Paolo Pinton Lab__Signal Transduction

 

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  1. Zavan B, Giorgi C, Bagnara GP, Vindigni V, Abatangelo G, Cortivo R (2007) Osteogenic and chondrogenic differentiation: comparison of human and rat bone marrow mesenchymal stem cells cultured into polymeric scaffolds. Eur J Histochem 51 Suppl 1:1-8
  2. Zecchini E, Siviero R, Giorgi C, Rizzuto R, Pinton P (2007) Mitochondrial calcium signalling: message of life and death. Ital J Biochem 56:235-42
  3. Giorgi C, Romagnoli A, Pinton P, Rizzuto R (2008) Ca2+ signaling, mitochondria and cell death. Current Molecular Medicine 8:119-130
  4. Rimessi A§, Giorgi C§, Pinton P, Rizzuto R (2008) The versatility of mitochondrial calcium signals: from stimulation of cell metabolism to induction of cell death. Biochim Biophys Acta (Bioenergetics) 1777/7-8:808-816 §equally contributed
  5. Pinton P§, Giorgi C§, Siviero R, Zecchini E, Rizzuto R (2008) Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis. Oncogene 27:6407-18 §equally contributed
  6. Marchi S, Rimessi A, Giorgi C, Baldini C, Ferroni L, Rizzuto R, Pinton P (2008) Akt kinase reducing Endoplasmic Reticulum Ca2+ release protects cells from Ca2+-dependent apoptotic stimuli. Biochem Biophys Res Commun 375:501-5
  7. Adinolfi E, Callegari MG, Cirillo M, Pinton P, Giorgi C, Cavagna D, Rizzuto R, Di Virgilio F (2009) Expression of the P2X7 receptor increases the Ca2+ content of the endoplasmic reticulum, activates NFATc1, and protects from apoptosis. J Biol Chem 284:10120-8
  8. Murgia M, Giorgi C, Pinton P, Rizzuto R (2009) Controlling metabolism and cell death: at the heart of mitochondrial calcium signalling. J Mol Cell Cardiol 46:781-8
  9. Rizzuto R, Marchi S, Bonora M, Aguiari P, Bononi A, De Stefani D, Giorgi C, Leo S, Rimessi A, Siviero R, Zecchini E, Pinton P. (2009) Ca(2+) transfer from the ER to mitochondria: when, how and why. Biochim Biophys Acta (Bioenergetics) 1787:1342-51
  10. Giorgi C, De Stefani D, Bononi A, Rizzuto R, Pinton P (2009) Structural and functional link between the mitochondrial network and the endoplasmic reticulum. Int J Biochem Cell Biol 41:1817-27
  11. Wieckowski MR§, Giorgi C§, Lebiedzinska M, Duszynski J, Pinton P (2009) Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells. Nat Protoc 4:1582-90 §equally contributed
  12. Giorgi C, Agnoletto C, Baldini C, Bononi A, Bonora M, Marchi S, Missiroli S, Patergnani S, Poletti F, Rimessi A, Zavan B, Pinton P (2010) Redox control of Protein Kinase C: cell and disease
 specific significances. Antioxid Redox Signal 13(7):1051-85
  13. Lebiedzinska M, Karkucinska-Wieckowska A, Giorgi C, Karczmarewicz E, Pronicka E, Pinton P, Duszynski P, Pronicki M, Wieckowski MR (2010) Oxidative stress-dependent p66Shc phosphorylation in skin fibroblasts of children with mitochondrial disorders. Biochim Biophys Acta (Bioenergetics) 1797(6-7):952-960
  14. Giorgi C, Ito K, Lin H, Santangelo C, Wieckowski MR, Lebiedzinska M, Bononi A, Bonora M, Duszynski J, Bernardi R, Rizzuto R, Tacchetti C, Pinton P*, Pandolfi PP (2010) PML regulates apoptosis at endoplasmic reticulum modulating calcium release. Science 330:1247-51 *corresponding author
  15. Demaria M, Giorgi C, Lebiedzinska M, Esposito G, D'Angeli L, Bartoli A, Gough DJ, Turkson J, Levy DE, Watson CJ, Wieckowski MR, Provero P, Pinton P, Poli V (2010) STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction. Aging 2(11):823-42
  16. Giorgi C, Wieckowski MR, Pandolfi PP, Pinton P (2011) Mitochondria associated membranes (MAMs) as critical hubs for apoptosis. Commun Integr Biol 4(3):334-5
  17. Giorgi C, Romagnoli A, Agnoletto C, Bergamelli L, Sorrentino G, Brini M, Pozzan T, Meldolesi J, Pinton P, Rizzuto R (2011) Translocation of signalling proteins to the plasma membrane revealed by a new bioluminescent procedure. BMC Cell Biology 12:27
  18. Suski JM, Karkucinska-Wieckowska A, Lebiedzinska M, Giorgi C, Szczepanowska J, Szabadkai G, Duszynski J, Pronicki M, Pinton P, Wieckowski MR (2011) p66Shc aging protein in control of fibroblasts cell fate. Int J Mol Sci 12(8):5373-89
  19. Bononi A, Agnoletto C, De Marchi E, Marchi S, Patergnani S, Bonora M, Giorgi C, Missiroli S, Poletti F, Rimessi A, Pinton P (2011) Protein kinases and phosphatases in the control of cell fate. Enzyme Res 2011:329098
  20. Patergnani S, Suski JM, Agnoletto C, Bononi A, Bonora M, De Marchi E, Giorgi C, Marchi S, Missiroli S, Poletti F, Rimessi A, Duszynski J, Wieckowski MR, Pinton P (2011) Calcium signaling around Mitochondria Associated Membranes (MAMs). Cell Commun Signal 9(1):19
  21. Pesaresi MG, Amori I, Giorgi C, Ferri A, Fiorenzo P, Gabanella F, Salvatore AM, Giorgio M, Pelicci PG, Pinton P, Carri MT, Cozzolino M (2011) Mitochondrial redox signaling by p66Shc mediates ALS-like disease through Rac1 inactivation. Hum Mol Genet 20(21):4196-208
  22. Tombolan L, Orso F, Guzzardo V, Casara S, Zin A, Bonora M, Romualdi C, Giorgi C, Bisogno G, Alaggio R, Pinton P, De Pittà C, Taverna D, Rosolen A, Lanfranchi G (2011) High IGFBP2 expression correlates with tumor severity in pediatric rhabdomyosarcoma. Am J Pathol 179(5):2611-24
  23. Pinton P §, Giorgi C §, Pandolfi PP (2011) The role of PML in the control of apoptotic cell fate: a new key player at ER-mitochondria sites. Cell Death Differ 18(9):1450-6 §equally contributed
  24. Marchi S, Giorgi C, Suski J, Agnoletto C, Bononi A, Bonora M, De Marchi E, Missiroli S, Patergnani S, Poletti F, Rimessi A, Duszynski J, Wieckowski MR, Pinton P (2012) Mitochondria-ROS crosstalk in the control of cell death and aging. J Signal Transduct 2012:329635
  25. Giorgi C, Agnoletto C, Bononi A, Bonora M, De Marchi E, Marchi S, Missiroli S, Patergnani S, Poletti F, Rimessi A, Suski JM, Wieckowski MR, Pinton P (2012) Mitochondrial calcium homeostasis as potential target for mitochondrial medicine. Mitochondrion 12:77-85
  26. Rimessi A, Zecchini E, Siviero R, Giorgi C, Leo S, Rizzuto R, Pinton P (2012) The selective inhibition of nuclear PKCζ restores the effectiveness of chemotherapeutic agents in chemoresistant cells. Cell Cycle 11(5):1040-48
  27. Bononi A, Missiroli S, Poletti F, Suski JM, Agnoletto C, Bonora M, De Marchi E, Giorgi C, Marchi S, Patergnani S, Rimessi A, Wieckowski MR, Pinton P (2012) Mitochondria-associated membranes (MAMs) as hotspot Ca2+ signalling units. Adv Exp Med Biol 740:411-38
  28. Garcia-Cao I, Song MS*, Hobbs RM*, Laurent G*, Giorgi C*, de Boer VC, Anastasiou D, Ito K, Sasaki A, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, Pandolfi PP (2012) Systemic elevation of PTEN induces a tumor suppressive metabolic state. Cell 149:49-62 *equally contributed
  29. Marchi S, Marinello M, Bononi A, Bonora M, Giorgi C, Rimessi A, Pinton P (2012) Selective modulation of subtype III IP3R by Akt regulates ER Ca2+ release and apoptosis. Cell Death Dis 3:e304
  30. Bonora M, Patergnani S, Rimessi A, De Marchi E, Suski JM, Bononi A, Giorgi C, Marchi S, Missiroli S, Poletti F, Wieckowski MR, Pinton P (2012) ATP synthesis and storage. Purinergic Signalling 8:343–357
  31. Giorgi C, Baldassari F, Bononi A, Bonora M, De Marchi E, Marchi S, Missiroli S, Patergnani S, Rimessi A, Suski JM, Wieckowski MR, Pinton P (2012) Mitochondrial Ca2+ and apoptosis. Cell Calcium 52:36-43
  32. Demaria M, Misale S, Giorgi C, Miano V, Campisi J, Pinton P, Poli V (2012) STAT3 can serve as a hit in the process of malignant transformation of primary cells. Cell Death Differ 19:1390–7
  33. Chiabrando D, Marro S, Mercurio S, Giorgi C, Petrillo S, Vinchi F, Fiorito V, Fagoonee S, Camporeale A, Turco E, Merlo GR, Silengo L, Altruda F, Pinton P, Tolosano E (2012) The mitochondrial isoform of the heme exporter FLVCR1 controls erythroid differentiation by exporting heme from mitochondria. J Clin Invest 122(12):4569-79
  34. Marchi S, Lupini L, Patergnani S, Rimessi A, Missiroli S, Bonora M, Bononi A, Corrà F, Giorgi C, De Marchi E, Poletti F, Gafà R, Lanza G, Negrini M, Rizzuto R, Pinton P (2013) Downregulation of the mitochondrial calcium uniporter by cancer-related miR-25. Current Biology 23:58-63
  35. Sorrentino G, Mioni M, Giorgi C, Pinton P, Moll U, Mantovani F, Del Sal G (2013) The prolyl-isomerase Pin1 activates the mitochondrial death program of p53. Cell Death Diff 20:198-208
  36. Zavan B, Ferroni L, Giorgi C, Calò G, Brun P, Cortivo R, Abatangelo G, Pinton P (2013) Hyaluronic acid induces activation of the κ-opioid receptor. PLoS One 8(1):e55510
  37. Bonora M, Bononi A, De Marchi E, Giorgi C, Lebiedzinska M, Marchi S, Patergnani S, Rimessi A, Suski JM, Wojtala A, Wieckowski MR, Kroemer G, Galluzzi L, Pinton P (2013) Role of the c subunit of the FO ATP synthase in mitochondrial permeability transition. Cell Cycle 12(4):674-683
  38. Bonora M §, Giorgi C §, Bononi A, Marchi S, Patergnani S, Rimessi A, Rizzuto R, Pinton P (2013) Subcellular calcium measurements in mammalian cells using jellyfish photoprotein aequorin-based probes.  Nat Protoc 8(11):2105-18 §equally contributed
  39. Patergnani S, Marchi S, Rimessi A, Bonora M, Giorgi C, Mehta KD, Pinton P (2013) PRKCB/protein kinase C β and the mitochondrial axis as key regulators of autophagy. Autophagy 9(9):1367-85
  40. Bononi A, Bonora M, Marchi S, Missiroli S, Poletti F, Giorgi C, Pandolfi PP, Pinton P (2013) Identification of PTEN at the ER and MAMs and its regulation of Ca2+ signaling and apoptosis in a protein phosphatase-dependent manner. Cell Death Diff 20:1631-43
  41. Suski JM, Lebiedzinska M, Wojtala A, Duszynski J, Giorgi C, Pinton P, Wieckowski MR (2014) Isolation of plasma membrane-associated membranes from rat liver. Nat Protoc 9(2):312-322
  42. Bonora M, De Marchi E, Patergnani S , Suski JM, Celsi F, Bononi A, Giorgi C, Marchi S, Rimessi A, Duszyński J, Pozzan T, Wieckowski MR, Pinton P (2014) Tumor necrosis factor-α impairs oligodendroglial differentiation through a mitochondria-dependent process. Cell Death Differ 21:1198–1208
  43. Camporeale A, Demaria M, Monteleone E, Giorgi C, Wieckowski MR, Pinton P, Poli V (2014) STAT3 activities and energy metabolism: dangerous liaisons. Cancers 6:1579-96
  44. Marchi S§, Giorgi C§, Oparka M, Duszynski J, Wieckowski MR, Pinton P (2014) Oncogenic and oncosuppressive signal transduction at mitochondria-associated endoplasmic reticulum membranes (MAM). Molecular & Cellular Oncology 1(2):e956469 §equally contributed
  45. De Marchi E, Bonora M, Giorgi C, Pinton P (2014) The mitochondrial permeability transition pore is a dispensable element for mitochondrial calcium efflux. Cell Calcium 56(1):1-13
  46. Marino M, Stoilova T, Giorgi C, Bachi A, Cattaneo A, Auricchio A, Pinton P, Zito E (2015) SEPN1, an endoplasmic reticulum-localized selenoprotein linked to skeletal muscle pathology, counteracts hyper-oxidation by means of redox- regulating SERCA2 pump activity. Hum Mol Genet 24(7):1843-55
  47. Morciano G§, Giorgi C§, Bonora M, Punzetti S, Pavasini R, Wieckowski MR, Campo G, Pinton P (2015) Molecular identity of the mitochondrial permeability transition pore and its role in ischemia-reperfusion injury. J Mol Cell Cardiol 78:142-153 §equally contributed
  48. Ghezzi D, Canavese C, Kovacevic G, Zamurovic D, Barzaghi C, Giorgi C, Zorzi G, Zeviani M, Pinton P, Garavaglia B, Nardocci N (2015) A family with paroxysmal nonkinesigenic dyskinesias (PNKD): Evidence of mitochondrial dysfunction. Eur J Paediatr Neurol 19:64-68
  49. Giorgi C, Bonora M, Sorrentino G, Missiroli S, Poletti F, Suski JM, Ramirez FG, Rizzuto R, Di Virgilio F, Zito E, Pandolfi PP, Wieckowski MR, Mammano F, Del Sal G, Pinton P (2015) p53 at the endoplasmic reticulum regulates apoptosis in a Ca 2+ -dependent manner. Proc Natl Acad Sci USA 112(6):1779-84
  50. Giorgi C, Bonora M, Missiroli S, Poletti F, Ramirez FG, Morciano G, Morganti C, Pandolfi PP, Mammano F, Pinton P (2015) Intravital imaging reveals p53-dependent cancer cell death induced by phototherapy via calcium signaling. Oncotarget 6(3):1435-45
  51. Giorgi C, Missiroli S, Patergnani S, Duszyński J, Wieckowski MR, Pinton P (2015) Mitochondria-associated Membranes (MAMs): Composition, Molecular Mechanisms and Physiopathological Implications. Antioxid Redox Signal 22(12):995-1019
  52. Giorgi C, Bonora M, Pinton P (2015) Inside the tumor: p53 modulates calcium homeostasis. Cell Cycle 14(7):933-4
  53. Venco P§ , Bonora M§ , Giorgi C§ , Papaleo E, Iuso A, Prokisch H, Pinton P, Tiranti V (2015) Mutations of C19orf12, coding for a transmembrane glycine 1 zipper containing mitochondrial protein, cause mis-localization of the protein, inability to respond to oxidative stress and increased mitochondrial Ca2+. Front Genet 6:185 §equally contributed
  54. Bonora M§, Giorgi C§, Pinton P (2015) Novel frontiers in calcium signaling: a possible target for chemotherapy. Pharmacol Res 99:82-85 §equally contributed
  55. Yang H, Pellegrini L, Napolitano A, Giorgi C, Jube S, Preti A, Jennings C, Marchis F, Flores E, Larson D, Pagano I, Tanji M, Power A, Kanodia S, Gaudino G, Pastorino S, Pass H, Pinton P, Bianchi M, Carbone M (2015) Aspirin Delays Mesothelioma Growth By Inhibiting HMGB1-Mediated Tumor Progression. Cell Death Dis 6:e1786
  56. Carelli V, Musumeci O, Caporali L, Zanna C, La Morgia C, Del Dotto V, Porcelli AM, Rugolo M, Valentino ML, Iommarini L, Maresca A, Barboni P, Carbonelli M, Trombetta C, Valente EM, Patergnani S, Giorgi C, Pinton P, Rizzo G, Tonon C, Lodi R, Avoni P, Liguori R, Baruzzi A, Toscano A, Zeviani M (2015) Syndromic parkinsonism and dementia associated with OPA1 missense mutations. Ann Neurol 78(1):21-38
  57. Patergnani S, Giorgi C, Maniero S, Missiroli S, Maniscalco P, Bononi I, Martini F, Cavallesco G, Tognon M, Pinton P (2015) The endoplasmic reticulum mitochondrial calcium cross talk is downregulated in malignant pleural mesothelioma cells and plays a critical role in apoptosis inhibition. Oncotarget 6(27):23427-49
  58. Patergnani S, Missiroli S, Marchi S, Giorgi C (2015) Mitochondria-Associated Endoplasmic Reticulum Membranes Microenvironment: Targeting Autophagic and Apoptotic Pathways in Cancer Therapy. Front Oncol 5:173
  59. Marchi S, Corricelli M, Trapani E, Bravi L , Pittaro A, Delle Monache S, Ferroni L, Patergnani S, Missiroli S, Goitre L, Trabalzini L, Rimessi A, Giorgi C, Zavan B, Cassoni P, Dejana E , Retta SF, Pinton P (2015) Defective autophagy is a key feature of cerebral cavernous malformations. EMBO Mol Med 7(11):1403-17
  60. Morciano G, Giorgi C, Balestra D, Marchi S, Perrone D, Pinotti M, Pinton P (2016) Mcl-1 involvement in mitochondrial dynamics is associated with apoptotic cell death. Mol Biol Cell 27(1):20-34
  61. Missiroli S, Morganti C, Giorgi C, Pinton P (2016) Methods to Study PTEN in Mitochondria and Endoplasmic Reticulum. Methods in Molecular Biology 1388:187-212
  62. Giorgi C, Bonora M, Missiroli S, Morganti C, Morciano G, Wieckowski MR, Pinton P (2016) Alterations in mitochondrial and endoplasmic reticulum signaling by p53 mutants. Front Oncol 6:42
  63. Bonora M, Morganti C , Morciano G , Giorgi C, Wieckowski MR, Pinton P (2016) Comprehensive analysis of mitochondrial permeability transition pore activity in living cells using fluorescence-imaging-based techniques. Nat Protoc 11(6):1067-1080
  64. Morciano G, Pedriali G, Sbano L, Iannitti T, Giorgi C*, Pinton P (2016) Intersection of mitochondrial fission and fusion machinery with apoptotic pathways: role of Mcl-1. Biol Cell 108:279-293 *co-corresponding author
  65. Campo G, Morciano G, Pavasini R, Bonora M, Sbano L, Biscaglia S, Bovolenta M, Pinotti M, Punzetti S, Rizzo P, Aquila G, Giorgi C, Ferrari R, Pinton P (2016) Fo ATP synthase C subunit serum levels in patients with ST-segment Elevation Myocardial Infarction: preliminary findings. Int J Cardiol 221:993-7
  66. Missiroli S, Bonora M, Patergnani S, Poletti F, Perrone M, Gafà R, Magri E, Raimondi A, Lanza G, Tacchetti C, Kroemer G, Pandolfi PP, Pinton P, Giorgi C (2016) PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development. Cell Rep 16(9):2415-27
  67. Patergnani S , Fossati V , Bonora M, Giorgi C, Marchi S , Missiroli S, Rusielewicz T, Wieckowski MR, Pinton P (2017) Mitochondria in multiple sclerosis: molecular mechanisms of pathogenesis. Int Rev Cell Mol Biol 328:49-103
  68. Sbano L, Bonora M , Marchi S , Baldassari F , Medina DL, Ballabio A , Giorgi C, Pinton P (2017) TFEB-mediated increase in peripheral lysosomes regulates store-operated calcium entry. Sci Rep 7:40797
  69. Marchi S, Bonora M, Patergnani S, Giorgi C, Pinton P (2017) Methods to Assess Mitochondrial Morphology in Mammalian Cells Mounting Autophagic or Mitophagic Responses. Methods Enzymol 588:171-186
  70. Szymiczek A, Pastorino S, Larson D, Tanji M, Pellegrini L, Xue J, Li S, Giorgi C, Pinton P, Takinishi Y, Pass HI, Furuya H, Gaudino G, Napolitano A, Carbone M, Yang H (2017) FTY720 inhibits mesothelioma growth in vitro and in a syngeneic mouse model. J Transl Med 15:58
  71. Morciano G , Bonora M , Giorgi C, Pinton P (2017) Other bricks for the correct construction of the mitochondrial permeability transition pore complex. Cell Death Dis 8:e2698
  72. Missiroli S, Danese A, Iannitti T, Patergnani S, Perrone M, Previati M, Giorgi C, Pinton P (2017) Endoplasmic reticulum-mitochondria Ca2+ crosstalk in the control of the tumor cell fate. Biochim Biophys Acta (Molecular Cell Research) 1864:858-864
  73. Danese A, Patergnani S, Bonora M , Wieckowski MR, Previati M , Giorgi C*, Pinton P (2017) Calcium regulates cell death in cancer: roles of the mitochondria and mitochondria-associated membranes (MAMs). Biochim Biophys Acta (Bioenergetics) 1858:615-627 *co-corresponding author
  74. Profilo E, Peña-Altamira LE, Corricelli M, Castegna A, Danese A, Agrimi G, Petralla S, Giannuzzi G, Porcelli V, Sbano L, Viscomi C, Massenzio F, Palmieri EM, Giorgi C, Fiermonte G, Virgili M, Palmieri L, Zeviani M, Pinton P, Monti B, Palmieri F, Lasorsa FM (2017) Down-regulation of the mitochondrial aspartate-glutamate carrier isoform 1 AGC1 inhibits proliferation and N-acetylaspartate synthesis in Neuro2A cells. Biochim Biophys Acta (Molecular Basis of Disease) 1863:1422-35
  75. Morciano G, Bonora M, Campo G, Aquila G, Rizzo P, Giorgi C, Wieckowski MR, Pinton P (2017) Mechanistic Role of mPTP in Ischemia-Reperfusion Injury. Adv Exp Med Biol 982:169-189
  76. Morciano G, Sarti A, Marchi S, Missiroli S, Falzoni S, Raffaghello L, Pistoia V, Giorgi C, Di Virgilio F, Pinton P (2017) Using luciferase probes to measure ATP in living cells and animals. Nat Protoc 12(8):1542-62
  77. Bonora M, Morganti C, Morciano G, Pedriali G, Lebiedzinska-Arciszewska M, Aquila G, Giorgi C, Rizzo P, Campo G, Ferrari R, Kroemer G,Wieckowski MR, Galluzzi L, Pinton P (2017) Mitochondrial permeability transition involves dissociation of F1FO ATP synthase dimers and C-ring conformation. EMBO Reports 18(7):1077-89
  78. Marchi S, Bittremieux M, Missiroli S, Morganti C, Patergnani S, Sbano L, Rimessi A, Kerkhofs M, Parys JB, Bultynck G, Giorgi C* , Pinton P (2017) Endoplasmic Reticulum-Mitochondria Communication Through Ca2+ Signaling: The Importance of Mitochondria-Associated Membranes (MAMs). Adv Exp Med Biol 997:49-67 *co-corresponding author
  79. Kerkhofs M, Giorgi C, Marchi S, Seitaj B, Parys JB, Pinton P, Bultynck G, Bittremieux M (2017) Alterations in Ca2+ Signalling via ER-Mitochondria Contact Site Remodelling in Cancer. Adv Exp Med Biol 997:225-254
  80. Bononi A, Giorgi C, Patergnani S, Larson D, Verbruggen K, Tanji M, Pellegrini L, Signorato V, Olivetto F, Pastorino S, Nasu M, Napolitano A, Gaudino G, Morris P, Sakamoto G, Ferris LK, Danese A, Raimondi A, Tacchetti C, Kuchay S, Pass HI, Affar EB, Yang H, Pinton P, Carbone M (2017) BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation. Nature 546:549-553
  81. Kuchay S*, Giorgi C*, Simoneschi D, Pagan J, Missiroli S, Saraf A, Florens L, Washburn MP, Collazo-Lorduy A, Castillo-Martin M, Cordon-Cardo C, Sebti SM, Pinton P, Pagano M (2017) PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth. Nature 546:554-558 *equally contributed
  82. Bononi A*, Yang H*, Giorgi C*, Patergnani S, Pellegrini L, Su M, Xie G, Signorato V, Pastorino S, Morris P, Sakamoto G, Kuchay S, Gaudino G, Pass HI, Napolitano A, Pinton P, Jia W, Carbone M (2017) Germline BAP1 mutations induce a Warburg effect. Cell Death Differ 24:1694-1704 *equally contributed
  83. Pedriali G, Rimessi A, Sbano L, Giorgi C, Wieckowski MR, Previati M, Pinton P (2017) Regulation of ER-mitochondria Ca2+ transfer and its importance for anti-cancer therapies. Front Oncol 7:180
  84. Missiroli S, Bonora M, Patergnani S, Giorgi C (2017) Novel function of the tumor suppressor PML at ER-mitochondria sites in the control of autophagy. Oncotarget 8(47):81723-81724
  85. Fiorica F, Belluomini L, Stefanelli A, Santini A, Urbini B, Giorgi C, Frassoldati A (2018) Immune Checkpoint Inhibitor Nivolumab and Radiotherapy in Pretreated Lung Cancer Patients: Efficacy and Safety of Combination. Am J Clin Oncol 41(11):1101-1105
  86. Patergnani S , Castellazzi M , Bonora M , Marchi S , Casetta I, Pugliatti M , Giorgi C , Granieri E, Pinton P (2018) Autophagy and mitophagy elements are increased in body fluids of Multiple Sclerosis-affected individuals. J Neurol Neurosurg Psychiatry 89(4):439-441
  87. Marchi S, Patergnani S, Missiroli S, Morciano G, Rimessi A, Wieckowski MR, Giorgi C, Pinton P (2018) Mitochondrial and Endoplasmic Reticulum Calcium Homeostasis and Cell Death. Cell Calcium 69:62-72
  88. Kerkhofs M, Bittremieux M, Morciano G, Giorgi C, Pinton P, Parys JB, Bultynck G (2018) Emerging molecular mechanisms in chemotherapy: Ca2+ signaling at the mitochondria-associated endoplasmic reticulum membranes. Cell Death Dis 9:334
  89. Morciano G, Marchi S, Morganti C, Sbano L, Bittremieux M, Kerkhofs M, Corricelli M, Danese A, Karkucinska-Wieckowska A, Wieckowski MR, Bultynck G, Giorgi C*, Pinton P (2018) Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific Settings. Neoplasia 20(5):510-523 *co-corresponding author
  90. Morganti C, Bonora M, Sbano L, Morciano G, Aquila G, Campo G, Wieckowski MR, Giorgi C, Pinton P (2018) The Mitochondrial Permeability Transition Pore. Mitochondrial Biology and Experimental Therapeutics 47-73
  91. Missiroli S, Patergnani S, Caroccia N, Pedriali G, Perrone M, Previati M, Wieckowski MR, Giorgi C (2018) Mitochondria-associated membranes (MAMs) and inflammation. Cell Death Dis 9(3):329
  92. Janikiewicz J, Szymański J, Malinska D, Patalas-Krawczyk P, Michalska B, Duszyński J, Giorgi C, Bonora M, Dobrzyn A, Wieckowski MR (2018) Mitochondria-associated membranes in aging and senescence: structure, function, and dynamics. Cell Death Dis 9(3):332
  93. Giorgi C, Marchi S, Simoes ICM, Ren Z, Morciano G, Perrone M, Patalas-Krawczyk P, Borchard S, Jędrak P, Pierzynowska K, Szymański J, Wang DQ, Portincasa P, Węgrzyn G, Zischka H, Dobrzyn P, Bonora M, Duszynski J, Rimessi A, Karkucinska-Wieckowska A, Dobrzyn A, Szabadkai G, Zavand B, Oliveira PJ, Sardao VA, Pinton P, Wieckowski MR (2018) Mitochondria and reactive oxygen species in aging and age related diseases. Int Rev Cell Mol Biol 340:209-344
  94. Giorgi C, Danese A, Missiroli S, Patergnani S, Pinton P (2018) Calcium dynamics as a machine for decoding signals. Trends Cell Biol 28(4):258-273
  95. Morciano G, Preti D, Pedriali G, Aquila G, Missiroli S, Fantinati A, Caroccia N, Pacifico S, Bonora M, Talarico A, Morganti C, Rizzo P, Ferrari R, Wieckowski MR, Campo G, Giorgi C, Trapella C, Pinton P (2018) Discovery of novel 1,3,8-triazaspiro[4.5]decane derivatives that target the c subunit of F1/FO-adenosine triphosphate (ATP) synthase for the treatment of reperfusion damage in myocardial infarction. J Med Chem 61:7131-43
  96. Carbone M, Amelio I, Affar EB, Brugarolas J, Cannon-Albright LA, Cantley LC, Cavenee WK, Chen Z, Croce CM, D’Andrea A, Gandara D, Giorgi C, Jia W, Lan Q, Mak TW, Manley JL, Mikoshiba K, Onuchic JN, Pass HI, Pinton P, Prives C, Rothman N, Sebti SM, Turkson J, Wu X, Yang H, Yu H, Melino G (2018) Consensus report of the 8 and 9th Weinman Symposia on Gene X Environment Interaction in carcinogenesis: novel opportunities for precision medicine. Cell Death Diff 25(11):1885-1904
  97. Giorgi C, Marchi S, Pinton P (2018) The machineries, regulation and cellular functions of mitochondrial calcium. Nat Rev Mol Cell Biol 19(11):713-730
  98. Kuchay S, Saeed M, Giorgi C, Li J, Hoffmann HH, Pinton P, Rice CM, Pagano M (2018) NS5A Promotes Constitutive Degradation of IP3R3 to Counteract Apoptosis Induced by Hepatitis C Virus. Cell Rep 25(4):833-840.e3
  99. Previati M, Missiroli S, Perrone M, Caroccia N, Paliotto F, Milani D, Giorgi C (2018) Functions and dys-functions of promyelocytic leukemia protein PML. Rendiconti Lincei 29(2):411-420
  100. Avalle L, Camporeale A, Morciano G, Caroccia N, Ghetti E, Orecchia V, Viavattene D, Giorgi C, Pinton P, Poli V (2019) STAT3 localizes to the ER, acting as a gatekeeper for ER-mitochondrion Ca2+ fluxes and apoptotic responses. Cell Death Differ 26(5):932-942
  101. Morganti C, Missiroli S, Lebiedzinska-Arciszewska M, Ferroni L, Morganti L, Perrone M, Ramaccini D, Occhionorelli S, Zavan B, Wieckowski MR, Giorgi C (2019) Regulation of PKCβ levels and autophagy by PML is essential for high-glucose-dependent mesenchymal stem cell adipogenesis. Int J Obes 43(5):963-973
  102. Pozzer D, Varone E, Chernorudskiy A, Schiarea S, Missiroli S, Giorgi C, Pinton P, Canato M, Germinario E, Nogara L, Blaauw B, Zito E (2019) A maladaptive ER stress response triggers dysfunction in highly active muscles of mice with SELENON loss. Redox Biology 20:354-366
  103. Marchi S, Corricelli M, Branchini A, Vitto VAM, Missiroli S, Morciano G, Perrone M, Ferrarese M, Giorgi C, Pinotti M, Galluzzi L, Kroemer G, Pinton P (2019) Akt-mediated phosphorylation of MICU1 regulates mitochondrial Ca2+ levels and tumor growth. EMBO J 38(2):e99435
  104. Marchi S, Vitto VAM, Danese A, Wieckowski MR, Giorgi C, Pinton P (2019) Mitochondrial calcium uniporter complex modulation in cancerogenesis. Cell Cycle 18(10):1068-1083
  105. Castellazzi M, Patergnani S, Donadio M, Giorgi C, Bonora M, Fainardi E, Casetta I, Granieri E, Pugliatti M, Pinton P (2019) Correlation between auto-/mitophagic processes and magnetic resonance imaging activity in multiple sclerosis patients. J Neuroinflammation 16:131
  106. Petralla S, Peña-Altamira LE, Poeta E, Massenzio F, Virgili M, Barile SN, Sbano L, Profilo E, Corricelli M, Danese A, Giorgi C, Ostan R, Capri M, Pinton P, Palmieri F, Lasorsa FM, Monti B (2019) Deficiency of Mitochondrial Aspartate-Glutamate Carrier 1 Leads to Oligodendrocyte Precursor Cell Proliferation Defects Both In Vitro and In Vivo. Int J Mol Sci 20(18):E4486
  107. Castellazzi M, Patergnani S, Donadio M, Giorgi C, Bonora M, Bosi C, Brombo G, Pugliatti M, Seripa D, Zuliani G, Pinton P (2019) Autophagy and mitophagy biomarkers are reduced in sera of patients with Alzheimer’s disease and mild cognitive impairment. Sci Rep 9(1):20009
  108. Morciano G, Imamura H, Patergnani S, Pedriali G, Giorgi C, Pinton P (2020) Measurement of ATP concentrations in mitochondria of living cells using luminescence and fluorescence approaches. Methods in Cell Biology 155:199-219
  109. Perrone M, Caroccia N, Genovese I, Missiroli S, Modesti L, Pedriali G, Vezzani B, Vitto VAM, Antenori M, Lebiedzinska-Arciszewska M, Wieckowski MR, Giorgi C, Pinton P (2020) The role of mitochondria-associated membranes in cellular homeostasis and diseases. Int Rev Cell Mol Biol 350:119-196
  110. Rimessi A, Pedriali G, Vezzani B, Tarocco A, Marchi S, Wieckowski MR, Giorgi C, Pinton P (2020) Interorganellar calcium signaling in the regulation of cell metabolism: A cancer perspective. Semin Cell Dev Biol 98:167-180
  111. La Morgia C, Maresca A, Amore G, Gramegna LL, Carbonelli M, Scimonelli E, Danese A, Patergnani S, Caporali L, Tagliavini F, Del Dotto V, Capristo M, Sadun F, Barboni P, Savini G, Evangelisti S, Bianchini C, Valentino ML, Liguori R, Tonon C, Giorgi C, Pinton P, Lodi R, Carelli V (2020) Calcium mishandling in absence of primary mitochondrial dysfunction drives cellular pathology in Wolfram Syndrome. Sci Rep 10:4785
  112. Morciano G, Patergnani S, Bonora M, Pedriali G, Tarocco A, Bouhamida E, Marchi S, Ancora G, Anania G, Wieckowski MR, Giorgi C, Pinton P (2020) Mitophagy in cardiovascular diseases. J Clin Med 9:892
  113. Morganti C, Bonora M, Marchi S, Ferroni L, Gardin C, Wieckowski MR, Giorgi C, Pinton P, Zavan B (2020) Citrate mediates crosstalk between mitochondria and the nucleus to promote human mesenchymal stem cell in vitro osteogenesis. Cells 9:1034
  114. Marchi S, Giorgi C, Galluzzi L, Pinton P (2020) Ca2+ Fluxes and Cancer. Mol Cell 78:1055-1069
  115. Bonora M, Patergnani S, Ramaccini D, Morciano G, Pedriali G, Kahsay AE, Bouhamida E, Giorgi C, Wieckowski MR, Pinton P (2020) Physiopathology of the Permeability Transition Pore: Molecular Mechanisms in Human Pathology. Biomolecules 10:998
  116. Pedriali G, Morciano G, Patergnani S, Cimaglia P, Morelli C, Mikus E, Ferrari R, Gasbarro V, Giorgi C, Wieckowski MR, Pinton P (2020) Aortic valve stenosis and mitochondrial dysfunctions: clinical and molecular perspectives. Int J Mol Sci 21(14):4899
  117. Danese A, Marchi S, Vitto VAM, Modesti L, Leo S, Wieckowski MR, Giorgi C, Pinton P (2020) Cancer-related increases and decreases in calcium signaling at the Endoplasmic Reticulum-mitochondria interface (MAMs). Rev Physiol Biochem Pharmacol doi: 10.1007/112_2020_43
  118. Missiroli S, Perrone M, Genovese I, Pinton P, Giorgi C (2020) Cancer metabolism and mitochondria: finding novel mechanisms to fight tumours. EBioMedicine 59:102943
  119. Xue J*, Patergnani S*, Giorgi C*, Suarez J, Goto K, Bononi A, Tanji M, Novelli F, Pastorino S, Xu R, Caroccia N, Dogan AU, Pass HI, Tognon M, Pinton P, Gaudino G, Mak TK, Carbone M, Yang H (2020) Asbestos induces mesothelial cell transformation via HMGB1-driven autophagy. Proc Natl Acad Sci USA 117(41):25543-25552 *equally contributed
  120. Vezzani B, Carinci M, Patergnani S, Pasquin MP, Guarino A, Aziz N, Pinton P, Simonato M, Giorgi C (2020) The Dichotomous Role of Inflammation in the CNS: A Mitochondrial Point of View. Biomolecules 10(10):E1437
  121. Genovese I, Vezzani B, Danese A, Modesti L, Vitto VAM, Corazzi V, Pelucchi S, Pinton P, Giorgi C (2020) Mitochondria as the decision makers for cancer cell fate: from signaling pathways to therapeutic strategies. Cell Calcium 92:102308
  122. Fiorica F, Colella M, Taibi R, Bonetti A, Giuliani J, Perrone M, Missiroli S, Giorgi C (2020) Glioblastoma: Prognostic Factors and Predictive Response to Radio- And Chemotherapy. Curr Med Chem 27(17):2814-2825
  123. Missiroli S, Genovese I, Perrone M, Vezzani B, Vitto VAM, Giorgi C (2020) The Role of Mitochondria in Inflammation: From Cancer to Neurodegenerative Disorders. J Clin Med 9(3):740
  124. Patergnani S, Danese A, Bouhamida E, Aguiari G, Previati M, Pinton P, Giorgi C (2020) Various Aspects of Calcium Signaling in the Regulation of Apoptosis, Autophagy, Cell Proliferation, and Cancer. Int J Mol Sci 21(21):E8323
  125. Genovese I, Giamogante F, Barazzuol L, Battista T, Fiorillo A, Vicario M, D'Alessandro G, Cipriani R, Limatola C, Rossi D, Sorrentino V, Poser E, Mosca L, Squitieri F, Perluigi M, Arena A, van Petegem F, Tito C, Fazi F, Giorgi C, Calì T, Ilari A, Colotti G (2020) Sorcin is an early marker of neurodegeneration, Ca2+ dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases. Cell Death Disease 11(10):861
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  131. Sarti AC, Vultaggio-Poma V, Falzoni S, Missiroli S, Giuliani AL, Boldrini P, Bonora M, Faita F, Di Lascio N, Kusmic C, Solini A, Novello S, Morari M, Rossato M, Wieckowski MR, Giorgi C, Pinton P, Di Virgilio F (2021) Mitochondrial P2X7 Receptor Localization Modulates Energy Metabolism Enhancing Physical Performance. Function 2(2):zqab005
  132. Morciano G, Pedriali G, Bonora M, Pavasini R, Mikus E, Calvi S, Bovolenta M, Lebiedzinska-Arciszewska M, Pinotti M, Albertini A, Wieckowski MR, Giorgi C, Ferrari R, Galluzzi L, Campo G, Pinton P (2021) A naturally occurring mutation in ATP synthase subunit c is associated with increased damage following hypoxia/reoxygenation in STEMI patients. Cell Rep 35:108983
  133. Carinci M, Testa B, Bordi M, Milletti G, Bonora M, Antonucci L, Ferraina C, Carro M, Kumar M, Ceglie D, Eck F, Nardacci R, le Guerroué F, Petrini S, Soriano ME, Caruana I, Doria V, Manifava M, Peron C, Lambrughi M, Tiranti V, Behrends C, Papaleo E, Pinton P, Giorgi C, Ktistakis NT, Locatelli F, Nazio F, Cecconi F (2021) TFG binds LC3C to regulate ULK1 localization and autophagosome formation. EMBO J e103563
  134. Bonora M, Missiroli S, Perrone M, Fiorica F, Pinton P, Giorgi C (2021) Mitochondrial Control of Genomic Instability in Cancer. Cancers (Basel) 13(8):1914
  135. Genovese I, Carinci M, Modesti L, Aguiari G, Pinton P, Giorgi C (2021) Mitochondria: Insights into Crucial Features to Overcome Cancer Chemoresistance. Int J Mol Sci 22(9):4770
  136. Morciano G, Vitto VAM, Bouhamida E, Giorgi C, Pinton P (2021) Mitochondrial bioenergetics and dynamism in the failing heart. Life 11:436
  137. Danese A, Leo S, Rimessi A, Wieckowski MR, Fiorica F, Giorgi C, Pinton P (2021) Cell death as a result of calcium signaling modulation: a cancer-centric prospective. Biochim Biophys Acta Mol Cell Res 1868:119061
  138. Modesti L, Danese A, Vitto VAM, Ramaccini D, Aguiari G, Gafà R, Lanza G, Giorgi C, Pinton P (2021) Mitochondrial Ca2+ Signaling in Health, Disease and Therapy. Cells 10:1317
  139. Missiroli S, Perrone M, Boncompagni C, Borghi C, Campagnaro A, Marchetti F, Anania G, Greco P, Fiorica F, Pinton P, Giorgi C (2021) Targeting the NLRP3 Inflammasome as a New Therapeutic Option for Overcoming Cancer. Cancers (Basel) 13(10):2297
  140. Fiorica F, Tebano U, Gabbani M, Perrone M, Missiroli S, Berretta M, Giuliani J, Bonetti A, Remo A, Pigozzi E, Tontini A, Napoli G, Luca N, Grigolato D, Pinton P, Giorgi C (2021) Beyond Abscopal Effect: A Meta-Analysis of Immune Checkpoint Inhibitors and Radiotherapy in Advanced Non-Small Cell Lung Cancer. Cancers (Basel) 13(10):2352
  141. Patergnani S, Bonora M, Ingusci S, Previati M, Marchi S, Zucchini S, Perrone M, Wieckowski MR, Castellazzi M, Pugliatti M, Giorgi C, Simonato M, Pinton P (2021) Antipsychotic drugs counteract autophagy and mitophagy in multiple sclerosis. Proc Natl Acad Sci U S A 118(24):e2020078118
  142. Patergnani S, Bonora M, Bouhamida E, Danese A, Marchi S, Morciano G, Previati M, Pedriali G, Rimessi A, Anania G, Giorgi C, Pinton P (2021) Methods to Monitor Mitophagy and Mitochondrial Quality: Implications in Cancer, Neurodegeneration, and Cardiovascular Diseases. Methods Mol Biol 2310:113-159
  143. Morciano G, Vezzani B, Missiroli S, Boncompagni C, Pinton P, Giorgi C (2021) An Updated Understanding of the Role of YAP in Driving Oncogenic Responses. Cancers 13:3100
  144. Silvagni E, Missiroli S, Perrone M, Patergnani S, Boncompagni C, Bortoluzzi A, Govoni M, Giorgi C, Alivernini S, Pinton P, Scirè CA (2021) From Bed to Bench and Back: TNF-α, IL-23/IL-17A, and JAK-Dependent Inflammation in the Pathogenesis of Psoriatic Synovitis. Front Pharmacol 12:672515
  145. Morciano G, Patergnani S, Pedriali G, Cimaglia P, Mikus E, Calvi S, Albertini A, Giorgi C, Campo G, Ferrari R, Pinton P (2021) Impairment of mitophagy and autophagy accompanies calcific aortic valve stenosis favoring cell death and the severity of disease. Cardiovascular Research 10;cvab267
  146. Patergnani S, Missiroli S, Morciano G, Perrone M, Mantovani CM, Anania G, Fiorica F, Pinton P and Giorgi C (2021) Understanding the Role of Autophagy in Cancer Formation and Progression Is a Real Opportunity to Treat and Cure Human Cancers. Cancers 13(22), 5622
  147. Fiorica F, Gabbani M, Zaninelli M, Muraro M, Pinton P and Giorgi C (2021) A tailored approach in geriatric oncology: turning a problem into an opportunity for the elderly. Eur Rev Med Pharmacol Sci. 25(22):6831-6833
  148. Bonora M, Giorgi C and Pinton P (2021) Molecular mechanisms and consequences of mitochondrial permeability transition. Nat Rev Mol Cell Biol In press
  149. Morciano G, Rimessi A, Patergnani S, Vitto V.A.M, Danese A, Kahsay A.E, Palumbo L, Bonora M, Wieckowski M.R., Giorgi C, Pinton P (2022) Calcium dysregulation in heart diseases: Targeting calcium channels to achieve a correct calcium homeostasis. Pharmacol Res2022 Feb 4;106119
  150. Bouhamida E, Morciano G, Perrone M,  Kahsay A, Della Sala M,  Wieckowski M R, Fiorica F, Pinton P, Giorgi C, Patergnani S (2022) The Interplay of Hypoxia Signaling on Mitochondrial Dysfunction and Inflammation in Cardiovascular Diseases and Cancer: From Molecular Mechanisms to Therapeutic Approaches. Biology 11(2):300
  151. Ramaccini D, Pedriali G, Perrone M, Bouhamida E, Modesti L, Wieckowski MR, Giorgi C, Pinton P, Morciano G. (2022) Some Insights into the Regulation of Cardiac Physiology and Pathology by the Hippo Pathway. Biomedicines 10(3):726
  152. Morciano G, Pedriali G, Mikus E, Cimaglia P, Calvi S, Pavasini R, Albertini A, Ferrari R, Wieckowski MR, Giorgi C, Campo G, Pinton P. (2021) Similarities between fibroblasts and cardiomyocytes in the study of the permeability transition pore. Eur J Clin Invest. e13764
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  154. Tarocco A, Morciano M, Perrone M, Cafolla C, Ferrè C, Vacca T, Pistocchi G, Meneghin F, Cocchi I, Lista G, Cetin I, Greco P, Garani G, Stella M, Natile M, Ancora G, Savarese I, Campi F, Bersani I, Dotta A, Tiberi E, Vento G, Chiodin E, Staffler A, Maranella E, Di Fabio S, Wieckowski MR, Giorgi C, Pinton P (2022) Increase of Parkin and ATG5 plasmatic levels following perinatal hypoxic‐ischemic encephalopathy. Sci Rep. 12:7795
  155. Missiroli S, Giorgi  C, Pinton P. (2022) The LRRC8C-STING-p53 axis in T cells: A Ca 2+ affair. Cell Calcium 2022 May 13;105:102596
  156. Fantinati A*, Morciano G*, Turrin G, Pedriali G, Pacifico S, Preti D, Albanese V, Illuminati D, Cristofori V, Giorgi C, Tremoli E, Pinton P, Trapella C. (2022) Identification of small-molecule urea derivatives as PTPC modulators targeting the c subunit of F1/Fo-ATP synthase. Bioorg Med Chem Lett 72:128822
  157. Danese A*, Patergnani S*, Maresca A, Peron C, Raimondi A, Caporali L, Marchi S, La Morgia C, Del Dotto V, Zanna C, Iannielli A, Segnali A, Di Meo I, Cavaliere A, Lebiedzinska-Arciszewska M, Wieckowski MR, Martinuzzi  A, Moraes-Filho MN, Salomao SR, Berezovsky A, Belfort Jr R, Buser C, Ross-Cisneros FN , Sadun AA, Tacchetti C, Broccoli V, Giorgi  C, Tiranti  V, Carelli V and Pinton P (2022) Pathological mitophagy disrupts mitochondrial homeostasis in Leber's hereditary optic neuropathy. Cell Rep 40(3):111124
  158. De Ventura T, Perrone M, Missiroli S, Pinton P, Marchetti P, Strazzabosco G, Turrin G, Illuminati D, Cristofori V, Fantinati A, Fabbri M, Giorgi C°, Trapella C, Zanirato V (2022) Synthesis and NLRP3-Inflammasome Inhibitory Activity of the Naturally Occurring Velutone F and of Its Non-Natural Regioisomeric Chalconoids. Int J Mol Sci °corresponding author
  159. Perrone M, Raimondi E, Costa M, Rasetto G, Rizzati R, Lanza G, Gafà R, Cavallesco G, Tamburini N, Maniscalco P, Mantovani MC, Tebano U, Coeli M, Missiroli S, Tilli M, Pinton P, Giorgi C, Fiorica F. Inflammatory Microenvironment in Early Non-Small Cell Lung Cancer: Exploring the Predictive Value of Radiomics. Cancers (Basel). 2022 Jul 8;14(14):3335
  160. Patergnani S, Giattino A, Bianchi N, Giorgi C, Pinton P, Aguiari G. The inhibition of MDM2 slows cell proliferation and activates apoptosis in ADPKD cell lines. Biol Cell. 2022 Sep 27.
  161. Perrone M, Patergnani S, Di Mambro T, Palumbo L, Więckowski M, Giorgi C, Pinton P. Calcium homeostasis in the control of mitophagy. Antioxid Redox Signal. 2022 Sep 16.
  162. Gabbani M, Giorgi C, Napoli G, Tebano U, Perrone MS, Missiroli S, Berretta M, Mandarà M, Zaninelli M, Luca N, Grigolato D, Muraro M, Rinaldi G, Pinton P, Fiorica F. Outcomes of Locally Advanced Rectal Cancer Patients Treated with Total Neoadjuvant Treatment: A Meta-Anaysis of Randomized Controlled Trials. Clin Colorectal Cancer. 2022 Sep 17:S1533-0028(22)00103-7
  163. Missiroli S, Perrone M, Gafà R, Nicoli F, Bonora M, Morciano G, Boncompagni C, Marchi S, Lebiedzinska-Arciszewska M, Vezzani B, Lanza G, Kricek F, Borghi A, Fiorica F, Ito K, Wieckowski MR, Di Virgilio F, Abelli L, Pinton P, Giorgi C. PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment. Cell Death Differ. 2022 Nov 30:1–13. doi: 10.1038/s41418-022-01095-9.
  164. Vezzani B, Neri M, D'Errico S, Papi A, Contoli M, Giorgi C. SARS-CoV-2 Infection Prompts IL-1β-Mediated Inflammation and Reduces IFN-λ Expression in Human Lung Tissue. Pathogens. 2022 Nov 21;11(11):1390
  165. Pedriali G, Ramaccini D, Bouhamida E, Wieckowski MR, Giorgi C, Tremoli E, Pinton P. Perspectives on mitochondrial relevance in cardiac ischemia/reperfusion injury. Front Cell Dev Biol. 2022 Dec 6;10:1082095
  166. Albanese V, Missiroli S, Perrone M, Fabbri M, Boncompagni C, Pacifico S, De Ventura T, Ciancetta A, Dondio G, Kricek F, Pinton P, Guerrini R, Preti D, Giorgi C. Novel Aryl Sulfonamide Derivatives as NLRP3 Inflammasome Inhibitors for the Potential Treatment of Cancer. J Med Chem. 2023 Mar 27.
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