PhD in Biomedical Sciences and Biotechnology
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- Bernardi F, Marchetti G., Bertagnolo V, Faggioli L, Volinia S, Patracchini P, Bartolai S, Vannini F, Felloni L, Rossi L, Panicucci F and Conconi F (1987) RFLPs analysis in families with sporadic haemophilia A. Estimate of the mutation ratio in male and female gametes. Hum Genet 76:253-256
- Bernardi F, Marchetti G, Bertagnolo V, Faggioli L, Del Senno L (1987) Two Taq I RFLPs in the human von Willebrand factor gene. Nucleic Acids Res 15:1347
- Capitani S, Bertagnolo V, Mazzoni M, Santi P, Previati M, Antonucci A and Manzoli FA (1989) Lipid phosphorylation in isolated rat liver nuclei. Synthesis of polyphosphoinositides at subnuclear level. FEBS Lett 254:194-198
- Capitani S, Helms B, Mazzoni M, Previati M, Bertagnolo V, Wirtz KWA and Manzoli FA (1990) Uptake and phosphorylation of phosphatidylinositol by rat liver nuclei. Role of phosphatidylinositol transfer protein. Biochim Biophys Acta 1044:193-200
- Capitani S, Mazzoni M, Bertagnolo V, Previati M, Daddona A, Ricci D, Manzoli FA (1990) Nuclear inositol lipids in Friend Erythroleukemia cells. Changes related to differentiation induced by hexamethylenebisacetamide. Cell Biol Int Rep 14:783-795
- Billi AM, Matteucci A, Bertagnolo V, Previati M, Manzoli FA Capitani S (1991) In vitro phosphorylation of lamin B protein kinase C in Friend Erythroleukemia. Effect of chemically induced differentiation. Cell Biol Int Rep 15:409-426
- Capitani S, Billi AM, Bertagnolo V, Previati M, Mazzoni M, Neri LM and Manzoli FA (1991) Inositol lipids in Friend Erythroleukemia Cells: evidence for changes in nuclear metabolism after differentiation. Cell Biochem Funct 9:135-145
- Martelli AM, Gilmour RS, Bertagnolo V, Neri LM, Manzoli L and Cocco L (1992) Nuclear localization and signalling activity of phosphoinositidase Cb1 in Swiss 3T3 cells. Nature 358: 242-244
- Mazzoni M, Carini C, Matteucci A, Martelli AM, Bertagnolo V, Previati M, Rana R, Cataldi A and Capitani S (1992) Increased phosphorylation of nuclear substrates for rat brain protein kinase C in regenerating rat liver nuclei. Cell Signal 4:313-319
- Mazzoni M, Bertagnolo V, Neri LM, Carini C, Marchisio M, Milani D, Manzoli FA and Capitani S (1992) Discrete subcellular localization of phosphoinositidase C beta, gamma and delta in PC12 rat pheochromocytoma cells. Biochem Biophys Res Commun 187:114-120
- Maraldi NM, Santi S, Zini N, Ognibene A, Rizzoli R, Mazzotti G, Di Primio R, Bareggi R, Bertagnolo V, Pagliarini C and Capitani S (1993) Decrease in nuclear phospholipids associated with DNA replication. J Cell Sci 104:853-859
- Zauli G, Marchisio M, Bertagnolo V, Celeghini C and Capitani S (1994) HIV-1 Tat protein suppresses the nerve growth-factor (NGF)-mediated differentiation of PC12 rat pheochromocytoma cell-line. Oncol Rep 1:773-777
- Previati M, Bertagnolo V, Mazzoni M, Osti F, Borgatti P and Capitani S (1994) Diacylglycerol kinase activity in rat liver nuclei. Cell Signal 6:393-403
- Neri LM, Milani D, Bertolaso L, Stroscio M, Bertagnolo V, Capitani S (1994) Nuclear translocation of phosphatidylinositol 3-kinase in rat pheochromocytoma PC12 cells after treatment with Nerve Growth Factor. Cell Mol Biol 40:619-626
- Santi P, Marmiroli S, Falcieri P, Bertagnolo V and Capitani S (1994) Inositol lipid phosphorylation and breakdown in rat liver nuclei is affected by hydrocortisone blood levels Cell Biochem Funct 12: 201-207
- Bertagnolo V, Mazzoni, M, Ricci D, Carini C, Neri LM, Previati M and Capitani S (1995) Identification of PI-PLC beta 1, gamma 1, and delta 1 in rat liver: subcellular distribution and relationship to inositol lipid nuclear signalling. Cell Signal 7: 669-678
- Previati M, Bertolaso L, Tramarin M, Bertagnolo V and Capitani S (1996) Low nanogram range quantitation of diglycerides and ceramide by high-performance liquid chromatography. Anal Biochem 233:108-114
- Zauli G, Visani G, Bassini A, Caramelli E, Ottaviani E, Bertolaso L, Bertagnolo V, Borgatti P, and Capitani S (1996) Nuclear translocation of protein kinase C-alpha and -zeta isoforms in HL-60 cells induced to differentiate along the granulocytic lineage by all-trans retinoic acid. Br J Haematol 93:542-550
- Neri LM, Ricci D, Carini C, Marchisio M, Capitani S and Bertagnolo V (1997) Changes of nuclear PI-PLC gamma 1 during rat liver regeneration. Cell Signal 9:353-362
- Bertagnolo V, Marchisio M, Capitani S, Neri LM (1997) Intranuclear translocation of phospholipase C b2 during HL-60 myeloid differentiation. Biochem Biophys Res Commun 235: 831-837
- Marchisio M, Bertagnolo V, Colamussi ML, Capitani S, Neri LM (1998) Phosphatidylinositol 3-kinase in HL-60 nuclei is bound to the nuclear matrix and increases during granulocytic differentiation. Biochem Biophys Res Commun 253:346-351
- Bertagnolo V, Marchisio M, Volinia S, Caramelli E, Capitani S (1998) Nuclear association of tyrosine-phosphorylated Vav to phospholipase C-g1 and phosphoinositide 3-kinase during granulocytic differentiation of HL-60 cells. FEBS Lett 441:480-484
- Bertagnolo V, Neri LM, Marchisio M, Mischiati C, Capitani S (1999) Phosphoinositide 3-kinase activity is essential for all-trans-retinoic-induced granulocytic differentiation of HL-60 cells. Cancer Res 59:542-546
- Marchisio M, Bertagnolo V, Celeghini C, Capitani S, Zauli G (1999) Selective modulation of specific protein kinase C (PKC) isoforms in primary human megakaryocytic vs erythroid cells. Anat Rec 255:7-14
- Neri LM, Marchisio M, Colamussi ML, Bertagnolo V (1999) Monocytic differentiation of HL-60 cells is characterized by the nuclear translocation of phosphatidylinositol 3-kinase and of definite phosphatidylinositol-specific phospholipase C isoforms. Biochem Biophys Res Commun 259:314-320
- Capitani S, Marchisio M, Neri LM, Brugnoli F, Gonelli A, Bertagnolo V (2000) Phosphoinositide 3-kinase is associated to the nucleus of HL-60 cells and is involved in their ATRA-induced granulocytic differentiation. Eur J Histochem 44:61-65
- Bertagnolo V, Marchisio M, Brugnoli F, Bavelloni A, Boccafogli L, Colamussi ML, Capitani S (2001) Requirement of tyrosine-phosphorylated Vav for morphological differentiation of all-trans-retinoic acid-treated HL-60 Cells. Cell Growth Differ 12:193-200
- Caselli M, Marchisio M, Gaudio M, Saragoni L, Lanza G, Alvisi V, Bertagnolo V, Concu M, Capitani S, Caramelli E (2001) Fhit protein expression in human gastric cancer and related precancerous lesions. Oncol Rep 8:1233-7
- Bertagnolo V, Marchisio M, Pierpaoli S, Colamussi ML, Brugnoli F, Visani G, Zauli G and Capitani S (2002) Selective up-regulation of phospholipase C-b2 during granulocytic differentiation of normal and leukemic hematopoietic progenitors. J Leukoc Biol 71:957-965
- Bertagnolo V, Puviani AC, Brogli M, Carini C, Brugnoli F, Colamussi ML, Bellini G, Morsiani E, Capitani S (2003) Retinoic acid maintains differentiated cell morphology and functions in long-term cultured porcine hepatocytes: obtaining functional cells for prolonged treatments with bioartificial liver. Int J Artif Organs 26:498-506
- Bertagnolo V, Brugnoli F, Marchisio M, Celeghini C, Carini C, Capitani S (2004) Association of PI 3-K with tyrosine phosphorylated Vav is essential for its activity in neutrophil-like maturation of myeloid cells. Cell Signal 16: 423-433
- Bertagnolo V, Brugnoli F, Bovolenta M, Capitani S (2004) Inositide-modifying enzymes in differentiation of myeloid cells. Minerva Biotecnologica 16:127-133
- Stabellini G, Brugnoli F, Calastrini C, Vizzotto L, Vertemati M, Baroni T, Caramelli E, Marinucci L, Pellati A, Bertagnolo V (2004) Ornithine decarboxylase, polyamines and CD11b expression in HL-60 cells during differentiation induced by retinoic acid. Biomed Pharmacother 58:401-406
- Bertagnolo V, Brugnoli F, Marchisio M, Capitani S (2004) Inosite-modifying enzymes: a cooperative role in regulating nuclear morphology during differentiation of myeloid cells. J Biol Regul Homeost Agents 18:381-386
- Bertagnolo V, Brugnoli F, Mischiati C, Sereni A, Bavelloni A, Carini C, Capitani S (2005) Vav promotes differentiation of human tumoral myeloid precursors. Exp Cell Res 306:56-63
- Bertagnolo V, Benedusi M, Querzoli P, Pedriali M, Magri E, Brugnoli F, Capitani S (2006) PLC-b2 is highly expressed in breast cancer and is associated with poor outcome: a study on tissue microarrays. Int. J Oncol 28:863-887
- Brugnoli F, Bovolenta M, Benedusi M, Miscia S, Capitani S, Bertagnolo V (2006) PLC-b2 monitors the drug-induced release of differentiation blockade in tumoral myeloid precursors. J Cell Biochem 98:160-173
- Matkovic K, Brugnoli F, Bertagnolo V, Banfic H, Visnjic D (2006) The role of the nuclear Akt activation and Akt inhibitors in all-trans-retinoic acid-differentiated HL-60 cells. Leukemia 20:941-951
- Lanuti P*, Bertagnolo V*, Gaspari AR, Ciccocioppo F, Pierdomenico L., Bascelli A, Sabatino G, Miscia S, and Marchisio M (2006) Parallel regulation of PKC-alpha and PKC-delta characterizes the occurrence of erythroid differentiation from human primary hematopoietic progenitors. Exp Hematol 34:1624-1634 *equally contributors
- Lanuti P, Marchisio M, Cantilena S, Paludi M, Bascelli A, Gaspari AR, Grifone G, Centurione MA, Papa S, Di Pietro R, Cataldi A, Miscia S, and Bertagnolo V (2006) A flow cytometry procedure for simultaneous characterization of cell DNA content and expression of intracellular protein kinase C-zeta. J Immunol Methods 315:37-48
- Marchisio M*, Bertagnolo V*, Lanuti P, Gaspari AR, Paludi M, Ercolino E, Bascelli A and Miscia S (2006) Nuclear protein kinase C-delta: a possible check-point of cell cycle progression. Int J Immunopathol Pharmacol 19:287-291 *equally contributors
- Bertagnolo V, Benedusi M, Brugnoli F, Lanuti P, Marchisio M, Querzoli P, Capitani S (2007) Phospholipase C-beta2 promotes mitosis and migration of human breast cancer derived cells. Carcinogenesis 28:1638-1645
- Brugnoli F, Bavelloni A, Benedusi M, Capitani S, Bertagnolo V (2007) PLC-beta2 activity on actin-associated polyphosphoinositides promotes migration of differentiating tumoral myeloid precursors. Cell Signal 19:1701-1712
- Bertagnolo V, Grassilli S, Bavelloni A, Brugnoli F, Piazzi M, Candiano G, Petretto A, Benedusi M, Capitani S (2008) Vav1 modulates protein expression during ATRA-induced maturation of APL-derived promyelocytes: a proteomic-based analysis. J Proteome Res 7:3729-3736
- Brugnoli F, Grassilli S, Benedusi M, Capitani S, Bertagnolo V (2008) RNA interference in the study of molecular mechanisms activated during agonist induced differentiation of acute promyelocytic leukemia derived promyelocytes. Minerva Biotecnologica 20:39-49
- Lanuti P, Bertagnolo V, Pierdomenico L, Bascelli A, Santavenere E, Alinari L, Capitani S, Miscia S, Marchisio M (2009) Enhancement of TRAIL cytotoxicity by AG-490 in human ALL cells is characterized by downregulation of cIAP-1 and cIAP-2 through inhibition of Jak2/Stat3. Cell Res 19:1079-1089
- Brugnoli F, Lambertini E, Varin-Blank N, Piva R, Marchisio M, Grassilli S, Miscia S, Capitani S, Bertagnolo V (2010) Vav1 and PU.1 are recruited to the CD11b promoter in APL-derived promyelocytes: Role of Vav1 in modulating PU.1-containing complexes during ATRA-induced differentiation. Exp Cell Res 316:38-47
- Bertagnolo V, Grassilli S, D'Aguanno S, Brugnoli F, Bavelloni A, Faenza I, Nika E, Urbani A, Cocco L, Capitani S (2010) Mass spectrometry-based identification of Y745 of Vav1 as a tyrosine residue crucial in maturation of acute promyelocytic leukemia-derived cells. J Proteome Res 9:752-760
- Bertagnolo V, Nika E, Brugnoli F, Bonora M, Grassilli S, Pinton P, Capitani S (2011) Vav1 is a crucial molecule in monocytic/macrophagic differentiation of myeloid leukemia-derived cells. Cell Tissue Res 345:163-175
- Bertagnolo V, Grassilli S, Petretto A, Lambertini E, Astati L, Bruschi M, Brugnoli F, Nika E, Candiano G, Piva R, Capitani S (2011) Nuclear proteome analysis reveals a role of Vav1 in modulating RNA processing during maturation of tumoral promyelocytes. J Proteomics 75:398-409
- Bertagnolo V, Brugnoli F, Grassilli S, Nika E, Capitani S (2012) Vav1 in differentiation of tumoral promyelocytes. Cell Signal 24:612-620
- Zucchetto A, Vaisitti T, Benedetti D, Tissino E, Bertagnolo V, Rossi D, Bomben R, Dal Bo M, Del Principe MI, Gorgone A, Pozzato G, Gaidano G, Del Poeta G, Malavasi F, Deaglio S, Gattei V (2012) The CD49d/CD29 complex is physically and functionally associated with CD38 in B-cell chronic lymphocytic leukemia cells. Leukemia 26:1301-1312
- Brugnoli F, Grassilli S, Piazzi M, Palomba M, Nika E, Bavelloni A, Capitani S, Bertagnolo V (2013) In triple negative breast tumor cells, PLC-beta 2 promotes the conversion of CD133(high) to CD133(low) phenotype and reduces the CD133-related invasiveness. Mol Cancer 12:165
- Bertagnolo V, Brugnoli F, Grassilli S, Nika E, Capitani S (2013) In triple negative breast tumor cells, PLC-β2 promotes the conversion of CD133high to CD133low phenotype and reduces the CD133-related invasiveness. Ital J Anat Embryol 118:25
- Nika E, Brugnoli F, Piazzi M, Lambertini E, Grassilli S, Bavelloni A, Piva R, Capitani S, Bertagnolo V (2014) hnRNP K in PU.1-containing complexes recruited at the CD11b promoter: a distinct role in modulating granulocytic and monocytic differentiation of AML-derived cells. Biochem J 463:115-122
- Grassilli S, Brugnoli F, Lattanzio R, Rossi C, Perracchio L, Mottolese M, Marchisio M, Palomba M, Nika E, Natali PG, Piantelli M, Capitani S, Bertagnolo V (2014) High nuclear level of Vav1 is a positive prognostic factor in early invasive breast tumors: a role in modulating genes related to the efficiency of metastatic process. Oncotarget 5:4320-4336
- Brugnoli F, Grassilli S, Al-Qassab Y, Capitani S, Bertagnolo V (2016) PLC-beta 2 is modulated by low oxygen availability in breast tumor cells and plays a phenotype dependent role in their hypoxia-related malignant potential. Mol Carcinog 55:2210-2221
- Grassilli S, Nika E, Lambertini E, Brugnoli F, Piva R, Capitani S, Bertagnolo V (2016) A network including PU.1, Vav1 and miR-142-3p sustains ATRA-induced differentiation of acute promyelocytic leukemia cells - a short report. Cell Oncol 39:483-489