Paolo Pinton Lab__Signal Transduction
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- Missiroli S, Danese A, Iannitti T, Patergnani S, Perrone M, Previati M, Giorgi C, Pinton P (2017) Endoplasmic reticulum-mitochondria Ca2+ crosstalk in the control of the tumor cell fate. Biochim Biophys Acta (Molecular Cell Research) 1864:858-864
- Danese A, Patergnani S, Bonora M , Wieckowski MR, Previati M , Giorgi C, Pinton P (2017) Calcium regulates cell death in cancer: roles of the mitochondria and mitochondria-associated membranes (MAMs). Biochim Biophys Acta (Bioenergetics) 1858:615-627
- Profilo E, Peña-Altamira LE, Corricelli M, Castegna A, Danese A, Agrimi G, Petralla S, Giannuzzi G, Porcelli V, Sbano L, Viscomi C, Massenzio F, Palmieri EM, Giorgi C, Fiermonte G, Virgili M, Palmieri L, Zeviani M, Pinton P, Monti B, Palmieri F, Lasorsa FM (2017) Down-regulation of the mitochondrial aspartate-glutamate carrier isoform 1 AGC1 inhibits proliferation and N-acetylaspartate synthesis in Neuro2A cells. Biochim Biophys Acta (Molecular Basis of Disease) 1863:1422-35
- Bononi A, Giorgi C, Patergnani S, Larson D, Verbruggen K, Tanji M, Pellegrini L, Signorato V, Olivetto F, Pastorino S, Nasu M, Napolitano A, Gaudino G, Morris P, Sakamoto G, Ferris LK, Danese A, Raimondi A, Tacchetti C, Kuchay S, Pass HI, Affar EB, Yang H, Pinton P, Carbone M (2017) BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation. Nature 546:549-553
- Wieckowski MR, Danese A, Morciano G, Pronicki M, Duszynski J, Pinton P, Karkucinska-Wieckowska A (2018) Recovering mitochondrial function in patients’ fibroblasts. Mitochondrial Biology and Experimental Therapeutics 359-378
- Morciano G, Marchi S, Morganti C, Sbano L, Bittremieux M, Kerkhofs M, Corricelli M, Danese A, Karkucinska-Wieckowska A, Wieckowski MR, Bultynck G, Giorgi C, Pinton P (2018) Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific Settings. Neoplasia 20(5):510-523
- Giorgi C, Danese A, Missiroli S, Patergnani S, Pinton P (2018) Calcium dynamics as a machine for decoding signals. Trends Cell Biol 28(4):258-273
- Angebault C, Fauconnier J, Patergnani S, Rieusset J, Danese A, Affortit CA, Jagodzinska J, Mégy C, Quiles M, Cazevieille C, Korchagina J, Bonnet-Wersinger D, Milea D, Hamel C, Pinton P, Thiry M, Lacampagne A, Delprat B, Delettre C (2018) ER-mitochondria crosstalk is regulated by the Ca2+ sensor NCS1 and is impaired in Wolfram syndrome. Sci Signal 11:eaaq1380
- Marchi S, Vitto VAM, Danese A, Wieckowski MR, Giorgi C, Pinton P (2019) Mitochondrial calcium uniporter complex modulation in cancerogenesis. Cell Cycle 18(10):1068-1083
- Petralla S, Peña-Altamira LE, Poeta E, Massenzio F, Virgili M, Barile SN, Sbano L, Profilo E, Corricelli M, Danese A, Giorgi C, Ostan R, Capri M, Pinton P, Palmieri F, Lasorsa FM, Monti B (2019) Deficiency of Mitochondrial Aspartate-Glutamate Carrier 1 Leads to Oligodendrocyte Precursor Cell Proliferation Defects Both In Vitro and In Vivo. Int J Mol Sci 20(18):E4486
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La Morgia C, Maresca A, Amore G, Gramegna LL, Carbonelli M, Scimonelli E, Danese A, Patergnani S, Caporali L, Tagliavini F, Del Dotto V, Capristo M, Sadun F, Barboni P, Savini G, Evangelisti S, Bianchini C, Valentino ML, Liguori R, Tonon C, Giorgi C, Pinton P, Lodi R, Carelli V (2020) Calcium mishandling in absence of primary mitochondrial dysfunction drives cellular pathology in Wolfram Syndrome. Sci Rep 10:4785
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Danese A, Marchi S, Vitto VAM, Modesti L, Leo S, Wieckowski MR, Giorgi C, Pinton P (2020) Cancer-related increases and decreases in calcium signaling at the Endoplasmic Reticulum-mitochondria interface (MAMs). Rev Physiol Biochem Pharmacol doi: 10.1007/112_2020_43
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Genovese I, Vezzani B, Danese A, Modesti L, Vitto VAM, Corazzi V, Pelucchi S, Pinton P, Giorgi C (2020) Mitochondria as the decision makers for cancer cell fate: from signaling pathways to therapeutic strategies. Cell Calcium 92:102308
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Patergnani S, Danese A, Bouhamida E, Aguiari G, Previati M, Pinton P, Giorgi C (2020) Various Aspects of Calcium Signaling in the Regulation of Apoptosis, Autophagy, Cell Proliferation, and Cancer. Int J Mol Sci 21(21):E8323
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Giorgi C, Bouhamida E, Danese A, Previati M, Pinton P, Patergnani P (2021) Relevance of Autophagy and Mitophagy Dynamics and Markers in Neurodegenerative Diseases. Biomedicines 9:149
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Danese A, Leo S, Rimessi A, Wieckowski MR, Fiorica F, Giorgi C, Pinton P (2021) Cell death as a result of calcium signaling modulation: a cancer-centric prospective. Biochim Biophys Acta Mol Cell Res 1868:119061
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Modesti L, Danese A, Vitto VAM, Ramaccini D, Aguiari G, Gafà R, Lanza G, Giorgi C, Pinton P (2021) Mitochondrial Ca2+ Signaling in Health, Disease and Therapy. Cells 10:1317
- Patergnani S, Bonora M, Bouhamida E, Danese A, Marchi S, Morciano G, Previati M, Pedriali G, Rimessi A, Anania G, Giorgi C, Pinton P (2021) Methods to Monitor Mitophagy and Mitochondrial Quality: Implications in Cancer, Neurodegeneration, and Cardiovascular Diseases. Methods Mol Biol 2310:113-159
- Morciano G, Rimessi A, Patergnani S, Vitto V.A.M, Danese A, Kahsay A, Palumbo L, Bonora M, Wieckowski M.R., Giorgi C, Pinton P (2022) Calcium dysregulation in heart diseases: Targeting calcium channels to achieve a correct calcium homeostasis. Pharmacol Res 2022 Feb 4;106119
- Crouzier L*, Danese A*, Yasui Y, Richard EM, Liévens J, Patergnani S, Couly S, Diez C, Denus M, Cubedo N, Rossel M, Thiry M, Su T, Pinton P, Maurice T, Delprat B (2022) Activation of the sigma-1 receptor chaperone alleviates symptoms of Wolfram syndrome in preclinical models. Sci Transl Med 14(631):eabh3763 *equally contributed
- Danese A*, Patergnani S*, Maresca A, Peron C, Raimondi A, Caporali L, Marchi S, La Morgia C, Del Dotto V, Zanna C, Iannielli A, Segnali A, Di Meo I, Cavaliere A, Lebiedzinska-Arciszewska M, Wieckowski MR, Martinuzzi A, Moraes-Filho MN, Salomao SR, Berezovsky A, Belfort Jr R, Buser C, Ross-Cisneros FN , Sadun AA, Tacchetti C, Broccoli V, Giorgi C, Tiranti V, Carelli V and Pinton P (2022) Pathological mitophagy disrupts mitochondrial homeostasis in Leber's hereditary optic neuropathy. Cell Rep 40(3):111124
- Trentini M, Zanolla I, Tiengo E, Zanotti F, Sommella E, Merciai F, Campiglia P, Licastro D, Degasperi M, Lovatti L, Bonora M, Danese A, Pinton P, Zavan B. Link between organic nanovescicles from vegetable kingdom and human cell physiology: intracellular calcium signalling. J Nanobiotechnology. 2024 Feb 19;22(1):68.
- Patergnani S, Bataillard MS, Danese A, Alves S, Cazevieille C, Valéro R, Tranebjærg L, Maurice T, Pinton P, Delprat B, Richard EM. The Wolfram-like variant WFS1E864K destabilizes MAM and compromises autophagy and mitophagy in human and mice. Autophagy. 2024 Sep;20(9):2055-2066