Paolo Pinton Lab__Signal Transduction
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- Morciano G, Giorgi C, Bonora M, Punzetti S, Pavasini R, Wieckowski MR, Campo G, Pinton P (2015) Molecular identity of the mitochondrial permeability transition pore and its role in ischemia-reperfusion injury. J Mol Cell Cardiol 78:142-153
- Giorgi C, Bonora M, Missiroli S, Poletti F, Ramirez FG, Morciano G, Morganti C, Pandolfi PP, Mammano F, Pinton P (2015) Intravital imaging reveals p53-dependent cancer cell death induced by phototherapy via calcium signaling. Oncotarget 6(3):1435-45
- Morciano G, Giorgi C, Balestra D, Marchi S, Perrone D, Pinotti M, Pinton P (2016) Mcl-1 involvement in mitochondrial dynamics is associated with apoptotic cell death. Mol Biol Cell 27(1):20-34
- Giorgi C, Bonora M, Missiroli S, Morganti C, Morciano G, Wieckowski MR, Pinton P (2016) Alterations in mitochondrial and endoplasmic reticulum signaling by p53 mutants. Front Oncol 6:42
- Bonora M*, Morganti C*, Morciano G*, Giorgi C, Wieckowski MR, Pinton P (2016) Comprehensive analysis of mitochondrial permeability transition pore activity in living cells using fluorescence-imaging-based techniques. Nat Protoc 11(6):1067-1080 *equally contributed
- Torrano V, Valcarcel-Jimenez L, Cortazar AR, Liu X, Urosevic J, Castillo-Martin M, Fernandez-Ruiz S, Morciano G, Caro-Maldonado A, Guiu M, Zuniga-García P, Graupera M, Bellmunt A, Pandya P, Lorente M, Martín-Martín N, David Sutherland J, Sanchez-Mosquera P, Bozal-Basterra L, Zabala-Letona A, Arruabarrena-Aristorena A, Berenguer A, Embade N, Ugalde-Olano A, Lacasa-Viscasillas I, Loizaga-Iriarte A, Unda-Urzaiz M, Schultz N, Aransay AM, Sanz-Moreno V, Barrio R, Velasco G, Pinton P, Cordon-Cardo C, Locasale JW, Gomis RR, Carracedo A (2016) The metabolic co-regulator PGC1α suppresses prostate cancer metastasis. Nat Cell Biol 18(6):645-58
- Morciano G, Pedriali G, Sbano L, Iannitti T, Giorgi C, Pinton P (2016) Intersection of mitochondrial fission and fusion machinery with apoptotic pathways: role of Mcl-1. Biol Cell 108:279-293
- Campo G, Morciano G, Pavasini R, Bonora M, Sbano L, Biscaglia S, Bovolenta M, Pinotti M, Punzetti S, Rizzo P, Aquila G, Giorgi C, Ferrari R, Pinton P (2016) Fo ATP synthase C subunit serum levels in patients with ST-segment Elevation Myocardial Infarction: preliminary findings. Int J Cardiol 221:993-7
- Morciano G, Bonora M, Giorgi C, Pinton P (2017) Other bricks for the correct construction of the mitochondrial permeability transition pore complex. Cell Death Dis 8:e2698
- Ferrari R, Balla C, Malagù M, Guardigli G, Morciano G, Bertini M, Biscaglia S, Campo G (2017) Reperfusion Damage - A Story of Success, Failure, and Hope. Circ J 81(2):131-141
- Morciano G, Bonora M, Campo G, Aquila G, Rizzo P, Giorgi C, Wieckowski MR, Pinton P (2017) Mechanistic Role of mPTP in Ischemia-Reperfusion Injury. Adv Exp Med Biol 982:169-189
- Morciano G, Sarti A, Marchi S, Missiroli S, Falzoni S, Raffaghello L, Pistoia V, Giorgi C, Di Virgilio F, Pinton P (2017) Using luciferase probes to measure ATP in living cells and animals. Nat Protoc 12(8):1542-62
- Bonora M, Morganti C, Morciano G, Pedriali G, Lebiedzinska-Arciszewska M, Aquila G, Giorgi C, Rizzo P, Campo G, Ferrari R, Kroemer G,Wieckowski MR, Galluzzi L, Pinton P (2017) Mitochondrial permeability transition involves dissociation of F1FO ATP synthase dimers and C-ring conformation. EMBO Reports 18(7):1077-89
- Campo G, Pavasini R, Morciano G, Lincoff AM, Gibson CM, Kitakaze M, Lonborg J, Ahluwalia A, Ishii H, Frenneaux M, Ovize M, Galvani M, Atar D, Ibanez B, Cerisano G, Biscaglia S, Neil BJ, Asakura M, Engstrom T, Jones DA, Dawson D, Ferrari R, Pinton P, Ottani F (2017) Clinical Benefit of Drugs Targeting Mitochondrial Function as an Adjunct to Reperfusion in ST-segment Elevation Myocardial Infarction: a Meta-Analysis of Randomized Clinical Trials. Int J Cardiol 244:59-66
- Campo G, Pavasini R, Morciano G, Lincoff AM, Gibson CM, Kitakaze M, Lonborg J, Ahluwalia A, Ishii H, Frenneaux M, Ovize M, Galvani M, Atar D, Ibanez B, Cerisano G, Biscaglia S, Neil BJ, Asakura M, Engstrom T, Jones DA, Dawson D, Ferrari R, Pinton P, Ottani F (2017) The role of cyclosporine, nicorandil, metoprolol and follow-up length on reperfusion related outcomes in ST elevation myocardial infarction treated with percutaneous coronary intervention: Sub-group analyses. Data in Brief 14:197-205
- Wieckowski MR, Danese A, Morciano G, Pronicki M, Duszynski J, Pinton P, Karkucinska-Wieckowska A (2018) Recovering mitochondrial function in patients’ fibroblasts. Mitochondrial Biology and Experimental Therapeutics 359-378
- Marchi S, Patergnani S, Missiroli S, Morciano G, Rimessi A, Wieckowski MR, Giorgi C, Pinton P (2018) Mitochondrial and Endoplasmic Reticulum Calcium Homeostasis and Cell Death. Cell Calcium 69:62-72
- Kerkhofs M, Bittremieux M, Morciano G, Giorgi C, Pinton P, Parys JB, Bultynck G (2018) Emerging molecular mechanisms in chemotherapy: Ca2+ signaling at the mitochondria-associated endoplasmic reticulum membranes. Cell Death Dis 9:334
- Giorgi C*, Marchi S*, Simoes ICM*, Ren Z*, Morciano G*, Perrone M, Patalas-Krawczyk P, Borchard S, Jedrak P, Pierzynowska K, Szymanski J, Wang DQ, Portincasa P, Wegrzyn G, Zischka H, Dobrzyn P, Bonora M, Duszynski J, Rimessi A, Karkucinska-Wieckowska A, Dobrzyn A, Szabadkai G, Zavand B, Oliveira PJ, Sardao VA, Pinton P, Wieckowski MR (2018) Mitochondria and reactive oxygen species in aging and age related diseases. Int Rev Cell Mol Biol 340:209-344 *equally contributed
- Morciano G, Marchi S, Morganti C, Sbano L, Bittremieux M, Kerkhofs M, Corricelli M, Danese A, Karkucinska-Wieckowska A, Wieckowski MR, Bultynck G, Giorgi C, Pinton P (2018) Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific Settings. Neoplasia 20(5):510-523
- Tonet E, Bernucci D, Morciano G, Campo G (2018) Pharmacological protection of reperfusion injury in ST-segment elevation myocardial infarction. Gone with the wind? Adv Interv Cardiol 14(51):5-8
- Morganti C, Bonora M, Sbano L, Morciano G, Aquila G, Campo G, Wieckowski MR, Giorgi C, Pinton P (2018) The Mitochondrial Permeability Transition Pore. Mitochondrial Biology and Experimental Therapeutics 47-73
- Morciano G, Preti D, Pedriali G, Aquila G, Missiroli S, Fantinati A, Caroccia N, Pacifico S, Bonora M, Talarico A, Morganti C, Rizzo P, Ferrari R, Wieckowski MR, Campo G, Giorgi C, Trapella C, Pinton P (2018) Discovery of novel 1,3,8-triazaspiro[4.5]decane derivatives that target the c subunit of F1/FO-adenosine triphosphate (ATP) synthase for the treatment of reperfusion damage in myocardial infarction. J Med Chem 61:7131-43
- Avalle L *, Camporeale A *, Morciano G *, Caroccia N, Ghetti E, Orecchia V, Viavattene D, Giorgi C, Pinton P, Poli V (2019) STAT3 localizes to the ER, acting as a gatekeeper for ER-mitochondrion Ca2+ fluxes and apoptotic responses. Cell Death Differ 26(5):932-942 *equally contributed
- Bittremieux M, La Rovere RM, Akl H, Martines C, Welkenhuyzen K, Dubron K, Baes M, Janssens A, Vandenberghe P, Laurenti L, Rietdorf K, Morciano G, Pinton P, Mikoshiba K, Bootman MD, Efremov DG, De Smedt H, Parys JB, Bultynck G (2019) Constitutive IP3 signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP3 receptor disruptor BIRD-2. Cell Death Differ 26:531–547
- Marchi S, Corricelli M, Branchini A, Vitto VAM, Missiroli S, Morciano G, Perrone M, Ferrarese M, Giorgi C, Pinotti M, Galluzzi L, Kroemer G, Pinton P (2019) Akt-mediated phosphorylation of MICU1 regulates mitochondrial Ca2+ levels and tumor growth. EMBO J 38(2):e99435
- Tarocco A, Caroccia N, Morciano G, Wieckowski MR, Ancora G, Garani G, Pinton P (2019) Melatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn care. Cell Death Dis 10(4):317
- Morciano G, Imamura H, Patergnani S, Pedriali G, Giorgi C, Pinton P (2020) Measurement of ATP concentrations in mitochondria of living cells using luminescence and fluorescence approaches. Methods in Cell Biology 155:199-219
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Morciano G, Patergnani S, Bonora M, Pedriali G, Tarocco A, Bouhamida E, Marchi S, Ancora G, Anania G, Wieckowski MR, Giorgi C, Pinton P (2020) Mitophagy in cardiovascular diseases. J Clin Med 9:892
- Rojas-Charry L, Calero-Martinez S, Morganti C, Morciano G, Park K, Hagel C, Marciniak SJ, Glatzel M, Pinton P, Sepulveda-Falla D (2020) Susceptibility to cellular stress in PS1 mutant N2a cells is associated with mitochondrial defects and altered calcium homeostasis. Sci Rep 10:6455
- Simoes ICM*, Morciano G*, Lebiedzinska-Arciszewska M, Aguiari G, Pinton P, Potes Y, Wieckowski MR (2020) The mystery of mitochondria-ER contact sites in physiology and pathology: a cancer perspective. Biochim Biophys Acta (Mol Basis Dis) 1866(10):165834 *equally contributed
- Bonora M, Patergnani S, Ramaccini D, Morciano G, Pedriali G, Kahsay AE, Bouhamida E, Giorgi C, Wieckowski MR, Pinton P (2020) Physiopathology of the Permeability Transition Pore: Molecular Mechanisms in Human Pathology. Biomolecules 10:998
- Pedriali G*, Morciano G*, Patergnani S, Cimaglia P, Morelli C, Mikus E, Ferrari R, Gasbarro V, Giorgi C, Wieckowski MR, Pinton P (2020) Aortic valve stenosis and mitochondrial dysfunctions: clinical and molecular perspectives. Int J Mol Sci 21(14):4899 *equally contributed
- Morciano G, Pedriali G, Bonora M, Pavasini R, Mikus E, Calvi S, Bovolenta M, Lebiedzinska-Arciszewska M, Pinotti M, Albertini A, Wieckowski MR, Giorgi C, Ferrari R, Galluzzi L, Campo G, Pinton P (2021) A naturally occurring mutation in ATP synthase subunit c is associated with increased damage following hypoxia/reoxygenation in STEMI patients. Cell Rep 35:108983
- Romagnoli R, Preti D, Hamel E, Bortolozzi R, Viola G, Brancale A, Ferla S, Morciano G, Pinton P (2021) Concise Synthesis and Biological Evaluation of 2-Aryl-3-Anilinobenzo[b]thiophene Derivatives as Potent Apoptosis-Inducing Agents. Bioorg Chem 112:104919
- Santulli G, Monaco G, Parra V, Morciano G (2021) Mitochondrial Remodeling and Dynamic Inter-Organellar Contacts in Cardiovascular Physiopathology. Front Cell Dev Biol In press
- Morciano G, Vitto VAM, Bouhamida E, Giorgi C, Pinton P (2021) Mitochondrial bioenergetics and dynamism in the failing heart. Life 11:436
- Prill M, Karkucińska-Wieckowska A, Lebiedzińska-Arciszewska M, Morciano G, Charzyńska A, Dabrowski M, Pronicki M, Pinton P, Grajkowska W, Wieckowski MR (2021) Ras and ShcA protein expression patterns in pediatric brain tumors. J Clin Med 10:2219
- Patergnani S, Bonora M, Bouhamida E, Danese A, Marchi S, Morciano G, Previati M, Pedriali G, Rimessi A, Anania G, Giorgi C, Pinton P (2021) Methods to Monitor Mitophagy and Mitochondrial Quality: Implications in Cancer, Neurodegeneration, and Cardiovascular Diseases. Methods Mol Biol 2310:113-159
- Morciano G, Vezzani B, Missiroli S, Boncompagni C, Pinton P, Giorgi C (2021) An Updated Understanding of the Role of YAP in Driving Oncogenic Responses. Cancers 13:3100
- Morciano G, Naumova N, Koprowski P, Valente S, Sardão VA, Potes Y, Rimessi A, Wieckowski MR, Oliveira PJ (2021) The mitochondrial permeability transition pore: an evolving concept critical for cell life and death. Biol Rev In press
- Morciano G, Patergnani S, Pedriali G, Cimaglia P, Mikus E, Calvi S, Albertini A, Giorgi C, Campo G, Ferrari R, Pinton P (2021) Impairment of mitophagy and autophagy accompanies calcific aortic valve stenosis favoring cell death and the severity of disease. Cardiovascular Research In press
- Gardin C, Morciano G, Ferroni L, Mikus E, Tripodi A, Pin M, Tremoli E, Albertini A, Zavan B (2021) Biological Characterization of Human Autologous Pericardium Treated with the Ozaki Procedure for Aortic Valve Reconstruction. J Clin Med 10(17):3954
- Patergnani S, Missiroli S, Morciano G, Perrone M, Mantovani CM, Anania G, Fiorica F, Pinton P and Giorgi C (2021) Understanding the Role of Autophagy in Cancer Formation and Progression Is a Real Opportunity to Treat and Cure Human Cancers. Cancers 13(22), 5622
- Morciano G, Rimessi A, Patergnani S, Vitto V.A.M, Danese A, Kahsay A, Palumbo L, Bonora M, Wieckowski M.R., Giorgi C, Pinton P (2022) Calcium dysregulation in heart diseases: Targeting calcium channels to achieve a correct calcium homeostasis. Pharmacol Res 2022 Feb 4;106119
- Morciano G, Patergnani S, Pedriali G, Cimaglia P, Mikus E, Calvi S, Albertini A, Giorgi C, Campo G, Ferrari R, Pinton P (2022) Impairment of mitophagy and autophagy accompanies calcific aortic valve stenosis favouring cell death and the severity of disease. Cardiovasc Res 10;cvab267
- Bouhamida E, Morciano G, Perrone M, Kahsay A, Della Sala M, Wieckowski M R, Fiorica F, Pinton P, Giorgi C, Patergnani S (2022) The Interplay of Hypoxia Signaling on Mitochondrial Dysfunction and Inflammation in Cardiovascular Diseases and Cancer: From Molecular Mechanisms to Therapeutic Approaches. Biology 11(2):300
- Morciano G, Pedriali G, Mikus E, Cimaglia P, Calvi S, Pavasini R, Albertini A, Ferrari R, Wieckowski MR, Giorgi C, Campo G, Pinton P. (2021) Similarities between fibroblasts and cardiomyocytes in the study of the permeability transition pore. Eur J Clin Invest. e13764
- Tarocco A, Morciano M, Perrone M, Cafolla C, Ferrè C, Vacca T, Pistocchi G, Meneghin F, Cocchi I, Lista G, Cetin I, Greco P, Garani G, Stella M, Natile M, Ancora G, Savarese I, Campi F, Bersani I, Dotta A, Tiberi E, Vento G, Chiodin E, Staffler A, Maranella E, Di Fabio S, Wieckowski MR, Giorgi C, Pinton P (2022) Increase of Parkin and ATG5 plasmatic levels following perinatal hypoxic‐ischemic encephalopathy. Sci Rep. 12:7795
- Ramaccini D, Pedriali G, Perrone M, Bouhamida E, Modesti L, Wieckowski MR, Giorgi C, Pinton P, Morciano G. (2022) Some Insights into the Regulation of Cardiac Physiology and Pathology by the Hippo Pathway. Biomedicines 10(3):726
- Fantinati A*, Morciano G*, Turrin G, Pedriali G, Pacifico S, Preti D, Albanese V, Illuminati D, Cristofori V, Giorgi C, Tremoli E, Pinton P, Trapella C. (2022) Identification of small-molecule urea derivatives as PTPC modulators targeting the c subunit of F1/Fo-ATP synthase. Bioorg Med Chem Lett 72:128822
- Patergnani S, Morciano G, Carinci M, Leo S, Pinton P, Rimessi R (2022) The "mitochondrial stress responses": the "Dr. Jekyll and Mr. Hyde" of neuronal disorders. Neural Regen Res (12):2563-2575
- Missiroli S, Perrone M, Gafà R, Nicoli F, Bonora M, Morciano G, Boncompagni C, Marchi S, Lebiedzinska-Arciszewska M, Vezzani B, Lanza G, Kricek F, Borghi A, Fiorica F, Ito K, Wieckowski MR, Di Virgilio F, Abelli L, Pinton P, Giorgi C. PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment. Cell Death Differ. 2022 Nov 30:1–13. doi: 10.1038/s41418-022-01095-9.
- Turrin G, Lo Cascio E, Giacon N, Fantinati A, Cristofori V, Illuminati D, Preti D, Morciano G, Pinton P, Agyapong ED, Trapella C, Arcovito A. Spiropiperidine-Based Oligomycin-Analog Ligands To Counteract the Ischemia-Reperfusion Injury in a Renal Cell Model. J Med Chem. 2024 Jan 11;67(1):586-602
- Chiara Mazziotta, Giada Badiale, Christian Felice Cervellera, Giampaolo Morciano, Giulia Di Mauro, Antoine Touzé, Paolo Pinton, Mauro Tognon, Fernanda Martini, John Charles Rotondo. All-trans retinoic acid exhibits anti-proliferative and differentiating activity in Merkel cell carcinoma cells via retinoid pathway modulation. JEADV. 2024.
- Pasquale Mone, Esther Densu Agyapong, Giampaolo Morciano, Stanislovas S. Jankauskas, Antonio De Luca, Fahimeh Varzideh, Paolo Pinton, Gaetano Santulli. Dysfunctional mitochondria elicit bioenergetic decline in the aged heart. JCA. 2024.
- Kubat GB, Bouhamida E, Ulger O, Turkel I, Pedriali G, Ramaccini D, Ekinci O, Ozerklig B, Atalay O, Patergnani S, Nur Sahin B, Morciano G, Tuncer M, Tremoli E, Pinton P. Mitochondrial dysfunction and skeletal muscle atrophy: Causes, mechanisms, and treatment strategies. Mitochondrion. 2023 Sep;72:33-58.
- Bouhamida E, Morciano G, Pedriali G, Ramaccini D, Tremoli E, Giorgi C, Pinton P, Patergnani S. The Complex Relationship between Hypoxia Signaling, Mitochondrial Dysfunction and Inflammation in Calcific Aortic Valve Disease: Insights from the Molecular Mechanisms to Therapeutic Approaches. Int J Mol Sci. 2023 Jul 5;24(13):11105
- Di Mambro T, Pellielo G, Agyapong ED, Carinci M, Chianese D, Giorgi C, Morciano G, Patergnani S, Pinton P, Rimessi A. The Tricky Connection between Extracellular Vesicles and Mitochondria in Inflammatory-Related Diseases. Int J Mol Sci. 2023 May 3;24(9):8181.
- Fortini F, Vieceli Dalla Sega F, Lazzarini E, Aquila G, Sysa-Shah P, Bertero E, Ascierto A, Severi P, Ouambo Talla AW, Schirone A, Gabrielson K, Morciano G, Patergnani S, Pedriali G, Pinton P, Ferrari R, Tremoli E, Ameri P, Rizzo P. ErbB2-NOTCH1 axis controls autophagy in cardiac cells. Biofactors. 2024 Jul 12.
- Agyapong ED, Pedriali G, Ramaccini D, Bouhamida E, Tremoli E, Giorgi C, Pinton P, Morciano G. Calcium signaling from sarcoplasmic reticulum and mitochondria contact sites in acute myocardial infarction. J Transl Med. 2024 Jun 9;22(1):552.
- Taliento C, Morciano G, Nero C, Froyman W, Vizzielli G, Pavone M, Salvioli S, Tormen M, Fiorica F, Scutiero G, Scambia G, Giorgi C, Greco P, Pinton P. Circulating tumor DNA as a biomarker for predicting progression-free survival and overall survival in patients with epithelial ovarian cancer: a systematic review and meta-analysis. Int J Gynecol Cancer. 2024 Jun 3;34(6):906-918