Pubblications Falzanaro

Selvatici R, Falzarano S, Traniello S, Pagani Zecchini G, Spisani S.

Formylpeptides trigger selective molecular pathways that are required in the

physiological functions of human neutrophils. Cell Signal. 2003

Apr;15(4):377-83. doi: 10.1016/s0898-6568(02)00123-7. PMID: 12618212.

Spisani S, Turchetti M, Varani K, Falzarano S, Cavicchioni G. Hydrophilic

residues at position 3 highlight unforeseen features of the fMLP receptor

pocket. Eur J Pharmacol. 2003 May 23;469(1-3):13-9. doi:

10.1016/s0014-2999(03)01672-8. PMID: 12782180.

Cavicchioni G, Turchetti M, Varani K, Falzarano S, Spisani S. Properties of a

novel chemotactic esapeptide, an analogue of the prototypical N-formylmethionyl

peptide. Bioorg Chem. 2003 Aug;31(4):322-30. doi: 10.1016/s0045-2068(03)00070-1.

PMID: 12877881.

Spisani S, Falzarano S, Traniello S, Nalli M, Selvatici R. A 'pure'

chemoattractant formylpeptide analogue triggers a specific signalling pathway in

human neutrophil chemotaxis. FEBS J. 2005 Feb;272(4):883-91. doi:

10.1111/j.1742-4658.2004.04497.x. PMID: 15691323.

Manzati E, Aguiari G, Banzi M, Manzati M, Selvatici R, Falzarano S, Maestri

I, Pinton P, Rizzuto R, del Senno L. The cytoplasmic C-terminus of polycystin-1

increases cell proliferation in kidney epithelial cells through serum-activated

and Ca(2+)-dependent pathway(s). Exp Cell Res. 2005 Apr 1;304(2):391-406. doi:

10.1016/j.yexcr.2004.10.023. Epub 2004 Dec 15. PMID: 15748886.

Cavicchioni G, Fraulini A, Turchetti M, Varani K, Falzarano S, Pavan B,

Spisani S. Biological activity of for-Met-Leu-Phe-OMe analogs: relevant

substitutions specifically trigger killing mechanisms in human neutrophils. Eur

J Pharmacol. 2005 Apr 4;512(1):1-8. doi: 10.1016/j.ejphar.2005.02.013. PMID:

15814083.

Trombella S, Vergura R, Falzarano S, Guerrini R, Calo G, Spisani S.

Nociceptin/orphanin FQ stimulates human monocyte chemotaxis via NOP receptor

activation. Peptides. 2005 Aug;26(8):1497-502. doi:

10.1016/j.peptides.2005.03.015. PMID: 15922491.

Selvatici R, Falzarano S, Mollica A, Spisani S. Signal transduction pathways

triggered by selective formylpeptide analogues in human neutrophils. Eur J

Pharmacol. 2006 Mar 18;534(1-3):1-11. doi: 10.1016/j.ejphar.2006.01.034. Epub

2006 Mar 3. PMID: 16516193.

Cavicchioni G, Fraulini A, Falzarano S, Spisani S. Structure-activity

relationship of for-L-Met L-Leu-L-Phe-OMe analogues in human neutrophils. Bioorg

Chem. 2006 Oct;34(5):298-318. doi: 10.1016/j.bioorg.2006.07.001. Epub 2006 Aug

17. PMID: 16919307.

Selvatici R, Falzarano S, Franceschetti L, Cavallini S, Marino S,

Siniscalchi A. Differential activation of protein kinase C isoforms following

chemical ischemia in rat cerebral cortex slices. Neurochem Int. 2006

Dec;49(8):729-36. doi: 10.1016/j.neuint.2006.06.003. Epub 2006 Sep 11. PMID:

16963162.

Siniscalchi A, Cavallini S, Marino S, Falzarano S, Franceschetti L,

Selvatici R. Effects of chemical ischemia on cerebral cortex slices: focus on

mitogen-activated protein kinase cascade. Ann N Y Acad Sci. 2006

Dec;1090:445-54. doi: 10.1196/annals.1378.047. PMID: 17384288.

Selvatici R, Falzarano S, Franceschetti L, Spisani S, Siniscalchi A. Effects

of PKI55 protein, an endogenous protein kinase C modulator, on specific PKC

isoforms activity and on human T cells proliferation. Arch Biochem Biophys. 2007

Jun 1;462(1):74-82. doi: 10.1016/j.abb.2007.03.018. Epub 2007 Apr 4. PMID:

17467651.

Spisani S, Fraulini A, Varani K, Falzarano S, Cavicchioni G. New chemotactic

dimeric peptides show high affinity and potency at the human formylpeptide

receptor. Eur J Pharmacol. 2007 Jul 12;567(1-2):171-6. doi:

10.1016/j.ejphar.2007.04.006. Epub 2007 Apr 14. PMID: 17481605.

Selvatici R, Falzarano S, Franceschetti L, Mollica A, Guerrini R,

Siniscalchi A, Spisani S. Study of synthetic peptides derived from the PKI55

protein, a protein kinase C modulator, in human neutrophils stimulated by the

methyl ester derivative of the hydrophobic N-formyl tripeptide for-Met-Leu-Phe-

OH. FEBS J. 2008 Feb;275(3):449-57. doi: 10.1111/j.1742-4658.2007.06212.x. Epub

2007 Dec 21. PMID: 18167144.

Borgatti M, Finotti A, Falzarano S, Selvatici R. Structural characterization

of promoter sequences of the gene coding human PKI55 protein, a protein kinase C

inhibitor. Biochimie. 2009 Apr;91(4):466-74. doi: 10.1016/j.biochi.2008.11.007.

Epub 2008 Dec 7. PMID: 19095038.

Selvatici R, Previati M, Marino S, Marani L, Falzarano S, Lanzoni I,

Siniscalchi A. Sodium azide induced neuronal damage in vitro: evidence for non-

apoptotic cell death. Neurochem Res. 2009 May;34(5):909-16. doi:

10.1007/s11064-008-9852-0. Epub 2008 Oct 8. PMID: 18841470.

Spitali P, Rimessi P, Fabris M, Perrone D, Falzarano S, Bovolenta M,

Trabanelli C, Mari L, Bassi E, Tuffery S, Gualandi F, Maraldi NM, Sabatelli-

Giraud P, Medici A, Merlini L, Ferlini A. Exon skipping-mediated dystrophin

reading frame restoration for small mutations. Hum Mutat. 2009

Nov;30(11):1527-34. doi: 10.1002/humu.21092. PMID: 19760747.

Cavicchioni G, Fraulini A, Falzarano S, Spisani S. Oligomeric formylpeptide

activity on human neutrophils. Eur J Med Chem. 2009 Dec;44(12):4926-30. doi:

10.1016/j.ejmech.2009.08.010. Epub 2009 Aug 31. PMID: 19748709.

Ferlini A, Sabatelli P, Fabris M, Bassi E, Falzarano S, Vattemi G, Perrone

D, Gualandi F, Maraldi NM, Merlini L, Sparnacci K, Laus M, Caputo A, Bonaldo P,

Braghetta P, Rimessi P. Dystrophin restoration in skeletal, heart and skin

arrector pili smooth muscle of mdx mice by ZM2 NP-AON complexes. Gene Ther. 2010

Mar;17(3):432-8. doi: 10.1038/gt.2009.145. Epub 2009 Nov 12. PMID: 19907501.

Rimessi P, Fabris M, Bovolenta M, Bassi E, Falzarano S, Gualandi F, Rapezzi

C, Coccolo F, Perrone D, Medici A, Ferlini A. Antisense modulation of both

exonic and intronic splicing motifs induces skipping of a DMD pseudo-exon

responsible for x-linked dilated cardiomyopathy. Hum Gene Ther. 2010

Sep;21(9):1137-46. doi: 10.1089/hum.2010.010. PMID: 20486769.

Bassi E, Falzarano S, Fabris M, Gualandi F, Merlini L, Vattemi G, Perrone D,

Marchesi E, Sabatelli P, Sparnacci K, Laus M, Bonaldo P, Rimessi P, Braghetta P,

Ferlini A. Persistent dystrophin protein restoration 90 days after a course of

intraperitoneally administered naked 2'OMePS AON and ZM2 NP-AON complexes in mdx

mice. J Biomed Biotechnol. 2012;2012:897076. doi: 10.1155/2012/897076. Epub 2012

Oct 2. PMID: 23091362; PMCID: PMC3471065.

Martoni E, Petrini S, Trabanelli C, Sabatelli P, Urciuolo A, Selvatici R,

D'Amico A, Falzarano S, Bertini E, Bonaldo P, Ferlini A, Gualandi F.

Characterization of a rare case of Ullrich congenital muscular dystrophy due to

truncating mutations within the COL6A1 gene C-terminal domain: a case report.

BMC Med Genet. 2013 Jun 5;14:59. doi: 10.1186/1471-2350-14-59. PMID: 23738969;

PMCID: PMC3681647.

Witkowska R, Zabrocki J, Spisani S, Falzarano MS, Toniolo C, Formaggio F.

Synthetic formyl tripeptide chemoattractants: a C(alpha,alpha)-dialkylated,

amphiphilic glycyl residue at position 1. J Pept Sci. 2003 Jun;9(6):354-60. doi:

10.1002/psc.461. PMID: 12846481.

Bruno O, Brullo C, Bondavalli F, Ranise A, Schenone S, Falzarano MS, Varani

K, Spisani S. 2-Phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives: new

potent inhibitors of fMLP-induced neutrophil chemotaxis. Bioorg Med Chem Lett.

2007 Jul 1;17(13):3696-701. doi: 10.1016/j.bmcl.2007.04.036. Epub 2007 Apr 19.

PMID: 17475488.

Bovolenta M, Neri M, Fini S, Fabris M, Trabanelli C, Venturoli A, Martoni E,

Bassi E, Spitali P, Brioschi S, Falzarano MS, Rimessi P, Ciccone R, Ashton E,

McCauley J, Yau S, Abbs S, Muntoni F, Merlini L, Gualandi F, Ferlini A. A novel

custom high density-comparative genomic hybridization array detects common

rearrangements as well as deep intronic mutations in dystrophinopathies. BMC

Genomics. 2008 Nov 28;9:572. doi: 10.1186/1471-2164-9-572. PMID: 19040728;

PMCID: PMC2612025.

Bruno O, Brullo C, Bondavalli F, Schenone S, Spisani S, Falzarano MS, Varani

K, Barocelli E, Ballabeni V, Giorgio C, Tognolini M. 1-Methyl and 1-(2-hydroxyal

kyl)-5-(3-alkyl/cycloalkyl/phenyl/naphthylureido)-1H-pyrazole-4-carboxylic acid

ethyl esters as potent human neutrophil chemotaxis inhibitors. Bioorg Med Chem.

2009 May 1;17(9):3379-87. doi: 10.1016/j.bmc.2009.03.035. Epub 2009 Mar 25.

PMID: 19362486.

Bovolenta M, Erriquez D, Valli E, Brioschi S, Scotton C, Neri M, Falzarano

MS, Gherardi S, Fabris M, Rimessi P, Gualandi F, Perini G, Ferlini A. The DMD

locus harbours multiple long non-coding RNAs which orchestrate and control

transcription of muscle dystrophin mRNA isoforms. PLoS One. 2012;7(9):e45328.

doi: 10.1371/journal.pone.0045328. Epub 2012 Sep 21. PMID: 23028937; PMCID:

PMC3448672.

Bovolenta M, Scotton C, Falzarano MS, Gualandi F, Ferlini A. Rapid,

comprehensive analysis of the dystrophin transcript by a custom micro-fluidic

exome array. Hum Mutat. 2012 Mar;33(3):572-81. doi: 10.1002/humu.22017. Epub

2012 Jan 25. PMID: 22223181.

Brioschi S, Gualandi F, Scotton C, Armaroli A, Bovolenta M, Falzarano MS,

Sabatelli P, Selvatici R, D'Amico A, Pane M, Ricci G, Siciliano G, Tedeschi S,

Pini A, Vercelli L, De Grandis D, Mercuri E, Bertini E, Merlini L, Mongini T,

Ferlini A. Genetic characterization in symptomatic female DMD carriers: lack of

relationship between X-inactivation, transcriptional DMD allele balancing and

phenotype. BMC Med Genet. 2012 Aug 16;13:73. doi: 10.1186/1471-2350-13-73. PMID:

22894145; PMCID: PMC3459813.

Falzarano MS, Passarelli C, Bassi E, Fabris M, Perrone D, Sabatelli P,

Maraldi NM, Donà S, Selvatici R, Bonaldo P, Sparnacci K, Laus M, Braghetta P,

Rimessi P, Ferlini A. Biodistribution and molecular studies on orally

administered nanoparticle-AON complexes encapsulated with alginate aiming at

inducing dystrophin rescue in mdx mice. Biomed Res Int. 2013;2013:527418. doi:

10.1155/2013/527418. Epub 2013 Dec 12. PMID: 24392452; PMCID: PMC3874323.

Falzarano MS, Passarelli C, Ferlini A. Nanoparticle delivery of antisense

oligonucleotides and their application in the exon skipping strategy for

Duchenne muscular dystrophy. Nucleic Acid Ther. 2014 Feb;24(1):87-100. doi:

10.1089/nat.2013.0450. PMID: 24506782; PMCID: PMC3922138.

Falzarano MS, Bassi E, Passarelli C, Braghetta P, Ferlini A. Biodistribution

studies of polymeric nanoparticles for drug delivery in mice. Hum Gene Ther.

2014 Nov;25(11):927-8. doi: 10.1089/hum.2014.073. Epub 2014 Sep 22. PMID:

25244215; PMCID: PMC4236061.

Wein N, Vulin A, Falzarano MS, Szigyarto CA, Maiti B, Findlay A, Heller KN,

Uhlén M, Bakthavachalu B, Messina S, Vita G, Passarelli C, Brioschi S, Bovolenta

M, Neri M, Gualandi F, Wilton SD, Rodino-Klapac LR, Yang L, Dunn DM, Schoenberg

DR, Weiss RB, Howard MT, Ferlini A, Flanigan KM. Corrigendum: Translation from a

DMD exon 5 IRES results in a functional dystrophin isoform that attenuates

dystrophinopathy in humans and mice. Nat Med. 2015 May;21(5):537. doi:

10.1038/nm0515-537c. Erratum for: Nat Med. 2014 Sep;20(9):992-1000. PMID:

25951531.

Falzarano MS, Scotton C, Passarelli C, Ferlini A. Duchenne Muscular

Dystrophy: From Diagnosis to Therapy. Molecules. 2015 Oct 7;20(10):18168-84.

doi: 10.3390/molecules201018168. PMID: 26457695; PMCID: PMC6332113.

Scotton C, Bovolenta M, Schwartz E, Falzarano MS, Martoni E, Passarelli C,

Armaroli A, Osman H, Rodolico C, Messina S, Pegoraro E, D'Amico A, Bertini E,

Gualandi F, Neri M, Selvatici R, Boffi P, Maioli MA, Lochmüller H, Straub V,

Bushby K, Castrignanò T, Pesole G, Sabatelli P, Merlini L, Braghetta P, Bonaldo

P, Bernardi P, Foley R, Cirak S, Zaharieva I, Muntoni F, Capitanio D, Gelfi C,

Kotelnikova E, Yuryev A, Lebowitz M, Zhang X, Hodge BA, Esser KA, Ferlini A.

Deep RNA profiling identified CLOCK and molecular clock genes as

pathophysiological signatures in collagen VI myopathy. J Cell Sci. 2016 Apr

15;129(8):1671-84. doi: 10.1242/jcs.175927. Epub 2016 Mar 4. PMID: 26945058;

PMCID: PMC4852766.

Falzarano MS, D'Amario D, Siracusano A, Massetti M, Amodeo A, La Neve F,

Maroni CR, Mercuri E, Osman H, Scotton C, Armaroli A, Rossi R, Selvatici R, Crea

F, Ferlini A. Duchenne Muscular Dystrophy Myogenic Cells from Urine-Derived Stem

Cells Recapitulate the Dystrophin Genotype and Phenotype. Hum Gene Ther. 2016

Oct;27(10):772-783. doi: 10.1089/hum.2016.079. PMID: 27530229.

Sardone V, Zhou H, Muntoni F, Ferlini A, Falzarano MS. Antisense

Oligonucleotide-Based Therapy for Neuromuscular Disease. Molecules. 2017 Apr

5;22(4):563. doi: 10.3390/molecules22040563. PMID: 28379182; PMCID: PMC6154734.

Gherardi S, Bovolenta M, Passarelli C, Falzarano MS, Pigini P, Scotton C,

Neri M, Armaroli A, Osman H, Selvatici R, Gualandi F, Recchia A, Mora M,

Bernasconi P, Maggi L, Morandi L, Ferlini A, Perini G. Transcriptional and

epigenetic analyses of the DMD locus reveal novel cis‑acting DNA elements that

govern muscle dystrophin expression. Biochim Biophys Acta Gene Regul Mech. 2017

Nov;1860(11):1138-1147. doi: 10.1016/j.bbagrm.2017.08.010. Epub 2017 Sep 1.

Erratum in: Biochim Biophys Acta Gene Regul Mech. 2020 Nov;1863(11):194646.

PMID: 28867298.

Falzarano MS, Flesia C, Cavalli R, Guiot C, Ferlini A. Nanodiagnostics and

Nanodelivery Applications in Genetic Alterations. Curr Pharm Des.

2018;24(15):1717-1726. doi: 10.2174/1381612824666180110151318. PMID: 29318963.

Hiller M, Falzarano MS, Garcia-Jimenez I, Sardone V, Verheul RC, Popplewell

L, Anthony K, Ruiz-Del-Yerro E, Osman H, Goeman JJ, Mamchaoui K, Dickson G,

Ferlini A, Muntoni F, Aartsma-Rus A, Arechavala-Gomeza V, Datson NA, Spitali P.

A multicenter comparison of quantification methods for antisense

oligonucleotide-induced DMD exon 51 skipping in Duchenne muscular dystrophy cell

cultures. PLoS One. 2018 Oct 2;13(10):e0204485. doi:

10.1371/journal.pone.0204485. PMID: 30278058; PMCID: PMC6168132.

Bigoni S, Neri M, Scotton C, Farina R, Sabatelli P, Jiang C, Zhang J,

Falzarano MS, Rossi R, Ognibene D, Selvatici R, Gualandi F, Bosshardt D, Perri

P, Campa C, Brancati F, Salvatore M, De Stefano MC, Taruscio D, Trombelli L,

Fang M, Ferlini A. Homozygous Recessive Versican Missense Variation Is

Associated With Early Teeth Loss in a Pakistani Family. Front Genet. 2019 Jan

21;9:723. doi: 10.3389/fgene.2018.00723. PMID: 30740127; PMCID: PMC6357929.

Falzarano MS, Ferlini A. Urinary Stem Cells as Tools to Study Genetic

Disease: Overview of the Literature. J Clin Med. 2019 May 8;8(5):627. doi:

10.3390/jcm8050627. PMID: 31071994; PMCID: PMC6572423.

Neri M, Rossi R, Trabanelli C, Mauro A, Selvatici R, Falzarano MS, Spedicato

N, Margutti A, Rimessi P, Fortunato F, Fabris M, Gualandi F, Comi G, Tedeschi S,

Seia M, Fiorillo C, Traverso M, Bruno C, Giardina E, Piemontese MR, Merla G, Cau

M, Marica M, Scuderi C, Borgione E, Tessa A, Astrea G, Santorelli FM, Merlini L,

Mora M, Bernasconi P, Gibertini S, Sansone V, Mongini T, Berardinelli A, Pini A,

Liguori R, Filosto M, Messina S, Vita G, Toscano A, Vita G, Pane M, Servidei S,

Pegoraro E, Bello L, Travaglini L, Bertini E, D'Amico A, Ergoli M, Politano L,

Torella A, Nigro V, Mercuri E, Ferlini A. The Genetic Landscape of Dystrophin

Mutations in Italy: A Nationwide Study. Front Genet. 2020 Mar 3;11:131. doi:

10.3389/fgene.2020.00131. PMID: 32194622; PMCID: PMC7063120.

Passarelli C, Selvatici R, Carrieri A, Di Raimo FR, Falzarano MS, Fortunato

F, Rossi R, Straub V, Bushby K, Reza M, Zharaieva I, D'Amico A, Bertini E,

Merlini L, Sabatelli P, Borgiani P, Novelli G, Messina S, Pane M, Mercuri E,

Claustres M, Tuffery-Giraud S, Aartsma-Rus A, Spitali P, T'Hoen PAC, Lochmüller

H, Strandberg K, Al-Khalili C, Kotelnikova E, Lebowitz M, Schwartz E, Muntoni F,

Scapoli C, Ferlini A. Tumor Necrosis Factor Receptor SF10A (TNFRSF10A) SNPs

Correlate With Corticosteroid Response in Duchenne Muscular Dystrophy. Front

Genet. 2020 Jul 3;11:605. doi: 10.3389/fgene.2020.00605. PMID: 32719714; PMCID:

PMC7350910.

Fortunato F, Rossi R, Falzarano MS, Ferlini A. Innovative Therapeutic

Approaches for Duchenne Muscular Dystrophy. J Clin Med. 2021 Feb 17;10(4):820.

doi: 10.3390/jcm10040820. PMID: 33671409; PMCID: PMC7922390.

Falzarano MS, Argenziano M, Marsollier AC, Mariot V, Rossi D, Selvatici R,

Dumonceaux J, Cavalli R, Ferlini A. Chitosan-Shelled Nanobubbles Irreversibly

Encapsulate Morpholino Conjugate Antisense Oligonucleotides and Are Ineffective

for Phosphorodiamidate Morpholino-Mediated Gene Silencing of DUX4.

Nucleic Acid Ther. 2021 Jun;31(3):201-207. doi: 10.1089/nat.2020.0862. Epub 2020

Jul 13. PMID: 32679000.

Rossi R, Falzarano MS, Osman H, Armaroli A, Scotton C, Mantuano P,

Boccanegra B, Cappellari O, Schwartz E, Yuryev A, Mercuri E, Bertini E, D'Amico

A, Mora M, Johansson C, Al-Khalili Szigyarto C, De Luca A, Ferlini A. Circadian

Genes as Exploratory Biomarkers in DMD: Results From Both the mdx Mouse

Model and Patients. Front Physiol. 2021 Jul 8;12:678974. doi:

10.3389/fphys.2021.678974. PMID: 34305639; PMCID: PMC8300012.

Betts CA, Jagannath A, van Westering TL, Bowerman M, Banerjee S, Meng J,

Falzarano MS, Cravo L, McClorey G, Meijboom KE, Bhomra A, Lim WF, Rinaldi C,

Counsell JR, Chwalenia K, O'Donovan E, Saleh AF, Gait MJ, Morgan JE, Ferlini A,

Foster RG, Wood MJ. Dystrophin involvement in peripheral circadian SRF

signalling. Life Sci Alliance. 2021 Aug 13;4(10):e202101014. doi:

10.26508/lsa.202101014. PMID: 34389686; PMCID: PMC8363758.

Falzarano MS, Rossi R, Grilli A, Fang M, Osman H, Sabatelli P, Antoniel M,

Lu Z, Li W, Selvatici R, Al-Khalili C, Gualandi F, Bicciato S, Torelli S,

Ferlini A. Urine-Derived Stem Cells Express 571 Neuromuscular Disorders Causing

Genes, Making Them a Potential in vitro Model for Rare Genetic Diseases.

Front Physiol. 2021 Oct 20;12:716471. doi: 10.3389/fphys.2021.716471. PMID:

34744760; PMCID: PMC8565768.

Falzarano MS, Grilli A, Zia S, Fang M, Rossi R, Gualandi F, Rimessi P, El

Dani R, Fabris M, Lu Z, Li W, Mongini T, Ricci F, Pegoraro E, Bello L, Barp A,

Sansone VA, Hegde M, Roda B, Reschiglian P, Bicciato S, Selvatici R, Ferlini A.

RNA-seq in DMD urinary stem cells recognized muscle-related transcription

signatures and addressed the identification of atypical mutations by whole-

genome sequencing. HGG Adv. 2021 Aug 24;3(1):100054. doi:

10.1016/j.xhg