PhD in Biomedical Sciences and Biotechnology

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CURRICULUM VITAE VALERIA BERTAGNOLO

Date and place of birth: Salara, Rovigo (Italy), August 22, 1961 Nationality: Italian

Affiliation and official address: Department of Morphology, Surgery and Experimental Medicine, Section of Anatomy and Histology, University of Ferrara, c/o CUBO Via Fossato di Mortara 70, 44121 Ferrara, Italy.

Telephone: +39 0532 455939 (office) +39 0532 455580 (lab)

e-mail: bgv@unife.it

EDUCATION
1986: Degree in Biological Sciences (University of Ferrara, Italy)
1990: PhD in Cellular and Molecular Biology (University of Ferrara, Italy)

CAREER/EMPLOYMENT
1990: Post-doc EMBO fellowship (University of Utrecht, NL)
1990-2004: Assistant Professor of Human Anatomy (University of Ferrara, Italy)
2005-present: Associate Professor of Human Anatomy (University of Ferrara, Italy)
2014-2020: National Scientific Qualification to Full Professor (PO) of 05/H1 Human Anatomy

RESEARCH EXPERIENCES
1990: Visiting scientist, Center for Biomembranes and Lipid Enzymology, Utrecht, NL
2010: Visiting scientist, Department of Physiology and Immunology and, University of Zagreb, HR

INTERNATIONAL COLLABORATIONS

KWA Wirtz, Centrum voor Biomembranen en Lipide Enzymologie”, University of Utrecht, NL.

N Varin-Blank, Istitut Cochin de Gènètique Molèculaire (ICGM), Hopital Cochin, Parigi, F.

D Visnjic, Department of Physiology and Immunology and, University of Zagreb, HR;

H Banfic, Zavod za neuroznanost, Hrvatski Institut za istrazivanje mozga, University of Zagreb, HR.

M P Tschan, Division of Experimental Pathology, Institute of Pathology, University of Bern, CH.

RESEARCH ACTIVITY

Her main research interest has been focused on the lipid dependent-signal transduction pathways during growth and differentiation of cells derived from myeloid leukemia and solid tumors. Her studies led to the identification and the possible role, in both whole cell and nuclear compartment, of specific isoforms of PKC, PI-PLC, PI3K and Vav1 during the granulocytic and monocytic differentiation of AML-derived cells (leukemic blasts, cell lines) induced by agonists (ATRA, As₂O₃, PMA). At present, her main research interest concerns the role of specific signalling molecules (PLC isoforms, Vav1), both cytoplasmic and nuclear, in the promotion and/or progression of breast cancer, in order to identify molecular targets for antineoplastic strategies.

The main skills acquired were related to all aspects of proteins study (functional proteomics), as immunochemical, immunocytochemical and immunohistochemical analysis, positive and negative modulation of protein expression, specific enzymatic activity assays, comparative analysis of protein expression by classical two-dimensional electrophoresis and DIGE coupled to mass spectrometry.

PROFESSIONAL SOCIETIES

Member of the Italian Society of Anatomy and Histology

TEACHING EXPERIENCES

1990-1995: Adjective Professor at the Ferrara University in different courses of Human Anatomy.

From 1996, Official teacher of Human Anatomy at several graduate courses at the University of Ferrara, including: 1996-2013: Medicine and Surgery; 1996-present: Speech Therapy; 1996-present: Dentistry; 1997-2012: Medical post Graduate school; 2001-2009: Sports and Exercise Sciences; 2003-present: Dental Hygiene; 2003-present: Sciences and techniques of preventive and adaptive sports activities.

2001-2002: Member of Ph.D. program board in Biomedical and Endocrinological Sciences, University of Ferrara, Italy.

2003-2016: Member of Ph.D. program board in Biomedical Sciences, University of Ferrara, Italy.
2013-present: Member of Ph.D. program board in Biomedical and Biotechnological Sciences, University of Ferrara, Italy.

GRANTS
1993-1995: Principal Investigator CNR (Consiglio nazionale per le Ricerche), ricerca bilaterale Italia-Olanda.

1998-2000: Principal Investigator COFIN 1998 (Italian Ministry of Education, University and Research)

2003-2005: Co-Investigator COFIN 2003 (Italian Ministry of Education, University and Research)

2004-2006: Principal Investigator COFIN 2004 (Italian Ministry of Education, University and Research)

2010-2011: Italian Scientific Coordinator MAE, Progetto Bilaterale Italia-Croazia 2009-2010 (Italian Ministryy of Foreign Affairs),

2013-2014: Scientific Coordinator SPINNER 2013 (European Union, Italian Ministry of Social Affairs and Regione Emilia Romagna).

2011-2014: Co-Investigator FIRB - ACCORDI DI PROGRAMMA 2010 (Italian Ministry of Education, University and Research)

PUBLICATIONS (at April 2017)

- 58 full-length manuscripts published in international peer-reviewed scientific journals impacted on Journal Citation Reports (ISI Times cited: 1564, h-index: 21)

- Atlas of Genetics and Cytogenetics in Oncology and Hematology as reference expert for PLC beta2.

Researcher unique identifiers: ORCID ID: 0000-0002-4742-2302; Scopus ID: 6603775944