Paolo Pinton Lab__Signal Transduction

 

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  1. Bianchi K, Rimessi A, Prandini A, Szabadkai G, Rizzuto R (2004) Calcium and mitochondria: mechanisms and functions of a troubled relationship. Biochim Biophys Acta 1742(1-3):119-31
  2. Pinton P, Bianchi K, Prandini A, Rimessi A, Rizzuto R (2004) Ca2+ Homeostasis of Intracellular Compartments: measurements using the jellyfish photo-protein aequorin. Minerva Biotec 16:119-26
  3. Rimessi A, Coletto L, Pinton P, Rizzuto R, Brini M, Carafoli E (2005) Inhibitory interaction of protein 14-3-3ɛ with isoform 4 of the plasma membrane Ca2+ pump. J Biol Chem 280:37195-203
  4. Pinton P*, Rimessi A*, Marchi S, Orsini F, Migliaccio E, Giorgio M, Contursi C, Minucci S, Mantovani F, Wieckowski MR, Del Sal G, Pelicci PG, Rizzuto R (2007) Protein Kinase C ß and Prolyl isomerase 1 regulate mitochondrial effects of the lifespan determinant p66Shc. Science 315: 659-63 *equally contributed
  5. Pinton P, Rimessi A, Romagnoli A, Prandini A, Rizzuto R (2007) Biosensors for the detection of calcium and pH. Methods Cell Biol 80C: 297-325
  6. Domi T, Di Leva F, Fedrizzi L, Rimessi A, Brini M (2007) Functional specificity of PMCA isoforms? Ann N Y Acad Sci 1099:237-46
  7. Rubbini M, Longobardi P, Rimessi A, Pinton P, Morri A, Semprini G, Pistone P, Volpinari L (2007) A new transportable machine for the preservation of livers to be transplanted by means of hyperbaric oxygenation perfusion. Chir Ital 59(5):723-34 (Italian)
  8. Romagnoli A, Aguiari P, De Stefani D, Leo S, Marchi S, Rimessi A, Zecchini E, Pinton P, Rizzuto R (2007) The ER/mitochondria Ca2+ crosstalk. Novartis Found Symp 287: 122-31
  9. Rimessi A, Rizzuto R, Pinton P (2007) Differential recruitment of PKC isoforms in HeLa cells during redox stress. Cell Stress & Chaperones 12: 291-8
  10. Aguiari P, Leo, Zavan B, Vindigni V, Rimessi A, Bianchi K, Franzin C, Cortivo R, Rossato M, Vettor R, Abatangelo G, Pozzan T, Pinton P, Rizzuto R (2008) High glucose induces adipogenic differentiation of muscle-derived stem cells. Proc Natl Acad Sci USA 105:1226-31
  11. Rimessi A, Giorgi C, Pinton P, Rizzuto R (2008) The versatility of mitochondrial calcium signals: from stimulation of cell metabolism to induction of cell death. Biochim Biophys Acta 1777/7-8:808-816
  12. Marchi S*, Rimessi A*, Giorgi C, Baldini C, Ferroni L, Rizzuto R, Pinton P (2008) Akt kinase reducing Endoplasmic Reticulum Ca2+ release protects cells from Ca2+-dependent apoptotic stimuli. Biochem Biophys Res Commun 375:501-5 *equally contributed
  13. Rizzuto R, Marchi S, Bonora M, Aguiari P, Bononi A, De Stefani D, Giorgi C, Leo S, Rimessi A, Siviero R, Zecchini E, Pinton P (2009) Ca(2+) transfer from the ER to mitochondria: when, how and why. Biochim Biophys Acta 1787:1342-51
  14. Rimessi A, Marchi S, Fotino C, Romagnoli A, Huebner K, Croce CM, Pinton P, Rizzuto R. (2009) Intramitochondrial calcium regulation by the FHIT gene product sensitizes to apoptosis. Proc Natl Acad Sci USA 106:12753-8
  15. Ferrari D, Pinton P, Campanella M, Callegari MG, Pizzirani C, Rimessi A, Di Virgilio F, Pozzan T, Rizzuto R. (2010) Functional and structural alterations in the endoplasmic reticulum and mitochondria during apoptosis triggered by C(2)-ceramide and CD95/APO-1/FAS receptor stimulation. Biochem Biophys Res Commun 391:575-81
  16. Pavan C, Vindigni V, Michelotto L, Rimessi A, Abatangelo A, Cortivo R, Pinton P, Zavan B (2010) Weight gain related to treatment with atypical antipsychotics is due to activation of PKCβ. Pharmacogenomics J 10(5):408-17
  17. Giorgi C, Agnoletto C, Baldini C, Bononi A, Bonora M, Marchi S, Missiroli S, Patergnani S, Poletti F, Rimessi A, Zavan B, Pinton P (2010) Redox control of Protein Kinase C: cell and disease
 specific significances. Antioxid Redox Signal 13(7):1051-85
  18. Bezzerri V*, d'Adamo P*, Rimessi A*, Lanzara C, Crovella S, Nicolis E, Tamanini A, Athanasakis E, Tebon M, Bisoffi G, Drumm ML, Knowles MR, Pinton P, Gasparini P, Berton G, Cabrini G (2011) Phospholipase C-{beta}3 Is a Key Modulator of IL-8 Expression in Cystic Fibrosis Bronchial Epithelial Cells. J Immunol 186(8):4946-58 *equally contributed
  19. Bononi A, Agnoletto C, De Marchi E, Marchi S, Patergnani S, Bonora M, Giorgi C, Missiroli S, Poletti F, Rimessi A, Pinton P (2011) Protein kinases and phosphatases in the control of cell fate. Enzyme Res 2011:329098
  20. Patergnani S, Suski JM, Agnoletto C, Bononi A, Bonora M, De Marchi E, Giorgi C, Marchi S, Missiroli S, Poletti F, Rimessi A, Duszynski J, Wieckowski MR, Pinton P (2011) Calcium signaling around Mitochondria Associated Membranes (MAMs). Cell Commun Signal 9(1):19
  21. Marchi S, Giorgi C, Suski J, Agnoletto C, Bononi A, Bonora M, De Marchi E, Missiroli S, Patergnani S, Poletti F, Rimessi A, Duszynski J, Wieckowski MR, Pinton P (2012) Mitochondria-ROS crosstalk in the control of cell death and aging. J Signal Transduct 2012:329635
  22. Giorgi C, Agnoletto C, Bononi A, Bonora M, De Marchi E, Marchi S, Missiroli S, Patergnani S, Poletti F, Rimessi A, Suski JM, Wieckowski MR, Pinton P (2012) Mitochondrial calcium homeostasis as potential target for mitochondrial medicine. Mitochondrion 12:77-85
  23. Rimessi A, Zecchini E, Siviero R, Giorgi C, Leo S, Rizzuto R, Pinton P (2012) The selective inhibition of nuclear PKCζ restores the effectiveness of chemotherapeutic agents in chemoresistant cells. Cell Cycle 11(5):1040-48
  24. Bononi A, Missiroli S, Poletti F, Suski JM, Agnoletto C, Bonora M, De Marchi E, Giorgi C, Marchi S, Patergnani S, Rimessi A, Wieckowski MR, Pinton P (2012) Mitochondria-associated membranes (MAMs) as hotspot Ca2+ signalling units. Adv Exp Med Biol 740:411-38
  25. Anelli T, Bergamelli L, Margittai E, Rimessi A, Fagioli C, Malgaroli A, Pinton P, Ripamonti M, Rizzuto R, Sitia R (2012) Ero1α Regulates Ca2+ Fluxes at the Endoplasmic Reticulum-Mitochondria Interface (MAM). Antioxid Redox Signal 16(10):1077-87
  26. Marchi S, Marinello M, Bononi A, Bonora M, Giorgi C, Rimessi A, Pinton P (2012) Selective modulation of subtype III IP3R by Akt regulates ER Ca2+ release and apoptosis. Cell Death Dis 3:e304
  27. Rabellino A, Carter B, Konstantinidou G, Wu SY, Rimessi A, Byers LA, Heymach JV, Girard L, Chiang CM, Teruya-Feldstein J, Scaglioni PP (2012) The SUMO E3-ligase PIAS1 Regulates the Tumor Suppressor PML and Its Oncogenic Counterpart PML-RARA. Cancer Res 72(9):2275-84
  28. Bonora M, Patergnani S, Rimessi A, De Marchi E, Suski JM, Bononi A, Giorgi C, Marchi S, Missiroli S, Poletti F, Wieckowski MR, Pinton P (2012) ATP synthesis and storage. Purinergic Signalling 8:343–357
  29. Giorgi C, Baldassari F, Bononi A, Bonora M, De Marchi E, Marchi S, Missiroli S, Patergnani S, Rimessi A, Suski JM, Wieckowski MR, Pinton P (2012) Mitochondrial Ca2+ and apoptosis. Cell Calcium 52:36-43
  30. Marchi S, Lupini L, Patergnani S, Rimessi A, Missiroli S, Bonora M, Bononi A, Corrà F, Giorgi C, De Marchi E, Poletti F, Gafà R, Lanza G, Negrini M, Rizzuto R, Pinton P (2013) Downregulation of the mitochondrial calcium uniporter by cancer-related miR-25. Current Biology 23:58-63
  31. Bonora M, Bononi A, De Marchi E, Giorgi C, Lebiedzinska M, Marchi S, Patergnani S, Rimessi A, Suski JM, Wojtala A, Wieckowski MR, Kroemer G, Galluzzi L, Pinton P (2013) Role of the c subunit of the FO ATP synthase in mitochondrial permeability transition. Cell Cycle 12(4):674-683
  32. Rimessi A, Patergnani S, Ioannidi E, Pinton P (2013) Chemoresistance and cancer-related inflammation: Two hallmarks of cancer connected by an atypical link, PKCzeta. Front Oncol 3(232):1-7
  33. Bonora M, Giorgi C, Bononi A, Marchi S, Patergnani S, Rimessi A, Rizzuto R, Pinton P (2013) Subcellular calcium measurements in mammalian cells using jellyfish photoprotein aequorin-based probes.  Nat Protoc 8(11):2105-18
  34. Patergnani S, Marchi S, Rimessi A, Bonora M, Giorgi C, Mehta KD, Pinton P (2013) PRKCB/protein kinase C β and the mitochondrial axis as key regulators of autophagy. Autophagy 9(9):1367-85
  35. Rimessi A, Bonora M , Marchi S , Patergnani S, Marobbio CMT , Lasorsa FM, Pinton P (2013) Perturbed mitochondrial Ca2+ signals as causes or consequences of mitophagy induction. Autophagy 9(11):1677-86
  36. Rimessi A, Marchi S, Patergnani S, Pinton P (2014) H-Ras-driven tumoral maintenance is sustained through caveolin-1-dependent alterations in calcium signaling. Oncogene 33:2329-40
  37. Bonora M, De Marchi E, Patergnani S, Suski JM, Celsi F, Bononi A, Giorgi C, Marchi S, Rimessi A, Duszyński J, Pozzan T, Wieckowski MR, Pinton P (2014) Tumor necrosis factor-α impairs oligodendroglial differentiation through a mitochondria-dependent process. Cell Death Differ 21:1198–1208
  38. Borghi A*, Rimessi A*, Minghetti S, Corazza M, Pinton P, Virgili A (2015) Efficacy of magnesium chloride in the treatment of Hailey-Hailey disease: from serendipity to evidence on its effect on intracellular Ca2+ homeostasis. Int J Dermatol 54:543-8 *equally contributed
  39. Rimessi A, Bezzerri V, Patergnani S, Marchi S, Cabrini G, Pinton P (2015) Mitochondrial Ca 2+-dependent NLRP3 activation exacerbates the Pseudomonas aeruginosa-driven inflammatory response in cystic fibrosis.  Nat Commun 6:6201
  40. Rimessi A, Patergnani S, Bonora M, Wieckowski MR, Pinton P (2015) Mitochondrial Ca2+ remodeling is a prime factor in oncogenic behavior. Front Oncol 5:143
  41. Pulli I, Blom T, Löf C, Magnusson M, Rimessi A, Pinton P, Törnquist K (2015) A novel chimeric aequorin fused with caveolin-1 reveals a sphingosine kinase 1 -regulated Ca2+ microdomain in the caveolar compartment. Biochim Biophys Acta (Molecular Cell Research) 1853:2173-82
  42. Marchi S, Corricelli M, Trapani E, Bravi L , Pittaro A, Delle Monache S, Ferroni L, Patergnani S, Missiroli S, Goitre L, Trabalzini L, Rimessi A, Giorgi C, Zavan B, Cassoni P, Dejana E , Retta SF, Pinton P (2015) Defective autophagy is a key feature of cerebral cavernous malformations. EMBO Mol Med 7(11):1403-17
  43. Prandini P, De Logu F, Fusi C, Provezza L, Nassini R, Montagner G, Materazzi S, Munari S, Gilioli E, Bezzerri V, Finotti A, Lampronti I, Tamanini A, Dechecchi M, Lippi G, Ribeiro CM, Rimessi A, Pinton P, Gambari R, Geppetti P, Cabrini G (2016) Transient Receptor Potential Ankyrin 1 Channels Modulate Inflammatory Response in Respiratory Cells from Patients with Cystic Fibrosis. Am J Respir Cell Mol Biol 55(5):645-656
  44. Rimessi A*, Previati M*, Nigro F, Wieckowski MR, Pinton P (2016) Mitochondrial Reactive Oxygen Species and inflammation: molecular mechanisms, diseases and promising therapies. Int J Biochem Cell Biol 81:281-293 *equally contributed
  45. Rimessi A, Pavan C, Ioannidi E, Nigro F, Morganti C, Brugnoli A, Longo F, Gardin C, Ferroni L, Morari M, Vindigni V, Zavan B, Pinton P (2017) Protein kinase C β: a new target therapy to prevent the long-term atypical antipsychotics-induced weight-gain. Neuropsychopharmacology 42(7):1491-1501
  46. Yoboue ED* , Rimessi A*, Anelli T, Pinton P, Sitia R (2017) Regulation of calcium fluxes by GPX8, a type-II transmembrane peroxidase enriched at the mitochondria-associated endoplasmic reticulum membrane. Antioxid Redox Signal 27(9):583-595 *equally contributed
  47. Lampronti I, Dechecchi MC, Rimessi A, Bezzerri V, Nicolis E, Guerrini A, Tacchini M, Tamanini A, Munari S, D'Aversa E, Santangelo A, Lippi G, Sacchetti G, Pinton P, Gambari R, Agostini M, Cabrini G (2017) β-sitosterol reduces the expression of chemotactic cytokine genes in cystic fibrosis bronchial epithelial cells. Front Pharmacol 8:236
  48. Canazza I, Ossato A, Vincenzi F, Gregori A, Di Rosa F, Nigro F, Rimessi A, Pinton P, Varani K, Borea P, Marti M (2017) Pharmaco-toxicological effects of the novel third-generation fluorinate synthetic cannabinoids, 5F-ADBINACA, AB-FUBINACA and STS-135 in mice. In vitro and in vivo studies. Hum Psychopharmacol 32(3):e2601
  49. Marchi S, Bittremieux M, Missiroli S, Morganti C, Patergnani S, Sbano L, Rimessi A, Kerkhofs M, Parys JB, Bultynck G, Giorgi C, Pinton P (2017) Endoplasmic Reticulum-Mitochondria Communication Through Ca2+ Signaling: The Importance of Mitochondria-Associated Membranes (MAMs). Adv Exp Med Biol 997:49-67
  50. Pedriali G, Rimessi A, Sbano L, Giorgi C, Wieckowski MR, Previati M, Pinton P (2017) Regulation of ER-mitochondria Ca2+ transfer and its importance for anti-cancer therapies. Front Oncol 7:180
  51. Marchi S, Patergnani S, Missiroli S, Morciano G, Rimessi A, Wieckowski MR, Giorgi C, Pinton P (2018) Mitochondrial and Endoplasmic Reticulum Calcium Homeostasis and Cell Death. Cell Calcium 69:62-72
  52. Gattazzo F, De Maria C, Rimessi A, Donà S, Braghetta P, Pinton P, Vozzi G, Bonaldo P (2018) Gelatin–genipin-based biomaterials for skeletal muscle tissue engineering. J Biomed Mater Res B Appl Biomater 106B(8):2763-77
  53. Giorgi C, Marchi S, Simoes ICM, Ren Z, Morciano G, Perrone M, Patalas-Krawczyk P, Borchard S, Jędrak P, Pierzynowska K, Szymański J, Wang DQ, Portincasa P, Węgrzyn G, Zischka H, Dobrzyn P, Bonora M, Duszynski J, Rimessi A, Karkucinska-Wieckowska A, Dobrzyn A, Szabadkai G, Zavand B, Oliveira PJ, Sardao VA, Pinton P, Wieckowski MR (2018) Mitochondria and reactive oxygen species in aging and age related diseases. Int Rev Cell Mol Biol 340:209-344
  54. Rimessi A, Bezzerri V, Salvatori F, Tamanini A, Nigro F, Dechecchi MC, Santangelo A, Prandini P, Munari S, Provezza L, Garreau de Loubresse N, Muller J, Ribeiro CMP, Lippi G, Gambari R, Pinton P, Cabrini G (2018) PLCB3 loss-of-function reduces P. aeruginosa-dependent IL-8 release in cystic fibrosis. Am J Respir Cell Mol Biol 59(4):428-436
  55. Shankaraiah RC, Callegari E, Guerriero P, Rimessi A, Pinton P, Gramantieri L, Silini EM, Sabbioni S, Negrini M (2019) Metformin prevents liver tumourigenesis by attenuating fibrosis in a transgenic mouse model of hepatocellular carcinoma. Oncogene 38(45):7035-7045
  56. Bestetti S, Gallia M, Sorrentino I, Pinton P, Rimessi A, Sitia R, Medraño-Fernandez I (2020) Human aquaporin-11 guarantees efficient transport of H2O2 across the endoplasmic reticulum membrane. Redox Biol 28:101326
  57. Rimessi A, Pedriali G, Vezzani B, Tarocco A, Marchi S, Wieckowski MR, Giorgi C, Pinton P (2020) Interorganellar calcium signaling in the regulation of cell metabolism: A cancer perspective. Semin Cell Dev Biol 98:167-180
  58. Rimessi A, Pozzato C, Carparelli L, Rossi A, Ranucci S, De Fino I, Cigana C, Talarico A, Wieckowski MR, Ribeiro CMP, Trapella C, Rossi G, Cabrini G, Bragonzi A, Pinton P (2020) Pharmacological modulation of mitochondrial calcium uniporter controls lung inflammation in cystic fibrosis. Sci Adv 6:eaax9093
  59. Cabrini G, Rimessi A, Borgatti M, Lampronti I, Finotti A, Pinton P, Gambari R (2020) Role of Cystic Fibrosis Bronchial Epithelium in Neutrophil Chemotaxis. Front Immunol 11:1438
  60. Patergnani S, Vitto VAM, Pinton P, Rimessi A (2020) Mitochondrial Stress Responses and “Mito-Inflammation” in Cystic Fibrosis. Front Pharmacol 11:581114
  61. Saliakoura M, Rossi Sebastiano M, Pozzato C, Heidel FH, Schnöder TM, Savic Prince S, Bubendorf L, Pinton P, Schmid RA, Baumgartner J, Freigang S, Berezowska SA, Rimessi A, Konstantinidou G (2020) PLCγ1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia. Nat Cell Biol 22(11):1382-1395
  62. Konstantinidou G, Rimessi A (2020) Editorial: Oncogenic RAS-Dependent Reprogramming of Cellular Plasticity. Front Oncol 10:588
  63. Scalia S, Bertoni S, Dozzo A, Rimessi A, Pinton P, Passerini N, Albertini B (2021) Glyceryl Tristearate-Based Lipid Microparticles Loaded with the Tattoo Colorant, Acid Red 87: Colorant Retention Capacity in Excised Porcine Skin. Skin Pharmacol Physiol 33(6):323-330
  64. Patergnani S, Bouhamida E, Leo S, Pinton P, Rimessi A (2021) Mitochondrial Oxidative Stress and “Mito-Inflammation”: Actors in the Diseases. Biomedicines 9(2):216
  65. Rimessi A, Vitto VAM, Patergnani S, Pinton P (2021) Update on Calcium Signaling in Cystic Fibrosis Lung Disease. Front Pharmacol 12:581645
  66. Danese A, Leo S, Rimessi A, Wieckowski MR, Fiorica F, Giorgi C, Pinton P (2021) Cell death as a result of calcium signaling modulation: a cancer-centric prospective. Biochim Biophys Acta Mol Cell Res 1868:119061
  67. Morciano G, Naumova N, Koprowski P, Valente S, Sardão VA, Potes Y, Rimessi A, Wieckowski MR, Oliveira PJ (2021) The mitochondrial permeability transition pore: an evolving concept critical for cell life and death. Biol Rev In press
  68. Patergnani S, Bonora M, Bouhamida E, Danese A, Marchi S, Morciano G, Previati M, Pedriali G, Rimessi A, Anania G, Giorgi C, Pinton P (2021) Methods to Monitor Mitophagy and Mitochondrial Quality: Implications in Cancer, Neurodegeneration, and Cardiovascular Diseases. Methods Mol Biol 2310:113-159
  69. Morciano G, Rimessi A, Patergnani S, Vitto V.A.M, Danese A, Kahsay A, Palumbo L, Bonora M, Wieckowski M.R., Giorgi C, Pinton P (2022) Calcium dysregulation in heart diseases: Targeting calcium channels to achieve a correct calcium homeostasis. Pharmacol Res 2022 Feb 4;106119
  70. Cabrini G, Rimessi A, Borgatti M, Pinton P, Gambari R (2022) Overview of CF lung pathophysiology. Curr Opin Pharmacol. 64:102214
  71. Patergnani S, Morciano G, Carinci M, Leo S, Pinton P, Rimessi R (2022) The "mitochondrial stress responses": the "Dr. Jekyll and Mr. Hyde" of neuronal disorders. Neural Regen Res (12):2563-2575
  72. Costantino L, Ferrari S, Santucci M, Salo-Ahen OMH, Carosati E, Franchini S, Lauriola A, Pozzi C, Trande M, Gozzi G, Saxena P, Cannazza G, Losi L, Cardinale D, Venturelli A, Quotadamo A, Linciano P, Tagliazucchi L, Moschella MG, Guerrini R, Pacifico S, Luciani R, Genovese F, Henrich S, Alboni S, Santarem N, da Silva Cordeiro A, Giovannetti E, Peters GJ, Pinton P, Rimessi A, Cruciani G, Stroud RM, Wade RC, Mangani S, Marverti G, D'Arca D, Ponterini G, Costi MP. Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth. Elife. 2022 Dec 7;11:e73862.
  73. Bezzerri V, Gentili V, Api M, Finotti A, Papi C, Tamanini A, Boni C, Baldisseri E, Olioso D, Duca M, Tedesco E, Leo S, Borgatti M, Volpi S, Pinton P, Cabrini G, Gambari R, Blasi F, Lippi G, Rimessi A, Rizzo R, Cipolli M. SARS-CoV-2 viral entry and replication is impaired in Cystic Fibrosis airways due to ACE2 downregulation. Nat Commun. 2023 Jan 10;14(1):132.
  1. Jakubek P, Pakula B, Rossmeisl M, Pinton P, Rimessi A, Wieckowski MR. Autophagy alterations in obesity, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease: the evidence from human studies. Intern Emerg Med. 2024 Aug;19(5):1473-1491.
  2. Palumbo L, Carinci M, Guarino A, Asth L, Zucchini S, Missiroli S, Rimessi A, Pinton P, Giorgi C. The NLRP3 Inflammasome in Neurodegenerative Disorders: Insights from Epileptic Models. Biomedicines. 2023 Oct 18;11(10):2825.
  3. Pellielo G, Agyapong ED, Pinton P, Rimessi A. Control of mitochondrial functions by Pseudomonas aeruginosa in cystic fibrosis. Int Rev Cell Mol Biol. 2023;377:19-43.
  4. Vitto VAM, Bianchin S, Zolondick AA, Pellielo G, Rimessi A, Chianese D, Yang H, Carbone M, Pinton P, Giorgi C, Patergnani S. Molecular Mechanisms of Autophagy in Cancer Development, Progression, and Therapy. Biomedicines. 2022 Jul 5;10(7):1596.