Paolo Pinton Lab__Signal Transduction

 

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  1. Rizzuto R, Pinton P, Carrington W, Fay FS, Fogarty KE, Lifshitz LM, Tuft RA, Pozzan T (1998) Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses. Science 280:1763-6
  2. Pinton P, Pozzan T, Rizzuto R (1998) The Golgi apparatus is an inositol 1,4,5-trisphosphate-sensitive Ca2+ store, with functional properties distinct from those of the endoplasmic reticulum. EMBO J 17:5298-308
  3. Pinton P, Brini M, Bastianutto C, Tuft RA, Pozzan T, Rizzuto R (1998) New light on mitochondrial calcium. Biofactors 8:243-53
  4. De Giorgi F, Ahmed Z, Bastianutto C, Brini M, Jouaville LS, Marsault R, Murgia M, Pinton P, Pozzan T, Rizzuto R (1999) Targeting GFP to organelles. Methods Cell Biol 58:75-85
  5. Brini M, Pinton P, King MP, Davidson M, Schon EA, Rizzuto R (1999) A calcium signaling defect in the pathogenesis of a mitochondrial DNA inherited oxidative phosphorylation deficiency. Nature Medicine 5:951-54
  6. Brini M, Pinton P, Pozzan T, Rizzuto R (1999) Targeted recombinant aequorins: tools for monitoring [Ca2+] in the various compartments of a living cell. Microsc Res Tech 46:380-9
  7. Jouaville LS, Pinton P, Bastianutto C, Rutter GA, Rizzuto R (1999) Regulation of mitochondrial ATP synthesis by calcium: evidence for a long-term metabolic priming. Proc Natl Acad Sci USA 96:13807-12
  8. Rizzuto R, Pinton P, Brini M, Chiesa A, Filippin L, Pozzan T (1999) Mitochondria as biosensors of calcium microdomains. Cell Calcium 26:193-9
  9. Pinton P, Ferrari D, Magalhaes P, Schulze-Osthoff K, Di Virgilio F, Pozzan T, Rizzuto R (2000) Reduced loading of intracellular Ca2+ stores and downregulation of capacitative Ca2+ influx in Bcl-2-overexpressing cells. J Cell Biol 148:857-62
  10. Robert V, Pinton P, Tosello V, Rizzuto R, Pozzan T (2000) Recombinant aequorin as tool for monitoring calcium concentration in subcellular compartments. Methods Enzymol 327:440-56
  11. Chiesa A, Rapizzi E, Tosello V, Pinton P, de Virgilio M, Fogarty KE, Rizzuto R (2001) Recombinant aequorin and green fluorescent protein as valuable tools in the study of cell signalling. Biochem J 355:1-12
  12. Porcelli AM, Pinton P, Ainscow EK, Chiesa A, Rugolo M, Rutter GA, Rizzuto R (2001) Targeting of reporter molecules to mitochondria to measure calcium, ATP, and pH. Methods Cell Biol 65:353-80
  13. Pinton P, Ferrari D, Rapizzi E, Di Virgilio FD, Pozzan T, Rizzuto R (2001) The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action. EMBO J 20:2690-701
  14. Chami M, Gozuacik D, Lagorce D, Brini M, Falson P, Peaucellier G, Pinton P, Lecoeur H, Gougeon ML, le Maire M, Rizzuto R, Brechot C, Paterlini-Brechot P (2001) SERCA1 truncated proteins unable to pump calcium reduce the endoplasmic reticulum calcium concentration and induce apoptosis. J Cell Biol 153:1301-14
  15. Mitchell KJ, Pinton P, Varadi A, Tacchetti C, Ainscow EK, Pozzan T, Rizzuto R, Rutter GA (2001) Dense core secretory vesicles revealed as a dynamic Ca2+ store in neuroendocrine cells with a vesicle-associated membrane protein aequorin chimaera. J Cell Biol 155:41-52
  16. Pinton P, Ferrari D, Di Virgilio F, Pozzan T, Rizzuto R (2001) Molecular machinery and signaling events in apoptosis. Drug Dev Res 52: 558-70
  17. Pinton P, Ferrari D, Rapizzi E, Di Virgilio F, Pozzan T, Rizzuto R (2002) A role for calcium in Bcl-2 action? Biochimie 84:195-201
  18. Piccioni F, Pinton P, Simeoni S, Pozzi P, Fascio U, Vismara G, Martini L, Rizzuto R, Poletti A (2002) Androgen receptor with elongated polyglutamine tract forms aggregates that alter axonal trafficking and mitochondrial distribution in motor neuronal processes. FASEB J 16:1418-20
  19. Pinton P, Tsuboi T, Ainscow EK, Pozzan T, Rizzuto R, Rutter GA (2002) Dynamics of Glucose-induced Membrane Recruitment of Protein Kinase C beta II in Living Pancreatic Islet beta -Cells. J Biol Chem 277:37702-10
  20. Rapizzi E, Pinton P, Szabadkai G, Wieckowski MR, Vandecasteele G, Baird G, Tuft RA, Fogarty KE, Rizzuto R (2002) Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria. J Cell Biol 159:613-24
  21. Ferrari D§, Pinton P§, Szabadkai G, Chami M, Campanella M, Pozzan T, Rizzuto R (2002) Endoplasmic reticulum, Bcl-2 and Ca2+ handling in apoptosis. Cell Calcium 32:413-20 §equally contributed
  22. Aguiari G, Campanella M, Manzati E, Pinton P, Banzi M, Moretti S, Rizzuto R, del Senno L. (2003) Expression of polycystin-1 C-terminal fragment enhances the ATP-induced Ca2+ release in human kidney cells. Biochem Biophys Res Commun 301:657-64
  23. Morelli A, Chiozzi P, Chiesa A, Ferrari D, Sanz JM, Falzoni S, Pinton P, Rizzuto R, Olson MF, Di Virgilio F (2003) Extracellular ATP causes ROCK I-dependent bleb formation in P2X7-transfected HEK293 cells. Mol Biol Cell 14:2655-6
  24. Lasorsa FM, Pinton P, Palmieri L, Fiermonte G, Rizzuto R, Palmieri F (2003) Recombinant expression of the Ca2+-sensitive aspartate/glutamate carrier increases mitochondrial ATP production in agonist-stimulated CHO cells. J Biol Chem 278:38686-92
  25. Rizzuto R, Pinton P, Ferrari D, Chami M, Szabadkai G, Magalhães PJ, Di Virgilio F, Pozzan T (2003) Calcium and apoptosis: facts and hypothesis. Oncogene 22:8619-27
  26. Campanella M, De Jong AS, Lanke KW, Melchers WJ, Willems PH, Pinton P, Rizzuto R, van Kuppeveld FJ (2004) The coxsackievirus 2B protein suppresses apoptotic host cell responses by manipulating intracellular Ca2+ homeostasis. J Biol Chem 279:18440-50
  27. Pinton P, Leo S, Wieckowski MR, Di Benedetto G, Rizzuto R (2004) Long-term modulation of mitochondrial Ca2+ signals by protein kinase C isozymes. J Cell Biol 165:223-32
  28. Pinton P, Bianchi K, Prandini A, Rimessi A, Rizzuto R (2004) Ca2+ Homeostasis of Intracellular Compartments: measurements using the jellyfish photo-protein aequorin. Minerva Biotec 16:119-26
  29. Tonachini L, Monticane M, Puri C, Tacchetti C, Pinton P, Rizzuto R, Cancedda R, Tavella S, Castagnola P (2004) Chondrocyte protein with a poly-proline region (CHPPR) is a novel mitochondrial protein and promotes mitochondrial fission. J Cell Physiol 201:470-82
  30. Chami M, Prandini A, Campanella M, Pinton P, Szabadkai G, Reed JC, Rizzuto R (2004) Bcl-2 and Bax exert opposing effects on Ca2+ signalling, which do not depend on their putative pore-forming region. J Biol Chem 279:54581-89
  31. Campanella M, Pinton P, Rizzuto R (2004) Mitochondrial Ca2+ homeostasis in health and disease. Biol Res 37:653-60
  32. Porcelli AM, Ghelli M, Zanna C, Pinton P, Rizzuto R, Rugolo M (2005) pH difference across the outer mitochondrial membrane measured with a green fluorescent protein mutant. Biochem Biophys Res Commun 326:799-804
  33. Biagioli M, Pinton P, Scudiero R, Ragghianti M, Bucci S, Rizzuto R (2005) Aequorin chimeras as valuable tool in the measurement of Ca2+ concentration during cadmium injury. Toxicology 208:389-98
  34. Manzati E, Aguiari G, Banzi M, Manzati M, Selvatici R, Falzarano S, Maestri I, Pinton P, Rizzuto R , del Senno L (2005) The cytoplasmic C-terminus of polycystin-1 increases cell proliferation in kidney epithelial cells through serum-activated and Ca2+-dependent pathway(s). Exp Cell Res 304:391-406
  35. Gallo A, Ceolotto G, Pinton P, Iori E, Murphy E, Rutter GA, Rizzuto R, Semplicini A, Avogaro A (2005) Metformin prevents glucose-induced PKC ß2 activation in Human Umbilical Vein Endothelial cells through an antioxidant mechanism. Diabetes 54:1123-31
  36. Adinolfi E, Callegari MG, Ferrari D, Bolognesi C, Minelli M, Wieckowski MR, Pinton P, Rizzuto R, Di Virgilio F (2005) Basal activation of the P2X7 ATP receptor elevates mitochondrial calcium and potential, increases cellular ATP levels and promotes serum-independent growth. Mol Biol Cell 16:3260-72
  37. Pellegatti P, Falzoni S, Pinton P, Rizzuto R, Di Virgilio F (2005) A novel recombinant plasma membrane-targeted luciferase reveals a new pathway for ATP secretion. Mol Biol Cell 16:3659-65
  38. Uccelletti D, Farina F, Pinton P, Goffrini P, Mancini P, Talora C, Rizzuto R, Palleschi C (2005) The Golgi Ca2+-ATPase KlPmr1p Function Is Required for Oxidative Stress Response by Controlling the Expression of the Heat Shock Element HSP60 in Kluyveromyces lactis. Mol Biol Cell 16:4636-47
  39. Giorgio M, Migliaccio E, Orsini F, Paolucci D, Moroni M, Contursi C, Pelliccia G, Luzi L, Minucci S, Marcaccio M, Pinton P, Rizzuto R, Bernardi P, Paolucci P, Pelicci PG (2005) Electron transfer between cytochrome c and p66shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell 122:221-33
  40. Rimessi A, Coletto L, Pinton P, Rizzuto R, Brini M, Carafoli E (2005) Inhibitory interaction of protein 14-3-3ɛ with isoform 4 of the plasma membrane Ca2+ pump. J Biol Chem 280:37195-203
  41. Pinotti M, Rizzotto L, Pinton P, Ferraresi P, Chuansumrit A, Charoenkwan P, Marchetti G, Rizzuto R, Mariani G, Bernardi F (2006) Intracellular readthrough of nonsense mutations by aminoglycosides in coagulation factor VII. Journal of Thrombosis and Haemostasis 4:1308-14
  42. Pinton P, Rizzuto R (2006) Bcl-2 and Ca2+ homeostasis in the endoplasmic reticulum. Cell Death Differ 13:1409-1418
  43. Wieckowski MR, Szabadkai G, Wasilewski M, Pinton P, Duszyński J, Rizzuto R (2006) Overexpression of adenine nucleotide translocase reduces Ca2+ signal transmission between the ER and mitochondria. Biochem Biophys Res Commun 348:393-9
  44. Banzi M, Aguiari G, Trimi V, Mangolini A, Pinton P, Witzgall R, Rizzuto R, del Senno L (2006) Polycystin-1 promotes PKCalpha-mediated NF-kappaB activation in kidney cells. Biochem Biophys Res Commun 350:257-62
  45. Rizzotto L, Pinotti M, Pinton P, Rizzuto R, Bernardi F (2006) Intracellular evaluation of ER targeting  elucidates a mild form of inherited coagulation deficiency. Molecular Medicine 12:137-42
  46. Rapizzi E, Donati C, Cencetti F, Pinton P, Rizzuto R, Bruni P (2007) Sphingosine 1-phosphate receptors modulate intracellular Ca2+ homeostasis. Biochem Biophys Res Commun 353:268-74
  47. Pinton P, Rimessi A, Marchi S, Orsini F, Migliaccio E, Giorgio M, Contursi C, Minucci S, Mantovani F, Wieckowski MR, Del Sal G, Pelicci PG, Rizzuto R (2007) Protein Kinase C ß and Prolyl isomerase 1 regulate mitochondrial effects of the lifespan determinant p66Shc. Science 315:659-63
  48. Pinton P, Rimessi A, Romagnoli A, Prandini A, Rizzuto R (2007) Biosensors for the detection of calcium and pH. Methods Cell Biol 80C:297-325
  49. Romagnoli A, Aguiari P, De Stefani D, Leo S, Marchi S, Rimessi A, Zecchini E, Pinton P, Rizzuto R. (2007) The ER/mitochondria Ca2+ crosstalk Novartis Found Symp 287:122-31
  50. Rimessi A, Rizzuto R, Pinton P (2007) Differential recruitment of PKC isoforms in HeLa cells during redox stress. Cell Stress & Chaperones 12:291-8
  51. Zecchini E, Siviero R, Giorgi C, Rizzuto R, Pinton P (2007) Mitochondrial calcium signalling: message of life and death. Ital J Biochem 56:235-42
  52. Biagioli M, Pifferi S, Ragghianti M, Bucci S, Rizzuto R, Pinton P (2008) Endoplasmic reticulum stress and alteration in calcium homeostasis are involved in cadmium-induced apoptosis. Cell Calcium 43:184-95
  53. Aguiari P, Leo, Zavan B, Vindigni V, Rimessi A, Bianchi K, Franzin C, Cortivo R, Rossato M, Vettor R, Abatangelo G, Pozzan T, Pinton P, Rizzuto R (2008) High glucose induces adipogenic differentiation of muscle-derived stem cells. Proc Natl Acad Sci USA 105:1226-31
  54. Pinton P, Rizzuto R (2008) p66Shc, oxidative stress and aging: importing a lifespan determinant into mitochondria. Cell Cycle 7:304-8
  55. Giorgi C, Romagnoli A, Pinton P, Rizzuto R (2008) Ca2+ signaling, mitochondria and cell death. Current Molecular Medicine 8:119-130
  56. Lasorsa FM§, Pinton P§, Palmieri L, Scarcia P, Rottensteiner H, Rizzuto R, Palmieri F (2008) Peroxisomes as novel players in cell calcium homeostasis. J Biol Chem 283:15300-8 §equally contributed
  57. Aguiari G, Trimi V, Bogo M, Mangolini A, Szabadkai G, Pinton P, Witzgall R, Harris PC, Borea PA, Rizzuto R, del Senno L (2008) Novel role for polycystin-1 in modulating cell proliferation through calcium oscillations in kidney cells. Cell Proliferation 41:554-573
  58. Tasdemir E, Maiuri MC, Galluzzi L, Vitale I, Djavaheri-Mergny M, D'Amelio M, Criollo A, Morselli E, Zhu C, Harper F, Nannmark U, Samara C, Pinton P, Vicencio JM, Carnuccio R, Moll UM, Madeo F, Paterlini-Brechot P, Rizzuto R, Szabadkai G, Pierron G, Blomgren K, Tavernarakis N, Codogno P, Cecconi F, Kroemer G (2008) Regulation of autophagy by cytoplasmic p53. Nat Cell Biol 10:676-687
  59. De Stefani D, Romagnoli A, Rizzuto R, Pinton P (2008) Gene silencing and mitochondrial signaling Minerva Biotec 20:89-98
  60. Pinton P, Giorgi C, Siviero R, Zecchini E, Rizzuto R (2008) Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis. Oncogene 27:6407-18
  61. Marchi S, Rimessi A, Giorgi C, Baldini C, Ferroni L, Rizzuto R, Pinton P (2008) Akt kinase reducing Endoplasmic Reticulum Ca2+ release protects cells from Ca2+-dependent apoptotic stimuli. Biochem Biophys Res Commun 375:501-5
  62. Rimessi A, Giorgi C, Pinton P*, Rizzuto R (2008) The versatility of mitochondrial calcium signals: from stimulation of cell metabolism to induction of cell death. Biochim Biophys Acta (Bioenergetics) 1777:808-16 *corresponding author
  63. Adinolfi E, Callegari MG, Cirillo M, Pinton P, Giorgi C, Cavagna D, Rizzuto R, Di Virgilio F (2009) Expression of the P2X7 receptor increases the Ca2+ content of the endoplasmic reticulum, activates NFATc1, and protects from apoptosis. J Biol Chem 284:10120-8
  64. Celsi F, Pizzo P, Brini M, Leo S, Fotino C, Pinton P, Rizzuto R (2009) Mitochondria, calcium and cell death: a deadly triad in neurodegeneration. Biochim Biophys Acta (Bioenergetics) 1787:335-44
  65. Murgia M, Giorgi C, Pinton P, Rizzuto R (2009) Controlling metabolism and cell death: at the heart of mitochondrial calcium signalling. J Mol Cell Cardiol 46:781-8
  66. Lebiedzinska M, Duszynski J, Rizzuto R, Pinton P, Wieckowski MR (2009) Age-related changes in levels of p66Shc and serine 36-phosphorylated p66Shc in organs and mouse tissues. Arch Biochem Biophys 486:73-80
  67. Rizzuto R, Marchi S, Bonora M, Aguiari P, Bononi A, De Stefani D, Giorgi C, Leo S, Rimessi A, Siviero R, Zecchini E, Pinton P (2009) Ca(2+) transfer from the ER to mitochondria: when, how and why. Biochim Biophys Acta (Bioenergetics) 1787:1342-51
  68. Giorgi C, De Stefani D, Bononi A, Rizzuto R, Pinton P (2009) Structural and functional link between the mitochondrial network and the endoplasmic reticulum. Int J Biochem Cell Biol 41:1817-27
  69. Kozieł K, Lebiedzinska M, Szabadkai G, Onopiuk M, Brutkowski W, Wierzbicka K, Wilczyński G, Pinton P, Duszyński J, Zabłocki K, Wieckowski MR (2009) Plasma membrane associated membranes (PAM) from Jurkat cells contain STIM1 protein is PAM involved in the capacitative calcium entry? Int J Biochem Cell Biol 41:2440-9
  70. Rimessi A, Marchi S, Fotino C, Romagnoli A, Huebner K, Croce CM, Pinton P, Rizzuto R (2009) Intramitochondrial calcium regulation by the FHIT gene product sensitizes to apoptosis. Proc Natl Acad Sci USA 106:12753-8
  71. Wieckowski MR, Giorgi C, Lebiedzinska M, Duszynski J, Pinton P (2009) Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells. Nat Protoc 4:1582-90
  72. Mangolini A, Bogo M, Durante C, Borgatti M, Gambari R, Harris PC, Rizzuto R, Pinton P, Aguiari G, Del Senno L (2010) NF-kappaB activation is required for apoptosis in fibrocystin/polyductin-depleted kidney epithelial cells. Apoptosis 15:94-104
  73. Ferrari D§, Pinton P§, Campanella M§, Callegari MG, Pizzirani C, Rimessi A, Di Virgilio F, Pozzan T, Rizzuto R (2010) Functional and structural alterations in the endoplasmic reticulum and mitochondria during apoptosis triggered by C(2)-ceramide and CD95/APO-1/FAS receptor stimulation. Biochem Biophys Res Commun 391:575-81 §equally contributed
  74. Pavan C, Vindigni V, Michelotto L, Rimessi A, Abatangelo A, Cortivo R, Pinton P, Zavan B (2010) Weight gain related to treatment with atypical antipsychotics is due to activation of PKCß. Pharmacogenomics J 10(5):408-17
  75. Giorgi C, Agnoletto C, Baldini C, Bononi A, Bonora M, Marchi S, Missiroli S, Patergnani S, Poletti F, Rimessi A, Zavan B, Pinton P (2010) Redox control of Protein Kinase C: cell and disease
 specific significances. Antioxid Redox Signal 13(7):1051-85
  76. Biasiotto R, Aguiari P, Rizzuto R, Pinton P, D'Agostino DM, Criminale V (2010) The p13 protein of human T-cell leukemia virus type 1 (HTLV-1) modulates mitochondrial membrane potential and calcium uptake. Biochim Biophys Acta (Bioenergetics) 1797(6-7):945-951
  77. Lebiedzinska M, Karkucinska-Wieckowska A, Giorgi C, Karczmarewicz E, Pronicka E, Pinton P, Duszynski P, Pronicki M, Wieckowski MR (2010) Oxidative stress-dependent p66Shc phosphorylation in skin fibroblasts of children with mitochondrial disorders. Biochim Biophys Acta (Bioenergetics) 1797(6-7):952-960
  78. Cortivo R, Vindigni V, Iacobellis L, Abatangelo G, Pinton P, Zavan B (2010) Nanoscale particle therapies for wound and ulcers. Nanomedicine 5(4):641-56
  79. Goitre L, Balzac F, Degani S, Degan P, Marchi S, Pinton P, Retta SF (2010) KRIT1 Regulates the Homeostasis of Intracellular Reactive Oxygen Species. PLoS One 5(7):e11786
  80. Giorgi C, Ito K, Lin H, Santangelo C, Wieckowski MR, Lebiedzinska M, Bononi A, Bonora M, Duszynski J, Bernardi R, Rizzuto R, Tacchetti C, Pinton P*, Pandolfi PP (2010) PML regulates apoptosis at endoplasmic reticulum modulating calcium release. Science 330:1247-51 *corresponding author
  81. Demaria M, Giorgi C, Lebiedzinska M, Esposito G, D'Angeli L, Bartoli A, Gough DJ, Turkson J, Levy DE, Watson CJ, Wieckowski MR, Provero P, Pinton P, Poli V (2010) STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction. Aging 2(11):823-42
  82. Bezzerri V, d'Adamo P, Rimessi A, Lanzara C, Crovella S, Nicolis E, Tamanini A, Athanasakis E, Tebon M, Bisoffi G, Drumm ML, Knowles MR, Pinton P*, Gasparini P*, Berton G*, Cabrini G* (2011) Phospholipase C-{beta}3 Is a Key Modulator of IL-8 Expression in Cystic Fibrosis Bronchial Epithelial Cells. J Immunol 186(8):4946-58 *share senior authorship
  83. Karkucinska-Wieckowska A, Lebiedzinska M, Jurkiewicz E, Pajdowska M, Trubicka J, Szymanska-Debinska T, Suski J, Pinton P, Duszynski J, Pronicki M, Wieckowski MR, Pronicka E (2011) Increased reactive oxygen species (ROS) production and low catalase level in fibroblasts of a girl with MEGDEL association (Leigh syndrome, deafness, 3-methylglutaconic aciduria). Folia Neuropathol 49(1):56-63
  84. Suski J, Lebiedzinska M, Machado NG, Oliveira PJ, Pinton P, Duszynski J,  Wieckowski MR (2011) Mitochondrial tolerance to drugs and toxic agents in ageing and disease. Current Drug Targets 12:827-849
  85. Pinton P, Giorgi C, Pandolfi PP (2011) The role of PML in the control of apoptotic cell fate: a new key player at ER-mitochondria sites. Cell Death Differ 18(9):1450-6
  86. Giorgi C, Wieckowski MR, Pandolfi PP, Pinton P (2011) Mitochondria associated membranes (MAMs) as critical hubs for apoptosis. Commun Integr Biol 4(3):334-5
  87. Pinton P, Pavan C, Zavan B (2011) PKC-β activation and pharmacologically induced weight gain during antipsychotic treatment. Pharmacogenomics 12(4):453-5
  88. Bertagnolo V, Nika E, Brugnoli F, Bonora M, Grassilli S, Pinton P, Capitani S (2011) Vav1 is a crucial molecule in monocytic/macrophagic differentiation of myeloid leukemia-derived cells. Cell Tissue Res 345(1):163-75
  89. Giorgi C, Romagnoli A, Agnoletto C, Bergamelli L, Sorrentino G, Brini M, Pozzan T, Meldolesi J, Pinton P*, Rizzuto R (2011) Translocation of signalling proteins to the plasma membrane revealed by a new bioluminescent procedure. BMC Cell Biology 12:27 *corresponding author
  90. Suski JM, Karkucinska-Wieckowska A, Lebiedzinska M, Giorgi C, Szczepanowska J, Szabadkai G, Duszynski J, Pronicki M, Pinton P, Wieckowski MR (2011) p66Shc aging protein in control of fibroblasts cell fate. Int J Mol Sci 12(8):5373-89
  91. Bononi A, Agnoletto C, De Marchi E, Marchi S, Patergnani S, Bonora M, Giorgi C, Missiroli S, Poletti F, Rimessi A, Pinton P (2011) Protein kinases and phosphatases in the control of cell fate. Enzyme Res 2011:329098
  92. Patergnani S, Suski JM, Agnoletto C, Bononi A, Bonora M, De Marchi E, Giorgi C, Marchi S, Missiroli S, Poletti F, Rimessi A, Duszynski J, Wieckowski MR, Pinton P (2011) Calcium signaling around Mitochondria Associated Membranes (MAMs). Cell Commun Signal 9(1):19
  93. Pesaresi MG, Amori I, Giorgi C, Ferri A, Fiorenzo P, Gabanella F, Salvatore AM, Giorgio M, Pelicci PG, Pinton P, Carri MT, Cozzolino M (2011) Mitochondrial redox signaling by p66Shc mediates ALS-like disease through Rac1 inactivation. Hum Mol Genet 20(21):4196-208
  94. Gardin C, Vindigni V, Bressan E, Ferroni L, Nalesso E, Della Puppa A, D’Avella D, Lops D, Pinton P, Zavan B (2011) Hyaluronan and fibrin based scaffolds for the improvement of the neuronal differentiation of  adult stem cells derived from adipose tissue and skin. Int J Mol Sci 12(10):6749-64
  95. Tombolan L, Orso F, Guzzardo V, Casara S, Zin A, Bonora M, Romualdi C, Giorgi C, Bisogno G, Alaggio R, Pinton P, De Pittà C, Taverna D, Rosolen A, Lanfranchi G (2011) High IGFBP2 expression correlates with tumor severity in pediatric rhabdomyosarcoma. Am J Pathol 179(5):2611-24
  96. De Stefani D, Bononi A, Romagnoli A, Messina A, De Pinto V, Pinton P, Rizzuto R (2012) VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria. Cell Death Differ 19:267-273
  97. Suski J, Lebiedzinska M, Bonora M, Pinton P, Duszynski J, Wieckowski MR (2012) Relation between mitochondrial membrane potential and ROS formation. Methods in Molecular Biology 810:183-205
  98. Marchi S, Giorgi C, Suski J, Agnoletto C, Bononi A, Bonora M, De Marchi E, Missiroli S, Patergnani S, Poletti F, Rimessi A, Duszynski J, Wieckowski MR, Pinton P (2012) Mitochondria-ROS crosstalk in the control of cell death and aging. J Signal Transduct 2012:329635
  99. Giorgi C, Agnoletto C, Bononi A, Bonora M, De Marchi E, Marchi S, Missiroli S, Patergnani S, Poletti F, Rimessi A, Suski JM, Wieckowski MR, Pinton P (2012) Mitochondrial calcium homeostasis as potential target for mitochondrial medicine. Mitochondrion 12:77-85
  100. Rimessi A, Zecchini E, Siviero R, Giorgi C, Leo S, Rizzuto R, Pinton P (2012) The selective inhibition of nuclear PKCζ restores the effectiveness of chemotherapeutic agents in chemoresistant cells. Cell Cycle 11(5):1040-48
  101. Bononi A, Missiroli S, Poletti F, Suski JM, Agnoletto C, Bonora M, De Marchi E, Giorgi C, Marchi S, Patergnani S, Rimessi A, Wieckowski MR, Pinton P (2012) Mitochondria-associated membranes (MAMs) as hotspot Ca2+ signalling units. Adv Exp Med Biol 740:411-38
  102. Gardin C, Bressan E, Ferroni L, Nalesso E, Vindigni V, Stellini E, Pinton P, Sivolella S, Zavan B (2012) In vitro concurrent endothelial and osteogenic commitment of adipose-derived stem cells and their genomical analyses through CGH array: novel strategies to increase the successful engraftment of a tissue engineered bone grafts. Stem Cells Dev 21(5):767-77
  103. Garcia-Cao I, Song MS*, Hobbs RM*, Laurent G*, Giorgi C*, de Boer VC, Anastasiou D, Ito K, Sasaki A, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, Pandolfi PP (2012) Systemic elevation of PTEN induces a tumor suppressive metabolic state. Cell 149:49-62 *equally contributed
  104. Anelli T, Bergamelli L, Margittai E, Rimessi A, Fagioli C, Malgaroli A, Pinton P, Ripamonti M, Rizzuto R, Sitia R (2012) Ero1α Regulates Ca2+ Fluxes at the Endoplasmic Reticulum-Mitochondria Interface (MAM). Antioxid Redox Signal 16(10):1077-87
  105. Bonora M, Patergnani S, Rimessi A, De Marchi E, Suski JM, Bononi A, Giorgi C, Marchi S, Missiroli S, Poletti F, Wieckowski MR, Pinton P (2012) ATP synthesis and storage. Purinergic Signalling 8:343–357
  106. Giorgi C, Baldassari F, Bononi A, Bonora M, De Marchi E, Marchi S, Missiroli S, Patergnani S, Rimessi A, Suski JM, Wieckowski MR, Pinton P (2012) Mitochondrial Ca2+ and apoptosis. Cell Calcium 52:36-43
  107. Retta SF, Chiarugi P, Trabalzini L, Pinton P, Belkin AM (2012) Reactive Oxygen Species: Friends and Foes of Signal Transduction. J Signal Trans 2012:534029
  108. Marchi S, Marinello M, Bononi A, Bonora M, Giorgi C, Rimessi A, Pinton P (2012) Selective modulation of subtype III IP3R by Akt regulates ER Ca2+ release and apoptosis. Cell Death Dis 3:e304
  109. Demaria M, Misale S, Giorgi C, Miano V, Campisi J, Pinton P, Poli V (2012) STAT3 can serve as a hit in the process of malignant transformation of primary cells. Cell Death Differ 19:1390–7
  110. Casadei A, Epis R, Ferroni L, Tocco I, Gardin C, Bressan E, Sivolella S, Vindigni V, Pinton P, Mucci G, Zavan B (2012) Adipose Tissue Regeneration: State Of Art. J Biomed Biotech 2012:462543
  111. Chiabrando D, Marro S, Mercurio S, Giorgi C, Petrillo S, Vinchi F, Fiorito V, Fagoonee S, Camporeale A, Turco E, Merlo GR, Silengo L, Altruda F, Pinton P, Tolosano E (2012) The mitochondrial isoform of the heme exporter FLVCR1 controls erythroid differentiation by exporting heme from mitochondria. J Clin Invest 122(12):4569-79
  112. Bressan E, Ferroni L, Gardin C, Pinton P, Stellini E, Botticelli D, Sivolella S, Zavan B (2012) Donor age-related biological properties of human dental pulp stem cells change in nanostructured scaffolds. PLoS One 7(11):e49146
  113. Suski JM, Shönfeld P, Bonora M, Pinton P, Więckowski MR (2012) Guanosine diphosphate exerts a lower effect on superoxide release from mitochondrial matrix in the brains of uncoupling protein-2 knockout mice: New evidence for a putative novel function of uncoupling proteins as superoxide anion transporters. Biochem Biophys Res Commun 428:234–238
  114. Lebiedzinska M, Karkucinska-Wieckowska A, Wojtala A, Suski JM, Szabadkai G, Wilczynski G, Wlodarczyk J, Diogo CV, Oliviera PJ, Tauber J, Jezek P, Pronicki M, Duszynski J, Pinton P, Wieckowski MR (2013) Disrupted ATP synthase activity and mitochondrial hyperpolarisation-dependent oxidative stress is associated with p66Shc phosphorylation in fibroblasts of NARP patients. Int J Biohem Cell Biol 45(1):141-50
  115. Diogo CV, Suski JM, Lebiedzinska M, Wojtala A, Duszynski J, Karkucinska-Wieckowska A, Pronicki M, Pinton P, Portincasa P, Oliveira PJ, Wieckowski MR (2013) Cardiac mitochondrial dysfunction during hyperglycaemia: the role of oxidative stress and p66Shc signalling. Int J Biochem Cell Biol 45:114–122
  116. Marchi S, Lupini L, Patergnani S, Rimessi A, Missiroli S, Bonora M, Bononi A, Corrà F, Giorgi C, De Marchi E, Poletti F, Gafà R, Lanza G, Negrini M, Rizzuto R, Pinton P (2013) Downregulation of the mitochondrial calcium uniporter by cancer-related miR-25. Current Biology 23:58-63
  117. Sorrentino G, Mioni M, Giorgi C, Pinton P, Moll U, Mantovani F, Del Sal G (2013) The prolyl-isomerase Pin1 activates the mitochondrial death program of p53. Cell Death Differ 20:198-208
  118. Zavan B, Ferroni L, Giorgi C, Calò G, Brun P, Cortivo R, Abatangelo G, Pinton P (2013) Hyaluronic acid induces activation of the κ-opioid receptor. PLoS One 8(1):e55510
  119. Bonora M, Bononi A, De Marchi E, Giorgi C, Lebiedzinska M, Marchi S, Patergnani S, Rimessi A, Suski JM, Wojtala A, Wieckowski MR, Kroemer G, Galluzzi L, Pinton P (2013) Role of the c subunit of the FO ATP synthase in mitochondrial permeability transition. Cell Cycle 12(4):674-683
  120. Marchi S, Pinton P (2013) Mitochondrial Calcium Uniporter, MiRNA and Cancer: Live and Let Die. Commun Integr Biol 6(3):e23818
  121. Piccoli C, Izzo A, Scrima R, Bonfiglio F, Manco R, Negri R, Quarato G, Cela O, Ripoli M, Prisco M, Gentile F, Calì G, Pinton P, Conti A, Nitsch L, Capitanio N (2013) Chronic Pro-oxidative State and Mitochondrial Dysfunctions are more Pronounced in Fibroblasts from Down Syndrome Foeti with Congenital Heart Defects. Hum Mol Genet 22(6):1218–32
  122. Bressan E, Carraro A, Ferroni L, Gardin C, Sbricoli L, Guazzo R, Stellini E, Roman M, Pinton P, Sivolella S, Zavan B (2013) Nanotechnology that drives stem cell commitment. Nanomedicine 8(3):469-86
  123. De Marchi E, Baldassari F, Bononi A, Wieckowski MR, Pinton P (2013) Oxidative stress in cardiovascular diseases and obesity: role of p66Shc and protein kinase C. Oxid Med Cell Longev 2013:564961
  124. Bononi A, Bonora M, Marchi S, Missiroli S, Poletti F, Giorgi C, Pandolfi PP, Pinton P (2013) Identification of PTEN at the ER and MAMs and its regulation of Ca2+ signaling and apoptosis in a protein phosphatase-dependent manner. Cell Death Differ 20:1631-43
  125. Patergnani S, Marchi S, Rimessi A, Bonora M, Giorgi C, Mehta KD, Pinton P (2013) PRKCB/protein kinase C β and the mitochondrial axis as key regulators of autophagy. Autophagy 9(9):1367-85
  126. Caliceti C, Aquila G, Pannella M, Morelli MB, Fortini C, Pinton P, Bonora M, Hrelia S, Pannuti A, Miele L, Rizzo P, Ferrari R (2013) 17beta-Estradiol Enhances Signalling Mediated by VEGF-A-Delta like ligand 4-Notch1 axis in Human Endothelial Cells. PLoS One 8(8):e71440
  127. Rimessi A, Patergnani S, Ioannidi E, Pinton P (2013) Chemoresistance and cancer-related inflammation: Two hallmarks of cancer connected by an atypical link, PKCzeta. Front Oncol 3(232):1-7
  128. Bonora M, Giorgi C, Bononi A, Marchi S, Patergnani S, Rimessi A, Rizzuto R, Pinton P (2013) Subcellular calcium measurements in mammalian cells using jellyfish photoprotein aequorin-based probes.  Nat Protoc 8(11):2105-18
  129. Rimessi A, Bonora M , Marchi S , Patergnani S , Marobbio CMT , Lasorsa FM, Pinton P (2013) Perturbed mitochondrial Ca2+ signals as causes or consequences of mitophagy induction. Autophagy 9(11):1677-86
  130. Bonon A, Mangolini A, Pinton P, Del Senno L, Aguiari G (2013) Berberine Slows Cell Growth in Autosomal Dominant Polycystic Kidney Disease Cells. Biochem Biophys Res Commun 441:668-674
  131. Hsieh YF, Liu GY, Lee YG, Yang JJ, Sandor K, Sarang Z, Bononi A, Pinton P, Tretter L, Szondy Z, Tsay GJ (2013) Transglutaminase 2 Contributes to Apoptosis Induction in Jurkat T Cells by Modulating Ca2+ Homeostasis via Cross-Linking RAP1GDS1. PLoS One 8(12):e81516
  132. Suski JM, Lebiedzinska M, Wojtala A, Duszynski J, Giorgi C, Pinton P, Wieckowski MR (2014) Isolation of plasma membrane-associated membranes from rat liver. Nat Protoc 9(2):312-322
  133. Pinton P, Kroemer G (2014) Cancer therapy: Altering mitochondrial properties. Nat Chem Biol 10:89-90
  134. Marchi S, Patergnani S, Pinton P (2014) The endoplasmic reticulum-mitochondria connection: One touch, multiple functions. Biochim Biophys Acta (Bioenergetics) 1837:461-469
  135. Marchi S, Pinton P (2014) The mitochondrial calcium uniporter complex: molecular components, structure and physiopathological implications. J Physiol 592(Pt 5):829-39
  136. Papa A, Wan L, Bonora M, Salmena L, Song MS, Hobbs RM, Lunardi A, Webster K, Ng C, Newton RH, Knoblauch N, Guarnerio J, Ito K, Turka LA, Beck AH, Pinton P, Bronson R, Wei W, Pandolfi PP (2014) Cancer-associated PTEN mutants act in a dominant negative manner to suppress PTEN protein function. Cell 157:595-610
  137. Rimessi A, Marchi S, Patergnani S, Pinton P (2014) H-Ras-driven tumoral maintenance is sustained through caveolin-1-dependent alterations in calcium signaling. Oncogene 33:2329-40
  138. Bonora M, De Marchi E, Patergnani S, Suski JM, Celsi F, Bononi A, Giorgi C, Marchi S, Rimessi A, Duszyński J, Pozzan T, Wieckowski MR, Pinton P (2014) Tumor necrosis factor-α impairs oligodendroglial differentiation through a mitochondria-dependent process. Cell Death Differ 21:1198–1208
  139. De Marchi E, Bonora M, Giorgi C, Pinton P (2014) The mitochondrial permeability transition pore is a dispensable element for mitochondrial calcium efflux. Cell Calcium 56(1):1-13
  140. Wojtala A, Bonora M, Malinska D, Pinton P, Duszynski J, Wieckowski MR (2014) Methods to Monitor ROS Production by Fluorescence Microscopy and Fluorometry. Methods Enzymol 542:243-62
  141. Patergnani S, Baldassari F, De Marchi E, Karkucinska-Wieckowska A, Wieckowski MR, Pinton P (2014) Methods to monitor and compare mitochondrial and glycolytic ATP production in cells. Methods Enzymol 542:313-32
  142. Pulido R, Baker SJ, Barata JT, Carracedo A, Cid VJ, Chin-Sang ID, Davé V, den Hertog J, Devreotes P, Eickholt BJ, Eng C, Furnari FB, Georgescu MM, Gericke A, Hopkins B, Jiang X, Lee SR, Lösche M, Malaney P, Matias-Guiu X, Molina M, Pandolfi PP, Parsons R, Pinton P, Rivas C, Rocha RM, Rodríguez MS, Ross AH, Serrano M, Stambolic V, Stiles B, Suzuki A, Tan SS, Tonks NK, Trotman LC, Wolff N, Woscholski R, Wu H, Leslie NR (2014) A Unified Nomenclature and Amino Acid Numbering for Human PTEN. Science Signaling 7(332):pe15
  143. Camporeale A, Demaria M, Monteleone E, Giorgi C, Wieckowski MR, Pinton P, Poli V (2014) STAT3 activities and energy metabolism: Dangerous liaisons. Cancers 6:1579-96
  144. Rutter GA, Pinton P (2014) Mitochondria-associated endoplasmic reticulum membranes in insulin signaling. Diabetes 63:3163–5
  145. Bonora M , Bravo-San Pedro JM, Kroemer G, Galluzzi L, Pinton P (2014) Novel insights into the mitochondrial permeability transition. Cell cycle 13(17):2666-70
  146. Marchi S, Giorgi C, Oparka M, Duszynski J, Wieckowski MR, Pinton P (2014) Oncogenic and oncosuppressive signal transduction at mitochondria-associated endoplasmic reticulum membranes (MAM). Molecular & Cellular Oncology 1(2):e956469
  147. Gibellini L, Pinti M, Boraldi F, Giorgio V, Bernardi P, Bartolomeo R, Nasi M, De Biasi S, Missiroli S, Tesei A, Pinton P, Quaglino D, Cossarizza A (2014) Silencing of mitochondrial Lon protease deeply impairs mitochondrial proteome and function in colon cancer cells. FASEB J 0892-6638/14/0028-0001:1-14
  148. Marchi S, Pinton P (2014) Molecular characterization of the dominant negative role of cancer-associated PTEN mutants: sometimes null is better. Front Oncol 4(276):1-2
  149. Marchi S, Pinton P (2014) The RED light is on! New tools for monitoring Ca2+ dynamics in the endoplasmic reticulum and mitochondria. Biochem J 464:e5-e6
  150. Bonora M, Pinton P (2014) Mitochondrial permeability transition pore and cancer: molecular mechanisms involved in cell death. Front Oncol 4(302):1-12
  151. Clauser L, Ferroni L, Gardin C, Tieghi R, Galiè M, Elia G, Piattelli A, Pinton P, Bressan E, Zavan B (2014) Selective Augmentation of Stem Cell Populations in Structural Fat Grafts for Maxillofacial Surgery. PLoS One 9(11):e110796
  152. Mangolini A, Bonon A, Volinia S, Lanza G, Gambari R, Pinton P, Russo GR, del Senno L, Dell’Atti L, Aguiari G (2014) Differential expression of microRNA501-5p affects the aggressiveness of clear cell renal carcinoma. FEBS Open Bio 4:952-965
  153. Izzo A , Manco R, Bonfiglio F , Calì G , de Cristofaro T , Patergnani S , Cicatiello R , Scrima R , Zannini M, Pinton P , Conti A, Nitsch L (2014) NRIP1/RIP140 siRNA-Mediated attenuation counteracts mitochondrial dysfunction in down syndrome. Hum Mol Genet 23(16):4406-19
  154. Marino M, Stoilova T, Giorgi C, Bachi A, Cattaneo A, Auricchio A, Pinton P, Zito E (2015) SEPN1, an endoplasmic reticulum-localized selenoprotein linked to skeletal muscle pathology, counteracts hyper-oxidation by means of redox- regulating SERCA2 pump activity. Hum Mol Genet 24(7):1843-55
  155. Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, Di Daniele N, Dixit VM, Dynlacht BD, El-Deiry WS, Fimia GM, Flavell RA, Fulda S, Garrido C, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Joseph B, Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ, Levine B, Linkerman A, Lipton SA, Lockshin RA, López-Otín C, Lugli E, Madeo F, Malorni W, Marine JC, SJ Martin, Martinou JC, Medema JP, Meier P, Melino S, Mizushima N, Moll U, Muñoz-Pinedo C, Nuñez G, Oberst A, Panaretakis T, Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H, Rabinovic GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinstein DC, Rudel T, Shi Y, Simon HU, Stockwell BR, Szabadkai G, Tait SW, Tang HL, Tavernarakis N, Tsujimoto Y, Berghe TV, Vandenabeele P, Villunger A, Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B, Melino G, Kroemer G (2015) Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ 22:58-73
  156. Morciano G, Giorgi C, Bonora M, Punzetti S, Pavasini R, Wieckowski MR, Campo G, Pinton P (2015) Molecular identity of the mitochondrial permeability transition pore and its role in ischemia-reperfusion injury. J Mol Cell Cardiol 78:142-153
  157. Patergnani S, Pinton P (2015) Mitophagy and mitochondrial balance. Methods Mol Biol 1241:181-94
  158. Lebiedzinska-Arciszewska M, Oparka M, Vega Naredo I, Karkucinska-Wieckowska A, Pinton P, Duszynski J, Wieckowski MR (2015) The interplay between p66Shc and Reactive Oxygen Species in cancer cell metabolism. Eur J Clin Invest 45:25-31
  159. Bonora M, Pinton P (2015) Shedding light on molecular mechanisms and identity of mPTP. Mitochondrion 21:11
  160. Ghezzi D, Canavese C, Kovacevic G, Zamurovic D, Barzaghi C, Giorgi C, Zorzi G, Zeviani M, Pinton P, Garavaglia B, Nardocci N (2015) A family with paroxysmal nonkinesigenic dyskinesias (PNKD): Evidence of mitochondrial dysfunction. Eur J Paediatr Neurol 19:64-68
  161. Borghi A, Rimessi A, Minghetti S, Corazza M, Pinton P, Virgili A (2015) Efficacy of magnesium chloride in the treatment of Hailey-Hailey disease: from serendipity to evidence on its effect on intracellular Ca2+ homeostasis. Int J Dermatol 54:543-8
  162. Bonora M, Wieckowski MR, Chinopoulos C, Kepp O, Kroemer G, Galluzzi L, Pinton P (2015) Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition. Oncogene 34:1475-86
  163. Fonseca AC, Moreira PI, Oliveira CR, Cardoso SM, Pinton P, Pereira CF (2015) Amyloid-Beta Disrupts Calcium and Redox Homeostasis in Brain Endothelial Cells. Mol Neurobiol 51:610-622
  164. Bononi A, Pinton P (2015) Study of PTEN subcellular localization. Methods 77-78:92-103
  165. Giorgi C, Bonora M, Missiroli S, Poletti F, Ramirez FG, Morciano G, Morganti C, Pandolfi PP, Mammano F, Pinton P (2015) Intravital imaging reveals p53-dependent cancer cell death induced by phototherapy via calcium signaling. Oncotarget 6(3):1435-45
  166. Adinolfi E , Capece M, Franceschini A, Falzoni S , Giuliani AL , Rotondo A, Sarti AC, Bonora M, Syberg S , Corigliano D , Pinton P , Jorgensen NR, Abelli L , Emionite L , Raffaghello L , Pistoia V, Di Virgilio F (2015) Accelerated tumor progression in mice lacking the ATP receptor P2X7. Cancer Research 75(4):635-44
  167. Giorgi C, Missiroli S, Patergnani S, Duszyński J, Wieckowski MR, Pinton P (2015) Mitochondria-associated Membranes (MAMs): Composition, Molecular Mechanisms and Physiopathological Implications. Antioxid Redox Signal 22(12):995-1019
  168. Ronco V, Potenza DM, Denti F, Vullo S, Gagliano G, Tognolina M, Guerra G, Pinton P, Genazzani AA, Mapelli L, Lim D, Moccia F (2015) A novel Ca2+-mediated cross-talk between endoplasmic reticulum and acidic organelles: Implications for NAADP-dependent Ca2+ signalling. Cell Calcium 57:89-100
  169. Giorgi C, Bonora M, Sorrentino G, Missiroli S, Poletti F, Suski JM, Ramirez FG, Rizzuto R, Di Virgilio F, Zito E, Pandolfi PP, Wieckowski MR, Mammano F, Del Sal G, Pinton P (2015) p53 at the endoplasmic reticulum regulates apoptosis in a Ca 2+ -dependent manner. Proc Natl Acad Sci USA 112(6):1779-84
  170. Rimessi A, Bezzerri V, Patergnani S, Marchi S, Cabrini G, Pinton P (2015) Mitochondrial Ca 2+-dependent NLRP3 activation exacerbates the Pseudomonas aeruginosa-driven inflammatory response in cystic fibrosis.  Nat Commun 6:6201
  171. Giorgi C, Bonora M, Pinton P (2015) Inside the tumor: p53 modulates calcium homeostasis. Cell Cycle 14(7):933-4
  172. Franceschini A, Capece M, Chiozzi P, Falzoni S, Sanz JM, Sarti AC, Bonora M, Pinton P, Di Virgilio F (2015) The P2X7 receptor directly interacts with the NLRP3 inflammasome scaffold protein. FASEB J 0892-6638/15/0029-0001
  173. Carelli V, Musumeci O, Caporali L, Zanna C, La Morgia C, Del Dotto V, Porcelli AM, Rugolo M, Valentino ML, Iommarini L, Maresca A, Barboni P, Carbonelli M, Trombetta C, Valente EM, Patergnani S, Giorgi C, Pinton P, Rizzo G, Tonon C, Lodi R, Avoni P, Liguori R, Baruzzi A, Toscano A, Zeviani M (2015) Syndromic parkinsonism and dementia associated with OPA1 missense mutations. Ann Neurol 78(1):21-38
  174. Bonora M, Pinton P, Ito K (2015) Mitochondrial control of hematopoietic stem cell balance and hematopoiesis. Frontiers in Biology 10(2):117-124
  175. Pulli I, Blom T, Löf C, Magnusson M, Rimessi A, Pinton P, Törnquist K (2015) A novel chimeric aequorin fused with caveolin-1 reveals a sphingosine kinase 1 -regulated Ca2+ microdomain in the caveolar compartment. Biochim Biophys Acta (Molecular Cell Research) 1853:2173-82
  176. Lambertini E, Penolazzi L , Morganti C , Lisignoli G , Zini N, Angelozzi M , Bonora M, Ferroni L, Pinton P, Zavan B , Piva R (2015) Osteogenic differentiation of human MSCs: specific occupancy of the mitochondrial DNA by NFATc1 transcription factor. Int J Biochem Cell Biol 64:212-219
  177. Venco P , Bonora M , Giorgi C , Papaleo E, Iuso A, Prokisch H, Pinton P, Tiranti V (2015) Mutations of C19orf12, coding for a transmembrane glycine 1 zipper containing mitochondrial protein, cause mis-localization of the protein, inability to respond to oxidative stress and increased mitochondrial Ca2+. Front Genet 6:185
  178. Yang H, Pellegrini L, Napolitano A, Giorgi C, Jube S, Preti A, Jennings C, Marchis F, Flores E, Larson D, Pagano I, Tanji M, Power A, Kanodia S, Gaudino G, Pastorino S, Pass H, Pinton P, Bianchi M, Carbone M (2015) Aspirin Delays Mesothelioma Growth By Inhibiting HMGB1-Mediated Tumor Progression. Cell Death Dis 6:e1786
  179. Bonora M , Giorgi C , Pinton P (2015) Novel frontiers in calcium signaling: a possible target for chemotherapy. Pharmacol Res 99:82-85
  180. Rimessi A, Patergnani S, Bonora M, Wieckowski MR, Pinton P (2015) Mitochondrial Ca2+ remodeling is a prime factor in oncogenic behavior. Front Oncol 5:143
  181. Malfacini D, Ambrosio C, Grò MC, Sbraccia M, Trapella C, Guerrini R, Bonora M, Pinton P, Costa T, Calò G (2015) Pharmacological profile of nociceptin/orphanin FQ receptors interacting with G-proteins and β-arrestins 2. PLoS One 10(8):e0132865
  182. Patergnani S, Giorgi C, Maniero S, Missiroli S, Maniscalco P, Bononi I, Martini F, Cavallesco G, Tognon M, Pinton P (2015) The endoplasmic reticulum mitochondrial calcium cross talk is downregulated in malignant pleural mesothelioma cells and plays a critical role in apoptosis inhibition. Oncotarget 6(27):23427-49
  183. Marchi S, Corricelli M, Trapani E, Bravi L , Pittaro A, Delle Monache S, Ferroni L, Patergnani S, Missiroli S, Goitre L, Trabalzini L, Rimessi A, Giorgi C, Zavan B, Cassoni P, Dejana E , Retta SF, Pinton P (2015) Defective autophagy is a key feature of cerebral cavernous malformations. EMBO Mol Med 7(11):1403-17
  184. Morciano G, Giorgi C, Balestra D, Marchi S, Perrone D, Pinotti M, Pinton P (2016) Mcl-1 involvement in mitochondrial dynamics is associated with apoptotic cell death. Mol Biol Cell 27(1):20-34
  185. Missiroli S, Morganti C, Giorgi C, Pinton P (2016) Methods to Study PTEN in Mitochondria and Endoplasmic Reticulum. Methods in Molecular Biology 1388:187-212
  186. 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  190. Marchi S, Trapani E, Corricelli M, Goitre L, Pinton P*, Retta SF (2016) Beyond Multiple Mechanisms and Unique Drugs: Defective Autophagy as Pivotal Player in Cerebral Cavernous Malformation Pathogenesis and Implications for Targeted Therapies. Rare Dis 4(1):e1142640 *corresponding author
  191. Giorgi C, Bonora M, Missiroli S, Morganti C, Morciano G, Wieckowski MR, Pinton P (2016) Alterations in mitochondrial and endoplasmic reticulum signaling by p53 mutants. Front Oncol 6:42
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  194. Torrano V, Valcarcel-Jimenez L, Cortazar AR, Liu X, Urosevic J, Castillo-Martin M, Fernández-Ruiz S, Morciano G, Caro-Maldonado A, Guiu M, Zúñiga-García P, Graupera M, Bellmunt A, Pandya P, Lorente M, Martín-Martín N, David Sutherland J, Sanchez-Mosquera P, Bozal-Basterra L, Zabala-Letona A, Arruabarrena-Aristorena A, Berenguer A, Embade N, Ugalde-Olano A, Lacasa-Viscasillas I, Loizaga-Iriarte A, Unda-Urzaiz M, Schultz N, Aransay AM, Sanz-Moreno V, Barrio R, Velasco G, Pinton P, Cordon-Cardo C, Locasale JW, Gomis RR, Carracedo A (2016) The metabolic co-regulator PGC1α suppresses prostate cancer metastasis. Nat Cell Biol 18(6):645-58
  195. Salaro E, Rambaldi A, Falzoni S, Amoroso FS, Franceschini A, Sarti AC, Bonora M, Cavazzini F, Rigolin GM, Ciccone M, Audrito V, Deaglio S, Pelegrin P, Pinton P, Cuneo A, Di Virgilio F (2016) Involvement of the P2X7-NLRP3 axis in leukemic cell proliferation and death. Sci Rep 6:26280
  196. Di Virgilio F, Pinton P, Falzoni S (2016) Assessing Extracellular ATP as Danger Signal In Vivo: The pmeLuc System. Methods Mol Biol 1417:115-29
  197. Morciano G, Pedriali G, Sbano L, Iannitti T, Giorgi C, Pinton P (2016) Intersection of mitochondrial fission and fusion machinery with apoptotic pathways: role of Mcl-1. Biol Cell 108:279-293
  198. Prandini P, De Logu F, Fusi C, Provezza L, Nassini R, Montagner G, Materazzi S, Munari S, Gilioli E, Bezzerri V, Finotti A, Lampronti I, Tamanini A, Dechecchi M, Lippi G, Ribeiro CM, Rimessi A, Pinton P, Gambari R, Geppetti P, Cabrini G (2016) Transient Receptor Potential Ankyrin 1 Channels Modulate Inflammatory Response in Respiratory Cells from Patients with Cystic Fibrosis. Am J Respir Cell Mol Biol 55(5):645-656
  199. De Stephanis L, Bonon A, Varani K, Lanza G, Gafà R, Pinton P, Pema M, Somlo S, Boletta A, Aguiari G (2017) Double inhibition of cAMP and mTOR signalling may potentiate the reduction of cell growth in ADPKD cells. Clin Exp Nephrol 21:203-211
  200. Campo G, Morciano G, Pavasini R, Bonora M, Sbano L, Biscaglia S, Bovolenta M, Pinotti M, Punzetti S, Rizzo P, Aquila G, Giorgi C, Ferrari R, Pinton P (2016) Fo ATP synthase C subunit serum levels in patients with ST-segment Elevation Myocardial Infarction: preliminary findings. Int J Cardiol 221:993-7
  201. Missiroli S, Bonora M, Patergnani S, Poletti F, Perrone M, Gafà R, Magri E, Raimondi A, Lanza G, Tacchetti C, Kroemer G, Pandolfi PP, Pinton P, Giorgi C (2016) PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development. Cell Rep 16(9):2415-27
  202. Rimessi A, Previati M, Nigro F, Wieckowski MR, Pinton P (2016) Mitochondrial Reactive Oxygen Species and inflammation: molecular mechanisms, diseases and promising therapies. Int J Biochem Cell Biol 81:281-293
  203. Di Virgilio F, Pinton P (2016) Editorial overview: Cancer. Current Opinion in Pharmacology 29:v-vii
  204. Del Prete D, Suski JM, Oulès B, Debayle D, Gay AS, Lacas-Gervais S, Bussiere R, Bauer C, Pinton P, Paterlini-Bréchot P, Wieckowski MR, Checler F, Chami M (2017) Localization and Processing of the Amyloid- Protein Precursor in Mitochondria-Associated Membranes. J Alzheimers Dis 55:1549-70
  205. Patergnani S , Fossati V, Bonora M, Giorgi C, Marchi S , Missiroli S, Rusielewicz T, Wieckowski MR, Pinton P (2017) Mitochondria in multiple sclerosis: molecular mechanisms of pathogenesis. Int Rev Cell Mol Biol 328:49-103
  206. Sbano L, Bonora M , Marchi S , Baldassari F , Medina DL, Ballabio A , Giorgi C, Pinton P (2017) TFEB-mediated increase in peripheral lysosomes regulates store-operated calcium entry. Sci Rep 7:40797
  207. Missiroli S, Danese A, Iannitti T, Patergnani S, Perrone M, Previati M, Giorgi C, Pinton P (2017) Endoplasmic reticulum-mitochondria Ca2+ crosstalk in the control of the tumor cell fate. Biochim Biophys Acta (Molecular Cell Research) 1864:858-864
  208. Izzo A, Nitti M , Mollo N , Paladino S , Procaccini C , Faicchia D , Cal G , Genesio R , Bonfiglio F, Cicatiello R , Polishchuk E, Polishchuk R , Pinton P , Matarese G , Conti A, Nitsch L (2017) Metformin restores the mitochondrial network and reverses mitochondrial dysfunction in Down syndrome cells. Hum Mol Genet 26(6):1056-1069
  209. Danese A, Patergnani S, Bonora M , Wieckowski MR, Previati M , Giorgi C, Pinton P (2017) Calcium regulates cell death in cancer: roles of the mitochondria and mitochondria-associated membranes (MAMs). Biochim Biophys Acta (Bioenergetics) 1858:615-627
  210. Rimessi A, Pavan C, Ioannidi E, Nigro F, Morganti C, Brugnoli A, Longo F, Gardin C, Ferroni L, Morari M, Vindigni V, Zavan B, Pinton P (2017) Protein kinase C β: a new target therapy to prevent the long-term atypical antipsychotics-induced weight-gain. Neuropsychopharmacology 42(7):1491-1501
  211. Yoboue ED , Rimessi A , Anelli T, Pinton P, Sitia R (2017) Regulation of calcium fluxes by GPX8, a type-II transmembrane peroxidase enriched at the mitochondria-associated endoplasmic reticulum membrane. Antioxid Redox Signal 27(9):583-595
  212. Marchi S, Bonora M, Patergnani S, Giorgi C, Pinton P (2017) Methods to Assess Mitochondrial Morphology in Mammalian Cells Mounting Autophagic or Mitophagic Responses. Methods Enzymol 588:171-186
  213. Straudi S, Manfredini F, Lamberti N, Zamboni P, Bernardi F, Marchetti G, Pinton P, Bonora M, Secchiero P, Tisato V, Volpato S, Basaglia N (2017) The effectiveness of Robot-Assisted Gait Training versus conventional therapy on mobility in severely disabled progressIve MultiplE sclerosis patients (RAGTIME): study protocol for a randomized controlled trial. Trials 18:88
  214. Szymiczek A, Pastorino S, Larson D, Tanji M, Pellegrini L, Xue J, Li S, Giorgi C, Pinton P, Takinishi Y, Pass HI, Furuya H, Gaudino G, Napolitano A, Carbone M, Yang H (2017) FTY720 inhibits mesothelioma growth in vitro and in a syngeneic mouse model. J Transl Med 15:58
  215. Morciano G , Bonora M , Giorgi C, Pinton P (2017) Other bricks for the correct construction of the mitochondrial permeability transition pore complex. Cell Death Dis 8:e2698
  216. Profilo E, Peña-Altamira LE, Corricelli M, Castegna A, Danese A, Agrimi G, Petralla S, Giannuzzi G, Porcelli V, Sbano L, Viscomi C, Massenzio F, Palmieri EM, Giorgi C, Fiermonte G, Virgili M, Palmieri L, Zeviani M, Pinton P, Monti B, Palmieri F, Lasorsa FM (2017) Down-regulation of the mitochondrial aspartate-glutamate carrier isoform 1 AGC1 inhibits proliferation and N-acetylaspartate synthesis in Neuro2A cells. Biochim Biophys Acta (Molecular Basis of Disease) 1863:1422-35
  217. Morciano G, Bonora M, Campo G, Aquila G, Rizzo P, Giorgi C, Wieckowski MR, Pinton P (2017) Mechanistic Role of mPTP in Ischemia-Reperfusion Injury. Adv Exp Med Biol 982:169-189
  218. Donato V, Bonora M, Simoneschi D, Sartini D, Kudo Y, Saraf A, Florens L, Washburn MP, Stadtfeld M, Pinton P, Pagano M (2017) The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells. Nat Cell Biol 19:341-351
  219. Morciano G, Sarti A, Marchi S, Missiroli S, Falzoni S, Raffaghello L, Pistoia V, Giorgi C, Di Virgilio F, Pinton P (2017) Using luciferase probes to measure ATP in living cells and animals. Nat Protoc 12(8):1542-62
  220. Lampronti I, Dechecchi MC, Rimessi A, Bezzerri V, Nicolis E, Guerrini A, Tacchini M, Tamanini A, Munari S, D'Aversa E, Santangelo A, Lippi G, Sacchetti G, Pinton P, Gambari R, Agostini M, Cabrini G (2017) β-sitosterol reduces the expression of chemotactic cytokine genes in cystic fibrosis bronchial epithelial cells. Front Pharmacol 8:236
  221. Canazza I, Ossato A, Vincenzi F, Gregori A, Di Rosa F, Nigro F, Rimessi A, Pinton P, Varani K, Borea P, Marti M (2017) Pharmaco-toxicological effects of the novel third-generation fluorinate synthetic cannabinoids, 5F-ADBINACA, AB-FUBINACA and STS-135 in mice. In vitro and in vivo studies. Hum Psychopharmacol 32(3):e2601
  222. Pinton P (2017) A mitochondrial drug to treat AML. Blood 129(19):2597-99
  223. Caldieri G, Barbieri E, Nappo G, Raimondi A, Bonora M, Conte A, Verhoef LGGC, Confalonieri S, Malabarba MG, Bianchi F, Cuomo A, Bonaldi T, Martini E, Mazza D, Pinton P, Tacchetti C, Polo S, Di Fiore PP, Sigismund S (2017) Reticulon 3–dependent ER-PM contact sites control EGFR nonclathrin endocytosis. Science 356:617-624
  224. Bonora M, Morganti C, Morciano G, Pedriali G, Lebiedzinska-Arciszewska M, Aquila G, Giorgi C, Rizzo P, Campo G, Ferrari R, Kroemer G,Wieckowski MR, Galluzzi L, Pinton P (2017) Mitochondrial permeability transition involves dissociation of F1FO ATP synthase dimers and C-ring conformation. EMBO Reports 18(7):1077-89
  225. Marchi S, Bittremieux M, Missiroli S, Morganti C, Patergnani S, Sbano L, Rimessi A, Kerkhofs M, Parys JB, Bultynck G, Giorgi C, Pinton P (2017) Endoplasmic Reticulum-Mitochondria Communication Through Ca2+ Signaling: The Importance of Mitochondria-Associated Membranes (MAMs). Adv Exp Med Biol 997:49-67
  226. Kerkhofs M, Giorgi C, Marchi S, Seitaj B, Parys JB, Pinton P, Bultynck G, Bittremieux M (2017) Alterations in Ca2+ Signalling via ER-Mitochondria Contact Site Remodelling in Cancer. Adv Exp Med Biol 997:225-254
  227. Campo G, Pavasini R, Morciano G, Lincoff AM, Gibson CM, Kitakaze M, Lonborg J, Ahluwalia A, Ishii H, Frenneaux M, Ovize M, Galvani M, Atar D, Ibanez B, Cerisano G, Biscaglia S, Neil BJ, Asakura M, Engstrom T, Jones DA, Dawson D, Ferrari R, Pinton P, Ottani F (2017) Clinical Benefit of Drugs Targeting Mitochondrial Function as an Adjunct to Reperfusion in ST-segment Elevation Myocardial Infarction: a Meta-Analysis of Randomized Clinical Trials. Int J Cardiol 244:59-66
  228. Bononi A, Giorgi C, Patergnani S, Larson D, Verbruggen K, Tanji M, Pellegrini L, Signorato V, Olivetto F, Pastorino S, Nasu M, Napolitano A, Gaudino G, Morris P, Sakamoto G, Ferris LK, Danese A, Raimondi A, Tacchetti C, Kuchay S, Pass HI, Affar EB, Yang H, Pinton P*, Carbone M (2017) BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation. Nature 546:549-553 *corresponding author
  229. Kuchay S, Giorgi C, Simoneschi D, Pagan J, Missiroli S, Saraf A, Florens L, Washburn MP, Collazo-Lorduy A, Castillo-Martin M, Cordon-Cardo C, Sebti SM, Pinton P*, Pagano M (2017) PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth. Nature 546:554-558 *corresponding author
  230. Bononi A, Yang H, Giorgi C, Patergnani S, Pellegrini L, Su M, Xie G, Signorato V, Pastorino S, Morris P, Sakamoto G, Kuchay S, Gaudino G, Pass HI, Napolitano A, Pinton P*, Jia W, Carbone M (2017) Germline BAP1 mutations induce a Warburg effect. Cell Death Differ 24:1694-1704 *corresponding author
  231. Szymanski J, Janikiewicz J, Michalska B, Patalas-Krawczyk P, Perrone M, Ziółkowski W, Duszynski J, Pinton P, Dobrzyn A, Wieckowski MR (2017) Interaction of mitochondria with the endoplasmic reticulum and plasma membrane in calcium homeostasis, lipid trafficking and mitochondrial structure. Int J Mol Sci 18:1576
  232. Campo G, Pavasini R, Morciano G, Lincoff AM, Gibson CM, Kitakaze M, Lonborg J, Ahluwalia A, Ishii H, Frenneaux M, Ovize M, Galvani M, Atar D, Ibanez B, Cerisano G, Biscaglia S, Neil BJ, Asakura M, Engstrom T, Jones DA, Dawson D, Ferrari R, Pinton P, Ottani F (2017) The role of cyclosporine, nicorandil, metoprolol and follow-up length on reperfusion related outcomes in ST elevation myocardial infarction treated with percutaneous coronary intervention: Sub-group analyses. Data in Brief 14:197-205
  233. Pedriali G, Rimessi A, Sbano L, Giorgi C, Wieckowski MR, Previati M, Pinton P (2017) Regulation of ER-mitochondria Ca2+ transfer and its importance for anti-cancer therapies. Front Oncol 7:180
  234. Civiero L, Cogo S, Kiekens A, Morganti C, Tessari I, Lobbestael E, Baekelandt V, Taymans J-M, Chartier-Harlin M-C, Franchin C, Arrigoni G, Lewis PA, Piccoli G, Bubacco L, Cookson MR, Pinton P, Greggio E (2017) PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2. Front Mol Neurosci 10:417
  235. Patergnani S , Castellazzi M , Bonora M , Marchi S , Casetta I, Pugliatti M , Giorgi C , Granieri E, Pinton P (2018) Autophagy and mitophagy elements are increased in body fluids of Multiple Sclerosis-affected individuals. J Neurol Neurosurg Psychiatry 89(4):439-441
  236. Marchi S, Patergnani S, Missiroli S, Morciano G, Rimessi A, Wieckowski MR, Giorgi C, Pinton P (2018) Mitochondrial and Endoplasmic Reticulum Calcium Homeostasis and Cell Death. Cell Calcium 69:62-72
  237. Simões ICM , Fontes A , Pinton P , Zischka H , Wieckowski MR (2018) Mitochondria in non-alcoholic fatty liver disease. Int J Biochem Cell Biol 95:93-99
  238. de Stephanis L, Mangolini A, Servello M, Harris PC, Dell'Atti L, Pinton P, Aguiari G (2018) MicroRNA501-5p induces p53 proteasome degradation through the activation of the mTOR/MDM2 pathway in ADPKD cells. J Cell Physiol 233(9):6911-6924
  239. Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK-M, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D’Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin K-M, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine J-C, Martin SJ, Martinou J-C, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon H-U, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G (2018) Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Diff 25:486–541
  240. Cardenas C, Pinton P, Bultynck G (2018) Editorial: Inter-Organelle Calcium Communication in Cancer. Front Oncol 8:14
  241. Gattazzo F, De Maria C, Rimessi A, Donà S, Braghetta P, Pinton P, Vozzi G, Bonaldo P (2018) Gelatin–genipin-based biomaterials for skeletal muscle tissue engineering. J Biomed Mater Res B Appl Biomater 106B(8):2763-77
  242. Tozzi A, Tantucci M, Marchi S, Mazzocchetti P, Morari M, Pinton P, Mancini A, Calabresi P (2018) Dopamine D2 receptor-mediated neuroprotection in a G2019S Lrrk2 genetic model of Parkinson’s disease. Cell Death Dis 9:204
  243. Kerkhofs M, Bittremieux M, Morciano G, Giorgi C, Pinton P, Parys JB, Bultynck G (2018) Emerging molecular mechanisms in chemotherapy: Ca2+ signaling at the mitochondria-associated endoplasmic reticulum membranes. Cell Death Dis 9:334
  244. Vezzali F, Grassilli S, Lambertini E, Brugnoli F, Patergnani S, Nika E, Piva R, Pinton P, Capitani S, Bertagnolo V (2018) Vav1 is necessary for PU.1 mediated upmodulation of miR-29b in acute myeloid leukaemia-derived cells. J Cell Mol Med 22:3149-58
  245. Pinton P (2018) Mitochondria-associated membranes (MAMs) and pathologies. Cell Death Dis 9:413
  246. Giorgi C, Marchi S, Simoes ICM, Ren Z, Morciano G, Perrone M, Patalas-Krawczyk P, Borchard S, Jędrak P, Pierzynowska K, Szymański J, Wang DQ, Portincasa P, Węgrzyn G, Zischka H, Dobrzyn P, Bonora M, Duszynski J, Rimessi A, Karkucinska-Wieckowska A, Dobrzyn A, Szabadkai G, Zavand B, Oliveira PJ, Sardao VA, Pinton P*, Wieckowski MR (2018) Mitochondria and reactive oxygen species in aging and age related diseases. Int Rev Cell Mol Biol 340:209-344 *share senior authorship
  247. Morciano G, Marchi S, Morganti C, Sbano L, Bittremieux M, Kerkhofs M, Corricelli M, Danese A, Karkucinska-Wieckowska A, Wieckowski MR, Bultynck G, Giorgi C, Pinton P (2018) Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific Settings. Neoplasia 20(5):510-523
  248. Wieckowski MR, Danese A, Morciano G, Pronicki M, Duszynski J, Pinton P, Karkucinska-Wieckowska A (2018) Recovering mitochondrial function in patients’ fibroblasts. Mitochondrial Biology and Experimental Therapeutics 359-378
  249. Morganti C, Bonora M, Sbano L, Morciano G, Aquila G, Campo G, Wieckowski MR, Giorgi C, Pinton P (2018) The Mitochondrial Permeability Transition Pore. Mitochondrial Biology and Experimental Therapeutics 47-73
  250. Rimessi A, Bezzerri V, Salvatori F, Tamanini A, Nigro F, Dechecchi MC, Santangelo A, Prandini P, Munari S, Provezza L, Garreau de Loubresse N, Muller J, Ribeiro CMP, Lippi G, Gambari R, Pinton P*, Cabrini G (2018) PLCB3 loss-of-function reduces P. aeruginosa-dependent IL-8 release in cystic fibrosis. Am J Respir Cell Mol Biol 59(4):428-436 *share senior authorship
  251. Giorgi C, Danese A, Missiroli S, Patergnani S, Pinton P (2018) Calcium dynamics as a machine for decoding signals. Trends Cell Biol 28(4):258-273
  252. Aquila G, Morelli MB, Vieceli Dalla Sega F, Fortini F, Nigro P, Caliceti C, Ferracin M, Negrini M, Pannuti A, Bonora M, Pinton P, Ferrari R, Rizzo P (2018) Heart rate reduction with ivabradine in the early phase of atherosclerosis is protective in the endothelium of ApoE-deficient mice. J Physiol Pharmacol 69(1):35-52
  253. Pignani S, Todaro A, Ferrarese M, Marchi S, Lombardi S, Balestra D, Pinton P, Bernardi F, Pinotti M, Branchini A (2018) The chaperone-like sodium phenylbutyrate improves factor IX intracellular trafficking and activity impaired by the frequent p.R294Q mutation. J Thromb Haemost 16:1-9
  254. Gibellini L, Losi L, De Biasi S, Nasi M, Lo Tartaro D, Pecorini S, Patergnani S, Pinton P, De Gaetano A, Carnevale G, Pisciotta A, Mariani F, Roncucci L, Iannone A, Cossarizza A, Pinti M (2018) LonP1 Differently Modulates Mitochondrial Function and Bioenergetics of Primary Versus Metastatic Colon Cancer Cells. Front Oncol 8:254
  255. Morciano G, Preti D, Pedriali G, Aquila G, Missiroli S, Fantinati A, Caroccia N, Pacifico S, Bonora M, Talarico A, Morganti C, Rizzo P, Ferrari R, Wieckowski MR, Campo G, Giorgi C, Trapella C, Pinton P (2018) Discovery of novel 1,3,8-triazaspiro[4.5]decane derivatives that target the c subunit of F1/FO-adenosine triphosphate (ATP) synthase for the treatment of reperfusion damage in myocardial infarction. J Med Chem 61:7131-43
  256. Carbone M, Amelio I, Affar EB, Brugarolas J, Cannon-Albright LA, Cantley LC, Cavenee WK, Chen Z, Croce CM, D’Andrea A, Gandara D, Giorgi C, Jia W, Lan Q, Mak TW, Manley JL, Mikoshiba K, Onuchic JN, Pass HI, Pinton P, Prives C, Rothman N, Sebti SM, Turkson J, Wu X, Yang H, Yu H, Melino G (2018) Consensus report of the 8 and 9th Weinman Symposia on Gene X Environment Interaction in carcinogenesis: novel opportunities for precision medicine. Cell Death Diff 25(11):1885-1904
  257. Angebault C, Fauconnier J, Patergnani S, Rieusset J, Danese A, Affortit CA, Jagodzinska J, Mégy C, Quiles M, Cazevieille C, Korchagina J, Bonnet-Wersinger D, Milea D, Hamel C, Pinton P, Thiry M, Lacampagne A, Delprat B, Delettre C (2018) ER-mitochondria crosstalk is regulated by the Ca2+ sensor NCS1 and is impaired in Wolfram syndrome. Sci Signal 11:eaaq1380
  258. Valladares D, Utreras-Mendoza Y, Campos C, Morales C, Diaz-Vegas A, Contreras-Ferrat A, Westermeier F, Jaimovich E, Marchi S, Pinton P, Lavandero S (2018) IP3 receptor blockade restores autophagy and mitochondrial function in skeletal muscle fibers of dystrophic mice. Biochim Biophys Acta (Molecular Basis of Disease) 1864:3685-95
  259. Bonora M, Pinton P (2018) Mitochondrial DNA keeps you young. Cell Death Dis 9:992
  260. Bonora M, Wieckowski MR, Sinclair DA, Kroemer G, Pinton P*, Galluzzi L (2018) Targeting mitochondria for cardiovascular disorders: therapeutic potential and persisting obstacles. Nat Rev Cardiol 16(1):33-55 *corresponding author
  261. Giorgi C, Marchi S, Pinton P (2018) The machineries, regulation and cellular functions of mitochondrial calcium. Nat Rev Mol Cell Biol 19(11):713-730
  262. Kuchay S, Saeed M, Giorgi C, Li J, Hoffmann HH, Pinton P, Rice CM, Pagano M (2018) NS5A Promotes Constitutive Degradation of IP3R3 to Counteract Apoptosis Induced by Hepatitis C Virus. Cell Rep 25(4):833-840.e3
  263. Bonora M, Ito K, Morganti C, Pinton P, Ito K (2018) Membrane-potential compensation reveals mitochondrial volume expansion during HSC commitment. Exp Hematol 68:30-37
  264. D’Eletto M, Rossin F, Occhigrossi L, Farrace MG, Faccenda D, Desai R, Marchi S, Refolo G, Falasca L, Antonioli M, Ciccosanti F, Fimia GM, Pinton P, Campanella M, Piacentini M (2018) Transglutaminase Type 2 Regulates ER-Mitochondria Contact Sites by Interacting with GRP75. Cell Rep 25:3573-81
  265. Avalle L, Camporeale A, Morciano G, Caroccia N, Ghetti E, Orecchia V, Viavattene D, Giorgi C, Pinton P *, Poli V (2019) STAT3 localizes to the ER, acting as a gatekeeper for ER-mitochondrion Ca2+ fluxes and apoptotic responses. Cell Death Differ 26(5):932-942 *corresponding author
  266. Pozzer D, Varone E, Chernorudskiy A, Schiarea S, Missiroli S, Giorgi C, Pinton P, Canato M, Germinario E, Nogara L, Blaauw B, Zito E (2019) A maladaptive ER stress response triggers dysfunction in highly active muscles of mice with SELENON loss. Redox Biology 20:354-366
  267. Marchi S, Corricelli M, Branchini A, Vitto VAM, Missiroli S, Morciano G, Perrone M, Ferrarese M, Giorgi C, Pinotti M, Galluzzi L, Kroemer G, Pinton P (2019) Akt-mediated phosphorylation of MICU1 regulates mitochondrial Ca2+ levels and tumor growth. EMBO J 38(2):e99435
  268. Bittremieux M, La Rovere RM, Akl H, Martines C, Welkenhuyzen K, Dubron K, Baes M, Janssens A, Vandenberghe P, Laurenti L, Rietdorf K, Morciano G, Pinton P, Mikoshiba K, Bootman MD, Efremov DG, De Smedt H, Parys JB, Bultynck G (2019) Constitutive IP3 signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP3 receptor disruptor BIRD-2. Cell Death Differ 26:531–547
  269. Marchi S, Vitto VAM, Patergnani S, Pinton P (2019) High mitochondrial Ca2+ content increases cancer cell proliferation upon inhibition of mitochondrial permeability transition pore (mPTP). Cell Cycle 18(8):914-916
  270. Tarocco A, Caroccia N, Morciano G, Wieckowski MR, Ancora G, Garani G, Pinton P (2019) Melatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn care. Cell Death Dis 10(4):317
  271. Marchi S, Vitto VAM, Danese A, Wieckowski MR, Giorgi C, Pinton P (2019) Mitochondrial calcium uniporter complex modulation in cancerogenesis. Cell Cycle 18(10):1068-1083
  272. Bonora M, Pinton P (2019) A New Current for the Mitochondrial Permeability Transition. Trends Biochem Sci 44(7):559-561
  273. Mollo N, Nitti M, Zerillo L, Faicchia D, Micicllo T, Accarino R, Secondo A, Petrozziello T, Calì G, Cicatiello R, Bonfiglio F, Sarnataro V, Genesio R, Izzo A, Pinton P, Matarese G, Paladino S, Conti A, Nitsch L (2019) Pioglitazone Improves Mitochondrial Organization and Bioenergetics in Down Syndrome Cells. Front Genet 10:606
  274. Castellazzi M, Patergnani S, Donadio M, Giorgi C, Bonora M, Fainardi E, Casetta I, Granieri E, Pugliatti M, Pinton P (2019) Correlation between auto-/mitophagic processes and magnetic resonance imaging activity in multiple sclerosis patients. J Neuroinflammation 16:131
  275. Ferroni L, Gardin C, Dalla Paola L, Campo G, Cimaglia P, Bellin G, Pinton P, Zavan B (2019) Characterization of Dermal Stem Cells of Diabetic Patients. Cells 8(7):e729
  276. De Biasi S, Simone AM, Bianchini E, Tartaro DL, Pecorini S, Nasi M, Patergnani S, Carnevale G, Gibellini L, Ferraro D, Vitetta F, Pinton P, Sola P, Cossarizza A, Pinti M (2019) Mitochondrial functionality and metabolism in T cells from progressive multiple sclerosis patients. Eur J Immunol 49(12):2204-2221
  277. Shankaraiah RC, Callegari E, Guerriero P, Rimessi A, Pinton P, Gramantieri L, Silini EM, Sabbioni S, Negrini M (2019) Metformin prevents liver tumourigenesis by attenuating fibrosis in a transgenic mouse model of hepatocellular carcinoma. Oncogene 38(45):7035-7045
  278. Petralla S, Peña-Altamira LE, Poeta E, Massenzio F, Virgili M, Barile SN, Sbano L, Profilo E, Corricelli M, Danese A, Giorgi C, Ostan R, Capri M, Pinton P, Palmieri F, Lasorsa FM, Monti B (2019) Deficiency of Mitochondrial Aspartate-Glutamate Carrier 1 Leads to Oligodendrocyte Precursor Cell Proliferation Defects Both In Vitro and In Vivo. Int J Mol Sci 20(18):E4486
  279. Vieceli Dalla Sega F, Mastrocola R, Aquila G, Fortini F, Fornelli C, Zotta A, Cento AS, Perrelli A, Boda E, Pannuti A, Marchi S, Pinton P, Ferrari R, Rizzo P, Retta SF (2019) KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction. Int J Mol Sci 20(19) pii: E4930
  280. Castellazzi M, Patergnani S, Donadio M, Giorgi C, Bonora M, Bosi C, Brombo G, Pugliatti M, Seripa D, Zuliani G, Pinton P (2019) Autophagy and mitophagy biomarkers are reduced in sera of patients with Alzheimer’s disease and mild cognitive impairment. Sci Rep 9(1):20009
  281. Lombardi S, Ferrarese M, Marchi S, Pinton P, Pinotti M, Bernardi F, Branchini A (2020) Translational readthrough of GLA nonsense mutations suggests dominant-negative effects exerted by the interaction of wild-type and missense variants. RNA Biol 17(2):254-263
  282. Morciano G, Imamura H, Patergnani S, Pedriali G, Giorgi C, Pinton P (2020) Measurement of ATP concentrations in mitochondria of living cells using luminescence and fluorescence approaches. Methods in Cell Biology 155:199-219
  283. Bestetti S, Gallia M, Sorrentino I, Pinton P, Rimessi A, Sitia R, Medraño-Fernandez I (2020) Human aquaporin-11 guarantees efficient transport of H2O2 across the endoplasmic reticulum membrane. Redox Biology 28:101326
  284. Perrone M, Caroccia N, Genovese I, Missiroli S, Modesti L, Pedriali G, Vezzani B, Vitto VAM, Antenori M, Lebiedzinska-Arciszewska M, Wieckowski MR, Giorgi C, Pinton P (2020) The role of mitochondria-associated membranes in cellular homeostasis and diseases. Int Rev Cell Mol Biol 350:119-196
  285. Rimessi A, Pedriali G, Vezzani B, Tarocco A, Marchi S, Wieckowski MR, Giorgi C, Pinton P (2020) Interorganellar calcium signaling in the regulation of cell metabolism: A cancer perspective. Semin Cell Dev Biol 98:167-180
  286. Ferroni L, Zago M, Patergnani S, Campbell SE, Hébert L, Nielsen M, Scarpa C, Bassetto F, Pinton P, Zavan B (2020) Fluorescent Light Energy (FLE) Acts on Mitochondrial Physiology ImprovingWound Healing. Clinical Med 9:559
  287. La Morgia C, Maresca A, Amore G, Gramegna LL, Carbonelli M, Scimonelli E, Danese A, Patergnani S, Caporali L, Tagliavini F, Del Dotto V, Capristo M, Sadun F, Barboni P, Savini G, Evangelisti S, Bianchini C, Valentino ML, Liguori R, Tonon C, Giorgi C, Pinton P, Lodi R, Carelli V (2020) Calcium mishandling in absence of primary mitochondrial dysfunction drives cellular pathology in Wolfram Syndrome. Sci Rep 10:4785
  288. Morciano G, Patergnani S, Bonora M, Pedriali G, Tarocco A, Bouhamida E, Marchi S, Ancora G, Anania G, Wieckowski MR, Giorgi C, Pinton P (2020) Mitophagy in cardiovascular diseases. J Clin Med 9:892
  289. Rojas-Charry L, Calero-Martinez S, Morganti C, Morciano G, Park K, Hagel C, Marciniak SJ, Glatzel M, Pinton P, Sepulveda-Falla D (2020) Susceptibility to cellular stress in PS1 mutant N2a cells is associated with mitochondrial defects and altered calcium homeostasis. Sci Rep 10:6455
  290. Morganti C, Bonora M, Marchi S, Ferroni L, Gardin C, Wieckowski MR, Giorgi C, Pinton P*, Zavan B (2020) Citrate mediates crosstalk between mitochondria and the nucleus to promote human mesenchymal stem cell in vitro osteogenesis. Cells 9:1034 *corresponding author
  291. Simoes ICM, Morciano G, Lebiedzinska-Arciszewska M, Aguiari G, Pinton P, Potes Y, Wieckowski MR (2020) The mystery of mitochondria-ER contact sites in physiology and pathology: a cancer perspective. Biochim Biophys Acta (Mol Basis Dis) 1866(10):165834
  292. Rimessi A, Pozzato C, Carparelli L, Rossi A, Ranucci S, De Fino I, Cigana C, Talarico A, Wieckowski MR, Ribeiro CMP, Trapella C, Rossi G, Cabrini G, Bragonzi A, Pinton P (2020) Pharmacological modulation of mitochondrial calcium uniporter controls lung inflammation in cystic fibrosis. Sci Adv 6:eaax9093
  293. Marchi S, Retta SF, Pinton P (2020) Detection of p62/SQSTM1 Aggregates in Cellular Models of CCM Disease by Immunofluorescence. Methods Mol Biol 2152:417-426
  294. Marchi S, Giorgi C, Galluzzi L, Pinton P (2020) Ca2+ Fluxes and Cancer. Mol Cell 78:1055-1069
  295. Bonora M, Patergnani S, Ramaccini D, Morciano G, Pedriali G, Kahsay AE, Bouhamida E, Giorgi C, Wieckowski MR, Pinton P (2020) Physiopathology of the Permeability Transition Pore: Molecular Mechanisms in Human Pathology. Biomolecules 10:998
  296. Pedriali G, Morciano G, Patergnani S, Cimaglia P, Morelli C, Mikus E, Ferrari R, Gasbarro V, Giorgi C, Wieckowski MR, Pinton P (2020) Aortic valve stenosis and mitochondrial dysfunctions: clinical and molecular perspectives. Int J Mol Sci 21(14):4899
  297. Danese A, Marchi S, Vitto VAM, Modesti L, Leo S, Wieckowski MR, Giorgi C, Pinton P (2020) Cancer-related increases and decreases in calcium signaling at the Endoplasmic Reticulum-mitochondria interface (MAMs). Rev Physiol Biochem Pharmacol doi: 10.1007/112_2020_43
  298. Cabrini G, Rimessi A, Borgatti M, Lampronti I, Finotti A, Pinton P, Gambari R (2020) Role of Cystic Fibrosis Bronchial Epithelium in Neutrophil Chemotaxis. Front Immunol 11:1438
  299. Patergnani S, Guzzo S, Mangolini A, dell’Atti L, Pinton P, Aguiari G (2020) The induction of AMPK-dependent autophagy leads to P53 degradation and affects cell growth and migration in kidney cancer cells. Exp Cell Res 395:112190
  300. Missiroli S, Perrone M, Genovese I, Pinton P, Giorgi C (2020) Cancer metabolism and mitochondria: finding novel mechanisms to fight tumours. EBioMedicine 59:102943
  301. Patergnani S, Vitto VAM, Pinton P, Rimessi A (2020) Mitochondrial Stress Responses and “Mito-Inflammation” in Cystic Fibrosis. Front Pharmacol 11:581114
  302. Xue J, Patergnani S, Giorgi C, Suarez J, Goto K, Bononi A, Tanji M, Novelli F, Pastorino S, Xu R, Caroccia N, Dogan AU, Pass HI, Tognon M, Pinton P, Gaudino G, Mak TK, Carbone M, Yang H (2020) Asbestos induces mesothelial cell transformation via HMGB1-driven autophagy. Proc Natl Acad Sci USA 117(41):25543-25552
  303. Vezzani B, Carinci M, Patergnani S, Pasquin MP, Guarino A, Aziz N, Pinton P, Simonato M, Giorgi C (2020) The Dichotomous Role of Inflammation in the CNS: A Mitochondrial Point of View. Biomolecules 10(10):E1437
  304. Genovese I, Vezzani B, Danese A, Modesti L, Vitto VAM, Corazzi V, Pelucchi S, Pinton P, Giorgi C (2020) Mitochondria as the decision makers for cancer cell fate: from signaling pathways to therapeutic strategies. Cell Calcium 92:102308
  305. Manfredini F, Straudi S, Lamberti N, Patergnani S, Tisato V, Secchiero P, Bernardi F, Ziliotto N, Marchetti G, Basaglia N, Bonora M, Pinton P (2020) Rehabilitation Improves Mitochondrial Energetics in Progressive Multiple Sclerosis: The Significant Role of Robot-Assisted Gait Training and of the Personalized Intensity. Diagnostics (Basel) 10(10):E834
  306. Saliakoura M, Rossi Sebastiano M, Pozzato C, Heidel FH, Schnöder TM, Savic Prince S, Bubendorf L, Pinton P, Schmid RA, Baumgartner J, Freigang S, Berezowska SA, Rimessi A, Konstantinidou G (2020) PLCγ1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia. Nat Cell Biol 22(11):1382-1395
  307. Patergnani S, Danese A, Bouhamida E, Aguiari G, Previati M, Pinton P, Giorgi C (2020) Various Aspects of Calcium Signaling in the Regulation of Apoptosis, Autophagy, Cell Proliferation, and Cancer. Int J Mol Sci 21(21):E8323
  308. Vallese F, Catoni C, Cieri D, Barazzuol L, Ramirez O, Calore V, Bonora M, Giamogante F, Pinton P, Brini M, Calì T (2020) An expanded palette of improved SPLICS reporters detects multiple organelle contacts in vitro and in vivo. Nat Commun 11:6069
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  328. Danese A, Leo S, Rimessi A, Wieckowski MR, Fiorica F, Giorgi C, Pinton P (2021) Cell death as a result of calcium signaling modulation: a cancer-centric prospective. Biochim Biophys Acta Mol Cell Res 1868:119061
  329. Prill M, Karkucińska-Wieckowska A, Lebiedzińska-Arciszewska M, Morciano G, Charzyńska A, Dabrowski M, Pronicki M, Pinton P, Grajkowska W, Wieckowski MR (2021) Ras and ShcA protein expression patterns in pediatric brain tumors. J Clin Med 10:2219
  330. Modesti L, Danese A, Vitto VAM, Ramaccini D, Aguiari G, Gafà R, Lanza G, Giorgi C, Pinton P (2021) Mitochondrial Ca2+ Signaling in Health, Disease and Therapy. Cells 10:1317
  331. Missiroli S, Perrone M, Boncompagni C, Borghi C, Campagnaro A, Marchetti F, Anania G, Greco P, Fiorica F, Pinton P, Giorgi C (2021) Targeting the NLRP3 Inflammasome as a New Therapeutic Option for Overcoming Cancer. Cancers (Basel) 13(10):2297
  332. Fiorica F, Tebano U, Gabbani M, Perrone M, Missiroli S, Berretta M, Giuliani J, Bonetti A, Remo A, Pigozzi E, Tontini A, Napoli G, Luca N, Grigolato D, Pinton P, Giorgi C (2021) Beyond Abscopal Effect: A Meta-Analysis of Immune Checkpoint Inhibitors and Radiotherapy in Advanced Non-Small Cell Lung Cancer. Cancers (Basel) 13(10):2352
  333. Patergnani S, Bonora M, Ingusci S, Previati M, Marchi S, Zucchini S, Perrone M, Wieckowski MR, Castellazzi M, Pugliatti M, Giorgi C, Simonato M, Pinton P (2021) Antipsychotic drugs counteract autophagy and mitophagy in multiple sclerosis. Proc Natl Acad Sci U S A 118(24):e2020078118
  334. Patergnani S, Bonora M, Bouhamida E, Danese A, Marchi S, Morciano G, Previati M, Pedriali G, Rimessi A, Anania G, Giorgi C, Pinton P (2021) Methods to Monitor Mitophagy and Mitochondrial Quality: Implications in Cancer, Neurodegeneration, and Cardiovascular Diseases. Methods Mol Biol 2310:113-159
  335. Fiorito V, Allocco AL, Petrillo S, Gazzano E, Torretta S, Marchi S, Destefanis F, Pacelli C, Audrito V, Provero P, Medico E, Chiabrando D, Porporato PE, Cancelliere C, Bardelli A, Trusolino L, Capitanio N, Deaglio S, Altruda F, Pinton P, Cardaci S, Riganti C, Tolosano E (2021) The heme synthesis-export system regulates the tricarboxylic acid cycle flux and oxidative phosphorylation. Cell Rep 35(11):109252
  336. Morciano G, Vezzani B, Missiroli S, Boncompagni C, Pinton P, Giorgi C (2021) An Updated Understanding of the Role of YAP in Driving Oncogenic Responses. Cancers 13:3100
  337. Silvagni E, Missiroli S, Perrone M, Patergnani S, Boncompagni C, Bortoluzzi A, Govoni M, Giorgi C, Alivernini S, Pinton P, Scirè CA (2021) From Bed to Bench and Back: TNF-α, IL-23/IL-17A, and JAK-Dependent Inflammation in the Pathogenesis of Psoriatic Synovitis. Front Pharmacol 12:672515
  338. Bonora M, Kahsay A, Pinton P (2021) Mitochondrial calcium homeostasis in hematopoietic stem cell: Molecular regulation of quiescence, function, and differentiation. Int Rev Cell Mol Biol 362:111-140
  339. Lebreton S, Paladino S, Liu D, Nitti M, von Blume J, Pinton P, Zurzolo C (2021) Calcium levels in the Golgi complex regulate clustering and apical sorting of GPI-APs in polarized epithelial cells. Proc Natl Acad Sci U S A 118(33):e2014709118
  340. Morciano G, Patergnani S, Pedriali G, Cimaglia P, Mikus E, Calvi S, Albertini A, Giorgi C, Campo G, Ferrari R, Pinton P (2021) Impairment of mitophagy and autophagy accompanies calcific aortic valve stenosis favoring cell death and the severity of disease. Cardiovascular Research 10;cvab267
  341. Marracino L, Fortini F, Bouhamida E, Camponogara F, Severi P, Mazzoni E, Patergnani S, D’Aniello E, Campana R, Pinton P, Martini F, Tognon M, Campo G, Ferrari R, Vieceli Dalla Sega F, Rizzo P (2021) Adding a "Notch" to Cardiovascular Disease Therapeutics: A Micro-RNA-Bases Approach. Front Cell Dev Biol 9:695114
  342. Marchi S, Morroni G, Pinton P, Galluzzi L (2021) Control of host mitochondria by bacterial pathogens. Trends Microbiol S0966-842X(21)00237-7
  343. Novelli F, Bononi A, Wang Q, Bai F, Patergnani S, Kricek F, Haglund E, Suarez JS, Tanji M, Xu R, Takanishi Y, Minaai M, Pastorino S, Morris P, Sakamoto G, Pass HI, Barbour H, Gaudino G, Giorgi C, Pinton P, Onuchic JN, Yang H, Carbone M (2021) BAP1 forms a trimer with HMGB1 and HDAC1 that modulates gene × environment interaction with asbestos. Proc Natl Acad Sci U S A 30;118(48):e2111946118 In press
  344. Patergnani S, Missiroli S, Morciano G, Perrone M, Mantovani CM, Anania G, Fiorica F, Pinton P and Giorgi C (2021) Understanding the Role of Autophagy in Cancer Formation and Progression Is a Real Opportunity to Treat and Cure Human Cancers. Cancers 13(22), 5622
  345. Fiorica F, Gabbani M, Zaninelli M, Muraro M, Pinton P and Giorgi C (2021) A tailored approach in geriatric oncology: turning a problem into an opportunity for the elderly. Eur Rev Med Pharmacol Sci. 25(22):6831-6833
  346. Bonora M, Giorgi C and Pinton P (2021) Molecular mechanisms and consequences of mitochondrial permeability transition. Nat Rev Mol Cell Biol In press
  347. Vultaggio-Poma V, Falzoni S, Chiozzi P, Sarti AC, Adinolfi E, Giuliani AL, Sánchez-Melgar A, Boldrini P, Zanoni M, Tesei A, Pinton P, Di Virgilio F. (2021) Extracellular ATP is increased by release of ATP-loaded microparticles triggered by nutrient deprivation. Theranostics12(2):859-874
  348. Tarocco A, Natile M, Sarajlija J, Aldrovandi A, Pinton P, Ancora G (2021) Amplitude-integrated EEG recorded at 32 weeks postconceptional age. Correlation with MRI at term. J Perinato
  349. Morciano G, Rimessi A, Patergnani S, Vitto V.A.M, Danese A, Kahsay A.E, Palumbo L, Bonora M, Wieckowski M.R., Giorgi C, Pinton P (2022) Calcium dysregulation in heart diseases: Targeting calcium channels to achieve a correct calcium homeostasis. Pharmacol Res2022 Feb 4;106119
  350. Crouzier L, Danese A, Yasui Y, Richard EM, Liévens J, Patergnani  S, Couly S, Diez C, Denus M, Cubedo N, Rossel M, Thiry M, Su T, Pinton P, Maurice T, Delprat B (2022) Activation of the sigma-1 receptor chaperone alleviates symptoms of Wolfram syndrome in preclinical models. Sci Transl Med 14(631):eabh3763
  351. Bouhamida E, Morciano G, Perrone M,  Kahsay A, Della Sala M,  Wieckowski M R, Fiorica F, Pinton P, Giorgi C, Patergnani S (2022) The Interplay of Hypoxia Signaling on Mitochondrial Dysfunction and Inflammation in Cardiovascular Diseases and Cancer: From Molecular Mechanisms to Therapeutic Approaches. Biology 11(2):300
  352. Mangolini A, Rocca C, Bassi C, Ippolito C, Negrini M, Dell'Atti L, Lanza G, Gafà R, Bianchi N, Pinton P, Aguiari G (2022) Detection od disease-causing mutations in prostate cancer by NSG sequencing. Cell Biol Int.
  353. Ramaccini D, Pedriali G, Perrone M, Bouhamida E, Modesti L, Wieckowski MR, Giorgi C, Pinton P, Morciano G. (2022) Some Insights into the Regulation of Cardiac Physiology and Pathology by the Hippo Pathway. Biomedicines 10(3):726
  354. Morciano G, Pedriali G, Mikus E, Cimaglia P, Calvi S, Pavasini R, Albertini A, Ferrari R, Wieckowski MR, Giorgi C, Campo G, Pinton P. (2021) Similarities between fibroblasts and cardiomyocytes in the study of the permeability transition pore. Eur J Clin Invest. e13764
  355. Vezzani B, Carinci M, Previati M, Giacovazzi S, Della Sala M, Gafà R, Lanza G, Wieckowski MR, Pinton P, Giorgi C. (2022) Epigenetic Regulation: A Link between Inflammation and Carcinogenesis. Cancers 14(5):1221
  356. Karkucinska-Wieckowska A, Simoes ICM, Kalinowski P, Lebiedzinska-Arciszewska M, Zieniewicz K, Milkiewicz P, Górska-Ponikowska M, Pinton P, Malik AN, Krawczyk M, Oliveira PJ, Wieckowski MR. (2022) Mitochondria, oxidative stress and nonalcoholic fatty liver disease: A complex relationship. Eur J Clin Invest. 52(3):e13622
  357. Cabrini G, Rimessi A, Borgatti M, Pinton P, Gambari R (2022) Overview of CF lung pathophysiology. Curr Opin Pharmacol. 64:102214
  358. Tarocco A, Morciano M, Perrone M, Cafolla C, Ferrè C, Vacca T, Pistocchi G, Meneghin F, Cocchi I, Lista G, Cetin I, Greco P, Garani G, Stella M, Natile M, Ancora G, Savarese I, Campi F, Bersani I, Dotta A, Tiberi E, Vento G, Chiodin E, Staffler A, Maranella E, Di Fabio S, Wieckowski MR, Giorgi C, Pinton P (2022) Increase of Parkin and ATG5 plasmatic levels following perinatal hypoxic‐ischemic encephalopathy. Sci Rep. 12:7795
  359. Missiroli S, Giorgi  C, Pinton P (2022) The LRRC8C-STING-p53 axis in T cells: A Ca 2+ affair. Cell Calcium 2022 May 13;105:102596
  360. Fantinati A*, Morciano G*, Turrin G, Pedriali G, Pacifico S, Preti D, Albanese V, Illuminati D, Cristofori V, Giorgi C, Tremoli E, Pinton P*, Trapella C. (2022) Identification of small-molecule urea derivatives as PTPC modulators targeting the c subunit of F1/Fo-ATP synthase. Bioorg Med Chem Lett 72:128822 *corresponding author
  361. Patergnani S, Morciano G, Carinci M, Leo S, Pinton P, Rimessi R (2022) The "mitochondrial stress responses": the "Dr. Jekyll and Mr. Hyde" of neuronal disorders. Neural Regen Res (12):2563-2575
  362. Marchi S, Pinton P (2022) Mitochondria in the line of fire. Cell Death Differ 10.1038/s41418-022-01034-8
  363. Danese A*, Patergnani S*, Maresca A, Peron C, Raimondi A, Caporali L, Marchi S, La Morgia C, Del Dotto V, Zanna C, Iannielli A, Segnali A, Di Meo I, Cavaliere A, Lebiedzinska-Arciszewska M, Wieckowski MR, Martinuzzi  A, Moraes-Filho MN, Salomao SR, Berezovsky A, Belfort Jr R, Buser C, Ross-Cisneros FN , Sadun AA, Tacchetti C, Broccoli V, Giorgi  C, Tiranti  V, Carelli V and Pinton P (2022) Pathological mitophagy disrupts mitochondrial homeostasis in Leber's hereditary optic neuropathy. Cell Rep 40(3):111124
  364. Ferroni L, De Francesco F, Pinton P, Gardin C, Zavan B. Methods to isolate adipose tissue-derived stem cells. Methods Cell Biol. 2022;171:215-228.
  365. De Ventura T, Perrone M, Missiroli S, Pinton P, Marchetti P, Strazzabosco G, Turrin G, Illuminati D, Cristofori V, Fantinati A, Fabbri M, Giorgi C, Trapella C, Zanirato V (2022) Synthesis and NLRP3-Inflammasome Inhibitory Activity of the Naturally Occurring Velutone F and of Its Non-Natural Regioisomeric Chalconoids. Int J Mol Sci
  366. Perrone M, Raimondi E, Costa M, Rasetto G, Rizzati R, Lanza G, Gafà R, Cavallesco G, Tamburini N, Maniscalco P, Mantovani MC, Tebano U, Coeli M, Missiroli S, Tilli M, Pinton P, Giorgi C, Fiorica F. Inflammatory Microenvironment in Early Non-Small Cell Lung Cancer: Exploring the Predictive Value of Radiomics. Cancers (Basel). 2022 Jul 8;14(14):333
  367. Patergnani S, Giattino A, Bianchi N, Giorgi C, Pinton P, Aguiari G. The inhibition of MDM2 slows cell proliferation and activates apoptosis in ADPKD cell lines. Biol Cell. 2022 Sep 27.
  368. Perrone M, Patergnani S, Di Mambro T, Palumbo L, Więckowski M, Giorgi C, Pinton P. Calcium homeostasis in the control of mitophagy. Antioxid Redox Signal. 2022 Sep 16.
  369. Gabbani M, Giorgi C, Napoli G, Tebano U, Perrone MS, Missiroli S, Berretta M, Mandarà M, Zaninelli M, Luca N, Grigolato D, Muraro M, Rinaldi G, Pinton P, Fiorica F. Outcomes of Locally Advanced Rectal Cancer Patients Treated with Total Neoadjuvant Treatment: A Meta-Anaysis of Randomized Controlled Trials. Clin Colorectal Cancer. 2022 Sep 17:S1533-0028(22)00103-7
  370. Missiroli S, Perrone M, Gafà R, Nicoli F, Bonora M, Morciano G, Boncompagni C, Marchi S, Lebiedzinska-Arciszewska M, Vezzani B, Lanza G, Kricek F, Borghi A, Fiorica F, Ito K, Wieckowski MR, Di Virgilio F, Abelli L, Pinton P, Giorgi C. PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment. Cell Death Differ. 2022 Nov 30:1–13. doi: 10.1038/s41418-022-01095-9.
  371. Pedriali G, Ramaccini D, Bouhamida E, Wieckowski MR, Giorgi C, Tremoli E, Pinton P. Perspectives on mitochondrial relevance in cardiac ischemia/reperfusion injury. Front Cell Dev Biol. 2022 Dec 6;10:1082095.
  372. Costantino L, Ferrari S, Santucci M, Salo-Ahen OMH, Carosati E, Franchini S, Lauriola A, Pozzi C, Trande M, Gozzi G, Saxena P, Cannazza G, Losi L, Cardinale D, Venturelli A, Quotadamo A, Linciano P, Tagliazucchi L, Moschella MG, Guerrini R, Pacifico S, Luciani R, Genovese F, Henrich S, Alboni S, Santarem N, da Silva Cordeiro A, Giovannetti E, Peters GJ, Pinton P, Rimessi A, Cruciani G, Stroud RM, Wade RC, Mangani S, Marverti G, D'Arca D, Ponterini G, Costi MP. Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth. Elife. 2022 Dec 7;11:e73862.
  373. Bezzerri V, Gentili V, Api M, Finotti A, Papi C, Tamanini A, Boni C, Baldisseri E, Olioso D, Duca M, Tedesco E, Leo S, Borgatti M, Volpi S, Pinton P, Cabrini G, Gambari R, Blasi F, Lippi G, Rimessi A, Rizzo R, Cipolli M. SARS-CoV-2 viral entry and replication is impaired in Cystic Fibrosis airways due to ACE2 downregulation. Nat Commun. 2023 Jan 10;14(1):132.
  374. Sassano ML, van Vliet AR, Vervoort E, Van Eygen S, Van den Haute C, Pavie B, Roels J, Swinnen JV, Spinazzi M, Moens L, Casteels K, Meyts I, Pinton P, Marchi S, Rochin L, Giordano F, Felipe-Abrio B, Agostinis P. PERK recruits E-Syt1 at ER-mitochondria contacts for mitochondrial lipid transport and respiration. J Cell Biol. 2023 Mar 6;222(3):e202206008
  375. Albanese V, Missiroli S, Perrone M, Fabbri M, Boncompagni C, Pacifico S, De Ventura T, Ciancetta A, Dondio G, Kricek F, Pinton P, Guerrini R, Preti D, Giorgi C. Novel Aryl Sulfonamide Derivatives as NLRP3 Inflammasome Inhibitors for the Potential Treatment of Cancer. J Med Chem. 2023 Mar 27.
  376. Turrin G, Lo Cascio E, Giacon N, Fantinati A, Cristofori V, Illuminati D, Preti D, Morciano G, Pinton P, Agyapong ED, Trapella C, Arcovito A. Spiropiperidine-Based Oligomycin-Analog Ligands To Counteract the Ischemia-Reperfusion Injury in a Renal Cell Model. J Med Chem. 2024 Jan 11;67(1):586-602
  377. Chiara Mazziotta, Giada Badiale, Christian Felice Cervellera, Giampaolo Morciano, Giulia Di Mauro, Antoine Touzé, Paolo Pinton, Mauro Tognon, Fernanda Martini, John Charles Rotondo. All-trans retinoic acid exhibits anti-proliferative and differentiating activity in Merkel cell carcinoma cells via retinoid pathway modulation. JEADV. 2024.
  378. Pasquale Mone, Esther Densu Agyapong, Giampaolo Morciano, Stanislovas S. Jankauskas, Antonio De Luca, Fahimeh Varzideh, Paolo Pinton, Gaetano Santulli. Dysfunctional mitochondria elicit bioenergetic decline in the aged heart. JCA. 2024.
  379. Kubat GB, Bouhamida E, Ulger O, Turkel I, Pedriali G, Ramaccini D, Ekinci O, Ozerklig B, Atalay O, Patergnani S, Nur Sahin B, Morciano G, Tuncer M, Tremoli E, Pinton P. Mitochondrial dysfunction and skeletal muscle atrophy: Causes, mechanisms, and treatment strategies. Mitochondrion. 2023 Sep;72:33-58.
  380. Bouhamida E, Morciano G, Pedriali G, Ramaccini D, Tremoli E, Giorgi C, Pinton P, Patergnani S. The Complex Relationship between Hypoxia Signaling, Mitochondrial Dysfunction and Inflammation in Calcific Aortic Valve Disease: Insights from the Molecular Mechanisms to Therapeutic Approaches. Int J Mol Sci. 2023 Jul 5;24(13):11105
  381. Di Mambro T, Pellielo G, Agyapong ED, Carinci M, Chianese D, Giorgi C, Morciano G, Patergnani S, Pinton P, Rimessi A. The Tricky Connection between Extracellular Vesicles and Mitochondria in Inflammatory-Related Diseases. Int J Mol Sci. 2023 May 3;24(9):8181.