Paolo Pinton Lab__Signal Transduction

 

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  1. Rizzuto R, Marchi S, Bonora M, Aguiari P, Bononi A, De Stefani D, Giorgi C, Leo S, Rimessi A, Siviero R, Zecchini E, Pinton P (2009) Ca(2+) transfer from the ER to mitochondria: when, how and why. Biochim Biophys Acta (Bioenergetics) 1787:1342-51
  2. Giorgi C, Agnoletto C, Baldini C, Bononi A, Bonora M, Marchi S, Missiroli S, Patergnani S, Poletti F, Rimessi A, Zavan B, Pinton P (2010) Redox control of Protein Kinase C: cell and disease
 specific significances. Antioxid Redox Signal 13(7):1051-85
  3. Giorgi C, Ito K, Lin H, Santangelo C, Wieckowski MR, Lebiedzinska M, Bononi A, Bonora M, Duszynski J, Bernardi R, Rizzuto R, Tacchetti C, Pinton P, Pandolfi PP (2010) PML regulates apoptosis at endoplasmic reticulum modulating calcium release. Science 330:1247-51
  4. Bertagnolo V, Nika E, Brugnoli F, Bonora M, Grassilli S, Pinton P, Capitani S (2011) Vav1 is a crucial molecule in monocytic/macrophagic differentiation of myeloid leukemia-derived cells. Cell Tissue Res 345(1):163-75
  5. Bononi A, Agnoletto C, De Marchi E, Marchi S, Patergnani S, Bonora M, Giorgi C, Missiroli S, Poletti F, Rimessi A, Pinton P (2011) Protein kinases and phosphatases in the control of cell fate. Enzyme Res 2011:329098
  6. Patergnani S, Suski JM, Agnoletto C, Bononi A, Bonora M, De Marchi E, Giorgi C, Marchi S, Missiroli S, Poletti F, Rimessi A, Duszynski J, Wieckowski MR, Pinton P (2011) Calcium signaling around Mitochondria Associated Membranes (MAMs). Cell Commun Signal 9(1):19
  7. Tombolan L, Orso F, Guzzardo V, Casara S, Zin A, Bonora M, Romualdi C, Giorgi C, Bisogno G, Alaggio R, Pinton P, De Pittà C, Taverna D, Rosolen A, Lanfranchi G (2011) High IGFBP2 expression correlates with tumor severity in pediatric rhabdomyosarcoma. Am J Pathol 179(5):2611-24
  8. Suski J, Lebiedzinska M, Bonora M, Pinton P, Duszynski J, Wieckowski MR (2012) Relation between mitochondrial membrane potential and ROS formation. Methods in Molecular Biology 810:183-205
  9. Marchi S, Giorgi C, Suski J, Agnoletto C, Bononi A, Bonora M, De Marchi E, Missiroli S, Patergnani S, Poletti F, Rimessi A, Duszynski J, Wieckowski MR, Pinton P (2012) Mitochondria-ROS crosstalk in the control of cell death and aging. J Signal Transduct 2012:329635
  10. Giorgi C, Agnoletto C, Bononi A, Bonora M, De Marchi E, Marchi S, Missiroli S, Patergnani S, Poletti F, Rimessi A, Suski JM, Wieckowski MR, Pinton P (2012) Mitochondrial calcium homeostasis as potential target for mitochondrial medicine. Mitochondrion 12:77-85
  11. Bononi A, Missiroli S, Poletti F, Suski JM, Agnoletto C, Bonora M, De Marchi E, Giorgi C, Marchi S, Patergnani S, Rimessi A, Wieckowski MR, Pinton P (2012) Mitochondria-associated membranes (MAMs) as hotspot Ca2+ signalling units. Adv Exp Med Biol 740:411-38
  12. Marchi S, Marinello M, Bononi A, Bonora M, Giorgi C, Rimessi A, Pinton P (2012) Selective modulation of subtype III IP3R by Akt regulates ER Ca2+ release and apoptosis. Cell Death Dis 3:e304
  13. Bonora M, Patergnani S, Rimessi A, De Marchi E, Suski JM, Bononi A, Giorgi C, Marchi S, Missiroli S, Poletti F, Wieckowski MR, Pinton P (2012) ATP synthesis and storage. Purinergic Signalling 8:343–357
  14. Giorgi C, Baldassari F, Bononi A, Bonora M, De Marchi E, Marchi S, Missiroli S, Patergnani S, Rimessi A, Suski JM, Wieckowski MR, Pinton P (2012) Mitochondrial Ca2+ and apoptosis. Cell Calcium 52:36-43
  15. Suski JM, Shönfeld P, Bonora M, Pinton P, Więckowski MR (2012) Guanosine diphosphate exerts a lower effect on superoxide release from mitochondrial matrix in the brains of uncoupling protein-2 knockout mice: New evidence for a putative novel function of uncoupling proteins as superoxide anion transporters. Biochem Biophys Res Commun 428:234–238
  16. Marchi S, Lupini L, Patergnani S, Rimessi A, Missiroli S, Bonora M, Bononi A, Corrà F, Giorgi C, De Marchi E, Poletti F, Gafà R, Lanza G, Negrini M, Rizzuto R, Pinton P (2013) Downregulation of the mitochondrial calcium uniporter by cancer-related miR-25. Current Biology 23:58-63
  17. Bonora M, Bononi A, De Marchi E, Giorgi C, Lebiedzinska M, Marchi S, Patergnani S, Rimessi A, Suski JM, Wojtala A, Wieckowski MR, Kroemer G, Galluzzi L, Pinton P (2013) Role of the c subunit of the FO ATP synthase in mitochondrial permeability transition. Cell Cycle 12(4):674-683
  18. Caliceti C, Aquila G, Pannella M, Morelli MB, Fortini C, Pinton P, Bonora M, Hrelia S, Pannuti A, Miele L, Rizzo P, Ferrari R (2013) 17beta-Estradiol Enhances Signalling Mediated by VEGF-A-Delta like ligand 4-Notch1 axis in Human Endothelial Cells. PLoS One 8(8):e71440
  19. Bonora M, Giorgi C, Bononi A, Marchi S, Patergnani S, Rimessi A, Rizzuto R, Pinton P (2013) Subcellular calcium measurements in mammalian cells using jellyfish photoprotein aequorin-based probes.  Nat Protoc 8(11):2105-18
  20. Patergnani S, Marchi S, Rimessi A, Bonora M, Giorgi C, Mehta KD, Pinton P (2013) PRKCB/protein kinase C β and the mitochondrial axis as key regulators of autophagy. Autophagy 9(9):1367-85
  21. Bononi A, Bonora M, Marchi S, Missiroli S, Poletti F, Giorgi C, Pandolfi PP, Pinton P (2013) Identification of PTEN at the ER and MAMs and its regulation of Ca2+ signaling and apoptosis in a protein phosphatase-dependent manner. Cell Death Diff 20:1631-43
  22. Rimessi A, Bonora M , Marchi S , Patergnani S, Marobbio CMT , Lasorsa FM, Pinton P (2013) Perturbed mitochondrial Ca2+ signals as causes or consequences of mitophagy induction. Autophagy 9(11):1677-86
  23. Papa A, Wan L, Bonora M, Salmena L, Song MS, Hobbs RM, Lunardi A, Webster K, Ng C, Newton RH, Knoblauch N, Guarnerio J, Ito K, Turka LA, Beck AH, Pinton P, Bronson R, Wei W, Pandolfi PP (2014) Cancer-associated PTEN mutants act in a dominant negative manner to suppress PTEN protein function. Cell 157:595-610
  24. Wojtala A, Bonora M, Malinska D, Pinton P, Duszynski J, Wieckowski MR (2014) Methods to Monitor ROS Production by Fluorescence Microscopy and Fluorometry. Methods Enzymol 542:243-62
  25. Bonora M , Bravo-San Pedro JM, Kroemer G, Galluzzi L, Pinton P (2014) Novel insights into the mitochondrial permeability transition. Cell cycle 13(17):2666-70
  26. Bonora M, De Marchi E, Patergnani S, Suski JM, Celsi F, Bononi A, Giorgi C, Marchi S, Rimessi A, Duszyński J, Pozzan T, Wieckowski MR, Pinton P (2014) Tumor necrosis factor-α impairs oligodendroglial differentiation through a mitochondria-dependent process. Cell Death Differ 21:1198–1208
  27. Bonora M, Pinton P (2014) Mitochondrial permeability transition pore and cancer: molecular mechanisms involved in cell death. Front Oncol 4(302):1-12
  28. De Marchi E, Bonora M, Giorgi C, Pinton P (2014) The mitochondrial permeability transition pore is a dispensable element for mitochondrial calcium efflux. Cell Calcium 56(1):1-13
  29. Morciano G, Giorgi C, Bonora M, Punzetti S, Pavasini R, Wieckowski MR, Campo G, Pinton P (2015) Molecular identity of the mitochondrial permeability transition pore and its role in ischemia-reperfusion injury. J Mol Cell Cardiol 78:142-153
  30. Bonora M, Pinton P (2015) Shedding light on molecular mechanisms and identity of mPTP. Mitochondrion 21:11
  31. Giorgi C§ , Bonora M§ , Sorrentino G, Missiroli S, Poletti F, Suski JM, Ramirez FG, Rizzuto R, Di Virgilio F, Zito E, Pandolfi PP, Wieckowski MR, Mammano F, Del Sal G, Pinton P (2015) p53 at the endoplasmic reticulum regulates apoptosis in a Ca 2+ -dependent manner. Proc Natl Acad Sci USA 112(6):1779-84 §equally contributed
  32. Giorgi C§, Bonora M§, Missiroli S, Poletti F, Ramirez FG, Morciano G, Morganti C, Pandolfi PP, Mammano F, Pinton P (2015) Intravital imaging reveals p53-dependent cancer cell death induced by phototherapy via calcium signaling. Oncotarget 6(3):1435-45 §equally contributed
  33. Franceschini A, Capece M, Chiozzi P, Falzoni S, Sanz JM, Sarti AC, Bonora M, Pinton P, Di Virgilio F (2015) The P2X7 receptor directly interacts with the NLRP3 inflammasome scaffold protein. FASEB J 0892-6638/15/0029-0001
  34. Adinolfi E , Capece M, Franceschini A, Falzoni S , Giuliani AL , Rotondo A, Sarti AC, Bonora M, Syberg S , Corigliano D , Pinton P , Jorgensen NR, Abelli L , Emionite L , Raffaghello L , Pistoia V, Di Virgilio F (2015) Accelerated tumor progression in mice lacking the ATP receptor P2X7. Cancer Research 75(4):635-44
  35. Bonora M, Wieckowski MR, Chinopoulos C, Kepp O, Kroemer G, Galluzzi L, Pinton P (2015) Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition. Oncogene 34:1475-86
  36. Giorgi C§, Bonora M§, Pinton P (2015) Inside the tumor: p53 modulates calcium homeostasis. Cell Cycle 14(7):933-4 §equally contributed
  37. Venco P§ , Bonora M§ , Giorgi C§ , Papaleo E, Iuso A, Prokisch H, Pinton P, Tiranti V (2015) Mutations of C19orf12, coding for a transmembrane glycine 1 zipper containing mitochondrial protein, cause mis-localization of the protein, inability to respond to oxidative stress and increased mitochondrial Ca2+. Front Genet 6:185 §equally contributed
  38. Bonora M , Giorgi C , Pinton P (2015) Novel frontiers in calcium signaling: a possible target for chemotherapy. Pharmacol Res 99:82-85
  39. Lambertini E, Penolazzi L , Morganti C , Lisignoli G , Zini N, Angelozzi M , Bonora M, Ferroni L, Pinton P, Zavan B , Piva R (2015) Osteogenic differentiation of human MSCs: specific occupancy of the mitochondrial DNA by NFATc1 transcription factor. Int J Biochem Cell Biol 64:212-219
  40. Rimessi A, Patergnani S, Bonora M, Wieckowski MR, Pinton P (2015) Mitochondrial Ca2+ remodeling is a prime factor in oncogenic behavior. Front Oncol 5:143
  41. Malfacini D, Ambrosio C, Grò MC, Sbraccia M, Trapella C, Guerrini R, Bonora M, Pinton P, Costa T, Calò G (2015) Pharmacological profile of nociceptin/orphanin FQ receptors interacting with G-proteins and β-arrestins 2. PLoS One 10(8):e0132865
  42. Bonora M, Pinton P, Ito K (2015) Mitochondrial control of hematopoietic stem cell balance and hematopoiesis. Frontiers in Biology 10(2):117-124
  43. Mediani L, Gibellini F, Bertacchini J, Frasson C, Bosco R, Accordi B, Basso G, Bonora M, Rampazzo E, Prodi L, Sgarbi G, Baracca A, Pinton P, Riva G, Milani D, Luppi M, Cocco L, Capitani S, Marmiroli S (2016) Reversal of the glycolytic phenotype of primary effusion lymphoma cells by combined targeting of cellular metabolism and PI3K/Akt/ mTOR signaling. Oncotarget 7(5):5521-37
  44. Giorgi C, Bonora M, Missiroli S, Morganti C, Morciano G, Wieckowski MR, Pinton P (2016) Alterations in mitochondrial and endoplasmic reticulum signaling by p53 mutants. Front Oncol 6:42
  45. Bonora M§, Morganti C§, Morciano G§, Giorgi C, Wieckowski MR, Pinton P (2016) Comprehensive analysis of mitochondrial permeability transition pore activity in living cells using fluorescence-imaging-based techniques. Nat Protoc 11(6):1067-1080 §equally contributed
  46. Salaro E, Rambaldi A, Falzoni S, Amoroso FS, Franceschini A, Sarti AC, Bonora M, Cavazzini F, Rigolin GM, Ciccone M, Audrito V, Deaglio S, Pelegrin P, Pinton P, Cuneo A, Di Virgilio F (2016) Involvement of the P2X7-NLRP3 axis in leukemic cell proliferation and death. Sci Rep 6:26280
  47. Campo G, Morciano G, Pavasini R, Bonora M, Sbano L, Biscaglia S, Bovolenta M, Pinotti M, Punzetti S, Rizzo P, Aquila G, Giorgi C, Ferrari R, Pinton P (2016) Fo ATP synthase C subunit serum levels in patients with ST-segment Elevation Myocardial Infarction: preliminary findings. Int J Cardiol 221:993-7
  48. Missiroli S, Bonora M, Patergnani S, Poletti F, Perrone M, Gafà R, Magri E, Raimondi A, Lanza G, Tacchetti C, Kroemer G, Pandolfi PP, Pinton P, Giorgi C (2016) PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development. Cell Rep 16(9):2415-27
  49. Patergnani S , Fossati V , Bonora M, Giorgi C, Marchi S , Missiroli S, Rusielewicz T, Wieckowski MR, Pinton P (2017) Mitochondria in multiple sclerosis: molecular mechanisms of pathogenesis. Int Rev Cell Mol Biol 328:49-103
  50. Sbano L, Bonora M , Marchi S , Baldassari F , Medina DL, Ballabio A , Giorgi C, Pinton P (2017) TFEB-mediated increase in peripheral lysosomes regulates store-operated calcium entry. Sci Rep 7:40797
  51. Marchi S, Bonora M, Patergnani S, Giorgi C, Pinton P (2017) Methods to Assess Mitochondrial Morphology in Mammalian Cells Mounting Autophagic or Mitophagic Responses. Methods Enzymol 588:171-186
  52. Straudi S, Manfredini F, Lamberti N, Zamboni P, Bernardi F, Marchetti G, Pinton P, Bonora M, Secchiero P, Tisato V, Volpato S, Basaglia N (2017) The effectiveness of Robot-Assisted Gait Training versus conventional therapy on mobility in severely disabled progressIve MultiplE sclerosis patients (RAGTIME): study protocol for a randomized controlled trial. Trials 18:88
  53. Morciano G §, Bonora M §, Giorgi C, Pinton P (2017) Other bricks for the correct construction of the mitochondrial permeability transition pore complex. Cell Death Dis 8:e2698 §equally contributed
  54. Donato V, Bonora M, Simoneschi D, Sartini D, Kudo Y, Saraf A, Florens L, Washburn MP, Stadtfeld M, Pinton P, Pagano M (2017) The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells. Nat Cell Biol 19:341-351
  55. Caldieri G, Barbieri E, Nappo G, Raimondi A, Bonora M, Conte A, Verhoef LGGC, Confalonieri S, Malabarba MG, Bianchi F, Cuomo A, Bonaldi T, Martini E, Mazza D, Pinton P, Tacchetti C, Polo S, Di Fiore PP, Sigismund S (2017) Reticulon 3–dependent ER-PM contact sites control EGFR nonclathrin endocytosis. Science 356:617-624
  56. Morciano G, Bonora M, Campo G, Aquila G, Rizzo P, Giorgi C, Wieckowski MR, Pinton P (2017) Mechanistic Role of mPTP in Ischemia-Reperfusion Injury. Adv Exp Med Biol 982:169-189
  57. Danese A, Patergnani S, Bonora M , Wieckowski MR, Previati M , Giorgi C, Pinton P (2017) Calcium regulates cell death in cancer: roles of the mitochondria and mitochondria-associated membranes (MAMs). Biochim Biophys Acta (Bioenergetics) 1858:615-627
  58. Bonora M, Morganti C, Morciano G, Pedriali G, Lebiedzinska-Arciszewska M, Aquila G, Giorgi C, Rizzo P, Campo G, Ferrari R, Kroemer G,Wieckowski MR, Galluzzi L, Pinton P (2017) Mitochondrial permeability transition involves dissociation of F1FO ATP synthase dimers and C-ring conformation. EMBO Reports 18(7):1077-89
  59. Missiroli S, Bonora M, Patergnani S, Giorgi C (2017) Novel function of the tumor suppressor PML at ER-mitochondria sites in the control of autophagy. Oncotarget 8(47):81723-81724
  60. Patergnani S , Castellazzi M , Bonora M , Marchi S , Casetta I, Pugliatti M , Giorgi C , Granieri E, Pinton P (2018) Autophagy and mitophagy elements are increased in body fluids of Multiple Sclerosis-affected individuals. J Neurol Neurosurg Psychiatry 89(4):439-441
  61. Morganti C, Bonora M, Sbano L, Morciano G, Aquila G, Campo G, Wieckowski MR, Giorgi C, Pinton P (2018) The Mitochondrial Permeability Transition Pore. Mitochondrial Biology and Experimental Therapeutics 47-73
  62. Janikiewicz J, Szymański J, Malinska D, Patalas-Krawczyk P, Michalska B, Duszyński J, Giorgi C, Bonora M, Dobrzyn A, Wieckowski MR (2018) Mitochondria-associated membranes in aging and senescence: structure, function, and dynamics. Cell Death Dis 9(3):332
  63. Morganti C, Bonora M, Sbano L, Morciano G, Aquila G, Campo G, Wieckowski MR, Giorgi C, Pinton P (2018) The Mitochondrial Permeability Transition Pore. Mitochondrial Biology and Experimental Therapeutics 47-73
  64. Giorgi C, Marchi S, Simoes ICM, Ren Z, Morciano G, Perrone M, Patalas-Krawczyk P, Borchard S, Jędrak P, Pierzynowska K, Szymański J, Wang DQ, Portincasa P, Węgrzyn G, Zischka H, Dobrzyn P, Bonora M, Duszynski J, Rimessi A, Karkucinska-Wieckowska A, Dobrzyn A, Szabadkai G, Zavand B, Oliveira PJ, Sardao VA, Pinton P, Wieckowski MR (2018) Mitochondria and reactive oxygen species in aging and age related diseases. Int Rev Cell Mol Biol 340:209-344
  65. Aquila G, Morelli MB, Vieceli Dalla Sega F, Fortini F, Nigro P, Caliceti C, Ferracin M, Negrini M, Pannuti A, Bonora M, Pinton P, Ferrari R, Rizzo P (2018) Heart rate reduction with ivabradine in the early phase of atherosclerosis is protective in the endothelium of ApoE-deficient mice. J Physiol Pharmacol 69(1):35-52
  66. Bonora M, Wieckowski MR, Sinclair DA, Kroemer G, Pinton P, Galluzzi L (2018) Targeting mitochondria for cardiovascular disorders: therapeutic potential and persisting obstacles. Nat Rev Cardiol 16(1):33-55
  67. Morciano G, Preti D, Pedriali G, Aquila G, Missiroli S, Fantinati A, Caroccia N, Pacifico S, Bonora M, Talarico A, Morganti C, Rizzo P, Ferrari R, Wieckowski MR, Campo G, Giorgi C, Trapella C, Pinton P (2018) Discovery of novel 1,3,8-triazaspiro[4.5]decane derivatives that target the c subunit of F1/FO-adenosine triphosphate (ATP) synthase for the treatment of reperfusion damage in myocardial infarction. J Med Chem 61:7131-43
  68. Bonora M, Pinton P (2018) Mitochondrial DNA keeps you young. Cell Death Dis 9:992
  69. Bonora M, Ito K, Morganti C, Pinton P, Ito K (2018) Membrane-potential compensation reveals mitochondrial volume expansion during HSC commitment. Exp Hematol 68:30-37
  70. Bonora M, Pinton P (2019) A New Current for the Mitochondrial Permeability Transition. Trends Biochem Sci 44(7):559-561
  71. Castellazzi M, Patergnani S, Donadio M, Giorgi C, Bonora M, Fainardi E, Casetta I, Granieri E, Pugliatti M, Pinton P (2019) Correlation between auto-/mitophagic processes and magnetic resonance imaging activity in multiple sclerosis patients. J Neuroinflammation 16:131
  72. Castellazzi M, Patergnani S, Donadio M, Giorgi C, Bonora M, Bosi C, Brombo G, Pugliatti M, Seripa D, Zuliani G, Pinton P (2019) Autophagy and mitophagy biomarkers are reduced in sera of patients with Alzheimer’s disease and mild cognitive impairment. Sci Rep 9(1):20009
  73. Morciano G, Patergnani S, Bonora M, Pedriali G, Tarocco A, Bouhamida E, Marchi S, Ancora G, Anania G, Wieckowski MR, Giorgi C, Pinton P (2020) Mitophagy in cardiovascular diseases. J Clin Med 9:892
  74. Morganti C, Bonora M, Marchi S, Ferroni L, Gardin C, Wieckowski MR, Giorgi C, Pinton P, Zavan B (2020) Citrate mediates crosstalk between mitochondria and the nucleus to promote human mesenchymal stem cell in vitro osteogenesis. Cells 9:1034
  75. Bonora M, Patergnani S, Ramaccini D, Morciano G, Pedriali G, Kahsay AE, Bouhamida E, Giorgi C, Wieckowski MR, Pinton P (2020) Physiopathology of the Permeability Transition Pore: Molecular Mechanisms in Human Pathology. Biomolecules 10:998
  76. Manfredini F, Straudi S, Lamberti N, Patergnani S, Tisato V, Secchiero P, Bernardi F, Ziliotto N, Marchetti G, Basaglia N, Bonora M, Pinton P (2020) Rehabilitation Improves Mitochondrial Energetics in Progressive Multiple Sclerosis: The Significant Role of Robot-Assisted Gait Training and of the Personalized Intensity. Diagnostics (Basel) 10(10):E834
  77. Vallese F, Catoni C, Cieri D, Barazzuol L, Ramirez O, Calore V, Bonora M, Giamogante F, Pinton P, Brini M, Calì T (2020) An expanded palette of improved SPLICS reporters detects multiple organelle contacts in vitro and in vivo. Nat Commun 11:6069
  78. Nair-Gill E, Bonora M, Zhong X, Liu A, Miranda A, Stewart N, Ludwig S, Russell J, Gallagher T, Pinton P, Beutler B (2021) Calcium flux control by Pacs1-Wdr37 promotes lymphocyte quiescence and lymphoproliferative diseases. EMBO J e104888
  79. Sarti AC, Vultaggio-Poma V, Falzoni S, Missiroli S, Giuliani AL, Boldrini P, Bonora M, Faita F, Di Lascio N, Kusmic C, Solini A, Novello S, Morari M, Rossato M, Wieckowski MR, Giorgi C, Pinton P, Di Virgilio F (2021) Mitochondrial P2X7 Receptor Localization Modulates Energy Metabolism Enhancing Physical Performance. Function 2(2):zqab005
  80. Morciano G, Pedriali G, Bonora M, Pavasini R, Mikus E, Calvi S, Bovolenta M, Lebiedzinska-Arciszewska M, Pinotti M, Albertini A, Wieckowski MR, Giorgi C, Ferrari R, Galluzzi L, Campo G, Pinton P (2021) A naturally occurring mutation in ATP synthase subunit c is associated with increased damage following hypoxia/reoxygenation in STEMI patients. Cell Rep 35:108983
  81. Carinci M, Testa B, Bordi M, Milletti G, Bonora M, Antonucci L, Ferraina C, Carro M, Kumar M, Ceglie D, Eck F, Nardacci R, le Guerroué F, Petrini S, Soriano ME, Caruana I, Doria V, Manifava M, Peron C, Lambrughi M, Tiranti V, Behrends C, Papaleo E, Pinton P, Giorgi C, Ktistakis NT, Locatelli F, Nazio F, Cecconi F (2021) TFG binds LC3C to regulate ULK1 localization and autophagosome formation. EMBO J e103563
  82. Bonora M, Missiroli S, Perrone M, Fiorica F, Pinton P, Giorgi C (2021) Mitochondrial Control of Genomic Instability in Cancer. Cancers (Basel) 13(8):1914
  83. Patergnani S, Bonora M, Ingusci S, Previati M, Marchi S, Zucchini S, Perrone M, Wieckowski MR, Castellazzi M, Pugliatti M, Giorgi C, Simonato M, Pinton P (2021) Antipsychotic drugs counteract autophagy and mitophagy in multiple sclerosis. Proc Natl Acad Sci U S A 118(24):e2020078118
  84. Patergnani S, Bonora M, Bouhamida E, Danese A, Marchi S, Morciano G, Previati M, Pedriali G, Rimessi A, Anania G, Giorgi C, Pinton P (2021) Methods to Monitor Mitophagy and Mitochondrial Quality: Implications in Cancer, Neurodegeneration, and Cardiovascular Diseases. Methods Mol Biol 2310:113-159
  85. Bonora M, Kahsay A, Pinton P (2021) Mitochondrial calcium homeostasis in hematopoietic stem cell: Molecular regulation of quiescence, function, and differentiation. Int Rev Cell Mol Biol 362:111-140
  86. Bonora M, Giorgi C and Pinton P (2021) Molecular mechanisms and consequences of mitochondrial permeability transition. Nat Rev Mol Cell Biol
  87. Morciano G, Rimessi A, Patergnani S, Vitto V.A.M, Danese A, Kahsay A.E, Palumbo L, Bonora M, Wieckowski M.R., Giorgi C, Pinton P(2022) Calcium dysregulation in heart diseases: Targeting calcium channels to achieve a correct calcium homeostasis. Pharmacol Res2022 Feb 4;106119
  88. Missiroli S, Perrone M, Gafà R, Nicoli F, Bonora M, Morciano G, Boncompagni C, Marchi S, Lebiedzinska-Arciszewska M, Vezzani B, Lanza G, Kricek F, Borghi A, Fiorica F, Ito K, Wieckowski MR, Di Virgilio F, Abelli L, Pinton P, Giorgi C. PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment. Cell Death Differ. 2022 Nov 30:1–13. doi: 10.1038/s41418-022-01095-9.
  89. Bonora M, Morganti C, van Gastel N, Ito K, Calura E, Zanolla I, Ferroni L, Zhang Y, Jung Y, Sales G, Martini P, Nakamura T, Lasorsa FM, Finkel T, Lin CP, Zavan B, Pinton P, Georgakoudi I, Romualdi C, Scadden DT, Ito K. A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate. Cell Stem Cell. 2024 Mar 7;31(3):359-377.e10.
  90. Chianese D, Bonora M, Sambataro M, Sambato L, Paola LD, Tremoli E, Cappucci IP, Scatto M, Pinton P, Picari M, Ferroni L, Zavan B. Exploring Mitochondrial Interactions with Pulsed Electromagnetic Fields: An Insightful Inquiry into Strategies for Addressing Neuroinflammation and Oxidative Stress in Diabetic Neuropathy. Int J Mol Sci. 2024 Jul 16;25(14):7783.
  91. Mesa D, Barbieri E, Raimondi A, Freddi S, Miloro G, Jendrisek G, Caldieri G, Quarto M, Schiano Lomoriello I, Malabarba MG, Bresci A, Manetti F, Vernuccio F, Abdo H, Scita G, Lanzetti L, Polli D, Tacchetti C, Pinton P, Bonora M, Di Fiore PP, Sigismund S. A tripartite organelle platform links growth factor receptor signaling to mitochondrial metabolism. Nat Commun. 2024 Jun 15;15(1):5119.
  92. Bertino F, Mukherjee D, Bonora M, Bagowski C, Nardelli J, Metani L, Zanin Venturini DI, Chianese D, Santander N, Salaroglio IC, Hentschel A, Quarta E, Genova T, McKinney AA, Allocco AL, Fiorito V, Petrillo S, Ammirata G, De Giorgio F, Dennis E, Allington G, Maier F, Shoukier M, Gloning KP, Munaron L, Mussano F, Salsano E, Pareyson D, di Rocco M, Altruda F, Panagiotakos G, Kahle KT, Gressens P, Riganti C, Pinton P, Roos A, Arnold T, Tolosano E, Chiabrando D. Dysregulation of FLVCR1a-dependent mitochondrial calcium handling in neural progenitors causes congenital hydrocephalus. Cell Rep Med. 2024 Jul 16;5(7):101647.
  93. Trentini M, Zanolla I, Tiengo E, Zanotti F, Sommella E, Merciai F, Campiglia P, Licastro D, Degasperi M, Lovatti L, Bonora M, Danese A, Pinton P, Zavan B. Link between organic nanovescicles from vegetable kingdom and human cell physiology: intracellular calcium signalling. J Nanobiotechnology. 2024 Feb 19;22(1):68.