PhD in Biomedical Sciences and Biotechnology

 

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              1. Bocci V, Valacchi G, Corradeschi F, Fanetti G. Studies on the biological effects of ozone: 8. Effects on the total antioxidant status and on interleukin-8 production. Mediators of Inflammation. 1998;7(5):313-7.
              2. Bocci V, Valacchi G, Corradeschi F, Aldinucci C, Silvestri S, Paccagnini E, Gerli R. Studies on the biological effects of ozone:7. Generation of reactive oxygen species (ROS) after exposure of human blood to ozone. Journal of Biological Regulators and Homeostatic Agents. 1998 Jul-Sep;12(3):67-75.
              3. Maioli E, Torricelli C, Valacchi G, Pacini A. Big atrial natriuretic peptide: investigation on specific hormone-binding proteins. Biochemical Archives. 1998;14,17-25.
              4. Bocci V, Borrelli E, Valacchi G, Luzzi E. Quasi-total body exposure to oxygen- ozone in a sauna cabin. European Journal of Applied Physiology and Occupational Physiology. 1999 Nov-Dec;80(6):549-54.
              5. Valacchi G and Bocci V. Studies on the biological effects of ozone: 10. Release of factors from ozonated human platelets. Mediators of Inflammation. 1999;8(4-5):205-9.
              6. Bocci V, Valacchi G, Rossi R, Giustarini D, Paccagnini E, Pucci AM, Di Simplicio P. Studies on the biological effects of ozone: 9. Effects of ozone on human platelets. Platelets. 1999;10(2-3):110-6.
              7. Bocci V, Di Paolo N, Garosi G, Aldinucci C, Borrelli E, Valacchi G, Cappelli F, Guerri L, Gavioli G, Corradeschi F, Rossi R, Giannerini F, Di Simplicio P. 1999. Ozonation of blood during extracorporeal circulation. I. Rationale, Methodology and preliminary studies. Int.J.Artif.Organs. 1999 Sep;22(9):645-51.
              8. Park YC, Rimbach G, Saliou C, Valacchi G, Packer L. Activity of monomeric, dimeric, and trimeric flavonoids on NO production, TNFa secretion, and NF-kB dependent gene expression in RAW 264.7 macrophages. FEBS lett. 2000 Jan 14; 465(2-3):93-7.
              9. Valacchi G, Weber SU, Luu C, Cross CE, Packer L. Ozone potentiates the vitamin E depletion by ultraviolet radiation in murine stratum corneum. FEBS lett. 2000 Jan 2;466(1):165-168.
              10. Rimbach G, Valacchi G, Canali R, Virgili F. Macrophages stimulated with IFN-g activate NF-kB and induce MCP-1 gene expression in primary human endothelial cells. Mol. Cell. Bio. Res. Comm. 2000 Apr;3(4):238-42.
              11. Valacchi G, Bocci V. Studies on the biological effects of ozone: 11. Release of factors from human endothelial cells. Mediators of Inflammation. 2000;9(6):271-6.
              12. Bocci V, Borrelli E, Corradeschi F, Valacchi G. Systemic effects after colorectal insufflation of oxygen/ozone in rabbit. Int. J. Med. Biol. & Environment. 2000, 28 No.2:109-113.
              13. Bocci, V., Aldinucci C., E. Borrelli, , Corradeschi F, A. Diadori, Fanetti G. and Valacchi G. Ozone In Medicine. Ozone-Science & Engineering. 2001, 23 : 207-17.
              14. Saliou C, Valacchi G, Rimbach G. Assessing the effectiveness of bioflavonoids as regulators of NF-kB activity and inflammatory gene expression in mammalian cells. Methods in Enzymology. 2001;335:380-7.
              15. Valacchi G, Rimbach G, Saliou C, Weber SU, Packer L. Effect of Benzoyl Peroxide on antioxidant status, NF-kB activity and interleukin-1a gene expression in human keratinocytes. Toxicology. 2001 Aug 28;165(2-3):225-34.
              16. Nardini M, Finkelstein EI, Reddy S, Valacchi G, Traber MG, Cross CE, van der Vliet A. Apoptosis mediated acrolein-induced cytotoxicity in cultured human bronchial epithelial cells. Modulation by alpha-tocopherol and ascorbic acid. Toxicology, 2002, 170(3):173-185. doi: 10.1016/S0300-483X(01)00540-6.
              17. Valacchi G, van der Vliet A, Schock BC, Okamoto T, Obermuller-Jevic U, Cross CE, Packer L. Ozone exposure activates oxidative stress responses in murine skin. Toxicology, 2002 Sep 30;179(1-2):163-70.
              18. Banerjee T, Valacchi G, Ziboh VA, van der Vliet A. Inhibition of TNFalpha- induced cyclooxygenase-2 expression by amentoflavone through suppression of NF- kappaB activation in A549 cells. Molecular Cellular Biochemistry. 2002 Sep;238(1-2):105-10.
              19. Packer L, Valacchi G. Antioxidants and the response of skin to oxidative stress: vitamin E a key indicator. J Skin Pharm and Appl  Skin Physiol. 2002 Sep-Oct;15(5):282-90.
              20. Cross CE, Valacchi G, Schock BC, Wilson M, Weber S, Eiserich JP, van der Vliet A. Environmental oxidant pollutant effects on biologic systems: a focus on micronutrient antioxidant-oxidant interactions.. American Journal of Respiratory and Critical Care Medicine. 2002 Dec 15;166(12 Pt 2):S44-50.
              21. Okamoto T, Valacchi G, Gohil K, Akaike T, van der Vliet A. S-nitrosothiols inhibit cytokine-mediated induction of matrix metalloproteinase-9 in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2002 Dec;59(12):2165-71.
              22. Fortino V, Torricelli C, Gardi C, Valacchi G, Rossi Paccani S, Maioli E. ERKS are the point of convergence/divergence of PKA and PKC pathways in human skin fibroblast mitogenic response to PTHRP. Cellular and Molecular Life Sciences. 2002 Dec;59(12):2165-71
              23. Weber SU, Thiele JJ, Han N, Luu C, Valacchi G, Weber S, Packer L. Topical alpha- tocotrienol supplementation inhibits lipid peroxidation but fails to mitigate increased transepidermal water loss after benzoyl peroxide treatment of human skin. Free Radicals in Biology and Medicine. 2003 Jan 15;34(2):170-6.
              24. Valacchi G, Pagnin E, Okamoto T, Corbacho AM, Olano E, Davis PA, van der Vliet A., Packer L. and Cross CE. Induction of stress proteins and MMP-9 by 0.8 ppm of ozone in murine skin. Biochem. Biophys. Res. Com. 2003 Jun 6;305(3):741-6.
              25. Obermuller-Jevic U, Olano-Martin E, Corbacho AM, Eiserich JP, van der Vliet A, Valacchi G, Cross CE, Packer L. Lycopene inhibits the growth of normal prostate epithelial cells in vitro. Journal of Nutrition. 2003, 133 (11):3356-60.
              26. Schock BC, van der Vliet A, Corbacho AM, Leonard SW, Finkelstein E, Valacchi G, Obermuller-Jevic U, Cross CE, Traber MG. Enhanced inflammatory responses in a- tocopherol transfer protein null mice. Archives of Biochemistry and Biophysics. 2004, 423(1):162-9.
              27. Valacchi G, Pagnin E, Corbacho AM, Olano E, Davis PA, Packer L, Cross CE. In vivo ozone exposure induces antioxidant/stress related responses in murine lung and skin. Free Radic Biol Med. 2004, 36(5):673-81.
              28. Corbacho A, Valacchi G, Kubala L, Olano-Martin E, Schock B, Kenny T, Cross CE. Tissue-specific gene expression of prolactin receptor in the acute phase response induced by lipopolysaccharides. American Journal of Physiology. Endocrinology and Metabolism. 2004 Oct;287(4):E750-7. Epub 2004 Jun 8.
              29. Valacchi G, Pagnin E, Phung A, Nardini M, Schock BC, Cross CE, van Der Vliet A. Inhibition of NFkB activation and IL-8 expression in human bronchial epithelial cells by acrolein. Antioxidants & Redox Signaling. 2005 Jan-Feb;7(1-2):25-31.
              30. Valacchi G, Fortino V, Bocci V. The dual action of ozone in the skin. British Journal of Dermatology. 2005 Dec;153 (6):1096-100.
              31. Lim Y, Phun A, Corbacho AM, Aung HH, Maioli E, Reznick AZ, Cross CE, Davis PA, Valacchi G. Modulation of cutaneous wound healing by ozone. Differences between young and aged mice. Toxicology Letters. 2006 Jan 5;160(2):127-34. Epub 2005 Aug 29.
              32. Davis PA, Valacchi G, Pagnin E, Shao Q, Gross HB, Calo L, Yokoyama W. Walnuts reduce aortic ET-1 mRNA levels in hamsters fed a high fat, atherogenic diet. Journal of Nutrition. 2006 Feb;136(2):428-32.
              33. Davis PA, Polagruto AJ, Valacchi G, Phung A, Soucek K, Keen LC, Gershwin ME. Effect of Apple Extracts on NF-kB Activation in Human Umbilical Vein Endothelial Cells. Experimental Biology and Medicine. 2006 May;231(5):594-8.
              34. Valacchi G. Ozone and skin: An overview. Journal of Cosmetic Science. 2007, 5; 58: 588-589.
              35. Corbacho AM, Eiserich JP, Zuniga LA, Valacchi G, Villablanca AC. Compromised aortic vasoreactivity in male estrogen receptor-alpha-deficient mice during acute lipopolysaccharide-induced inflammation. Endocrinology. 2007 Mar;148(3):1403-11. Epub 2006 Dec 7.
              36. Valacchi G, Vasu VT, Yokohama W, Corbacho AM, Phung A, Lim Y, Aung H, Cross CE, Davis PA. Lung vitamin E transport processes are affected by both age and environmental oxidants in mice. Toxicology and Applied Pharmacology. 2007 Jul 15;222(2):227-34. Epub 2007 May 1.
              37. Fortino V, Maioli E, Torricelli C, Davis PA and Valacchi G. Cutaneous MMPs are differently modulated by environmental stressors in old and young mice. Toxicology Letters. 2007 Sep 10;173(2):73-9. Epub 2007 Jun 16.
              38. Bocci V, Aldinucci C, Mosci F , Carraro C and Valacchi G. Ozonation of human blood induces a remarkable upregulation of heme-oxygenase-1 and heat stress protein-70. Mediators of Inflammation. 2007;2007:26785. doi: 10.1155/2007/26785.
              39. Fortino V, Torricelli C, Capurro E, Sacchi G, Valacchi G. and Maioli E. Antiproliferative and survival properties of PMA in MCF-7 breast cancer cells. Cancer Investigation. 2008 Feb;26(1):13-21. doi: 10.1080/07357900701637949.
              40. Torricelli C, Fortino V, Capurro E, Valacchi G, Pacini A, Muscettola M, Soucek K and Maioli E. Rottlerin inhibits the NFkB/Cyclin-D1 cascade in MCF-7 breast cancer cells. Life Science. 2008 Mar 12;82(11-12):638-43. doi: 10.1016/j.lfs.2007.12.020. Epub 2008 Jan 11.
              41. Lim Y, Vasu VT, Valacchi G, Leonard S, Aung HH, Shock BC, Kenyon NJ, Li CS, Traber MG and Cross CE. Severe Vitamin E deficiency modulates airway allergic inflammatory responses in the murine asthma model. Free Radical Research. 2008 Apr;42(4):387-96. doi: 10.1080/10715760801976600.
              42. Aung H, Vasu VT, Valacchi G, Corbacho AM, Kota RS, Lim Y, Obermueller-Jevic UC, Packer L, Cross CE, Gohil K. Effects if dietary carotenoids on mouse lung genomic profiles and their modulatory effects on short term cigarette smoke exposures. Genes & Nutrition. 2009 Mar;4(1):23-39. doi: 10.1007/s12263-008-0108-z. Epub 2008 Dec 18.
              43. Castagna R, Davis PA, Vasu VT, Soucek K, Cross CE, Greci L, Valacchi G. Nitroxide radical TEMPO reduces ozone-induced chemokine IL-8 production in lung epithelial cells. Toxicology in Vitro. 2009 Apr;23(3):365-70. doi: 10.1016/j.tiv.2008.12.016. Epub 2008 Dec 30.
              44. Valacchi G. Editorial: First International Conference on Environmental Stressors in Biology and Medicine – Siena, 4th–6th June 2009. Toxicology and Industrial Health. 2009 May-Jun;25(4-5):217. doi: 10.1177/0748233709106924.
              45. Valacchi G, Pecorelli A, Mencarelli M, Maioli E, Davis PA. Beta-carotene prevents ozone-induced proinflammatory markers in murine skin. Toxicology and Industrial Health. 2009 May-Jun;25(4-5):241-7. doi: 10.1177/0748233709103030.
              46. Valacchi G, Pecorelli A, Mencarelli M, Carbotti P,  Fortino V, Muscettola M, Maioli E. Rottlerin: a multifaced regulator of keratinocyte cell cycle. Experimental Dermatology. 2009 Jun;18(6):516-21. doi: 10.1111/j.1600-0625.2008.00816.x.
              47. De Felice C, Ciccoli L, Leoncini S, Signorini C, Rossi M, Vannuccini L, Guazzi G, Latini G, Comporti M, Valacchi G Hayek J. Systemic oxidative stress in classic Rett syndrome. Free Radicals in Biology & Medicine. 2009 Aug 15;47(4):440-8. doi: 10.1016/j.freeradbiomed.2009.05.016. Epub 2009 May 21. [Epub ahead of print].
              48. Mencarelli M, Pecorelli A, Carbotti P, Valacchi G, Grasso G, Muscettola M. Endothelin receptor A expression in human inflammatory cells. Regulatory Peptides. 2009 Nov 27;158(1-3):1-5. doi: 10.1016/j.regpep.2009.06.004. Epub 2009 Jun 12. [Epub ahead of print].
              49. Maioli E, Greci L, Soucek K, Hyzdalova M, Pecorelli A, Fortino V, Valacchi G. Rottlerin inhibits ROS formation and prevents NFkappaB activation in MCF-7 and HT- 29 cells. Journal of Biomedicine and Biotechnology. 2009;2009:742936. doi: 10.1155/2009/742936. Epub 2010 Feb 3.
              50. Vasu VT, Oommen S, Lim Y, Valacchi G, Hobson B, Eiserich JP, Leonard SW, Traber MG, Cross CE, Gohil K. Modulation of ozone-sensitive genes in alpha-tocopherol transfer protein null mice. Inhalation Toxicology. 2010 Jan;22(1):1-16. doi: 10.3109/08958370902838145. [Epub ahead of print].
              51. Vecchio D, Arezzini B, Pecorelli A, Valacchi G, Martorana PA, Gardi C. Reactivity of Mouse Alveolar Macrophages to Cigarette Smoke is Strain. Am J Physiol Lung Cell Mol Physiol. 2010 May;298(5):L704-13. doi: 10.1152/ajplung.00013.2009. Epub 2010 Feb 12.
              52. Maioli E, Valacchi G. Rottlerin: bases for a possible usage in psoriasis. Current Drug Metabolism. 2010 Jun 1;11(5):425-30.
              53. Travagli V, Zanardi I, Valacchi G, and Bocci V. Ozone and ozonated oils in skin diseases: a review.. Mediators of Inflammation. 2010;2010:610418. doi: 10.1155/2010/610418. Epub 2010 Jul 4.
              54. De Felice C, Guazzi G, Rossi M, Ciccoli L, Signorini C, Leoncini S, Tonni G, Latini G, Valacchi G, and Hayek J. Unrecognized interstitial lung disease in classic Rett syndrme. CHEST. 2010 Aug;138(2):386-92. doi: 10.1378/chest.09-3021. Epub 2010 Mar 26. [Epub ahead of print].
              55. Kostyuk V, Potapovich A, Cesareo E, Brescia S, Guerra L, Valacchi G, Pecorelli A, Deeva IB, Raskovic D, De Luca C, Pastore S, Korkina L. Dysfunction of glutathione S-transferase leads to excess 4-hydroxy-2-nonenal and H(2)O(2) and impaired cytokine pattern in cultured keratinocytes and blood of vitiligo patients.. Antioxid Redox Signal. 2010 Sep 1;13(5):607-20. doi: 10.1089/ars.2009.2976.
              56. Park Na-Y, Valacchi G, and Lim Y. Effect of Dietary Conjugated Linoleic Acid (CLA) Supplementation on Early Inflammatory Responses during Cutaneous Wound Healing. Mediators in Inflammation. 2010;2010. pii: 342328. doi: 10.1155/2010/342328. Epub 2010 Aug 17.
              57. De Luca C, Valacchi G. Surface lipids as multifunctional mediators of skin responses to environmental stimuli. Mediators of Inflammation. 2010;2010:321494. doi: 10.1155/2010/321494. Epub 2010 Oct 20.
              58. Sticozzi C, Pecorelli A, Belmonte G, Valacchi G. Cigarette Smoke Affects ABCAl Expression via Liver X Receptor Nuclear Translocation in Human Keratinocytes. International Journal of Molecular Sciences. 2010 Sep 17;11(9):3375-86. doi: 10.3390/ijms11093375.
              59. De Luca C. Scordo GM, Cesareo E, Pastore S, Mariani S, Maiani G, Stancato A, Loreti B, Valacchi G, Lubrano C, Raskovic D, De Padova L, Genovesi G, Korkina LG. Biological Definition of Multiple Chemical Sensitivity from Redox State and Cytokine Profiling and not from Polymorphisms of Xenobiotic-Metabolizing Enzymes. Toxicology and Applied Pharmacology. 2010 Nov 1;248(3):285-92. doi: 10.1016/j.taap.2010.04.017. Epub 2010 Apr 27.
              60. Aldinucci C, Maiorca SM, De Rosa P, Palmi M, Sticozzi C, Ciccoli L, Leoncini S, Signorini C, Valacchi G and Pessina GP. The physiological behaviour of IMR-32 neuroblastoma cells is affected by a 12-h hypoxia/24-h reoxigenation period. Neurochemical Research. 2010 Nov;35(11):1691-9. doi: 10.1007/s11064-010-0231-2. Epub 2010 Jul 18.
              61. Valacchi G, De Luca C and Wertz P. Lipid mediators in skin inflammation: updates and current views. Editorial Special Issue. Mediators of Inflammation. 2010;2010:398926. doi: 10.1155/2010/398926. Epub 2010 Oct 21.
              62. Toricelli C, Valacchi G and Maioli E. Novel PKCs activate ERK through PKD1 in MCF-7 cells. In vitro cellular and development biology. Animal. 2011 Jan;47(1):73-81. doi: 10.1007/s11626-010-9355-6. Epub 2010 Nov 13.
              63. Valacchi G, Lim Y, Belmonte G, Miracco C, Zanardi I, Bocci V, Travagli V. Ozonated sesame oil enhances cutaneous wound healilng in SKH1 mice. Wound Repair and Regeneration. 2011 Jan-Feb;19(1):107-15. doi: 10.1111/j.1524-475X.2010.00649.x. Epub 2010 Dec 6.
              64. Pecorelli A, Ciccoli L, Signorini C, Leoncini S, Giardini A, D’Esposito M, Filosa S, Hayek J, De Felice C and Valacchi G. Increased levels of 4HNE-protein plasma adducts in Rett Syndrome. Clinical Biochemistry. 2011 Apr;44(5-6):368-71. doi: 10.1016/j.clinbiochem.2011.01.007. Epub 2011 Jan 26.
              65. Pastore S, Mariani V, Lulli D, Gubinelli E, Raskovic D, Mariani S, Stancato A, De Luca C, Pecorelli A, Valacchi G, Potapovich AI, Kostyuk VA and Korkina L. Glutathione peroxidase activity in the blood cells of psoriatic patients correlates with their responsiveness to Efalizumab. Free Radicals Research. 2011 May;45(5):585-99. doi: 10.3109/10715762.2011.560150. Epub 2011 Feb 16.
              66. Valacchi G, Pecorelli A, Sticozzi C, Torricelli C, Muscettola M, Aldinucci C and Maioli E. Rottlerin exhibits antiangiogenic effects in vitro. Chemical Biology & Drug Design. 2011 Jun;77(6):460-70. doi: 10.1111/j.1747-0285.2011.01121.x. Epub 2011 May 4. [Epub ahead of print].
              67. Signorini C, De Felice C, Leoncini S, Giardini A, M D'Esposito, Filosa S, Della Ragione F, Rossi M, Pecorelli A, Valacchi G; Ciccoli L; Hayek J. F4-neuroprostanes mediate neurological severity in Rett syndrome. Clinica Chimica Acta. 2011 Jul 15;412(15-16):1399-406. doi: 10.1016/j.cca.2011.04.016. Epub 2011 Apr 17.
              68. Leoncini S, De Felice C, Signorini C, Pecorelli A, Durand T, Valacchi G, Ciccoli L, Hayek J. Oxidative stress in Rett Syndrome: natural history, genotype and variants. Redox Report. 2011;16(4):145-53. doi: 10.1179/1351000211Y.0000000004.
              69. Valacchi G, Davis PA, Khan EM, Lanir R, Maioli E, Pecorelli A, Cross CE, Goldkorn T. Cigarette smoke exposure causes changes in Scavenger Receptor B1 level and distribution in lung cells. Int J Biochem Cell Biol. 2011 Jul;43(7):1065-70. doi: 10.1016/j.biocel.2009.05.014. Epub 2009 Jun 2.
              70. Valacchi G, Sticozzi C, Lim Y, Pecorelli A. Scavenger receptor class B type I: a multifunctional receptor. Annals of the New York Academy of Sciences. 2011 Jul;1229:E1-7. doi: 10.1111/j.1749-6632.2011.06205.x.
              71. Sticozzi C and Valacchi G. Troposphere ozone as a source of oxidative stress in cutaneous tissues. Journal of Scientific and Industrial Research. 2011 Nov;70:918- 922.
              72. De Felice C, Signorini C, Durand T, Oger C, Guy A, Bultel-Poncé V, Galano J, Ciccoli L , Leoncini S, D’Esposito M, Filosa S, Pecorelli A, Valacchi G and Hayek J. F2- Dihomo-isoprostanes as potential early biomarkers of lipid oxidative damage in Rett syndrome. Journal of Lipid Research. 2011 Dec;52(12):2287-97. doi: 10.1194/jlr.P017798. Epub 2011 Sep 13.
              73. Sticozzi C, Pecorelli A, Lim Y, Maioli E, Pagnin E, Davis PA and Valacchi G. Modulation of skin oxidative stress and inflammatory markers by environmental stressors. Differences between young and old. Journal of Dermatological Sciences. 2012 Mar;65(3):226-8. doi: 10.1016/j.jdermsci.2011.11.004. Epub 2011 Nov 18.
              74. Jang S, Lim Y, Valacchi G, Sorn S, Park H, Park NY, Lee M. Preventive effects of protopanaxadiol and protopanaxatriol ginsenosides on liver inflammation and apoptosis in hyperlipidemic apoE KO mice. Genes & Nutr. 2012 Apr;7(2):319-29. doi: 10.1007/s12263-011-0245-7. Epub 2011 Aug 19.
              75. De Felice C, Maffei S, Signorini C, Leoncini S, Lunghetti S, Valacchi G, D’Esposito M, Filosa S, Della Ragione F, Butera G, Favilli R, Ciccoli L and Hayek J. Subclinical myocardial dysfunction in Rett Syndrome. European Heart Journal- Cardiovasc. Imaging. 2012 Apr;13(4):339-45. doi: 10.1093/ejechocard/jer256. Epub 2011 Nov 23.
              76. Maioli E, Torricelli C and Valacchi G. Rottlerin and cancer: novel evidences and mechanisms. TheScientificWorldJOURNAL. 2012;2012:350826. doi: 10.1100/2012/350826. Epub 2012 Jan 4.
              77. Ciccoli L, De Felice C, Paccagnini E, Leoncini S, Pecorelli A, Signorini C, Belmonte G, Valacchi G, Rossi M, Hayek J. Morphological changes and oxidative damage in Rett Syndrome erythrocytes. Biochim Biophys Acta (General Subjects). 2012 Apr;1820(4):511-20. doi: 10.1016/j.bbagen.2011.12.002. Epub 2011 Dec 13.
              78. De Felice C, Signorini C, Durand T, Ciccoli L, Leoncini S, D’Esposito M, Filosa S, Oger C, Guy A, Bultel-Poncé V, Galano JM, Pecorelli A, De Felice L, Valacchi G, Hayek J. Partial rescue of Rett synfrome by ω-3 polynsaturated fatty acids (PUFAs) oil. Genes & Nutr. 2012 Jul;7(3):447-58. doi: 10.1007/s12263-012-0285-7. Epub 2012 Mar 8. [Epub ahead of print].
              79. Maioli E, Torricelli C, Valacchi G. Rottlerin and curcumin: a comparative review. Annals of the New York Academy of Sciences. 2012 Jul;1259:65-76. doi: 10.1111/j.1749-6632.2012.06514.x.
              80. Sticozzi C, Belmonte G, Pecorelli A, Arezzini B, Gardi C, Maioli E, Miracco C, Toscano M, Forman HJ, Valacchi G. Cigarette Smoke affects keratinocytes SRB1 expression and localization via H2O2 production and HNE protein adducts formation. PLoS ONE. 2012;7(3):e33592. doi: 10.1371/journal.pone.0033592. Epub 2012 Mar 19.
              81. Park S, Park NY, Valacchi G, Lim Y. Calorie restriction with a high fat diet effectively attenuated inflammatory response and oxidative stress related markers in obese tissues of the high diet fed rats. Mediators of Inflammation. 2012;2012:984643. doi: 10.1155/2012/984643. Epub 2012 Jun 19.
              82. Gardi C, Valacchi G. Cigarette Smoke and Ozone effect on murine inflammatory responses. Annals of the New York Academy of Sciences. 2012 Jul;1259:104-11. doi: 10.1111/j.1749-6632.2012.06605.x.
              83. Valacchi G, Zanardi, I, Sticozzi C, Bocci V, Travagli V. Emerging topics in cutaneous wound repair. Annals of the New York Academy of Sciences. 2012 Jul;1259:136-44. doi: 10.1111/j.1749-6632.2012.06636.x.
              84. De Felice C, Signorini C, Leoncini S, Pecorelli A, Durand T, Valacchi G, Ciccoli L, Hayek J. The role of Oxidative stress in Rett syndrome: an overview. Annals of the New York Academy of Sciences. 2012 Jul;1259:121-35. doi: 10.1111/j.1749-6632.2012.06611.x.
              85. Vítecek J, Lojekb A, Valacchi G, Kubala L. Arginine Based Inhibitors of Nitric Oxide Synthase: Therapeutic Potential and Challenges. Mediators of Inflammation. 2012;2012:318087. doi: 10.1155/2012/318087. Epub 2012 Sep 4.
              86. Valacchi G, Sticozzi C, Pecorelli A, Cervellati F, Cervellati C and Maioli E. Cutaneous Responses to Environmental Stressors. Annals of the New York Academy of Sciences. 2012 Oct;1271:75-81. doi: 10.1111/j.1749-6632.2012.06724.x.
              87. Lampariello LR, Cortelazzo A, Guerranti R, Sticozzi C, Valacchi G. The “Magic” Velvet Bean of Mucuna pruriens. Journal of Traditional and Complementary Medicine. 2012 Oct;2(4):331-9.
              88. Torricelli C, Salvadori S, Valacchi G, Souček K, Slabáková E Muscettola M, Volpi N and Maioli E. Alternative pathways of cancer cell death by Rottlerin: apoptosis versus autophagy. Evidence-Based Complementary and Alternative Medicine. 2012;2012:980658. doi: 10.1155/2012/980658. Epub 2012 Dec 20.
              89. Durand T, De Felice C, Signorini C, Oger C, Bultel-Poncé V, Guy A, Galano JM, Leoncini S, Ciccoli L, Pecorelli A, Valacchi G, Hayek J. F2-Dihomo-Isoprostanes and brain white matter damage in stage 1 Rett syndrome. Biochimie. 2013 Jan;95(1):86-90. doi: 10.1016/j.biochi.2012.09.017. Epub 2012 Sep 23.
              90. Pecorelli A, Leoncini S, De Felice C, Signorini C, Cerrone C, Valacchi G, Ciccoli L, Hayek J. Non-Protein-Bound Iron and 4-Hydroxynonenal Protein Adducts in Autism Spectrum Disorders. Brain and Development. 2013 Feb;35(2):146-54. doi: 10.1016/j.braindev.2012.03.011. Epub 2012 Apr 23. [Epub ahead of print].
              91. Pecorelli A, Bocci V, Acquaviva A, Belmonte G, Gardi C, Virgili F, Ciccoli L , Valacchi G. NRF2 activation is involved in ozonated human serum upregulation of HO1 in endothelial cells. Toxicology and Applied Pharmacology. 2013 Feb 15;267(1):30-40. doi: 10.1016/j.taap.2012.12.001. Epub 2012 Dec 16.
              92. Sticozzi C, Belmonte G, Cervellati F, Di Capua A, Maioli E, Cappelli A, Giordani A, Biava M, Anzini M, Valacchi G. Antiproliferative effect of two novel COX-2 inhibitors on human keratinocytes. European Journal of Pharmaceutical Sciences. 2013 May 13;49(2):133-41. doi: 10.1016/j.ejps.2013.02.009. Epub 2013 Feb 26.
              93. Bocci V, Valacchi G. Free Radicals and Antioxidants: How to reestablish redox homeostasis in chronic diseases? Current Medicinal Chemistry. 2013;20(27):3397-415.
              94. Sticozzi C, Belmonte G, Pecorelli A, Cervellati F, Leoncini S, Signorini C, Ciccoli L, De Felice C, Hayek J, Valacchi G. Scavenger receptor B1 post-translational modifications in Rett syndrome. FEBS Lett. 2013 Jul 11;587(14):2199-204. doi: 10.1016/j.febslet.2013.05.042. Epub 2013 May 24.
              95. Cervellati F, Valacchi G, Lunghi L, Fabbri E, Valbonesi V, Marci R, Biondi C, Vesce F.  17 ß-Estradiol counteracts the effects of high frequency electromagnetic fields on trophoblastic connexins and integrins. Oxidative Medicine and Cellular Longevity. 2013;2013:280850. doi: 10.1155/2013/280850. Epub 2013 May 30.
              96. Volpi N, Pecorelli A, Lorenzoni P, Di Lazzaro F, Belmonte G, Aglianò M, Cantarini L, Giannini F, Grasso G, Valacchi  G. Antiangiogenic Vegf Isoform In Inflammatory Myopathies. Mediators of Inflammation. 2013;2013:219313. doi: 10.1155/2013/219313. Epub 2013 Jun 12.
              97. Signorini C, De Felice C, Durand T, Oger C, Galano JM, Leoncini S, Pecorelli A, Valacchi G, Ciccoli L, Hayek J. Isoprostanes and 4-hydroxy-2-nonenal: markers or mediators of disease? Focus on Rett syndrome as a model of autism spectrum disorder. Oxidative Medicine and Cellular Longevity. 2013;2013:343824. doi: 10.1155/2013/343824. Epub 2013 Jun 13.
              98. De Felice C, Signorini C, Leoncini S, Pecorelli A, Durand T, Galano JM, Bultel-Poncé V, Guy A,  Oger C, Zollo G, Valacchi G, Ciccoli L, Hayek J. Fatty Acids and Autism Spectrum Disorders: The Rett syndrome conundrum. Food Nutrition Sciences. 2013, 4, 71-75. doi: 10.4236/fns.2013.49A1012.
              99. Scalia S, Trotta V, Traini D, Young PM, Sticozzi C, Cervellati F, Valacchi G. Incorporation of quercetin in respirable lipid microparticles: effect on stability and cellular uptake on A549 pulmonary alveolar epithelial cells. Colloids and Surfaces B: Biointerfaces. 2013 Dec 1;112:322-9. doi: 10.1016/j.colsurfb.2013.07.067. Epub 2013 Aug 8.
              100. Valacchi G, Zanardi I, Lim Y, Belmonte G, Miracco C, Sticozzi C, Bocci V, Travagli V. Ozonated oils as functional dermatological matrices: effect on the wound healing process using SKH1 mice. International Journal of Pharmaceutics. 2013 Dec 15;458(1):65-73. doi: 10.1016/j.ijpharm.2013.09.039. Epub 2013 Oct 19.
              101. Valacchi G, Caccamo D, Pelle E, De Luca C. Innovative Approaches in Environmental Medicine: Redox/Detoxification Biomarkers in Environmental Intolerances. Oxidative Medicine and Cellular Longevity. 2013;2013:691624. doi: 10.1155/2013/691624. Epub 2013 Dec 5.
              102. Pecorelli A, Leoni G, Cervellati F, Canali R, Signorini C, Leoncini S, Cortelazzo A, De Felice C, Ciccoli L, Hayek J, Valacchi G. Genes related to mitochondrial ATP production, protein degradation and chromatin folding are differentially expressed in lymphomonocytes of Rett syndrome patients. Mediators of Inflammation. 2013; 2013:137629. Epub 2013 Dec 12.
              103. De Felice C, Cortelazzo A, Signorini C, Guerranti R, Leoncini S, Pecorelli A, Durand T, Galano JM, Oger C, Zollo G, Montomoli B, Landi C, Bini L, Valacchi G, Ciccoli L, Hayek J. Effects of ω-3 polyunsaturated fatty acids on plasma proteome in Rett Syndrome. Mediators of Inflammation. 2013;2013:723269. doi: 10.1155/2013/723269. Epub 2013 Dec 9.
              104. Ciccoli L, De Felice C, Paccagnini E, Leoncini S, Pecorelli A, Signorini C, Belmonte G, Guerranti R, Cortelazzo A, Gentile M, Zollo G, Durand T, Valacchi G, Rossi M, Hayek J. Erythrocyte Shape Abnormalities, Membrane Oxidative Damage and beta-Actin alterations: An unrecognized Triad in Classical Autism.   Mediators of Inflammation. 2013;2013:432616. doi: 10.1155/2013/432616. Epub 2013 Dec 21.
              105. Cortelazzo A, Guerranti R, De Felice C, Signorini C, Leoncini S, Pecorelli A, Landi C, Bini L, Montomoli B, Sticozzi C, Ciccoli L, Valacchi G, Hayek J. A plasma proteomic approach in Rett Syndrome: classical versus preserved speech variant. Mediators of Inflammation. 2013;2013:438653. doi: 10.1155/2013/438653. Epub 2013 Dec 23.
              106. Cortelazzo A; Lampariello LR, Sticozzi C, Guerranti R, Mirasole C, Zolla L, Sacchetti G, Hayek J, Valacchi G. Proteomic profiling and post-translational modifications in human keratinocytes treated with Mucuna pruriens leaf extract. Journal of Ethnopharmacology. 2014 Feb 3;151(2):873-81. doi: 10.1016/j.jep.2013.11.053. Epub 2013 Dec 5.
              107. De Felice C, Rossi M, Leoncini S, Chisci G, Signorini C, Lonetti G, Vannuccini L, Spina D, Ginori A, Iacona I, Cortelazzo A, Pecorelli A, Valacchi G, Ciccoli L, Pizzorusso T, Hayek J. Inflammatory Lung Disease in Rett Syndrome. Mediators of Inflammation. 2014;2014:560120. doi: 10.1155/2014/560120. Epub 2014 Mar 17.
              108. Cortelazzo A, De Felice C, Guerranti R, Signorini C, Leoncini S, Pecorelli S, Zollo G, Landi C, Valacchi G, Ciccoli G, Bini L, Hayek J.  Subclinical inflammatory status in Rett Syndrome. Mediators of Inflammation. 2014;2014:480980. doi: 10.1155/2014/480980. Epub 2014 Jan 6.
              109. Esposito E, Ravani L, Mariani P, Huang N, Boldrini P, Drechsler M, Valacchi G, Cortesi R, Puglia C. Effect of nanostructured lipid vehicles on percutaneous absorption of curcumin. European Journal of Pharmaceutics & Biopharmaceutics. Eur J Pharm Biopharm. 2014 Feb;86(2):121-32. doi: 10.1016/j.ejpb.2013.12.011. Epub 2013 Dec 20.
              110. Valacchi G, Belmonte G, Miracco C, Eo H, Lim Y. Effect of mulberry leaves and fruit extracts on liver and skin cholesterol transporters in high fat diet induced obese mice. Nutrition Research and Practice. 2014 Feb;8(1):20-6. doi: 10.4162/nrp.2014.8.1.20. Epub 2014 Jan 29.
              111. Cervellati F, Cervellati C, Romani A, Cremonini E, Sticozzi C, Belmonte G, Pessina F, Valacchi G. Hypoxia induces cell damage via oxidative stress in retinal epithelial cells. Free Radical Research. 2014 Mar;48(3):303-12. doi: 10.3109/10715762.2013.867484. Epub 2014 Jan 7.
              112. Cervellati C, Romani A, Seripa D, Cremonini E, Bosi C, Magon S, Bergamini CM, Valacchi G, Pilotto A, Zuliani G. Systemic oxidative stress and conversion to dementia of elderly patients with mild cognitive impairment. Biomed Research International. 2014;2014:309507. doi: 10.1155/2014/309507. Epub 2014 Jan 12.
              113. De Felice C, Rossi M, Leoncini S, Chisci G, Signorini C, Lonetti G, Vannuccini L, Spina D, Ginori A, Iacona I, Cortelazzo A, Pecorelli A, Valacchi G, Ciccoli L, Pizzorusso T, Hayek J. Inflammatory lung disease in rett syndrome. Mediators of  Inflammation. 2014;2014:560120. doi: 10.1155/2014/560120. Epub 2014 Mar 17.
              114. Cortelazzo A, De Felice C, Pecorelli A, Belmonte G, Signorini C, Leoncini S, Zollo G, Capone A, Della Giovampaola C, Sticozzi C, Valacchi G, Ciccoli L, Guerranti R, Hayek J. Erythrocyte β-actin deficiency with oxidative posttranslational modifications: insights into an altered cytoskeletal organization in Rett syndrome. PLoS ONE. 2014 Mar 26;9(3):e93181. doi: 10.1371/journal.pone.0093181. eCollection 2014.
              115. Valacchi G and Ashwood P. ASD: Biochemical Mechanisms behind Behavioral Disorders. Mediators of Inflammation. 2014;2014:758473. doi: 10.1155/2014/758473. Epub 2014 Mar 27.
              116. Sticozzi C, Belmonte G, Cervellati F, Muresan X, Pessina F, Lim Y, Forman HJ, Valacchi G. Resveratrol protects SR-B1 levels in keratinocytes exposed to cigarette smoke. FRBM. 2014 Apr;69:50-7. doi: 10.1016/j.freeradbiomed.2014.01.007. Epub 2014 Jan 12.
              117. De Felice C,  Della Ragione F, Signorini C, Leoncini S, Pecorelli A, Ciccoli L, Sacalabrì F, Marracino F, Madonna M, Belmonte G, Ricceri L, De Filippis B, Laviola G, Valacchi G, Durand T, Galano JM, Oger C, Guy A, Bultel-Poncé V, Guy J, Filosa S, Hayek J, D'Esposito M. Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome. Neurobiology of Disease. 2014 Aug;68:66-77. doi: 10.1016/j.nbd.2014.04.006. Epub 2014 Apr 24.
              118. Cervellati F, Muresan X, Sticozzi C, Gambari R, Montagner G, Forman HJ, Torricelli C, Maioli E, Valacchi G. Comparative effects between electronic and cigarette smoke in human keratinocytes and epithelial lung cells. Toxicology in Vitro. 2014 Aug;28(5):999-1005. doi: 10.1016/j.tiv.2014.04.012. Epub 2014 May 5.
              119. Signorini C, Leoncini S, De Felice C, Pecorelli A, Meloni I, Ariani F, Mari F, Amabile S, Paccagnini E, Gentile M, Belmonte G, Zollo G, Valacchi G, Durand T, Galano JM, Ciccoli L, Renieri A and Hayek J. Redox imbalance and morphofunctional changes in skin fibroblasts from patients with typical Rett syndrome. Oxidative Medicine and Cellular Longevity. 2014;2014:195935.
              120. Segatto M, Trapani L, Di Tunno I, Sticozzi C, Valacchi G, Hayek J, Pallottini V. Cholesterol metabolism is altered in primary fibroblasts from Rett syndrome patients. PLoS ONE. 2014 Aug 12;9(8):e104834. doi: 10.1371/journal.pone.0104834. eCollection 2014.
              121. Tyrovolas S, Haro JM, Polychronopoulos E, Mariolis A, Piscopo S, Valacchi G, Makri K, Zeimbekis A, Tyrovola D, Bountziouka V, Gotsis E, Metallinos G, Katsoulis Y, Tur JA, Matalas A, Lionis C, Panagiotakos D. Factors associated with components of arterial pressure among older individuals (the multinational MEDIS study): the role of the Mediterranean diet and alcohol consuption. Journal of Clinical Hypertension. 2014 Sep;16(9):645-51. doi: 10.1111/jch.12370. Epub 2014 Jul 24.
              122. Sticozzi C, Cervellati F, Muresan XM, Cervellati C, Valacchi G. Resveratrol prevents cigarette smoke induced keratinocytes damage. Food and Functions. 2014 Sep;5(9):2348-56. doi: 10.1039/c4fo00407h.
              123. Calò L, Davis PA, Valacchi G. Angiotensin II roles in human vascular tone control. CIEMD. 2014,1(1); 20-26.
              124. Signorini C, De Felice C, Leoncini S, Durand T, Galano JM, Cortelazzo A, Zollo G, Guerranti R, Gonnelli S, Caffarelli C, Rossi M, Pecorelli A, Valacchi G, Ciccoli L, Hayek J. Altered erythrocyte membrane fatty acid profile in typical Rett syndrome: effects of omega-3 polyunsaturated fatty acid supplementation. Prostaglandins, Leukotrienes & Essential Fatty Acids. 2014 Nov;91(5):183-93. doi: 10.1016/j.plefa.2014.08.002. Epub 2014 Sep 6.
              125. Pessina F, Capasso R, Borrelli F, Aveta T, Buono L, Valacchi G, Fiorenzani P, Di Marzo V, Orlando P, Izzo AA.  Protective Effect of Palmitoylethanolamide, a Naturally-Occurring Molecule, in a Rat Model of Cystitis. The Journal of Urology. 2014 Nov 18. pii: S0022-5347(14)04930-1. doi: 10.1016/j.juro.2014.11.083.
              126. Tyrovolas S, Haro JM, Mariolis A, Piscopo S, Valacchi G, Tsakountakis N, Zeimbekis A, Tyrovola D, Bountziouka V, Gotsis E, Metallinos G, Tur JA, Matalas A, Lionis C, Polychronopoulos E, Panagiotakos D. Successful ageing, dietary habits and health status of elderly individuals: a k-dimensional approach within the multi-national MEDIS study. Experimental Gerontology. 2014 Dec;60:57-63. doi: 10.1016/j.exger.2014.09.010. Epub 2014 Sep 18.
              127. Aiello F, Valacchi G. Synthesis and Evaluation of Indole Based Molecules for Treatment of Oxidative Stress Related Diseases. Current Topics in Medicinal Chemistry. 2014;14(22):2576-89.
              128. Kousha T and Valacchi G. The air quality health index and emergency department visits for urticaria in Windsor, Canada. Journal of Toxicology and Environmental Health. 2015;78(8):524-533.
              129. Valacchi G, Porada E, Rowe B. Ambient ozone and bacterium Streptococcus: A link between cellulitis and pharyngitis. International Journal of Occupational Medicine and Environmental Health. 2015;28(4):771-4. doi: 10.13075/ijomeh.1896.00267.
              130. Bocci V, Valacchi G. Nrf2 activation as target to implement therapeutic treatments. Frontiers in Chemistry. Cellular Biochemistry. 2015 Feb 2;3:4. doi: 10.3389/fchem.2015.00004. eCollection 2015.
              131. Muresan XM, Cervellati F, Sticozzi C, Belmonte G, Chui CH, Lampronti I, Borgatti M, Gambari R, Valacchi G. The loss of cellular junctions in epithelial lung cells induced by cigarette smoke is attenuated by corilagin. Oxidative Medicine and Cellular Longevity. 2015;2015:631758. doi: 10.1155/2015/631758. Epub 2015 Feb 24.
              132. Pecorelli A, Natrella F, Belmonte G, Miracco C, Cervellati F, Ciccoli L, Mariottini A, Rocchi R, Vatti G, Bua A, Canitano R, Hayek J, Forman HJ, Valacchi G. NADPH oxidase activation and 4-hydroxy-2-nonenal/aquaporin-4 adducts as possible new players in oxidative neuronal damage presents in drug-resistant epilepsy. Biochim Biophys Acta; Molecular Basis of Diseases. 2015 Mar;1852(3):507-19. doi: 10.1016/j.bbadis.2014.11.016. Epub 2014 Nov 22.
              133. Rom O, Pecorelli A, Valacchi G, Reznick AZ. Are E-cigarettes a safe and good alternative to cigarette smoking?Annals of the New York Academy of Sciences. 2015 Mar;1340:65-74. doi: 10.1111/nyas.12609. Epub 2014 Dec 31.
              134. Valacchi G, Maioli E, Sticozzi C, Cervellati F, Pecorelli A, Cervellati C, Hayek J. Exploring the link between SR-B1 expression and COPD pathogenesis. Annals of the New York Academy of Sciences. 2015 Mar;1340:47-54. doi: 10.1111/nyas.12714. Epub 2015 Mar 12.
              135. Torricelli C, Daveri E, Salvadori S, Valacchi G, Ietta F, Muscettola MM, Maioli E. Phosphorylation-independent mTORC1 inhibition by the autophagy inducer Rottlerin. Cancer Letters. 2015 Apr 28;360(1):17-27.
              136. Bocci V, Zanardi I, Valacchi G, Borrelli E, Travagli V. Validity of Oxygen-Ozone therapy as integrated madication form in chronic inflammation diseases. Cardiovascular & Hematological Disorders-Drug Targets. 2015;15(2):127-38. [head of print].
              137. Lubrano C, Valacchi G, Specchia P, Gnessi L, Rubanenko EP, Shuginina E, Trukhanov AI, Korkina LG and De Luca C. Integrated hematological profiles of redox status, lipid, and inflammatory protein biomarkers in obesity and metabolic syndrome: relevance for the personalized management of the chronically inflamed obese subject. Oxidative Medicine and Cellular Longevity. 2015;2015:490613. doi: 10.1155/2015/490613. Epub 2015 May 18.
              138. Daveri E, Valacchi G, Romagnoli R, Maellaro E, Maioli E. Antiproliferative Effect of Rottlerin on Sk-Mel-28 Melanoma Cells. Evidence-Based Complementary and Alternative Medicine. 2015;2015:545838. doi: 10.1155/2015/545838. Epub 2015 May 28.
              139. Esposito E,  Sticozzi C,  Ravani L, Drechsler M, Muresan XM, Cervellati F, Cortesi R, Valacchi G. Effect of new Curcumin-containing nanostructured lipid dispersions on human keratinocytes proliferative responses. Experimental Dermatology. 2015 Jun;24(6):449-54. doi: 10.1111/exd.12696.
              140. Valacchi G, Sticozzi C, Belmonte G, Cervellati F, Demaude J, Chen N, Krol Y, Oresajo C. Vitamin C compounds mixture prevent ozone-induced oxidative damage in human keratinocytes as initial assessment of pollution protection. PLoS ONE. 2015 Aug 13;10(8):e0131097. doi: 10.1371/journal.pone.0131097.
              141. Pecorelli A, Belmonte G, Meloni I, Cervellati F, Gardi C, Sticozzi C, De Felice C, Signorini C, Cortelazzo A, Leoncini S, Ciccoli L, Renieri A, Forman HJ, Hayek J, Valacchi G. Alteration of serum lipid profile, SRB1 loss and impaired Nrf2 activation in CDKL5 disorder. Free Radicals in Biology and Medicine. 2015 Sep;86:156-65. doi: 10.1016/j.freeradbiomed.2015.05.010. Epub 2015 May 22.
              142. Cheleschi S, Pascarelli NA, Valacchi G, Di Capua A, Biava M, Belmonte G, Giordani A, Sticozzi C, Anzini M, Fioravanti A. Chondroprotective effect of three different classes of anti-inflammatory agents on human osteoarthritic chondrocytes exposed to IL-1β. International Immunopharmacology. 2015 Sep;28(1):794-801. doi: 10.1016/j.intimp.2015.07.003.
              143. Cervellati C, Sticozzi C, Romani A, Belmonte G, De Rasmo D, Signorile A, Cervellati F, Milanese C, Mastroberardino PG, Pecorelli A, Savelli I, Forman HJ, Hayek J, Valacchi G. Impaired enzymatic defensive activity, mitochondrial and proteasome dysfunction are involved in RTT cells oxidative damage. BBA Molecular Basis of Diseases. 2015 Oct;1852(10 Pt A):2066-74. doi: 10.1016/j.bbadis.2015.07.014.
              144. Valacchi G, Grisci G, Sticozzi C, Lim Y, Paolino M, Giuliani G, Mendichi R, Belmonte G, Artusi G, Zanardi A, Garofalo P, Giorgi G, Cappelli A, Rovati L. Wound Healing Properties of Hyaluronan Derivatives Bearing Ferulate Residues. Journal of Materials Chemistry B. 2015;3:7037-7045.
              145. Cortelazzo A, De Felice C, Guerranti R, Signorini C, Leoncini S, Zollo G, Mirasole C, Zolla L, Pecorelli A, Valacchi G, Ciccoli L, Hayek J. Abnormal N-glycosylation pattern for brain nucleotide pyrophosphatase-5 (NPP-5) in Mecp2-mutant murine models of Rett syndrome. Neuroscience Research. 2015 Oct 20. pii: S0168-0102(15)00234-5. doi: 10.1016/j.neures.2015.10.002.
              146. Filosa S, Pecorelli A, D’Esposito M, Valacchi G, Hayek J. Exploring the possible link between MeCP2 and oxidative stress in Rett syndrome. Free Radicals in Biology and Medicine. Submitted. Corresponding author. 2015 Nov;88(Pt A):81-90. doi: 10.1016/j.freeradbiomed.2015.04.019.
              147. Valacchi G, van der Vliet A. Redox Biology and Chemistry in Orphan Diseases. Free Radicals in Biology and Medicine. 2015 Nov;88 (PtA):1-2.
              148. Wood PL, Locke VA, Herling P, Passaro A, Vigna GB, Volpato S, Valacchi G, Cervellati C, Zuliani G. Targeted Lipidomics of Diacylglycerols and Ethanolamine Plasmalogens Distinguishes Patient Subgroups in Mild Cognitive Impairment (MCI) and Late Onset Alzheimer’s Disease (LOAD). BBA Clinical. 2015 Nov 14;5:25-8. doi: 10.1016/j.bbacli.2015.11.004. eCollection 2016.
              149. Tyrovolas S, Haro JM, Mariolis A, Piscopo S, Valacchi G, Makri K, Zeimbekis A, Tyrovola D, Bountziouka V, Gotsis E, Metallinos G, Tur JA, Matalas A, Lionis C, Polychronopoulos E, Panagiotakos D. The role of energy balance in successful ageing among elderly individuals: the multinational MEDIS study.  Journal of Aging and Health. 2015 Dec;27(8):1375-91. doi: 10.1177/0898264315583053. Epub 2015 Apr 22.
              150. Sticozzi C, Aiello F, Bassi Andreasi R, Muresan XM , Belmonte G, Cervellati F, Maellaro E, Maioli E, Valacchi G. Antitubulinic effect of new fluorazone derivatives on melanoma cells. Anti-Cancer Agents in Medicinal Chemistry. 2016, 16, 601-608.
              151. Zanardi I, Borrelli E, Valacchi G, Travagli V, Bocci V. Ozone: a multifaceted molecule with unexpected therapeutic activity. Curr Med Chem. 2016;23(4):304-14.
              152. Pecorelli A, Cervellati F, Belmonte G, Montagner G, Waldon P, Hayek J, Gambari R, Valacchi G. Cytokines profile and peripheral blood mononuclear cells morphology in Rett and autistic patients. Cytokine. 2016 Jan;77:180-8. doi: 10.1016/j.cyto.2015.10.002. Epub 2015 Oct 21.
              153. Magnani ND, Muresan XM, Belmonte G, Cervellati F, Sticozzi C, Pecorelli A, Miracco C, Marchini T, Evelson P, Valacchi G. Skin damage mechanisms related to airborne particulate matter exposure. Toxicological Sciences. 2016 Jan;149(1):227-36. doi: 10.1093/toxsci/kfv230. Epub 2015 Oct 26.
              154. Cervellati C, Wood PL, Romani A, Valacchi G, Squerzanti M, Sanz Molina JM, Ortolani B, Zuliani G. Oxidative challenge in Alzheimer's disease: state of knowledge and future needs. Journal of Investigative Medicine. 2016 Jan;64(1):21-32. doi: 10.1136/jim-2015-000017.
              155. Di Capua A, Sticozzi C, Brogi S, Brindisi M, Cappelli A, Sautebin L, Rossi A, Pace S, Ghelardini C, Di Cesare Mannelli L, Valacchi G, Giorgi G, Giordani A, Poce G, Biava M and Anzini M. Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity. European Journal of Medicinal Chemistry. 2016 Feb 15;109:99-106. doi: 10.1016/j.ejmech.2015.12.044.
              156. Tyrovolas S, Polychronopoulos E, Mariolis A, Piscopo S, Valacchi G, Makri K, Zeimbekis A, Tyrovola D, Bountziouka V, Gotsis E, Metallinos G, Tur GA, Matalas A, Lionis C, Haro JM, Panagiotakos D. Is parental longevity associated with the cardiovascular risk and the successful ageing of their offspring’s? Results from the multinational MEDIS study. Angiology. 2016 Apr 10. pii: 0003319716642140.
              157. Mariolis A, Foscolou A, Tyrovolas S, Piscopo S, Valacchi G, Tsakountakis N, Zeimbekis A, Bountziouka V, Gotsis E, Metallinos G, Tyrovola D, Tur JA, Matalas AL, Lionis C, Polychronopoulos E, Panagiotakos D; MEDIS study group. Successful Aging among Elders Living in the Mani Continental Region vs. Insular Areas of the Mediterranean: the MEDIS Study. Aging and Disease. 2016 May 27;7(3):285-94. doi: 10.14336/AD.2015.1002. eCollection 2016 May.
              158. Valacchi G, Muresan XM, Sticozzi C, Belmonte G, Pecorelli A, Cervellati F, Demaude J, Krol Y, Oresajo C. Ozone-Induced Oxidative Damage in 3D-Skin Model is prevented by topical vitamin C and vitamin E compound mixtures application. Journal of Dermatological Sciences. 2016 Jun;82(3):209-12. doi: 10.1016/j.jdermsci.2016.02.007.
              159. Aiello F, Badolato M, Pessina F, Sticozzi C, Maestrini V, Aldinucci C, Luongo L, Guida F, Ligresti A, Artese A, Allarà M, Costa G, Frosini M, Schiano MA, De Petrocellis L, Valacchi G, Alcaro S, Maione S, Di Marzo V, Corelli F, Brizzi A. Design and synthesis of new Transient Receptor Potential Vanilloid Type-1 (TRPV1) channel modulators: identification, molecular modelling analysis and pharmacological characterization of the N-(4-hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide, a small molecule endowed with agonist TRPV1 activity and protective effects against oxidative stress. ACS Chemical Neuroscience. 2016 Jun 15;7(6):737-48. doi: 10.1021/acschemneuro.5b00333.
              160. Szyszkowicz M, Kousha T, Valacchi G. Ambient air pollution and emergency department visits for skin conditions. Journal of Global Dermatology. 2016 Jun. Vol 3 (3): 323-329. doi: 10.15761/GOD.1000184.
              161. Cervellati C, Bonaccorsi G, Bergamini CM, Fila E, Greco P, Valacchi G, Massari L, Gonelli A, Tisato V. Association between circulatory levels of adipokines and bone mineral density in postmenopausal women. Menopause. 2016 Sep;23(9):984-92. doi: 10.1097/GME.0000000000000655.
              162. Daveri E, Maellaro E, Valacchi G, Ietta F, Muscettola F, Maioli M. Inhibition of mTORC1 and 4EBP-1 are key events orchestrated by Rottlerin in SK-Mel-28 cell killing. Cancer Letters. 2016 Sep 28;380(1):106-13. doi: 10.1016/j.canlet.2016.06.018.
              163. Valacchi G, Sticozzi C, Zanardi I, Belmonte G, Cervellati F, Bocci V, Travagli V. Ozone mediators effect on “in vitro” scratch wound closure. Free Radical Research. 2016 Sep;50(9):1022-3. doi: 10.1080/10715762.2016.1219731.
              164. Tyrovolas S, Haro JM, Mariolis A, Piscopo S, Valacchi G, Bountziouka V, Anastasiou F, Zeimbekis A, Tyrovola D, Foscolou A, Gotsis E, Metallinos G, Tur JA, Matalas A, Lionis C, Polychronopoulos E, Panagiotakos D. Skeletal muscle mass and body fat in relation to successful ageing of older adults: the multi-national MEDIS study. Archives of Gerontology and Geriatrics. 2016 Sep-Oct;66:95-101. doi: 10.1016/j.archger.2016.04.017.
              165. Crivellari I, Sticozzi C, Belomonte G, Muresan XM, Cervellati F, Pecorelli A, Cavicchio C, Maioli E, Zouboulis CC, Benedusi M, Cervellati C, Valacchi G. SRB1 as a new redox target of cigarette smoke in human sebocytes. Free Radicals in Biology and Medicine. 2016 Nov 16;102:47-56.
              166. Canella R, Martini M, Borriello R, Cavicchio C, Muresan XM, Benedusi M, Cervellati F, Valacchi G. Modulation of Chloride Currents in Human Lung Epithelial Cells Exposed to Exogenous Oxidative Stress. J Cell Physiol. 2016 Nov 25. doi: 10.1002/jcp.25705.
              167. Pecorelli A, Cervellati C, Hayek J, Valacchi G. OxInflammation in Rett Syndrome. Int J Biochem Cell Biol. 2016 Dec;81(PtB):246-253. doi: 10.1016/j.biocel.2016.07.015.
              168. Pecorelli A, Cervellati C, Cortelazzo A, Cervellati F, Sticozzi C, Mirasole C, Guerranti R, Trentini A, Zolla L, Savelli V, Hayek J, Valacchi G. Proteomic analysis of 4-hydroxynonenal and Nitrotyrosine modified proteins in RTT fibroblasts. Int J Biochem Cell Biol. 2016 Dec 8(PtB):236-245. doi: 10.1016/j.biocel.2016.08.001.
              169. Valacchi G, Cervellati C, Evelson P, Rhaman I. Redox Regulation of inflammatory processes. Int J Biochem Cell Biol. 2016 Dec 8(PtB):234-235. doi: 10.1016/j.biocel.2016.11.002.
              170. Cheleschi S, De Palma A, Pecorelli A, Pascarelli NA, Valacchi G, Belmonte G, Carta S, Galeazzi M, Fioravanti A. Hydrostatic pressure regulates microRNA expression levels in osteoarthritic chondrocyte cultures via Wnt/β-catenin pathway. International Journal of Molecular Sciences. Int J Mol Sci. 2017 Jan 12;18(1). pii: E133. doi: 10.3390/ijms18010133.
              171. Valacchi G, Pecorelli A, Cervellati C, Hayek J. 4HNE protein adducts: key mediators in Rett Syndrome OxInflammation. Free Radicals in Biology and Medicine. 2017 Jan 5. pii: S0891-5849(16)31148-0. doi: 10.1016/j.freeradbiomed.2016.12.045.
              172. Tyrovolas S, Polychronopoulos E, Morena M, Mariolis A, Piscopo S, Valacchi G, Bountziouka V, Anastasiou F, Zeimbekis A, Tyrovola D, Foscolou A, Gotsis E, Metallinos G, Soulis G, Tur JA, MatalasA, Lionis C, Sidossis LS, Panagiotakos D. Is car use related with successful ageing of older adults? Results from the multi-national MEDIS study. Annals of Epidemiology. 2017 Mar;27(3):225-229.
              173. Cortesi R, Valacchi G, Muresan XM, Drechsler M, Contado C, Esposito E, Grandini A, Guerrini A, Forlani G, Sacchetti G. Nanostructured lipid carriers (NLC) for the delivery of natural molecules with antimicrobial activity: production, characterisation and in vitro studies. Journal of Microencapsulation. 2017 Feb 2:1-10. doi: 10.1080/02652048.2017.1284276.
              174. Foscolou A, Tyrovolas S, Soulis G, Mariolis A, Piscopo S, Valacchi G, Anastasiou F, Lionis C, Zeimbekis A, Tur JA, Bountziouka V, Tyrovola D, Gotsis E, Metallinos G, Matalas AL, Polychronopoulos E, Sidossis LS, Panagiotakos D. The Impact of the Financial Crisis on Lifestyle Health Determinants Among Older Adults Living in the Mediterranean Region: The Multinational MEDIS Study (2005-2015) (2005-2015). J Prev Med Public Health. 2017 Jan;50(1):1-9. doi: 10.3961/jpmph.16.101.
              175. Valacchi G, Pecorelli A, Belmonte G, Pambianchi E, Cervellati F, Lynch S, Krol Y, Oresajo C. Protective effects of topical vitamin C compound mixtures agains ozone-induced damage in human skin. Journal of Investigative Dermatology. 017 Feb 17. pii: S0022-202X(17)30184-7. doi: 10.1016/j.jid.2017.01.034.
              176. Georgousopoulou EN, Mellor DD, Naumovski N, Polychronopoulos E, Tyrovolas1 S, Piscopo S, Valacchi G, Anastasiou F, Zeimbekis A, Bountziouka V, Gotsis E, Metallinos G, Tyrovola D, Foscolou A, Tur JA, Matalas AL, Lionis C, Sidossis L, Panagiotakos D and the MEDIS study group. Mediterranean lifestyle and cardiovascular disease prevention. Cardiovascular Diagnosis and Therapy. 2017 Apr;7(Suppl 1):S39-S47. doi: 10.21037/cdt.2017.03.11.
              177. Cortesi R, Cappellozza E, Drechsler M, Contado C, Baldisserotto A, Mariani P, Carducci F, Pecorelli A, Esposito E, Valacchi G. Monoolein aqueous dispersion as a delivery system for quercetin. Biomed Microdevices.  2017 Jun;19(2):41. doi: 10.1007/s10544-017-0185-0.
              178. Brogi S, Ramunno A, Savi L, Chemi G, Alfano G, Pecorelli A, Pambianchi E, Galatello P, Compagnoni G, Focher F, Biamonti G, Valacchi G, Butini S, Gemma S, Campiani G, Brindisi M. First Dual AK/GSK-3β Allosteric Inhibitors Endowed with Antioxidant Properties as Multifunctional, Potential Neuroprotective Agents. European Journal of Medicinal Chemistry.  2017 Sep 29;138:438-457. doi: 10.1016/j.ejmech.2017.06.017.
              179. Tyrovolas S, Haro JH, Foscolou A, Tyrovola D, Mariolis A, Bountziouka V, Piscopo S, Valacchi G, Anastasiou F, Gotsis F, Metallinos G, Papairakleous N, Polychronopoulos E, Matalas AL, Lionis C, Zeimbekis A, Tur JA, Sidossis LS, Panagiotakos D; for the MEDIS Study Group. Anti - inflammatory nutrition and successful ageing in elderly individuals: the multi-national MEDIS study. Gerontology. 2017 Sep 9. doi: 10.1159/000479065.
              180. Cavicchio C, Benedusi M, Pambianchi E, Pecorelli A, Cervellati F, Savelli V, Calamandrei D, Maellaro E, Rispoli G, Maioli E, Valacchi G. Potassium ascorbate with ribose – promising therapeutic approach for malignant melanoma. Oxidative Medicine and Cellular Longevity. Volume 2017 (2017), Article ID 4256519, 12 pages.
              181. Rosseto HC, de Alcântara Sica de Toledo L, Esposito E, Lim Y, Valacchi G, Cortesi R, Bruschi ML. Nanostructured lipid systems containing waste material of propolis for wound healing: formulation and biological evaluation. Colloids Surf B Biointerfaces. 2017 Jul 10; 158:441-452.
              182. Muresan X, Sticozzi C, Belmonte G, Savelli V, Evelson P, Valacchi G. Modulation of cutaneous Scavenger Receptor B1 levels by exogenous stressors impairs “in vitro” wound closure. Mechanism of Ageing and Development. In Press.
              183. Romani A, Cervellati C, Muresan X, Belmonte G, Pecorelli A, Cervellati F, Benedusi M, Evelson P, Valacchi G. Keratinocytes oxidative damage mechanisms related to airbone particle matter exposure. Mechanism of Ageing and Development. In Press.
              184. Benedusi M, Frigato E, Beltramello M, Bertolucci C, Valacchi G. Circadian clock as a possible protective mechanism to pollution induced keratinocytes damage. Mechanism of Ageing and Development. 2017 Aug 30. pii: S0047-6374(17)30101-X.
              185. Sbardella D, Tundo GR,  Campagnolo L, Valacchi G, Orlandi A, Curatolo P, Borsellino G, D’Esposito M, Ciaccio, C, Di Cesare, S, Di Pierro D, Galasso C, Santarone ME, Hayek J, Coletta M, Marini S. Retention of Mitochondria in Mature Human Red Blood Cells as the Result of Autophagy Impairment in Rett Syndrome. Scientific Reports. 2017 Sep 26;7(1):12297.
              186. Chedea VS, Vicaș SI, Sticozzi C, Pessina F, Frosini M, Maioli E, Valacchi G. Resveratrol from diet to topical usage. Food & Function. 2017 Oct 16. doi: 10.1039/c7fo01086a

               

              BOOKS:

              “Oxidants in Biology: a question of balance”
Editor: Valacchi, G.; Co-Editor Davis, PA. Edited by: SPRINGER. Netherlands, Amsterdam. 2008.

               

              BOOK CHAPTERS:

              Valacchi G. Cutaneous Responses to Trophospheric Ozone Exposure. Textbook of Aging Skin. ed: Farage AM., Miller WK., Maibach IH. 17 Feb, 2016

              Bocci V., Di Paolo N., Aldinucci C., Borrelli E., Garosi G., Cappelli F. and Valacchi G. Exposure of blood ex vivo to O2-O3 during extracorporeal circulation in the sheep and in patients. L’Ozonoterapia nel 2000 ed: Francesco Ceccherelli e Giampiero Giron. 2000, 145-146.

              Borrelli E., Valacchi G., Bocci V. L’esposizione corporea quasi totale ed ossigeno- ozono con ipertermia come sistema modificatore della risposta biologica. L’Ozonoterapia nel 2000 ed: Francesco Ceccherelli e Giampiero Giron. 2000, 47-54.

              Valacchi G. Effect of Ozone on Cutaneous Tissues. Textbook of Aging Skin. ed: Farage AM., Miller WK., Maibach IH. SPRINGER. 2010.

              Valacchi G. Epidermis as a shield from radiation and oxidative stress. Innate immune system of skin and oral mucosa: properties and impact in pharmaceutics, cosmetics and personal care products. Eds. Wertz PW & Dayan N. John Wiley & Sons, Inc. 2010

              Valacchi G, Pecorelli A, Signorini C, Leoncini S, Ciccoli L, De Felice C, Hayek J. 4HNE protein adducts in Autistic Spectrum Disorders: Rett syndrome and Autism. The Comprehensive Guide to Autism. Eds. Vinood B Patel, Victor R Preedy, Colin R Martin. SPRINGER. Pp. 2667-2687. ISBN: 978-1-4614-4787-0 (Print) 978-1-4614-4788-7 (Online). 2014

              De Felice C, Leoncini S, Signorini C, Pecorelli A, Durand T, Galano JM, Guy A, Valacchi G, Ciccoli L, Hayek J. Neuroprostanes and neurological severity in Rett syndrome. The Comprehensive Guide to Autism. Eds. Vinood B Patel, Victor R Preedy, Colin R Martin. SPRINGER. Pp. 2633-2645. ISBN: 978-1-4614-4787-0 (Print) 978-1-4614-4788-7 (Online). 2014

              De Felice C, Leoncini S, Signorini C, Pecorelli A, Durand T, Galano JM, Guy A, Valacchi G, Ciccoli L, Hayek J. Biomarkers of lipid oxidative damage in Rett syndrome. The Comprehensive Guide to Autism. Eds. Vinood B Patel, Victor R Preedy, Colin R Martin. SPRINGER. Pg. 2617-2632. ISBN: 978-1-4614-4787-0 (Print) 978-1-4614-4788-7 (Online).

              Aiello F., Grande F., Sticozzi C., Valacchi G. (2015) Outdoor Air Pollutants. In: Roberts S., Kehrer J., Klotz LO. (eds) Studies on Experimental Toxicology and Pharmacology. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, Cham

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