PhD in Biomedical Sciences and Biotechnology

 

Home –  PhD students –  Faculty –  Seminars

 

                      1. Bernath, V.A., Muro, A.F., Vitullo, A.D., Bley, M.A., Baranao, J.L. and Kornblihtt, A.R. (1990) Cyclic AMP inhibits fibronectin gene expression in a newly developed granulosa cell line by a mechanism that suppresses cAMP-responsive element-dependent transcriptional activation. J Biol Chem, 265, 18219-18226.
                      2. Altschuler, D.L., Muro, A., Schijman, A., Almonacid, F.B. and Torres, H.N. (1990) Neurospora crassa cDNA clones coding for a new member of the ras protein family. FEBS Lett, 273, 103-106.
                      3. Muro, A., Puricelli, L., Kornblihtt, A.R. and Bal de Kier Joffe, E. (1991) Inverse correlation between fibronectin mRNA levels and the metastatic potential of two murine mammary adenocarcinomas. Invasion Metastasis, 11, 281-287.
                      4. Muro, A.F., Bernath, V.A. and Kornblihtt, A.R. (1992) Interaction of the -170 cyclic AMP response element with the adjacent CCAAT box in the human fibronectin gene promoter. J Biol Chem, 267, 12767-12774.
                      5. Srebrow, A., Muro, A.F., Werbajh, S., Sharp, P.A. and Kornblihtt, A.R. (1993) The CRE-binding factor ATF-2 facilitates the occupation of the CCAAT box in the fibronectin gene promoter. FEBS Lett, 327, 25-28.
                      6. Muro, A.F., Pesce, C.G. and Kornblihtt, A.R. (1993) DNA sequencing by the chemical method: a 10 minute procedure for the G+A reaction. Trends Genet, 9, 337-338.
                      7. Pesce, C.G., Rossi, M.S., Muro, A.F., Reig, O.A., Zorzopulos, J. and Kornblihtt, A.R. (1994) Binding of nuclear factors to a satellite DNA of retroviral origin with marked differences in copy number among species of the rodent Ctenomys. Nucleic Acids Res, 22, 656-661.
                      8. Tripodi, G., Casari, G., Tisminetzky, S., Bianchi, G., Devescovi, G., Muro, A., Tuteja, R. and Baralle, F.E. (1995) Characterisation and chromosomal localisation of the rat alpha- and beta-adducin-encoding genes. Gene, 166, 307-311.
                      9. Tisminetzky, S., Devescovi, G., Tripodi, G., Muro, A., Bianchi, G., Colombi, M., Moro, L., Barlati, S., Tuteja, R. and Baralle, F.E. (1995) Genomic organisation and chromosomal localisation of the gene encoding human beta adducin. Gene, 167, 313-316.
                      10. Kornblihtt, A.R., Pesce, C.G., Alonso, C.R., Cramer, P., Srebrow, A., Werbajh, S. and Muro, A.F. (1996) The fibronectin gene as a model for splicing and transcription studies. FASEB J, 10, 248-257.
                      11. Gajovic, S., Muro, A.F. and Baralle, F.E. (1997) Appearance of vaginal duplication in outbred CD1 mice. Veterinarski Arhiv, 67, 145-150.
                      12. Urtreger, A., Porro, F., Puricelli, L., Werbajh, S., Baralle, F.E., Bal de Kier Joffe, E., Kornblihtt, A.R. and Muro, A.F. (1998) Expression of RGD minus fibronectin that does not form extracellular matrix fibrils is sufficient to decrease tumor metastasis. Int J Cancer, 78, 233-241.
                      13. Muro, A.F., Iaconcig, A. and Baralle, F.E. (1998) Regulation of the fibronectin EDA exon alternative splicing. Cooperative role of the exonic enhancer element and the 5' splicing site. FEBS Lett, 437, 137-141.
                      14. Urtreger, A.J., Aguirre Ghiso, J.A., Werbajh, S.E., Puricelli, L.I., Muro, A.F. and Bal de Kier Joff, E. (1999) Involvement of fibronectin in the regulation of urokinase production and binding in murine mammary tumor cells. Int J Cancer, 82, 748-753.
                      15. Muro, A.F., Caputi, M., Pariyarath, R., Pagani, F., Buratti, E. and Baralle, F.E. (1999) Regulation of fibronectin EDA exon alternative splicing: possible role of RNA secondary structure for enhancer display. Mol Cell Biol, 19, 2657-2671.
                      16. Cramer, P., Caceres, J.F., Cazalla, D., Kadener, S., Muro, A.F., Baralle, F.E. and Kornblihtt, A.R. (1999) Coupling of transcription with alternative splicing: RNA pol II promoters modulate SF2/ASF and 9G8 effects on an exonic splicing enhancer. Mol Cell, 4, 251-258.
                      17. Baralle, M., Vergnes, L., Muro, A.F., Zakin, M.M., Baralle, F.E. and Ochoa, A. (1999) Regulation of the human apolipoprotein AIV gene expression in transgenic mice. FEBS Lett, 445, 45-52.
                      18. Sorol, M.R., Pastori, R.L., Muro, A., Moreno, S. and Rossi, S. (2000) Structural and functional analysis of the cAMP binding domain from the regulatory subunit of Mucor rouxii protein kinase A. Arch Biochem Biophys, 382, 173-181.
                      19. Muro, A.F., Marro, M.L., Gajovic, S., Porro, F., Luzzatto, L. and Baralle, F.E. (2000) Mild spherocytic hereditary elliptocytosis and altered levels of alpha- and gamma-adducins in beta-adducin-deficient mice. Blood, 95, 3978-3985.
                      20. Marro, M.L., Scremin, O.U., Jordan, M.C., Huynh, L., Porro, F., Roos, K.P., Gajovic, S., Baralle, F.E. and Muro, A.F. (2000) Hypertension in beta-adducin-deficient mice. Hypertension, 36, 449-453.
                      21. Yang, H., Francis, S.C., Sellers, K., DeBarros, M., Sun, C., Sumners, C., Ferrario, C.M., Katovich, M.J., Muro, A.F. and Raizada, M.K. (2002) Hypertension-linked decrease in the expression of brain gamma-adducin. Circ Res, 91, 633-639.
                      22. Muro, A.F., Chauhan, A.K., Gajovic, S., Iaconcig, A., Porro, F., Stanta, G. and Baralle, F.E. (2003) Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan. J Cell Biol, 162, 149-160.
                      23. Porro, F., Costessi, L., Marro, M.L., Baralle, F.E. and Muro, A.F. (2004) The erythrocyte skeletons of beta-adducin deficient mice have altered levels of tropomyosin, tropomodulin and EcapZ. FEBS Lett, 576, 36-40.
                      24. Echeverria, V., Ducatenzeiler, A., Alhonen, L., Janne, J., Grant, S.M., Wandosell, F., Muro, A., Baralle, F., Li, H., Duff, K. et al. (2004) Rat transgenic models with a phenotype of intracellular Abeta accumulation in hippocampus and cortex. J Alzheimers Dis, 6, 209-219.
                      25. Chauhan, A.K., Iaconcig, A., Baralle, F.E. and Muro, A.F. (2004) Alternative splicing of fibronectin: a mouse model demonstrates the identity of in vitro and in vivo systems and the processing autonomy of regulated exons in adult mice. Gene, 324, 55-63.
                      26. Buratti, E., Muro, A.F., Giombi, M., Gherbassi, D., Iaconcig, A. and Baralle, F.E. (2004) RNA folding affects the recruitment of SR proteins by mouse and human polypurinic enhancer elements in the fibronectin EDA exon. Mol Cell Biol, 24, 1387-1400.
                      27. Arrisi-Mercado, P., Romano, M., Muro, A.F. and Baralle, F.E. (2004) An exonic splicing enhancer offsets the atypical GU-rich 3' splice site of human apolipoprotein A-II exon 3. J Biol Chem, 279, 39331-39339.
                      28. Fededa, J.P., Petrillo, E., Gelfand, M.S., Neverov, A.D., Kadener, S., Nogues, G., Pelisch, F., Baralle, F.E., Muro, A.F. and Kornblihtt, A.R. (2005) A polar mechanism coordinates different regions of alternative splicing within a single gene. Mol Cell, 19, 393-404.
                      29. Chauhan, A.K., Moretti, F.A., Iaconcig, A., Baralle, F.E. and Muro, A.F. (2005) Impaired motor coordination in mice lacking the EDA exon of the fibronectin gene. Behav Brain Res, 161, 31-38.
                      30. Gajovic, S., Mitrecic, D., Augustincic, L., Iaconcig, A. and Muro, A.F. (2006) Unexpected rescue of alpha-synuclein and multimerin1 deletion in C57BL/6JOlaHsd mice by beta-adducin knockout. Transgenic Res, 15, 255-259.
                      31. Costessi, L., Devescovi, G., Baralle, F.E. and Muro, A.F. (2006) Brain-specific promoter and polyadenylation sites of the beta-adducin pre-mRNA generate an unusually long 3'-UTR. Nucleic Acids Res, 34, 243-253.
                      32. Moretti, F.A., Chauhan, A.K., Iaconcig, A., Porro, F., Baralle, F.E. and Muro, A.F. (2007) A major fraction of fibronectin present in the extracellular matrix of tissues is plasma-derived. J Biol Chem, 282, 28057-28062.
                      33. White, E.S., Baralle, F.E. and Muro, A.F. (2008) New insights into form and function of fibronectin splice variants. J Pathol, 216, 1-14.
                      34. Muro, A.F., Moretti, F.A., Moore, B.B., Yan, M., Atrasz, R.G., Wilke, C.A., Flaherty, K.R., Martinez, F.J., Tsui, J.L., Sheppard, D. et al. (2008) An essential role for fibronectin extra type III domain A in pulmonary fibrosis. Am J Respir Crit Care Med, 177, 638-645.
                      35. Chauhan, A.K., Kisucka, J., Cozzi, M.R., Walsh, M.T., Moretti, F.A., Battiston, M., Mazzucato, M., De Marco, L., Baralle, F.E., Wagner, D.D. et al. (2008) Prothrombotic effects of fibronectin isoforms containing the EDA domain. Arterioscler Thromb Vasc Biol, 28, 296-301.
                      36. Babaev, V.R., Porro, F., Linton, M.F., Fazio, S., Baralle, F.E. and Muro, A.F. (2008) Absence of regulated splicing of fibronectin EDA exon reduces atherosclerosis in mice. Atherosclerosis, 197, 534-540.
                      37. Bazigou, E., Xie, S., Chen, C., Weston, A., Miura, N., Sorokin, L., Adams, R., Muro, A.F., Sheppard, D. and Makinen, T. (2009) Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis. Dev Cell, 17, 175-186.
                      38. White, E.S., Sagana, R.L., Booth, A.J., Yan, M., Cornett, A.M., Bloomheart, C.A., Tsui, J.L., Wilke, C.A., Moore, B.B., Ritzenthaler, J.D. et al. (2010) Control of fibroblast fibronectin expression and alternative splicing via the PI3K/Akt/mTOR pathway. Exp Cell Res, 316, 2644-2653.
                      39. Porro, F., Rosato-Siri, M., Leone, E., Costessi, L., Iaconcig, A., Tongiorgi, E. and Muro, A.F. (2010) beta-adducin (Add2) KO mice show synaptic plasticity, motor coordination and behavioral deficits accompanied by changes in the expression and phosphorylation levels of the alpha- and gamma-adducin subunits. Genes Brain Behav, 9, 84-96.
                      40. Morgan, M., Iaconcig, A. and Muro, A.F. (2010) CPEB2, CPEB3 and CPEB4 are coordinately regulated by miRNAs recognizing conserved binding sites in paralog positions of their 3'-UTRs. Nucleic Acids Res, 38, 7698-7710.
                      41. Kohan, M., Muro, A.F., White, E.S. and Berkman, N. (2010) EDA-containing cellular fibronectin induces fibroblast differentiation through binding to alpha4beta7 integrin receptor and MAPK/Erk 1/2-dependent signaling. FASEB J, 24, 4503-4512.
                      42. White, E.S. and Muro, A.F. (2011) Fibronectin splice variants: understanding their multiple roles in health and disease using engineered mouse models. IUBMB Life, 63, 538-546.
                      43. Kohan, M., Muro, A.F., Bader, R. and Berkman, N. (2011) The extra domain A of fibronectin is essential for allergen-induced airway fibrosis and hyperresponsiveness in mice. J Allergy Clin Immunol, 127, 439-446 e431-435.
                      44. Morgan, M., Iaconcig, A. and Muro, A.F. (2012) Identification of 3' gene ends using transcriptional and genomic conservation across vertebrates. BMC genomics, 13, 708.
                      45. Curlin, M., Kapuralin, K., Muro, A.F., Baralle, F.E., Chowdhury, K. and Gajovic, S. (2012) Stam2 expression pattern during embryo development. Gene expression patterns : GEP, 12, 68-76.
                      46. Bortolussi, G., Zentilin, L., Baj, G., Giraudi, P., Bellarosa, C., Giacca, M., Tiribelli, C. and Muro, A.F. (2012) Rescue of bilirubin-induced neonatal lethality in a mouse model of Crigler-Najjar syndrome type I by AAV9-mediated gene transfer. FASEB J, 26, 1052-1063.
                      47. Booth, A.J., Wood, S.C., Cornett, A.M., Dreffs, A.A., Lu, G., Muro, A.F., White, E.S. and Bishop, D.K. (2012) Recipient-derived EDA fibronectin promotes cardiac allograft fibrosis. J Pathol, 226, 609-618.
                      48. Nedeljkovic, M., Costessi, L., Iaconcig, A., Porro, F. and Muro, A.F. (2013) Long-distance regulation of Add2 pre-mRNA3'end processing. RNA biology, 10, 516-527.
                      49. Losino, N., Waisman, A., Solari, C., Luzzani, C., Espinosa, D.F., Sassone, A., Muro, A.F., Miriuka, S., Sevlever, G., Baranao, L. et al. (2013) EDA-containing fibronectin increases proliferation of embryonic stem cells. PloS one, 8, e80681.
                      50. Hirshoren, N., Kohan, M., Assayag, M., Neuman, T., Vernea, F., Muro, A., Eliashar, R. and Berkman, N. (2013) Extra domain-A fibronectin is necessary for the development of nasal remodeling in chronic allergen-induced rhinitis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 110, 322-327.
                      51. Danussi, C., Del Bel Belluz, L., Pivetta, E., Modica, T.M., Muro, A., Wassermann, B., Doliana, R., Sabatelli, P., Colombatti, A. and Spessotto, P. (2013) EMILIN1/alpha9beta1 integrin interaction is crucial in lymphatic valve formation and maintenance. Mol Cell Biol, 33, 4381-4394.
                      52. Costessi, L., Porro, F., Iaconcig, A., Nedeljkovic, M. and Muro, A.F. (2013) Characterization of the distal polyadenylation site of the ss-adducin (Add2) pre-mRNA. PloS one, 8, e58879.
                      53. Porro, F., Bockor, L., De Caneva, A., Bortolussi, G. and Muro, A.F. (2014) Generation of Ugt1-deficient murine liver cell lines using TALEN technology. PloS one, 9, e104816.
                      54. Bortolussi, G., Zentillin, L., Vanikova, J., Bockor, L., Bellarosa, C., Mancarella, A., Vianello, E., Tiribelli, C., Giacca, M., Vitek, L. et al. (2014) Life-long correction of hyperbilirubinemia with a neonatal liver-specific AAV-mediated gene transfer in a lethal mouse model of Crigler-Najjar Syndrome. Human gene therapy, 25, 844-855.
                      55. Bortolussi, G., Baj, G., Vodret, S., Viviani, G., Bittolo, T. and Muro, A.F. (2014) Age-dependent pattern of cerebellar susceptibility to bilirubin neurotoxicity in vivo in mice. Disease models & mechanisms, 7, 1057-1068.
                      56. Costessi, L., Porro, F., Iaconcig, A. and Muro, A.F. (2014) TDP-43 regulates beta-adducin (Add2) transcript stability. RNA biology, 11, 1280-1290.
                      57. Bortolussi, G., Codarin, E., Antoniali, G., Vascotto, C., Vodret, S., Arena, S., Cesaratto, L., Scaloni, A., Tell, G. and Muro, A.F. (2015) Impairment of enzymatic antioxidant defenses is associated with bilirubin-induced neuronal cell death in the cerebellum of Ugt1 KO mice. Cell death & disease, 6, e1739.
                      58. Pulakazhi Venu, V.K., Uboldi, P., Dhyani, A., Patrini, A., Baetta, R., Ferri, N., Corsini, A., Muro, A.F., Catapano, A.L. and Norata, G.D. (2015) Fibronectin extra domain A stabilises atherosclerotic plaques in apolipoprotein E and in LDL-receptor-deficient mice. Thromb Haemost, 114, 186-197.
                      59. Vodret, S., Bortolussi, G., Schreuder, A.B., Jasprova, J., Vitek, L., Verkade, H.J. and Muro, A.F. (2015) Albumin administration prevents neurological damage and death in a mouse model of severe neonatal hyperbilirubinemia. Scientific reports, 5, 16203.
                      60. Ronzitti, G., Bortolussi, G., van Dijk, R., Collaud, F., Charles, S., Leborgne, C., Vidal, P., Martin, S., Gjata, B., Sola, M.S. et al. (2016) A translationally optimized AAV-UGT1A1 vector drives safe and long-lasting correction of Crigler-Najjar syndrome. Molecular therapy. Methods & clinical development, 3, 16049.
                      61. Malara, A., Gruppi, C., Celesti, G., Romano, B., Laghi, L., De Marco, L., Muro, A.F. and Balduini, A. (2016) Brief Report: Alternative Splicing of Extra Domain A (EIIIA) of Fibronectin Plays a Tissue-Specific Role in Hematopoietic Homeostasis. Stem Cells, 34, 2263-2268.
                      62. Gortan Cappellari, G., Barazzoni, R., Cattin, L., Muro, A.F. and Zanetti, M. (2016) Lack of Fibronectin Extra Domain A Alternative Splicing Exacerbates Endothelial Dysfunction in Diabetes. Scientific reports, 6, 37965.
                      63. Vodret, S., Bortolussi, G., Jasprova, J., Vitek, L. and Muro, A.F. (2017) Inflammatory signature of cerebellar neurodegeneration during neonatal hyperbilirubinemia in Ugt1 -/- mouse model. J Neuroinflammation, 14, 64.
                      64. Bockor, L., Bortolussi, G., Vodret, S., Iaconcig, A., Jasprova, J., Zelenka, J., Vitek, L., Tiribelli, C. and Muro, A.F. (2017) Modulation of bilirubin neurotoxicity by the Abcb1 transporter in the Ugt1-/- lethal mouse model of neonatal hyperbilirubinemia. Hum Mol Genet, 26, 145-157.
                      65. Porro, F., Bortolussi, G., Barzel, A., De Caneva, A., Iaconcig, A., Vodret, S., Zentilin, L., Kay, M.A. and Muro, A.F. (2017) Promoterless gene targeting without nucleases rescues lethality of a Crigler-Najjar syndrome mouse model. EMBO Molecular Medicine, In press.
                      66. Bočkor, L., Bortolussi, G., Iaconcig, A., Chiaruttini, G., Tiribelli, C., Giacca, M., Benvenuti, F., Zentilin, L. and Muro, A.F. (2017) Repeated AAV-mediated gene transfer by serotype switching enables long-lasting therapeutic levels of hUgt1a1 enzyme in a mouse model of Crigler-Najjar Syndrome Type I. Gene Therapy, In press
                                          Azioni sul documento