%PDF-1.3
%
2 0 obj
<>
endobj
11 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 53/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T0 q-Br44C@B 9 s
(P
endstream
endobj
6 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 54/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T R
Ɩf
!\!Y\ !p )P
endstream
endobj
28 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 55/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T0P02S04S @$P5 )1
endstream
endobj
8 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 53/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T0 q-Br44C@B 9 s
(P
endstream
endobj
16 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 55/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T0P02S04S @$P5 )1
endstream
endobj
18 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 54/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T R
Ɩf
!\!Y\ !p )P
endstream
endobj
14 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 53/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T0 q-Br44C@B 9 s
(P
endstream
endobj
29 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 53/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T0 q-Br44C@B 9 s
(P
endstream
endobj
5 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 53/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T0 q-Br44C@B 9 s
(P
endstream
endobj
30 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 54/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T R
Ɩf
!\!Y\ !p )P
endstream
endobj
25 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 55/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T0P02S04S @$P5 )1
endstream
endobj
31 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 55/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T0P02S04S @$P5 )1
endstream
endobj
15 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 54/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T R
Ɩf
!\!Y\ !p )P
endstream
endobj
7 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 55/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T0P02S04S @$P5 )1
endstream
endobj
1 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 53/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T0 q-Br44C@B 9 s
(P
endstream
endobj
33 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 54/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T R
Ɩf
!\!Y\ !p )P
endstream
endobj
17 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 53/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T0 q-Br44C@B 9 s
(P
endstream
endobj
27 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 54/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T R
Ɩf
!\!Y\ !p )P
endstream
endobj
13 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 55/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T0P02S04S @$P5 )1
endstream
endobj
9 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 54/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T R
Ɩf
!\!Y\ !p )P
endstream
endobj
3 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 54/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T R
Ɩf
!\!Y\ !p )P
endstream
endobj
4 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 55/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T0P02S04S @$P5 )1
endstream
endobj
22 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 55/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T0P02S04S @$P5 )1
endstream
endobj
19 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 55/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T0P02S04S @$P5 )1
endstream
endobj
32 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 53/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T0 q-Br44C@B 9 s
(P
endstream
endobj
21 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 54/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T R
Ɩf
!\!Y\ !p )P
endstream
endobj
26 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 53/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T0 q-Br44C@B 9 s
(P
endstream
endobj
24 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 54/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T R
Ɩf
!\!Y\ !p )P
endstream
endobj
23 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 53/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T0 q-Br44C@B 9 s
(P
endstream
endobj
10 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 55/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T0P02S04S @$P5 )1
endstream
endobj
12 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 54/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T R
Ɩf
!\!Y\ !p )P
endstream
endobj
20 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 53/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T0 q-Br44C@B 9 s
(P
endstream
endobj
34 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 55/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T0P02S04S @$P5 )1
endstream
endobj
35 0 obj
<>stream
2012-03-24T19:59:28+05:30
Arbortext Advanced Print Publisher 9.0.114/W
2012-04-18T22:27:47-07:00
Acrobat Distiller 8.1.0 (Windows)
application/pdf
untitled
uuid:0a524d8c-ba77-4c95-9ab9-bc7a9032b648
uuid:5ec415a6-8c55-4863-957a-32f8791018df
endstream
endobj
36 0 obj
<>stream
x+ |
endstream
endobj
37 0 obj
<>stream
xS**T0T0 BiUD* 8
endstream
endobj
38 0 obj
<>stream
x+ |
endstream
endobj
39 0 obj
<>stream
xS**T0T0 BiU)D* 9V
endstream
endobj
40 0 obj
<>stream
x+ |
endstream
endobj
41 0 obj
<>stream
xS**T0T0 Bid]D. qdj
endstream
endobj
42 0 obj
<>stream
x+ |
endstream
endobj
43 0 obj
<>stream
xS**T0T0 Bil]D. pa
endstream
endobj
44 0 obj
<>stream
x+ |
endstream
endobj
45 0 obj
<>stream
xS**T0T0 Bid]%D. rs
endstream
endobj
46 0 obj
<>stream
x+ |
endstream
endobj
47 0 obj
<>stream
xS**T0T0 BiU !D. _e1
endstream
endobj
48 0 obj
<>stream
x+ |
endstream
endobj
49 0 obj
<>stream
xS**T0T0 Bih]9D. qaj
endstream
endobj
50 0 obj
<>stream
x+ |
endstream
endobj
51 0 obj
<>stream
xS**T0T0 BiUD* :
endstream
endobj
52 0 obj
<>stream
x+ |
endstream
endobj
53 0 obj
<>stream
xS**T0T0 Bih] D. pa
endstream
endobj
54 0 obj
<>stream
x+ |
endstream
endobj
55 0 obj
<>stream
xS**T0T0 Bid]1D. pa
endstream
endobj
56 0 obj
<>stream
x+ |
endstream
endobj
57 0 obj
<>stream
xS**T0T0 Bih]D. r^j
endstream
endobj
58 0 obj
<>/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]/XObject<>/Font<>>>/Thumb 71 0 R/MediaBox[0 0 612 792]/Rotate 0>>
endobj
72 0 obj
<>/ProcSet[/PDF/Text/ImageC]/XObject<>/Font<>>>
endobj
60 0 obj
<>stream
/GS1 gs
BT
/F9 1 Tf
8.9663 0 0 8.9663 62.022 725.7825 Tm
0 0 0 1 k
0 Tc
0 Tw
[(diffusible)-432.5(oxidants)-433.5(\(25\))-423.6(that)-433.8(could)-427.3(act)-429.2(as)-430.8(intracellular)-429.9(mes-)]TJ
0 -1.2203 TD
[(sengers)-282.8(and)-284.1(impact)-279.9(redox)-280.4(homeostasis)-285.7(\(20,)-280.6(33\).)]TJ
1.1128 -1.2266 TD
[(Several)-198.8(ndings)-199.1(highlight)-200.8(the)-199.8(existence)-205.8(of)-199.2(tight)-202(connections)]TJ
-1.1128 -1.2203 TD
[(between)-414.3(the)-408.4(ER)-411.9(luminal)-410.8(redox)-413.2(and)-410.6(Ca)]TJ
6.7246 0 0 5.9768 219.4582 696.8691 Tm
(2)Tj
/F3 1 Tf
.666 0 TD
(+)Tj
/F9 1 Tf
8.9663 0 0 8.9663 232.4409 692.9006 Tm
[(homeostasis.)-415.1(The)]TJ
-19.0067 -1.2203 TD
(Ca)Tj
6.7246 0 0 5.9768 72.8504 685.9274 Tm
(2)Tj
/F3 1 Tf
.666 0 TD
(+)Tj
/F9 1 Tf
8.9663 0 0 8.9663 82.2047 681.9589 Tm
[(-ATPase)-253.5(SERCA2b,)-260.7(inositol)-255.3(1,4,5-trisphosphate)-264.6(receptor)]TJ
-2.251 -1.2266 TD
[(type)-429.8(1)-429.5(\(IP3R1\),)-434.2(ryanodine)-431.6(receptors)-436.3(\(RyRs\),)-429(and)-429.5(the)-433.7(Ca)]TJ
6.7246 0 0 5.9768 288.907 674.9856 Tm
(2)Tj
/F3 1 Tf
.666 0 TD
(+)Tj
/F9 1 Tf
8.9663 0 0 8.9663 298.2613 670.9604 Tm
(-)Tj
-26.3476 -1.2203 TD
[(sensor)-205.4(s)-26.6(t)-19.4(r)-26(o)-21.7(m)-22.9(a)-18.5(l)-224.8(i)-22.5(n)-22.4(t)-25.8(e)-25.2(r)-19.7(a)-24.8(c)-18.2(t)-25.8(i)-22.5(o)-21.7(n)-224.7(m)-22.9(o)-21.7(l)-22.5(e)-25.2(c)-18.2(u)-26.6(l)-22.5(e)-227.5(1)-220.8(\()-25.8(S)-23.8(T)-22(I)-21.1(M)-24.1(1)-18.5(\))-228.1(a)-18.5(r)-26(e)-221.2(a)-24.8(l)-22.5(l)-224.8(r)-19.7(e)-25.2(d)-22(o)-21.7(x)-27.5(-)]TJ
T*
[(regulated)-455.4(\(18,)-451.3(23,)-444.5(39,)-450.9(41\).)-451.3(Furthermore,)-457.4(a)-448.4(circuit)-450.8(involving)]TJ
0 -1.2266 TD
[(IP3R1)-386.1(and)-391.6(Ero1)]TJ
/F2 1 Tf
7.0753 0 TD
(a)Tj
/F9 1 Tf
.8852 0 TD
[(has)-389.9(been)-387(recently)-391(implicated)-391.1(in)-392.6(the)-389.5(mala-)]TJ
-7.9605 -1.2203 TD
[(daptive)-191.9(shift)-192.5(during)-193.4(prolonged)-198.9(ER)-190.6(stress)-194.7(\(22\).)-186.2(Ca)]TJ
6.7246 0 0 5.9768 249.5621 631.1053 Tm
(2)Tj
/F3 1 Tf
.666 0 TD
(+)Tj
/F9 1 Tf
8.9663 0 0 8.9663 260.5605 627.1368 Tm
[(release)-194.4(via)]TJ
-22.1428 -1.2203 TD
[(IP3R1)-297.6(is)-295.7(inhibited)-303.4(by)-299.7(ERp44)-292.1(\(18\),)-300.1(a)-296.7(multitask)-303(chaperone)-301(that)]TJ
T*
[(prevents)-267(secretion)-270.5(of)-262.5(mammalian)-260.9(Ero1)]TJ
/F2 1 Tf
16.8885 0 TD
(a)Tj
/F9 1 Tf
.7651 0 TD
[(and)-265.1(Ero1)]TJ
/F2 1 Tf
3.9708 0 TD
(b)Tj
/F9 1 Tf
.8157 0 TD
[(and)-258.8(other)]TJ
-22.44 -1.2266 TD
[(substrates)-263.7(of)-262.5(thiol-dependent)-275.1(quality)-257.5(control)-265.8(\(1,)-262.1(2,)-261.7(10,)-261.2(11,)-261.2(30\).)]TJ
0 -1.2203 TD
[(Therefore,)-216(the)-218.7(Ero1)]TJ
/F2 1 Tf
8.2893 0 TD
(a)Tj
/F9 1 Tf
.4995 0 TD
[(ERp44)-215.8(axis)-215.2(could)-212.3(play)-211.1(an)-217.9(important)-212.1(role)]TJ
-8.7888 -1.2203 TD
[(in)-278.8(regulating)-286.8(Ca)]TJ
6.7246 0 0 5.9768 125.9716 576.34 Tm
(2)Tj
/F3 1 Tf
.666 0 TD
(+)Tj
/F9 1 Tf
8.9663 0 0 8.9663 137.8204 572.3715 Tm
[(homeostasis)-285.7(and)-277.8(release.)]TJ
-7.3409 -1.2266 TD
[(We)-397.3(show)-401.1(here)-402.2(that)-395.9(Ero1)]TJ
/F2 1 Tf
11.0651 0 TD
(a)Tj
/F9 1 Tf
.8979 0 TD
[(accumulates)-401.4(where)-403.9(the)-402.1(ER)-399.3(es-)]TJ
-13.0758 -1.2203 TD
[(tablishes)-396.8(contacts)-404.8(with)-394.7(mitochondria)-399.3(\()-82.7(MAM\).)-400.7(The)-392(levels)-400.9(of)]TJ
T*
[(redox-active)-366.5(Ero1)]TJ
/F2 1 Tf
7.8025 0 TD
(a)Tj
/F9 1 Tf
.8599 0 TD
[(impact)-368.4(Ca)]TJ
6.7246 0 0 5.9768 180.7936 543.4581 Tm
(2)Tj
/F3 1 Tf
.666 0 TD
(+)Tj
/F9 1 Tf
8.9663 0 0 8.9663 193.3795 539.4896 Tm
[(storage)-369.5(and)-360(IP3-dependent)]TJ
-14.6502 -1.2266 TD
[(uxes.)-244.6(Ero1)]TJ
/F2 1 Tf
5.1216 0 TD
(a)Tj
/F9 1 Tf
.7398 0 TD
[(silencing)-249.9(has)-250.8(profound)-243.4(effects)-254.7(on)-246.4(mitochondrial)]TJ
-5.8613 -1.2203 TD
(Ca)Tj
6.7246 0 0 5.9768 72.8504 521.5179 Tm
(2)Tj
/F3 1 Tf
.666 0 TD
(+)Tj
/F9 1 Tf
8.9663 0 0 8.9663 84.3023 517.5494 Tm
[(uptake,)-237.6(likely)-234.3(modifying)-238.1(the)-237.7(MCU)-234.3(activity.)-242.5(Thus,)-233.3(Ero1)]TJ
/F2 1 Tf
23.6856 0 TD
(a)Tj
/F9 1 Tf
-26.1705 -1.2203 TD
[(links)-281.7(redox)-280.4(and)-284.1(Ca)]TJ
6.7246 0 0 5.9768 136.7999 510.5762 Tm
(2)Tj
/F3 1 Tf
.666 0 TD
(+)Tj
/F9 1 Tf
8.9663 0 0 8.9663 148.6488 506.6077 Tm
[(homeostasis)-285.7(and)-277.8(signaling)-286.3(in)-278.8(MAM.)]TJ
/F7 1 Tf
18.3364 24.4444 TD
(Results)Tj
/F13 1 Tf
0 -1.8336 TD
(Ero1)Tj
/F5 1 Tf
2.1055 0 TD
(a)Tj
/F13 1 Tf
.8852 0 TD
[(is)-337.9(enriched)-330.5(in)-336.5(MAM)]TJ
/F9 1 Tf
-1.8779 -1.8336 TD
[(Subcellular)-230.6(fractionation)-228.5(of)-224.5(HeLa)-223.7(cells)-228.9(revealed)-228.5(that)-225.1(a)-220.8(large)]TJ
-1.1128 -1.2203 TD
[(fraction)-237.8(of)-230.9(endogenous)-237.2(Ero1)]TJ
/F2 1 Tf
12.2854 0 TD
(a)Tj
/F9 1 Tf
.7335 0 TD
[(accumulates)-237(in)-228.2(MAM)-232.9(\(Fig.)-230.7(1A\),)]TJ
-13.0189 -1.2266 TD
[(conrming)-378.5(recent)-376.7(results)-375.3(\(15\).)-375.9(As)-375.8(expected,)-375.6(porin)-372.2(\(VDAC1\))]TJ
0 -1.2203 TD
[(and)-220.9(cytochrome)-225.5(c)-220.6(were)-223.4(enriched)-221.7(in)-221.9(mitochondria)-222.2(\()-82.7(MP\),)-224.8(while)]TJ
T*
[(ribophorin)-469.2(and)-461.2(Grp94)-467.7(accumulated)-466.3(mainly)-460.9(in)-462.2(microsomes)]TJ
0 -1.2266 TD
[(\()-89(Mic\).)-302.2(Calnexin)-306.4(and)-309.4(IP3R1)-303.9(distributed)-306.2(similarly)-308.5(between)-306.8(the)]TJ
0 -1.2203 TD
[(microsomal)-413.2(and)-410.6(MAM)-416.3(fractions,)-412.7(while)-410.3(ERp44)-412.3(was)-407.1(slightly)]TJ
T*
[(more)-367.7(abundant)-369.1(in)-361(MAM.)-368.6(PDI)-365.3(was)-362.9(abundant)-369.1(in)-361(both)-371.5(MAM)]TJ
T*
[(and)-322(microsomes)-322.9(\(not)-316.9(shown\).)-325.7(Immunouorescence)-325.4(analyses)]TJ
0 -1.2266 TD
[(conrmed)-351.1(the)-351.5(presence)-353.5(of)-351(both)-352.5(ERp44)-349(and)-347.3(Ero1)]TJ
/F2 1 Tf
21.5295 0 TD
(a)Tj
/F9 1 Tf
.8536 0 TD
[(at)-347.7(sites)-348(of)]TJ
-22.3831 -1.2203 TD
[(contact)-334(with)-325.2(mitochondria,)-332.7(where)-328(the)-332.5(two)-327.3(proteins)-329.6(partially)]TJ
T*
[(co-localize)-254.4(\(Fig.)-249.7(1B)-249.1(and)-252.5(Supplementary)-252.2(Fig.1;)-251.7(Supplementary)]TJ
0 -1.2266 TD
[(Data)-298.1(are)-291(available)-292.4(online)-301(at)-290.8(www.liebertonline.com/ars\).)-300.1(As)]TJ
0 -1.2203 TD
[(previously)-487.5(described)-482.9(\(3\))-481(ERp44)-481.8(was)-476.7(abundant)-482.9(also)-481.3(in)-481.1(the)]TJ
T*
[(ERGIC)-318.1(area)-315.8(\(Fig.)-312.9(1B\).)-315.7(In)-315.3(professional)-324.1(secretory)-312.9(cells,)-320.3(such)-315.2(as)]TJ
0 -1.2266 TD
[(myeloma)-460.5(cell)-461.5(lines,)-463.5(a)-461.1(larger)-457.7(fraction)-465.4(of)-458.5(endogenous)-464.8(Ero1)]TJ
/F2 1 Tf
26.1705 0 TD
(a)Tj
/F9 1 Tf
-26.1705 -1.2203 TD
[(accumulated)-428.4(in)-424.2(the)-421.1(ER)-424.5(\(not)-424.4(shown\).)-426.9(Upon)-426.2(overexpression,)]TJ
T*
(Ero1)Tj
/F2 1 Tf
2.036 0 TD
(a)Tj
/F9 1 Tf
.9864 0 TD
[(is)-491.7(found)-491.5(in)-493.8(virtually)-492(all)-493.4(substations)-494.1(of)-490.1(the)-490.6(exocytic)]TJ
ET
q
1 i
62.022 488.806 m
416.92 488.806 l
416.92 57.6 l
62.022 57.6 l
W n
q
355.146 0 0 431.206 62.022 57.6 cm
/Im1 Do
Q
Q
BT
/F11 1 Tf
8.9663 0 0 8.9663 429.7322 404.6172 Tm
[(FI)20.2(G.)-458.1(1)13.1(.)-989.3(Er)15.3(o)14.6(1)]TJ
/F14 1 Tf
6.1775 0 TD
(a)Tj
/F11 1 Tf
1.018 0 TD
[(e)13.1(n)0(r)15.3(i)12.2(ch)16.7(m)12.4(e)0(n)22.8(t)-468.4(in)]TJ
-7.1955 -1.1128 TD
[(MA)18.5(M.)-836.6(\(A)17.1(\))]TJ
/F9 1 Tf
6.0826 0 TD
[(Su)19.1(bc)21.6(el)15.5(lu)20.4(la)22.2(r)-848(f)0(r)17.8(a)13.1(c-)]TJ
-6.0826 -1.1065 TD
[(ti)15(on)19.1(a)13.1(t)0(i)21.3(o)0(n)12.8(.)-496.1(Al)20.4(iq)17.3(uo)21.2(ts)-495(\()12.2(3)13.1(0)]TJ
/F2 1 Tf
10.2431 0 TD
(l)Tj
/F9 1 Tf
.5438 0 TD
.4976 Tc
[(gp)497.6(r)514.5(o)497.6(-)]TJ
-10.7869 -1.1128 TD
0 Tc
[(te)18.6(in)18.4(\))-696(f)12.2(ro)15.5(m)-686.8(e)0(a)19.6(c)0(h)-685.5(f)0(r)17.8(a)13.1(ct)12.9(i)15.4(o)0(n)-689(\()12.2(48)19.9(\))]TJ
T*
[(we)17.4(re)-474.8(re)18.4(so)21.2(lv)14.7(e)12.7(d)-489.9(un)20.6(de)22.4(r)-487.6(r)0(e)18.4(d)0(u)20.9(c)0(i)16.2(n)0(g)]TJ
T*
[(co)16.9(nd)18.9(it)21.3(io)19(ns)-270.3(a)13.1(n)0(d)-271.9()0(l)25.1(t)0(e)12.3(r)0(s)-267.6(d)16(ec)13.5(or)21.8(at)19(ed)]TJ
0 -1.1065 TD
[(wi)20.1(th)-541.3(t)12.2(h)0(e)-540.7(i)0(n)18.4(d)0(i)18.8(c)0(a)20.2(t)0(e)18.6(d)-546.8(an)16.1(t)12.2(i)0(b)17.3(o)0(d)19.5(i)0(e)21.9(s)0(.)]TJ
0 -1.1128 TD
[(Cy)20.7(t,)-762.1(c)13.4(y)0(t)20.4(o)0(s)14.9(o)0(l)19(;)-768(H)12.7(o)0(m)18.6(,)-768(ho)19.1(mo)18.6(g)14.5(e)0(-)]TJ
T*
[(na)16.1(t)12.2(e)0(;)-843.8(M)13.9(ic)16.2(,)-850.2(m)0(i)17.9(c)13.4(ro)15.5(so)21.2(me)21.5(s;)-845.2(M)13.9(P)0(,)]TJ
0 -1.1065 TD
[(mi)17.9(t)12.2(o)0(-)15.7(p)0(u)22.6(r)0(e)18.4(.)-692.1(Tw)14.3(o)-692(p)0(a)18.1(r)0(t)24.1(s)-696.8(of)-679.8(th)15.1(e)]TJ
0 -1.1128 TD
[(sa)18.1(me)-515.9(ge)21(l,)-518.6(or)15.5(ig)23.7(in)18.4(al)15.9(l)15.4(y)-529.2(se)17.8(pa)18.1(ra)18.8(t)12.2(e)0(d)]TJ
T*
[(by)-369.2(ir)21.1(re)18.4(le)21.9(va)18.7(nt)-370.6(la)22.2(ne)15.7(s,)-364.6(ar)18.7(e)-379.3(s)0(h)20.6(o)0(w)14.6(n)0(.)]TJ
/F11 1 Tf
T*
[(\(B)20.6(\))]TJ
/F9 1 Tf
1.6566 0 TD
[(Im)19.3(mu)20(no)19.1(u)20.9(or)15.5(e)12.7(s)0(c)18.4(e)0(n)15.7(c)13.4(e.)-356.9(He)19.1(La)]TJ
-1.6566 -1.1065 TD
[(ce)19.8(ll)18.2(s)-399.7(t)12.2(ra)18.8(ns)14.3(ie)21.9(nt)15.1(l)15.4(y)-402.8(e)12.7(x)0(p)15.5(r)0(e)18.4(s)0(s)22.7(i)0(n)18.4(g)-396.4(mi)17.9(-)]TJ
0 -1.1128 TD
[(to)15.7(c)13.4(h)0(o)19.1(n)0(d)18.9(r)0(i)14.7(a)13.1(l)-363.9(E)0(Y)18.1(F)0(P)-353.5(w)0(e)17.4(r)0(e)-354.7(s)0(t)17.2(a)13.1(in)18.4(ed)]TJ
T*
[(wi)20.1(th)-503.4(an)16.1(t)12.2(i)0(-)15(E)0(r)21.6(o)0(1)]TJ
/F2 1 Tf
6.4367 0 TD
(a)Tj
/F9 1 Tf
1.0117 0 TD
[(or)-503(an)16.1(t)12.2(i)0(-)21.3(E)0(R)18.1(p)0(4)18.1(4)]TJ
-7.4484 -1.1128 TD
[(an)16.1(t)12.2(i)0(b)17.3(o)0(d)19.5(i)0(e)21.9(s)-526.1(a)13.1(s)-526.1(in)18.4(di)18.8(c)13.4(a)0(t)19(e)0(d)16.1(.)-521.4(Er)21.6(o1)]TJ
/F2 1 Tf
13.1517 0 TD
(a)Tj
/F9 1 Tf
-13.1517 -1.1065 TD
[(fr)17.8(eq)21(ue)17.7(nt)15.1(ly)-1158.7(co)16.9(-)12.2(l)0(o)19(c)0(a)20.2(l)0(i)18.2(z)13.1(es)-1164.6(wi)20.1(th)]TJ
0 -1.1128 TD
[(mi)17.9(t)12.2(o)0(c)16.9(h)0(o)19.1(n)0(d)18.9(r)0(i)21.1(a)0(,)-217.4(y)0(i)23.7(e)0(l)15.5(d)0(i)18.8(n)0(g)-216.5(a)-220.8(ye)21(ll)18.2(ow)]TJ
T*
[(st)17.2(a)13.1(i)0(n)18.4(i)0(n)18.4(g)0(,)-437.3(w)0(h)20.3(i)0(l)18.2(e)-442.5(ER)18.1(p4)24.4(4)-448.4(s)0(t)23.5(a)0(i)15.9(n)0(i)18.4(n)0(g)]TJ
0 -1.1065 TD
[(is)-485.4(of)22(te)18.6(n)-496.6(a)13.1(dj)17.3(a)13.1(c)0(e)19.8(n)0(t)-484.4(t)0(o)-483.8(m)0(i)17.9(t)12.2(oc)16.9(ho)19.1(n-)]TJ
0 -1.1128 TD
-.0187 Tc
[(d)-18.7(r)-3.4(ia)-840.2(b)-18.7(u)-5.5(t)-841.1(r)-18.7(a)6.4(r)-18.7(el)-18.7(y)-836(o)-18.7(ve)-18.7(rl)-18.7(ap)-18.7(pi)-18.7(ng)-18.7(.)]TJ
T*
0 Tc
[(Ab)19.5(un)14.2(d)16(a)0(n)16.1(t)-569.5(ER)18.1(p4)18.1(4)-568.6(i)0(s)-561.3(f)12.2(ou)14.8(nd)-562.8(i)15.4(n)]TJ
T*
[(ER)18.1(GI)18.1(C)-265.7(a)13.1(nd)-259.3(ci)16.2(sG)18.9(ol)25.3(gi)-260.9(\()12.2(3)0(\))19(.)-268.5(\()12.2(T)0(o)-258.7(s)0(e)17.8(e)]TJ
0 -1.1065 TD
[(th)15.1(is)-757.3(il)18.2(lu)20.4(st)17.2(ra)18.8(t)12.2(i)0(o)19(n)-774.8(in)-759.3(co)16.9(lo)19(r)-765.8(t)0(h)15.1(e)]TJ
0 -1.1128 TD
[(re)18.4(ad)16.5(e)12.7(r)-550.8(is)-542.3(re)18.4(f)12.2(e)0(r)18.4(r)0(e)18.4(d)-546.8(to)-540.7(th)15.1(e)-550(w)0(e)17.4(b)]TJ
T*
[(ve)18.3(rs)17(io)19(n)-427(o)0(f)-426.9(t)12.2(hi)18.4(s)-431.3(a)0(r)18.8(t)0(i)21.3(c)0(l)16.2(e)-429.9(at)-423.6(ww)22(w)]TJ
T*
[(.l)18.8(ie)21.9(be)14.7(rt)17.8(on)19.1(li)24.6(ne)15.7(.c)16.8(om)25(/a)16.5(rs)23.3(\).)]TJ
/F7 1 Tf
-41.0104 68.4835 TD
(1078)Tj
47.4914 0 TD
[(ANELLI)-334.5(ET)-338.7(AL.)]TJ
ET
endstream
endobj
62 0 obj
<>stream
Adobe d
s !1AQa"q2B#R3b$r%C4Scs5D'6Tdt&
EFVU(eufv7GWgw8HXhx)9IYiy*:JZjz m !1AQa"q2#BRbr3$4CS%cs5DT
&6E'dtU7()euFVfvGWgw8HXhx9IYiy*:JZjz ? N*KKM?Vv6'/7 ce Zgo
EҐD[Ä"v͊_͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ث/ɏ/y7wcՓ˧Ξ6%9$s#Cnĭ" \تsO)y\ -