers (Basel) 13(10):2352
  16. Patergnani S, Bonora M, Ingusci S, Previati M, Marchi S, Zucchini S, Perrone M, Wieckowski MR, Castellazzi M, Pugliatti M, Giorgi C, Simonato M, Pinton P (2021) Antipsychotic drugs counteract autophagy and mitophagy in multiple sclerosis. Proc Natl Acad Sci U S A 118(24):e2020078118
  17. Silvagni E, Missiroli S, Perrone M, Patergnani S, Boncompagni C, Bortoluzzi A, Govoni M, Giorgi C, Alivernini S, Pinton P, Scirè CA (2021) From Bed to Bench and Back: TNF-α, IL-23/IL-17A, and JAK-Dependent Inflammation in the Pathogenesis of Psoriatic Synovitis. Front Pharmacol 12:672515
  18. Patergnani S, Missiroli S, Morciano G, Perrone M, Mantovani CM, Anania G, Fiorica F, Pinton P and Giorgi C (2021) Understanding the Role of Autophagy in Cancer Formation and Progression Is a Real Opportunity to Treat and Cure Human Cancers. Cancers 13(22), 5622 Download
  19. Bouhamida E, Morciano G, Perrone M,  Kahsay A, Della Sala M,  Wieckowski M R, Fiorica F, Pinton P, Giorgi C, Patergnani S (2022) The Interplay of Hypoxia Signaling on Mitochondrial Dysfunction and Inflammation in Cardiovascular Diseases and Cancer: From Molecular Mechanisms to Therapeutic Approaches. Biology 11(2):300
  20. Ramaccini D, Pedriali G, Perrone M, Bouhamida E, Modesti L, Wieckowski MR, Giorgi C, Pinton P, Morciano G. (2022) Some Insights into the Regulation of Cardiac Physiology and Pathology by the Hippo Pathway. Biomedicines 10(3):726
  21. Tarocco A, Morciano M, Perrone M, Cafolla C, Ferrè C, Vacca T, Pistocchi G, Meneghin F, Cocchi I, Lista G, Cetin I, Greco P, Garani G, Stella M, Natile M, Ancora G, Savarese I, Campi F, Bersani I, Dotta A, Tiberi E, Vento G, Chiodin E, Staffler A, Maranella E, Di Fabio S, Wieckowski MR, Giorgi C, Pinton P (2022) Increase of Parkin and ATG5 plasmatic levels following perinatal hypoxic‐ischemic encephalopathy. Sci Rep. 12:7795
  22. De Ventura T, Perrone M*, Missiroli S, Pinton P, Marchetti P, Strazzabosco G, Turrin G, Illuminati D, Cristofori V, Fantinati A, Fabbri M, Giorgi C, Trapella C, Zanirato V (2022) Synthesis and NLRP3-Inflammasome Inhibitory Activity of the Naturally Occurring Velutone F and of Its Non-Natural Regioisomeric Chalconoids. Int J Mol Sci *co-first
  23. Perrone M, Raimondi E, Costa M, Rasetto G, Rizzati R, Lanza G, Gafà R, Cavallesco G, Tamburini N, Maniscalco P, Mantovani MC, Tebano U, Coeli M, Missiroli S, Tilli M, Pinton P, Giorgi C, Fiorica F. Inflammatory Microenvironment in Early Non-Small Cell Lung Cancer: Exploring the Predictive Value of Radiomics. Cancers (Basel). 2022 Jul 8;14(14):3335
  24. Perrone M, Patergnani S, Di Mambro T, Palumbo L, Więckowski M, Giorgi C, Pinton P. Calcium homeostasis in the control of mitophagy. Antioxid Redox Signal. 2022 Sep 16.
  25. Gabbani M, Giorgi C, Napoli G, Tebano U, Perrone MS, Missiroli S, Berretta M, Mandarà M, Zaninelli M, Luca N, Grigolato D, Muraro M, Rinaldi G, Pinton P, Fiorica F. Outcomes of Locally Advanced Rectal Cancer Patients Treated with Total Neoadjuvant Treatment: A Meta-Anaysis of Randomized Controlled Trials. Clin Colorectal Cancer. 2022 Sep 17:S1533-0028(22)00103-7
  26. Missiroli S, Perrone M, Gafà R, Nicoli F, Bonora M, Morciano G, Boncompagni C, Marchi S, Lebiedzinska-Arciszewska M, Vezzani B, Lanza G, Kricek F, Borghi A, Fiorica F, Ito K, Wieckowski MR, Di Virgilio F, Abelli L, Pinton P, Giorgi C. PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment. Cell Death Differ. 2022 Nov 30:1–13. doi: 10.1038/s41418-022-01095-9.
  27. Albanese V, Missiroli S, Perrone M, Fabbri M, Boncompagni C, Pacifico S, De Ventura T, Ciancetta A, Dondio G, Kricek F, Pinton P, Guerrini R, Preti D, Giorgi C. Novel Aryl Sulfonamide Derivatives as NLRP3 Inflammasome Inhibitors for the Potential Treatment of Cancer. J Med Chem. 2023 Mar 27.